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Objective. Studying of morphological characteristics of the duodenal papilla magna malignant tumors on the own material of the Division of Pathological Anatomy and Cytology of the Shalimov National Institute of Surgery and Transplantology. Materials and methods. Into the investigation 82 patients were included, to whom pancreaticoduodenectomy was performed for duodenal papilla magna malignant tumors in 2019 – 2021 yrs with further conduction of morphological analysis of the specimen excised. The average age of the patients have constituted (61.1 ± 8.1) yrs old. Results. There were revealed 8 histological types of the tumors, most frequent of them – adenocarcinomas of pancreatobiliary and intestinal types. These two variants were compared. They did not differ for the age and gender (р>0,05), but statistically significantly differed for the histological differentiation degree and tumoral spread: р =0.039 and р = 0.003, accordingly. Thus, in the pancreatobiliary type of adenocarcinoma the tumors with low differentiation level (G3) were in 1.9 times more frequent, than in adenocarcinomas of intestinal type: 22.9 and 11.8%, and in 2.8 times more frequently the more spread tumors were revealed (рТ3а–Т3b): 65.7 and 23.5%, accordingly. As well, in the patients with adenocarcinomas of pancreatobiliary type a positive status of regional lymph nodes was revealed more frequently – in 57.1%, than in patients with adenocarcinomas of intestinal type – 44.1%. Conclusion. Duodenal papilla magna malignant tumors – a heterogeneous group of tumors. Adenocarcinomas of pancreatobiliary and intestinal types are the most prevalent. Pancreatobiliary adenocarcinoma, as a histological type, is more aggressive, than intestinal adenocarcinoma.

The paper presents the results of a comprehensive morphological study of the surgical material from 5 patients (males aged 49 to 69 years) with intraductal papillary mucinous tumors (IDPMT) of the pancreas. The pancreatobiliary type of IDPMT was established in 4 cases (one adenoma from the peripheral branches of the pancreatic duct, one IDPMT with the borderline malignancy potential from the major pancreatic duct, and two intraductal papillary mucinous carcinomas from the major pancreatic duct). The expression of MUC1 and MUC5AC, cytokeratins 7, 19, and 18 was immunohistochemically shown. One patient was diagnosed as having an enteric type of a tumor (IDPMT with the borderline malignancy from the major pancreatic duct), which was characterized by the expression in the MUC2 and MUC5AC cells and by that of cytokeratin 20.