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A comparison of the number of follicular epithelium cells and its proliferative activity with the oocyte diameter upon normal (ICR mice) and abnormal (LT/Sv mice) oogenesis was carried out. Two populations of monolayered follicles were found in the LT/Sv mice. The population of normal follicles providing for reproductive function is characterized by a distinct correlation between the follicle size, number of DNA-synthesizing follicular cells and oocyte diameter. The group of abnormal follicles contains large oocytes the growth of which is ahead of the development of granulosa cells. The number of DNA-synthesizing cells of monolayered follicular epithelium is 6 times less than in the normal follicles. 96% of parthenogenetically cleaving eggs were found in such abnormal monolayered follicles as well, the number of DNA-synthesizing cells being 14 to 17 times less than that in the normal follicles. Possible mechanism of this phenomenon are discussed.

The long duration of the estrous cycle, the absence of the ovulated oocytes was observed in histomorphological studies of estrous cycles and ovaries in hr rhY-/hr rhY-mutants of B10-hr rhY mice strain. The absence of mutation division, ovulation and corpora lutea in ovaries was found in contrast to normal isogenic B10 females. The extragonadal cause of hairless mutant female infertility was shown. The effective method of mutant strain B10-hr rhY reproduction by using the transplantation of homozygous hairless female ovaries to isogenic recipients (+/+ or +/hr rhY) was proposed.