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The results of 225 operations made in 140 patients with Moya-Moya disease are analyzed. All the patients had clinical manifestations of this disease and were examined in accordance with the approved protocol of the Unit of Neurosurgery, Nagoya Daini Red Cross Hospital (Nagoya, Japan). The examination included computed tomography, magnetic resonance imaging, magnetic resonance angiography, preoperative angiography, single photon emission computed tomography with acetazolamide challenge. The surgical method consisted of a combination of direct arterial microanastomosis and indirect synangiosis (EMS, EDAS, EGS, cranial burr hole). The number of surgical complications was minimal (2.9%). There were excellent and good clinical results (disappearance of clinical symptoms or clinical improvement) in 92.9% of cases. Postoperative examinations confirmed the high percentage of positive results as cerebral circulation normalization in 97.1% of cases. The results of surgical treatment provided strong evidence that progression of the disease could be prevented.

Using a modified type of Masugi's nephritis, quantitative changes in several connective tissue components of renal cortex during the process of nephritis were compared with those of the contents of urinary protein and serum cholesterol. Levels of urinary protein and serum cholesterol were highest 10 days after anti-kidney serum injection and nearly normal levels were reverted to on the 30th day. The levels of sialic acid, uronic acid and hydroxyproline in the renal cortex of the nephritic group significantly increased from the 1st, 5th and 10th days, respectively compared with the normal group. The sialic acid content reached a peak with an increase of approx. 40% on the 15th day, reverting to almost the normal level on the 30th day, while the uronic acid and hydroxyproline levels continued to increase slowly after the 15th day, reaching rates of approx. 70% and 40%, respectively on the 30th day. The hexosamine content reached a maximum of 20% on the 20th day. Quantitative changes in connective tissue components of the renal cortex due to nephritis appear to reflect the degree of the repair of injured renal tissue.