1. [Structural and functional organization of hepatitis C virus genome].
- Author
-
Dunaeva NV and Esaulenko EV
- Subjects
- Carrier Proteins genetics, Carrier Proteins physiology, Complementarity Determining Regions, Hepacivirus physiology, Interferons genetics, Intracellular Signaling Peptides and Proteins, Metalloproteases genetics, Metalloproteases physiology, Nucleocapsid, Polyproteins genetics, Polyproteins physiology, Protein Precursors genetics, Protein Precursors metabolism, RNA, Viral genetics, RNA-Dependent RNA Polymerase genetics, Serine Endopeptidases genetics, Serine Endopeptidases physiology, Untranslated Regions, Viral Envelope Proteins genetics, Viral Envelope Proteins physiology, Viral Nonstructural Proteins genetics, Viral Nonstructural Proteins physiology, Viral Proteins genetics, Viral Proteins physiology, Virus Replication, Genome, Viral, Hepacivirus genetics
- Abstract
The review gives recent data on the structure of hepatitis C virus genome. Linear RNA comprises one translated and two nontranslated regions: 5'UTR and 3'UTR. Translation of viral RNA gives rise to a single polyprotein precursor that contains structural and nonstructural regions. The structural region comprises one nucleocapsid core-protein and two envelope proteins known as E1 and E2. E2 protein includes two hypervariable regions: HVR1 and HVR2. The nonstructural region consists of 7 proteins: p7 (NS1), NS (metalloproteinase), NS (serine protease/ helicase), NS4A (co-factor protease, co-factor RNA-dependent RNA polymerase), and NS4B, NS5A, NS5B (RNA-dependent RNA polymerase). NS5A includes ISDR (interferon-sensitivity-determining region).
- Published
- 2006