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Your search keyword '"Toxoplasmosis, Cerebral blood"' showing total 3 results
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3 results on '"Toxoplasmosis, Cerebral blood"'

1. [Use of immunological and molecular biological methods to diagnose cerebral toxoplasmosis in HIV infection].

Author

Gubareva EV, Goncharov DB, Domonova ÉA, Sil'veĭstrova OIu, Peregudova AB, Tishkevich OA, Ievleva ES, Kobets NV, and Shipulina OIu

Subjects
Adult, Antibodies, Protozoan cerebrospinal fluid, Brain parasitology, Brain virology, Coinfection, DNA, Protozoan cerebrospinal fluid, Disease Progression, Female, HIV Infections blood, HIV Infections cerebrospinal fluid, HIV Infections virology, Humans, Immunoassay, Immunoglobulin A blood, Immunoglobulin A cerebrospinal fluid, Immunoglobulin G blood, Immunoglobulin G cerebrospinal fluid, Immunoglobulin M blood, Immunoglobulin M cerebrospinal fluid, Magnetic Resonance Imaging, Male, Middle Aged, Polymerase Chain Reaction, Toxoplasma immunology, Toxoplasmosis, Cerebral blood, Toxoplasmosis, Cerebral cerebrospinal fluid, Toxoplasmosis, Cerebral parasitology, Antibodies, Protozoan blood, Brain pathology, DNA, Protozoan blood, HIV, HIV Infections pathology, Toxoplasma isolation & purification, Toxoplasmosis, Cerebral diagnosis
Abstract

Cerebral toxoplasmosis is one of the leading causes of neurologic diseases with high mortality rates in patients with HIV infection. Invasion was difficult to diagnose for a number of objective reasons. The objective of the investigation was to determine the clinical sensitivity of different laboratory techniques as both a single study and their various combinations to verify the diagnosis of cerebral toxoplasmosis in HIV-infected patients. Blood and cerebrospinal fluid were tested in 51 patients with Stage 4B HIV infection (AIDS) with the verified diagnosis of cerebral toxoplasmosis. Separate determination of specific antibodies of IgG, IgM, IgA and toxoplasma DNA in the blood and cerebrospinal fluid was shown to have an insufficient clinical sensitivity (37.3-68.6%). The benefits of various combinations of immunological and molecular biological assays enhancing the diagnostic efficiency up to 76.5-96.1% are demonstrated.

Published
2013

2. [Cerebral toxoplasmosis in the pattern of secondary CNS involvements in HIV-infected patients in the Russian federation: clinical and diagnostic features].

Author

Ermak TN, Peregudova AB, Shakhgil'dian VI, and Goncharov DB

Subjects
Adult, Brain microbiology, Brain parasitology, Brain virology, Coinfection, Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections pathology, Cytomegalovirus Infections virology, Disease Progression, Female, HIV Infections epidemiology, HIV Infections virology, Humans, Magnetic Resonance Imaging, Male, Russia epidemiology, Toxoplasma isolation & purification, Toxoplasmosis, Cerebral blood, Toxoplasmosis, Cerebral epidemiology, Toxoplasmosis, Cerebral parasitology, Tuberculosis, Pulmonary epidemiology, Tuberculosis, Pulmonary microbiology, Tuberculosis, Pulmonary pathology, Antibodies, Protozoan blood, Brain pathology, HIV, HIV Infections pathology, Immunoglobulin G blood, Toxoplasmosis, Cerebral pathology
Abstract

The incidence of cerebral toxoplasmosis (CT) among all brain involvements was determined in patients with Stage 4B HIV infection (AIDS) in 2003-2009. Clinical and laboratory parameters were estimated in 156 patients to reveal diagnostic criteria. As a result, CT was shown to be a leading cause of neurologic diseases in patients with late-stage HIV infection (34.7% of cases of brain involvement). In 11.5%, it took place as a generalized process. CT concurrent with cytomegalovirus infection, tuberculosis, or other secondary lesions was frequently diagnosed. Of importance in the diagnosis of CT are magnetic resonance imaging results in addition to basic, clinical data that can assume this diagnosis. The high and moderate serum concentrations of T.gondii IgG are of diagnostic value, which may be used as an auxiliary method to verify the diagnosis.

Published
2013

3. [Toxoplasmosis in HIV infection: invasion reactivation criteria].

Author

Goncharov DB, Gubareva EV, Kobets NV, Domonova EA, and Ievleva ES

Subjects
Antibodies, Protozoan immunology, Biomarkers analysis, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes pathology, Coinfection, HIV physiology, HIV Infections blood, HIV Infections immunology, Humans, Immunoglobulin G blood, Immunoglobulin G immunology, Magnetic Resonance Imaging, Recurrence, Toxoplasma physiology, Toxoplasmosis, Cerebral blood, Toxoplasmosis, Cerebral immunology, Antibodies, Protozoan blood, HIV Infections virology, RNA, Protozoan blood, Toxoplasma pathogenicity, Toxoplasmosis, Cerebral diagnosis, Toxoplasmosis, Cerebral parasitology
Abstract

Contemporary representation of toxoplasmosis reactivation criteria in HIV infection is generalized. Significance of the issue is justified: toxoplasmosis is a leading neurological pathology in AIDS with a high lethality percentage due to complexity of clinical confirmation and difficulties of laboratory confirmation of the start of reactivation. Clinical, instrumental, immunologic, molecular genetic invasion reactivation criteria are discussed in the article and analysis of their effectiveness is performed; their most feasible combinations are justified. Further system analysis of the cerebral toxoplasmosis reactivation criteria specified in the article in combination with search of new pathogen dissemination markers will allow to obtain important information that has both fundamental interest and important practical significance.

Published
2012

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