1. [Ftorafur concentration in the blood and urine of oncological patients].
- Author
-
Blokhina NG, Smolianskaia AZ, Aledseev VM, and Sokolova VD
- Subjects
- Biopharmaceutics, Biotransformation, Breast Neoplasms drug therapy, Breast Neoplasms metabolism, Dose-Response Relationship, Drug, Female, Gastrointestinal Neoplasms drug therapy, Gastrointestinal Neoplasms metabolism, Humans, Kinetics, Neoplasm Metastasis, Tegafur analysis, Time Factors, Tissue Distribution, Fluorouracil analogs & derivatives, Neoplasms metabolism, Tegafur metabolism
- Abstract
The concentration of the active principle of ftorafur in blood and urine varied depending on the activity of metabolic processes in a patient, size and sensitivity of tumor, etc. The concentrations increased in repeat injections of the substance. The efficacy was related with the intensity of formation of active components, but is not dependent on the substance level dtermined in biological fluids of the organism.
- Published
- 1977