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1. Effect of selenium-containing products on antioxidant enzyme activity in the kidneys, liver, and blood of guinea pigs.

Author

Sirota TV

Subjects
Animals, Glutathione metabolism, Glutathione Peroxidase blood, Glutathione Peroxidase metabolism, Glutathione Reductase blood, Glutathione Reductase metabolism, Guinea Pigs, Male, Organosilicon Compounds pharmacology, Oxidative Stress drug effects, Selenic Acid, Superoxide Dismutase metabolism, Antioxidants metabolism, Kidney drug effects, Liver drug effects, Selenium Compounds pharmacology
Abstract

The antioxidant system of some tissues in guinea pigs with no selenium deficiency was studied after treatment with selenium-containing products. Activity of a selenium-containing enzyme glutathione peroxidase was significantly reduced in the kidneys and blood. The kidneys were characterized by low activity of glutathione reductase and high activity of SOD. These features illustrate the development of oxidative stress in the kidneys.

Published
2010
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