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Cytostatic colchicine is widely used in the treatment of Familial Mediterranean fever, but it has several side effects. For finding new, more effective drugs with higher affinity and diminishside effects we carried out virtual screening of potential inhibitors of the main target of colchicine, the polymerization of tubulin by evaluating affinity 25745 compounds, structurally related to the colchicine. We have identified 11 commercially available compounds with higher affinity to tubulin. Compounds with highest binding scores include trimethoxybenzene and its derivatives; these compounds bind to the same site in similar orientation. Information provided can form the basis for design of new cytostatics.

Virtual electrophoresis in proteomics can be used to search localization of proteins and their proteoforms (especially those existing in low concentrations), to identify proteoforms found in experiments etc. Although the problem of predicting the isoelectric point is well studied, the need of electrophoretic shift correction is usually ignored. Researchers simply use the brutto molecular weight of the protein. In this study four data sets taken from the literature sources and the SWISS-2DPAGE database have been used to build correction equations for prediction of the electrophoretic shift (123, 72, 118 and 470 points, respectively). Two groups of models were built. The first model was based on the amino acid composition of proteins, the second one, on analysis of parameters calculated by amino acid sequences (theoretical molecular weight, hydrophobicity, charge distribution, ability to form helix structures). The coefficient of determination ranged from 0.35 to 0.75 in each single set, but cross-prediction between samples did not gave satisfactory results. At the same time, the direction of correction was predicted correctly in 74% of cases. After combining of the samples and dividing pooled data into 2 representative sets, the coefficient of determination during in the process of learning ranged from 0.44 to 0.51, and R2 of predictions were not less than 0.39. The direction of correction was predicted correctly in 80% of cases. This prediction models have been integrated into the program pIPredict v.2, freely available at http://www.ibmc.msk.ru/LPCIT/pIPredict.

Aim: To assess the effectiveness of neuropsychological computer programs in comparison with entertainment computer games., Material and Methods: Patients (n=68), aged 40-65 years, were randomized into three groups: an intervention group (neuropsychological computer programs), an active control group (entertaining computer games), a passive control group (conventional treatment)., Results: An analysis of the coefficient of effectiveness showed significant improvements in the intervention group comparing with the passive control group (MoCA, MMSE, Schulte test) and the active control group (MoCA)., Conclusion: Neuropsychological computer programs confirmed their effectiveness for recovery of post stroke cognitive impairments comparing with conventional treatment and entertainment computer games as well.

Aim: The objective of the present study was to elaborate the method for the evaluation of the fine motor activity of the wrist in the patients presenting with wrist movement disorders resulting from central hemiparesis and to demonstratee the reliability of such method through the calculation of the standard error of measurements and minimal the detectable change (MDC95%)., Material and Methods: The study population was comprised of 42 patients who had undergone ischaemic stroke and suffered from the impairment of the upper limb functions . The deficit of the fine motor skills was estimated with the use of the original multi-touch diagnostic technique. The results of the assessment were compared with those of the measurement of upper limb motor activity based on the validated scales, such as the Fugl-Meyer Assessment (FMA) scale and the Nine Hole Peg Test (PHT)., Results: The study with the application of the multi-touch method for diagnostics of the fine motor skills has demonstrated the high internal consistency of the measurements, with the Cronbach's Alpha Reliability Coefficient amounting to 0.98. The re-test reliability was high, with the ICC=0.98 (95% CI 0.97-0.99). The Spearman rank-order correlation with the locomotion scale estimates gave evidence of the good associative links, with the Fugl-Meyer Assessment scale correlation coefficient making 0.55-0.66 and the Nine Hole Peg Test findings being -0.7. The Minimal Detectable Change (MDC95%) for the multi-touch method was found to be 12.67%., Conclusion: The objective diagnostics of the fine motor skill disturbances with the use of the original multi-touch method has demonstrated its high reliability and a high degree of correlation with the estimates obtained with the application of the modern validated scales in the patients who had undergone ischaemic stroke. Therefore, this method can be recommended for clinical use.

Pathology is one of the most dynamically developed medical specialties. The wide spread of whole-slide imaging systems has leaded to the development of microscopic image analysis software. This review shows the possibilities of these programs and their role in the routine work of a pathologist.

In this work, information relating to charge states of biomolecule ions in solution obtained using the electrospray ionization mass spectrometry of different biopolymers is analyzed. The data analyses have mainly been carried out by solving an inverse problem of calculating the probabilities of retention of protons and other charge carriers by ionogenic groups of biomolecules with known primary structures. The approach is a new one and has no known to us analogues. A program titled "Decomposition" was developed and used to analyze the charge distribution of ions of native and denatured cytochrome c mass spectra. The possibility of splitting of the charge-state distribution of albumin into normal components, which likely corresponds to various conformational states of the biomolecule, has been demonstrated. The applicability criterion for using previously described method of decomposition of multidimensional charge-state distributions with two charge carriers, e.g., a proton and a sodium ion, to characterize the spatial structure of biopolymers in solution has been formulated. In contrast to known mass-spectrometric approaches, this method does not require the use of enzymatic hydrolysis or collision-induced dissociation of the biopolymers.

On the purpose to detect in EEG specific patterns associated with any verbal performance the gamma activity were investigated. The technique which allows the subject to initiate the mental pronunciation of words and phrases (inner speech) was created. Wavelet analysis of EEG has been experimentally demonstrated that the preparation and implementation stages are related to the specific spatio-temporal patterns in frequency range 64-68 Hz. Sustainable reproduction and efficient identification of such patterns can solve the fundamentally problem of alphabet control commands formation for Brain Computer Interface and Brain to Braine Interface systems.

The M680I and M694V mutations located in the B30.2 pyrin domain are responsible for the manifestation of the most common forms of Familial Mediterranean fever. It is well known that a malfunction of the pyrin-caspase-1 complex is the main cause of inflammation in FMF. The purpose of this study was to identify possible changes in the tertiary structure of mutated B30.2 domain and to determine their potential consequences in the formation of the pyrin-caspase-1 complex. Using computer modeling, it was found that the above mutations change the tertiary structure of B30.2 domain, causing shifts of binding sites and altering the energy of interaction between B30.2 and caspase-1.

The article considers application of technology of analysis of cytological slides in external quality control of clinical diagnostic laboratories. The advantages of virtual slides are demonstrated against other applied technologies of external evaluation of quality i.e. slide plate and digital micro-photography. The conditions of formation of virtual slides for external evaluation of quality of clinical diagnostic laboratories. The technology of their application is described. The success of practical application of considered technology in the Federal system of external evaluation of quality is emphasized.

We used the ratio of spectral characteristics of the EEG alpha and beta frequencies recorded in 10 apparently healthy subjects (university students) to control a computer cursor in the graphic interface in three scenarios with the use of neurofeedback. Our results showed that the scenario which uses the power of alpha- and beta-2-frequencies provided the highest accuracy and the best speed control. The parameters of beta-1-frequency were found to be less effective since an increase or a decrease of their power could result from an increase or a decrease of the power of alpha- and beta-2-frequencies. However, the subjects got the skill of cursor control with efficiency of 81%, gradually growing during learning, after a relatively short period of time (5 trainings per 2 weeks).

The experiments showed that pilot's perception of symbolic information on the helmet-mounted display (HMD) depends on type of HMD (mono- or binocular), and structural complexity of the background image. Complex background extends time and increases errors in perception, particularly when monocular HMD is used. In extremely complicated visual situations (symbolic information on a background intricately structured by supposition of a TV image on real visual environment) significantly increases time and lowers precision of symbols perception no matter what the HMD type.

Methionine γ-lyase [EC 4.4.1.11] participates in a methionine catabolism at a number of bacteria and protozoa eukaryotes, including pathogenic microorganisms. Lack of this enzyme at mammals allows consider it as a perspective target for rational antibacterial drug design. Currently in medical practice there are no the preparations based on an inhibition of methionine γ-lyase activity. We present results of the search of potential inhibitors of the enzyme using the NMR screening techniques based on identification of compounds, which able to bind specifically to their biological target. Study included a stage of in silico virtual screening of the library of commercially available compounds and subsequent experimental selection of the leading compounds, capable to interact with enzyme. Identification of binding was carried out by means of saturation transfer difference (STD) spectroscopy and WaterLOGSY technique. At the final stage the experimental assessment of inhibiting ability of the selected compounds in the reaction of γ-elimination of L-methionine catalyzed by methionine γ-lyase was carried out. Binding constants of two leading compounds were determined using the WaterLOGSY method. The research expands structural group of potential inhibitors of methionine γ-lyase and allows approach to the design of the inhibitors with higher efficacy.

The functional interaction between prefrontal cortex and other cortices was analyzed during the pre-stimulus period in the task in which human subjects (n = 36) were asked to recognize a set of incomplete images of different degree of fragmentation. The imaginary part of the complex-valued coherency was used to measure a strength of inter-area coupling at the alpha-rhythm frequency. Based on the analysis of individual responses the two equal sub-groups (n = 13) showing the lowest and highest recognition scores were extracted from the whole group of subjects. It is shown that the pattern of the functional cortico-cortical interactions as well as the direction of its' changes differ in the two sub-groups. In those subjects who successfully solve the cognitive task, the changes in functional connectivity indices in the situation of focused attention are most pronounced in the right hemisphere if stimulus-to-come would not be recognized. Period preceding recognized stimulus is characterized by the increased cortico-cortical coupling in the left hemisphere. In that sub-group, the values of imaginary part of alpha-coherency show the growth in both hemispheres when the period of focused attention is compared against the period of nonspecific attention. On the contrary, the similar comparison for the sub-group of the least successful subjects shows the imaginary coherency decreases in both hemispheres. These results suggest the constructive role of the alpha-rhythm in functional assembling the prefrontal cortex during the period that precedes the recognition of incomplete images.

The traveling wave trajectories connected with the movements of the right hand were revealed. Above sensomotor cortex 28 electrodes were set as a rectangle--4 rows with 7 electrodes in each one. 2D center-out reaching task was used. The target appeared on the screen edge through the random intervals 0.5-2.5 s equiprobably at the left, on the right, from above or from below. The task was to touch the target with the joystick-operated cursor displacing the cursor in one of the sides from the center to edge. EEG from the target occurrence till cursor contact with it was analyzed. Leading on phase of spontaneous EEG waves in the local area of the left sensomotor cortex and in the centre of back-parietal cortex during cursor movement downwards (the hand with joystick moves to oneself) comparing to rest state and movements in three other directions is revealed. The over time smoothing of data concerning phase alignment reveals hidden constant components in EEG resembling evoked potentials.

Comparative experimental study covered speech characteristics in speakers with normal hearing and pilot speakers with neurosensory deafness. Evaluation criteria were duration, speech volume, spectral characteristics of words. Main difference of speach in pilot speakers with hearing disorders was higher variability of its characteristics.

Objective: To assess the capabilities of and the first experience with an ACUSON S2000 automated breast volume scanner (ABVS) (Siemens, Germany) to detect abnormal breast lumps., Material and Methods: Examinations were made in 97 patients who underwent radiological studies encompassing digital mammography, B-mode ultrasonography of the breast, and its pathomorphological examination. All the cases were classified according to the BI-RADS system. Abnormal breast lumps (BI-RADS 1) were not found in 27 cases; clearly defined benign masses (BI-RADS 2) were detected in 18, and pathomorphologically verified breast cancer (BC) (BI-RADS 5) in 29 cases. All the patients also underwent breast ultrasonography using an ACUSON S2000 system (Siemens, Germany). The results of ABVS examination were compared with those of standard comprehensive breast radiologic examination. Having no preliminary additional information on each patient, an independent expert--a radiologic diagnostician appraised all ultrasound scanning data at a special review station., Results: The sensitivity of the automated scanning assay in detecting breast abnormalities was 100%; its specificity and diagnostic accuracy were 40 and 88%, respectively. The independent expert established the diagnosis of BC in 26 (90%) of the 29 cases. According to the results of automated breast scanning, pre-examination using a set of radiation methods was recommended in 66 (66%) cases. The hyperdiagnosis was 24%., Conclusion: Taking into consideration the fact that none of the BC case was overlooked, the first experience with ABVS showed encouraging results and the need for further clinical tests of the automated breast scanning system.

"GelAnalyzer" software, which is used to identify and correctly compare DNA fingerprints consisting of a large number of discrete bands, has been developed by the project to study the quantitative changes in DNA polymorphism patterns in animals and humans exposed to gamma radiation. The actual capabilities of this program are much broader and include the possibility to analyze the images of any multicomponent gels containing fragments of DNA, RNA, and proteins. This software product runs on Windows. "GelAnalyzer" allows one to analyze gel images obtained by a scanner, camera, or digital camera and ensures the visual control of the identification and comparative analysis of bands; it also makes it possible to take into account the bands that are poorly identified automatically and exclude the artifacts (incidental marks) on images. The operation of "GelAnalyzer" software is based on the determination of the values of normalized coordinates of bands with allowance for the relative electrophoretic mobility (Rf) of PCR products and comparison of their spectra (set of bands in gel lanes) to reveal the similarities or differences in their components with subsequent statistical data processing and display the results of the analysis.

The paper examines neurophysiological basis for development and performance of brain-computer interface (BCI) that permits cerebral activity alone to control computers or other external technical devices. BCI based on the discrimination of EEG patterns related to an imagery of extremity movements is considered. The problem of BCI application to restoring of motor functions in patients with motor disabilities is discussed.

The mechanisms underlying the process of motor imagery are similar to the motor control mechanisms. It can be used for motor learning in patients with movement disorders. Motor imagery may be the only one method for recovery of motor function in patients with severe paresis. It was the prerequisite of increased scientist interest in motor imagery during last decade. Brain-computer interface technology can support the motor imagery trainings.

The P300 brain-computer interface (BCI) is currently the most efficient BCI. This interface is based on detection of the P300 wave of the brain potentials evoked when a symbol related to the intended input is highlighted. To increase operation speed of the P300 BCI, reduction of the number of stimuli repetitions is needed. This reduction leads to increase of the relative contribution to the input symbol detection from the reaction to the first target stimulus. It is known that the event-related potentials (ERP) to the first stimulus presentations can be different from the ERP to stimuli presented latter. In particular, the amplitude of responses to the first stimulus presentations is often increased, which is beneficial for their recognition by the BCI. However, this effect was not studied within the BCI framework. The current study examined the ERP obtained from healthy participants (n = 14) in the standard P300 BCI paradigm using 10 trials, as well as in the modified P300 BCI with stimuli presented on moving objects in triple-trial (n = 6) and single-trial (n = 6) stimulation modes. Increased ERP amplitude was observed in response to the first target stimuli in both conditions, as well as in the single-trial mode comparing to triple-trial. We discuss the prospects of using the specific features of the ERP to first stimuli and the single-trial ERP for optimizing the high-speed modes in the P300 BCIs.

This paper proposes Bayesian approach to classification of EEG patterns on the basis of imaginary movements of extremities based on analysis ofcovariance matrices of native EEG recordings. An efficacy of a Brain-Computer Interface (BCI) based on the proposed classifier is evaluated. Bayesian classifier is shown to be competitive with the MCSP (Multiclass Common Spatial Patterns) classifier known from the literature as one of the efficient variant for BCI implementation. The influence of eye movement and blinking artifacts on the BCI performance is investigated. It is shown that the presence of such artifacts does not affect the classification accuracy.

The experience of single institution of 43 robotic-assisted operations in the abdomen and retroperitoneal space has been analyzed. The problem of port placement conditioned the preoperative computed 3D-modelling of the operative course. The procedure allowed to optimize the movements of the robotic manipulators, decrease the risk of organ injury and overall incidence of intra- an postoperative complications.

The problems pertaining to the safety of information and communication technologies used in the spheres of education and leisure activities of children and adolescents are discussed. The relevant risk factors are identified. Results of physiological and hygienic studies for substantiating regulations of continuous work with a personal computer are presented taking into account the children's age and hygienic requirements to electronic teaching aids.

An interactive information program has been elaborated for the cytological diagnosis of colonic and rectal diseases. Images of cytological specimens obtained at colonoscopy in patients with various colonic and rectal diseases are entered into the database of the interactive program. The information program has been tested by medical cytologists and clinical diagnostic laboratory physicians.

There are several software packages that allow the user to model main types of biopolymers with molecular dynamics methods. However, the work with most of these packages is quite complicated, especially for non-experts in computational structural biology. We have created GUI-BioPASED, a Web-based GUI for molecular dynamics software BioPASED, to partially automate the tasks usually responsible for the majority of errors. GUI-BioPASED creates a task as a standalone executable file, which can be exported to the client side, and ensures its execution. A user-friendly cross-platform interface is created that performs data check, reports errors and hints at possible ways to correct them. BioPASED, a general purpose molecular dynamics program, and GUI-BioPASED along with their typical example of usage are described.

The authors provide a rationale for mathematically processing medical images for the progression of a medical diagnostic process. The tools made by the real-time conveyor 2D processing and visualization technology are proposed for work with medical images. The results of conveyor 2D processing of medical images as graphical presentations are given.

The advantages and disadvantages of software packages IGL Trace and 3D-Viewer for brain microanatomy 3D reconstruction (on the basis of stereotaxic brain atlases) were described. The algorithm use the technology of 3D-reconstruction of serial brain sections. The 3-D models of brain anatomical structures may be helpful in solving scientific problems and performing educational tasks.

In 12 adult healthy subjects we studied Brain-Computer-Interface recognition of different intended letters by the square of P300 wave in the averaged VEP. Horizontal and vertical spatial gradient of this square was studied as well as tuning acuteness of visual attention to a significant letter. High acuteness of this tuning was found (width of the tuning curve at its half height was equal to 1.6 grad) independent of the letter position on the letter matrix. Horizontal and vertical gradient of P300 were found to be very similar, but in the half of cases the first one revealed some kind of the "lateral inhibition": decrease of P300 square for the columns neighboring to the meaningful one. Tuning acuteness was found to be reliable and directly interrelated with P300 square. The data are discussed in relation to selectivity of the local visual attention.

Multipurpose modular software for an analog interface based on Lcard 761 is considered. Algorithms for pipeline processing of medical signals under Windows with dynamic control of computational resources are suggested. The software consists of user-friendly completable modifiable modules. The module hierarchy is based on object-oriented heritage principles, which make it possible to construct various real-time systems for long-term detection, processing, and imaging of multichannel medical signals.

Method for the restoration of self-service ability in patients with tetraplegia was proposed. The use of the elaborated computer controlled device in creases the efficacy of rehabilitation. A basic realization of technical facilities and software can be further developed. In particular, the plan is drawn to expand the software functional for the possibility of prompt input of the required word from the dictionary. Application of this technology has shown to give a possibility toa great number of handicapped people with limitations in using a computer and thus realizing their intellectual potential in education, work and leisure to restore their self-service ability. A significantsocial and economic effect from the introduction of this technology into practice is expected.

In four adult healthy subjects in 18 experiments, we studied Brain-Computer-Interface recognition of different intended words by P300 wave in the VEP. The set of optimal characteristics of visual stimulation which rise reliability of recognition up to 100 %, as well as effective registration locus (Pz) were determined. It was found that the best processing criteria for letter recognition were: P300 square and superposition of all three criteria (P300 amplitude, square and covariation coefficient).

The authors studied influence of new computer device--video helmet--on visual functions of children, adolescents and adults.

The intraoperative navigation computer system Stealth Station is an effective technique of stereotactic guidance during endoscopic endonasal interventions. Use of navigation allows performance of a radical operation without damaging basic anatomical structures of the base of the skull (vision nerve, cribriform lamina, internal carotid arteries, cavernous sonus, etc.). In rhinosurgery, Stealth Station is indicated in borderline pathology of the paranasal sinuses and base of the skull. Ten cases of patients with combined pathology of the paranasal sinuses and base of the skull, cases of endoscopic endonasal removal of the lesions of the base of the skull and foreign bodies with application of the navigation system are reported.

A method is suggested for the interactive input, conversion and presentation of data about the structure of irradiated organism preset as Data Reference Planes (DRP). The possibility to build a library of DRP and the simplicity of their adjustment to each disease case witness to that the method of input, storage, conversion and presentation of data about the irradiated organism is promising in tumor radiotherapy.

The paper contains a description of electroencephalography (EEG) photostimulator for examining the induced cerebral potentials. The device was designed to function within the EEG computer complexes; a high-intensity irradiation LED matrix is used as the light source. The 1.1 USB control bus serves as the communication interface; there is an extra external synchronization bus. It is possible to preset the frequency, brightness, on-off time ratio and pattern of light stimuli. A library of application programmer is supplied to monitor the photostimulation.

Between 1998 and 2002, 256 tomographic investigations of the abdominal aorta were performed. Aortic aneurysms were identified in 29 (11.3%) patients. Computed tomographic angiography (CTA) was provided to 16 patients 4 patients were examined by an electron-radiation tomograph, 6 by a spiral tomograph, 6 by a multispiral tomograph, and 13 patients underwent magnetic resonance angiography (MRA), with contrast enforcement. Two- and three-dimensional reconstructions of CT- and MR-angiograms were accomplished using special computerized working stations. Good quality MR- or CT- angiograms were obtained in all the patients examined. Interpretation of the angiograms did not cause noticeable difficulties. None of the patients required conventional contrast angiography. The investigations have demonstrated the benefits of multispiral CTA recognized as the method of choice for the diagnosis of aortic aneurysms. Of the 29 patients with the verified diagnosis of aneurysm of the abdominal aorta, aneurysms in 26 subjects were located in the infrarenal aorta. Of these, 5 patients were identified to have an aneurysm extending to the iliac arteries. In two patients, aneurysms extended to the renal arteries or to the suprarenal segment. A thoracoabdominal aneurysm (type III) was revealed in one patient. Associated aneurysm and occlusive lesions of lower extremity arteries (iliac, femoral) were present in 15 (51.7%) cases. In the majority of cases (89.7%), aneurysms ran an uncomplicated course. The complications encountered by us consisted in incomplete (intramural) rupture (2 patients) and dissection (one patient). 22 patients were operated on. Comparison of the intraoperative revision data with the results of preoperative CT and MR angiography has established that the sensitivity of the tomographic methods for the diagnosis of aneurysms was 95.7% and specificity 99%. With an accuracy of up to 2-3 mm there were determined the size of aneurysms, the distance to the renal arteries, the diameter of the proximal and distal "neck", the extension of aneurysms to the iliac arteries, the presence of occlusive lesions of lower extremity arteries. CT and MR angiography with bolus contrast enforcement are safe and noninvasive methods for the diagnosis of aortic aneurysms. They have the high information content and thus allow to plan surgical (and possibly endovascular) interventions without the use of conventional contrast angiography.

Experience of spiral computed tomography with bolus contrast enhancement and subsequent 3D-reconstruction of picture for virtual modeling of surgeries is presented. The method was used in 204 patients with tumors and diseases of the liver, pancreas, spleen, kidneys, adrenal glands, parapapillary diverticula of the duodenum, coarctations and aneurysms of aorta, extraorganic tumors of the retroperitoneal cavity and neck. Coincidence of virtual and real types of surgeries reached 75-92.8% depending on the disease and clinical situation. Perspectives of 3D-reconstruction for evaluation of normal and pathologic anatomic features in an individual patient, choice of an optimal surgical variant, prognosis of possible complications and their prophylaxis are demonstrated. Integration of surgeon's and radiologist's thinking is very important for correct diagnosis and surgical policy.

Aim: To elaborate an innovating computer learning system allowing experienced doctors to share their knowledge with beginning physicians; to apply a computer expert system in teaching interns to detect pulmonary artery thromboembolism (PAT) with emphasis on PAT risk factors and symptoms, on fixation of diagnostic skills., Material and Methods: The latest achievements in the field of artificial intellect served the basis for design of OSTELA educational computer system which operates with decisive rules of a highly skilled cardiologist. In this system interns study PAT diagnosis without a direct contact of the teacher with a learner. The computer system and its operation are described., Results: Skills of PAT diagnosis were taught to 48 interns. The number of correct answers to the control test increased by 30%, on the average., Conclusion: The proposed computer learning system OSTELA was successfully tried in clinics (pilot trials) and is recommended for postgraduate education of physicians.

Clinical aspects of creating a software system for simulation and prediction of operative interventions and hearing function changes are considered. The system will make simulation and prediction transparent and convenient for the user. The technical challenge is to create mediation languages which enforce rigorous mathematical computation while supporting intuitive behaviour. The prevalent textual interface of command lines and pull-down menus is replaced by physical behaviour within an environment. The system is based on new possibilities of computer-integrated environments for problem solving such as virtual environments and it will be presented in a form of a virtual operating room. The following aspects are taken into consideration: a model of the middle ear, database for existing methods of operative interventions, x-ray and computed tomography imaging of the temporal bone, determination and localization of otosclerosis foci, modeling and determination of acoustic parameters for transplantation materials, simulation and prognosis of potential complications.

The paper describes a new method for organizing an ultrasound angioplastic process. Computed technology makes it possible to control acoustic parameters during sonication and to analyze them. The system includes an ultrasound apparatus, a computer with a special interface, which is called an "electronic assistant".

At present, personal computers (PC) are most available multimedia devices and used in the design of medical complexes. A problem occurs while choosing a device PC interface. The paper considers a USB interface and the use of its based computer medical complexes. A lot of advantages provided by the new interface, low cost and high efficiency make it possible to design up-to-date devices having high consumer qualities.