1. [Knotted proteins].
- Author
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Stepanenko OV, Bublikov GS, Stepanenko OV, Rychkov GN, Povarova OI, Verkhusha VV, Turoverov KK, and Kuznetsova IM
- Subjects
- Animals, Humans, Models, Molecular, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, Bacterial Proteins chemistry, Cystine-Knot Miniproteins chemistry, Phytochrome chemistry, Plant Proteins chemistry, tRNA Methyltransferases chemistry
- Abstract
For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.
- Published
- 2015