1. [Synthesis of some thiourea derivatives and their influence on biological and genetic effects of gamma rays].
- Author
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Mehandjiev AD, Vassilev GN, and Shevchenko VA
- Subjects
- Biochemistry methods, Chromosome Aberrations, Dose-Response Relationship, Radiation, Drug Evaluation, Preclinical methods, Germination drug effects, Germination radiation effects, Gibberellins metabolism, Mutation, Pisum sativum drug effects, Pisum sativum genetics, Pisum sativum metabolism, Pisum sativum radiation effects, Pyridines chemical synthesis, Radiation-Protective Agents chemical synthesis, Thiourea analogs & derivatives, Thiourea chemical synthesis, Gamma Rays, Pyridines pharmacology, Radiation-Protective Agents pharmacology, Thiourea chemistry, Thiourea pharmacology
- Abstract
The synthesis of the new radioprotective compounds ATB (I, 2-allylthioureidobenzoic acid), PTB (II, 2-phenylthioureidobenzoic acid), A-2-PTU (III, N-allyl-N'-2-pyridylthiourea), and P-2-PTU (IV, N-phenyl-N'-2-pyridylthiourea) and their influence on biological and genetic effects of gamma rays was studied. In result of investigations it must be noted that PTB displayed radioprotective effect as a result of which more plants in M1 germination and survive in M2 of the induced mutations is increased. The cytological analysis reveals that the studied substance (PTB) decreases chromosome aberration in meristem cells of pea roots almost twice as a result of postirradiation treatment. The effect of A-2-PTU in the experiments with peas greatly depends on the dose of irradiation, i.e., on the degree of damaging of the processes of cell restoration and the possibility of their partial restoration after the treatment with the protector. The results obtained suggest that chemical compounds of N,N'-disubstituted thiourea group (A-2-PTU and P-2-PTU) exert strong radioprotective effect in the experiments with peas. This is of great importance to modern radiobiology and radiation mutagenesis and also to protect hereditary structures against radiation.
- Published
- 2003