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Aim: To study a role of MTHFR mutations and their associations with the disturbances of basic parameters of the folate cycle in the development of ischemic stroke (IS)., Material and Methods: Fifty-one post-stroke patients, 26 women and 25 men, aged from 29 to 87 years, were included in the study. The control group consisted of 47 healthy people, 23 women and 24 men, aged from 30 to 83 years. MTHFR: rs1801131 and rs1801133 polymorphisms were genotyped. Contents of folate, B12 and homocysteine were measured., Results: The risk group which was characterized by the presence of risk variants of rs1801131 and rs1801133 polymorphisms, changes in the parameters of the folate cycle (the decrease in B12 concentration (≤500 pg/ml)) in the combination with hyperhomocysteinemia (≥13 mcmol/L) was identified., Conclusion: The disturbance of the folate cycle, including gene variations, is a basic pathogenetic link in the development of cerebral atherosclerosis and associated cerebrovascular diseases.

The author analyses experience gained with the use of the pyrogenic drugs sulfazin and pyrogenal in the treatment of schizophrenic patients. Pyrogenal and sulfazin were administered to 26 patients with different forms of schizophrenia to overcome psychopharmacotherapeutic resistance and to 11 patients to enhance the sensitivity to insulin during insulin coma therapy. Based on the clinical analysis the author demonstrates the efficacy of the use of the pyrogenic drugs, particularly pyrogenal, in schizophrenic patients in order to overcome the resistance to pharmacotherapy and insulin.

The results of the use of plasmapheresis in multimodality treatment of patients with endogenous psychoses are provided for the first time. The use of plasmapheresis was shown to be highly effective in overcoming resistance to psychotropic agents as well as in the treatment of lingering and chronic extrapyramidal neuroleptic disorders. The beneficial effect on the mental and neurologic status of the patients is coupled with pronounced immunocorrective action of the procedure.

The authors review febrile attacks of schizophrenia and the febrile period of the malignant neuroleptic syndrome in schizophrenia. Twenty-five schizophrenia patients were observed to establish the effect of the ECT on their status. The ECT was found to be highly effective in combination with intensive infusion therapy aimed at the correction of homeostasis. It was revealed that the prognosis and efficacy of the use of the ECT is determined by the stage of the development of febrile condition, the leading syndrome and the gravity of somatovegetative disorders. The use of the ECT was ineffective in cases where the development of a febrile attack reaches the level of amential dull consciousness.