Search

Multichamber toxicokinetic model studies of the resorption, distribution and excretion properties of poorly soluble substances in subchronic action of suspensions administered intragastrically can be the first step in prognosing the toxicokinetic properties of the inhaled aerosols of the substances mostly discharged from the respiratory into the gastrointestinal tract (GIT). The generally accepted quantitative characteristics of the particles' deposition and translocation into GIT can provide a further application of the model for a mathematical description of a prolonged inhalational exposure to some substances. This technique was tested with the boron compounds characterized by low solubility and revealed a good correlation between the prognosed and actual deposits of the substance in the organ and excretions. At the same time, detected were some qualitative and quantitative differences in the boron toxicokinetics influenced by magnesium deboride and hexaborate, which were explained by differences in their solubility.

Detailed observational data on urolithiasis incidence at the territory of the Amur Region are presented. 4 foci with a high level of disease incidence have been detected. The content of calcium, magnesium, and strontium has been determined in drinking water and correlation of urolithic disease rates with rations Ca/Sr and Mg/Sr were established. Certain dependence of the disease rates on the above ratios shows that their elevation corresponds to the reduction of urolithiasis rates, and vice versa. Application of the given technique in the urolithiasis endemic areas with the established level of disease incidence provides analogous results. It is assumed that in a number of cases unfavourable distribution of some chemical elements in drinking water, i. e., Ca/Sr and Mg/Sr, has affected the high level of urolithiasis incidence.