1. [Primitive neuroectodermal tumor of the kidney in children; its differential diagnosis with Wilms tumor].
- Author
-
Popov SD, Sebire NJ, Popova ED, and Vujanic GM
- Subjects
- 12E7 Antigen, Antigens, CD biosynthesis, Antigens, CD genetics, Cell Adhesion Molecules biosynthesis, Cell Adhesion Molecules genetics, Child, Child, Preschool, Chromosomes, Human, Pair 11 genetics, Chromosomes, Human, Pair 11 metabolism, Chromosomes, Human, Pair 22 genetics, Chromosomes, Human, Pair 22 metabolism, Diagnosis, Differential, Female, Gene Expression Regulation, Neoplastic genetics, Humans, Kidney Neoplasms genetics, Kidney Neoplasms metabolism, Kidney Neoplasms pathology, Male, Neuroectodermal Tumors, Primitive genetics, Neuroectodermal Tumors, Primitive metabolism, Neuroectodermal Tumors, Primitive pathology, Proto-Oncogene Protein c-fli-1 biosynthesis, Proto-Oncogene Protein c-fli-1 genetics, RNA-Binding Protein EWS biosynthesis, RNA-Binding Protein EWS genetics, Translocation, Genetic genetics, Wilms Tumor genetics, Wilms Tumor metabolism, Wilms Tumor pathology, Kidney Neoplasms diagnosis, Neuroectodermal Tumors, Primitive diagnosis, Wilms Tumor diagnosis
- Abstract
There may be a number of tumors made up by small round blue cells in the kidneys of children. One of them is primitive neuroectodermal tumor (PNET). The differences in therapeutic approaches determine the need to establish an accurate diagnosis. The differential diagnosis of PNET and the blastemal component of Wilms tumor can be difficult due to the similar histological pattern. There is a need for a close analysis of morphological manifestations, by keeping in mind the age of patients, and supplementary studies. A strong CD99 membrane expression and nuclear FLI1 expression in tumor cells are the signs of PNET. Reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization can determine PNET-specific translocations [t(11;22)(q24;q12), by involving the EWS gene.
- Published
- 2009