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AIM. To study the clinical effect of body composition-based lifestyle intervention in patients with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS. In the period of November, 2020 – July, 2021, 91 patients diagnosed with PCOS in the First People's Hospital of Urumqi were prospectively selected and divided into a control group (46 cases) and an experimental group (45 cases) according to random number method. The patients in the control group were treated with Drospirenone and Ethinylestradiol tablets (II), while the patients in the experimental group were treated with Drospirenone and Ethinylestradiol tablets (II) and lifestyle adjustment based on body composition. The changes of the indices before and after 3 months of treatment were compared between the two groups. RESULTS. The indices of PCOS patients in the two groups after treatment (except 1 basal metabolic rate and muscle weight, 2. FSH and 3. HDL) were decreased, and the decrease in the experimental group was more significant (P < 0.05). Patients in the experimental group had significantly increased spontaneous ovulation and pregnancy rate / Conducive to ovulation and pregnancy. CONCLUSION. In PCOS patients, the combination of Drospirenone and Ethinylestradiol tablets (II) and lifestyle intervention based on human body components can improve reproductive hormone, glucose metabolism and insulin resistance more effectively, which is beneficial to spontaneous ovulation and pregnancy, and reduce the weight of patients.