1. [Diagnostics of nasopharyngeal carcinoma with Epstein-Barr virus (Herpesviridae, Lymphocryptovirus, HHV-4) serological and molecular markers in cases of undetected primary tumor location.]
- Author
-
Senyuta NB, Smirnova KV, Kondratova VN, Ignatova AV, Mudunov AM, Dushenkina TE, Liechtenstein AV, and Gurtsevich VE
- Subjects
- Adult, Biomarkers, Tumor genetics, Biomarkers, Tumor immunology, Case-Control Studies, Convalescence, DNA, Viral genetics, DNA, Viral immunology, Epstein-Barr Virus Infections immunology, Epstein-Barr Virus Infections pathology, Epstein-Barr Virus Infections virology, Female, Herpesvirus 4, Human genetics, Herpesvirus 4, Human immunology, Humans, Immunoglobulin A blood, Immunoglobulin G blood, Lymph Nodes immunology, Lymph Nodes pathology, Lymph Nodes virology, Lymphatic Metastasis, Male, Middle Aged, Nasopharyngeal Carcinoma immunology, Nasopharyngeal Carcinoma pathology, Nasopharyngeal Carcinoma virology, Nasopharyngeal Neoplasms immunology, Nasopharyngeal Neoplasms pathology, Nasopharyngeal Neoplasms virology, Nasopharynx immunology, Nasopharynx pathology, Nasopharynx virology, Recurrence, Viral Load genetics, Viral Load immunology, Antibodies, Viral blood, Biomarkers, Tumor blood, DNA, Viral blood, Epstein-Barr Virus Infections diagnosis, Herpesvirus 4, Human pathogenicity, Nasopharyngeal Carcinoma diagnosis, Nasopharyngeal Neoplasms diagnosis
- Abstract
Introduction: The reasons of late diagnosis of nasopharyngeal carcinoma (NPC) are the long asymptomatic course of the pathological process, the anatomical structure of the nasopharynx, often small, visually and endoscopically undetectable tumor and other factors. It is proved that the Epstein-Barr virus (EBV) is an etiological agent in the most common undifferentiated non-keratinizing histological type of NPC (uNPC)., Objectives: The aim of the work was to assess the significance of diagnostic markers of EBV (titers of humoral antibodies to the virus and the concentration of viral DNA in plasma) for the diagnosis of uNPC in a group of patients with metastatic lesions of the cervical lymph nodes without an identified localization of the primary tumor focus., Material and Methods: The material for the study was blood plasma of 83 patients with metastatic lesions of the cervical lymph nodes and not established localization of the primary tumor. Plasma samples were tested for the anti-EBV IgG and IgA antibody content and titers and the concentration of viral DNA., Results and Discussion: The data obtained indicate that the parallel testing of blood plasma for EBV-specific antibodies and viral load is a useful tool for preliminary screening of uNPC patients. The final diagnosis is confirmed by the data of subsequent morphological and instrumental studies. Several examples also show that the concentration of viral DNA in the blood plasma of patients with uNPC reflects the effect of the therapy and the prognosis of the disease: remission, stabilization of the tumor process, relapse or metastasis., Conclusion: Although the titers of virus-specific antibodies are found to reflect clinical manifestations of the disease less accurately than the plasma concentrations of viral DNA, serological markers are extremely important for the preliminary diagnostics of uNPC in cases of undetected primary tumor location. They are also useful for primary screening of this neoplasm among individuals at risk., Competing Interests: The authors declare no conflict of interest.
- Published
- 2019
- Full Text
- View/download PDF