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Data on the existence of organelles, binding and inactivating xenobiotics on the subcellular level in animal and plant cells is presented. The morphology of these organelles both the enzymatic constituents and their expected physiological function in immunological homeostasis are discussed. The data presented suggests that the previously discussed organelles such as chloragosomes, cadmosomes, metallogranules, keratinosomes, lamellar and myeloid bodies of animal and plant cells belong to the united class of organelles--antixenosomes which segregate, bind and inactivate xenobiotics protecting both cells and the entire organism from their harmful effect.