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Introduction. Progress in X-ray angiographic surgery allows us to reconsider traditional approaches to treating ischemic stroke due to thrombosis in the internal carotid artery (ICA) basin. Objective. To study early and long-term results of urgent selective thrombolysis in the ICA basin with acute thrombosis. Material and methods. The subject of the study were 13 patients. The age of patients ranged from 40 to 64 years. As a thrombolytic was used a plasminogen tissue activator - Actilizae-Boehring Ingelheim. Results. At the end of the early postoperative period, 10 patients were discharged for outpatient treatment, 3 died of progression of the underlying disease. When examining patients in terms of 1 to 5 years in 9 cases, recovery of motor activity and speech was noted. Conclusions. Improving the results of selective thrombolysis in the basin of the ICA requires a reduction in the time from the onset of thrombosis until the patient enters the angiographic room.

Aim: Study the structure of homogenous microbial communities of Corynebacterium diphtheriae gravis tox+ strains during formation of biofilms in vitro., Materials and Methods: Object of study--typical and biofilm cultures of C. diphtheriae gravis tox+ museum and circulating strains. Intensity of biofilm formation was evaluated by OD on microplate reader at 540 nm wave length studying 120 and 720 hour cultures. S-450 (Hitachi, Japan) scanning electron microscope was used., Results: The peak of exopolysaccharide matrix (EPS) formation, that is formed in the process of biofilm formation, by museum strain takes place at earlier terms of cultivation (120 hours) than circulating (720 hours). An inverse correlation was established during analysis of bacterial cells of museum and circulating strains of C. diphtheriae during biofilm formation between them and intensity of EPS formation. At maximum EPS content, that took place at various terms of cultivation of the 2 studied strains of diphtheria causative agent, a reduction of corynebacteria cells was observed., Conclusion: Bacterial biofilms of museum and circulating strains of C. diphtheriae and patterns of dynamics of EPS reflect, probably, adaptive abilities of the causative agent, that determine its competitiveness in the fight for adhesion sites, resistance to factors of natural immunity and as a result--prolonged persistence in the organism of bacterial carriers.

The objective of the present work was to develop methods and a scientifically sound rationale for the optimization of clinical results of the treatment of patients presenting with arterial hypertension (AH) associated with coronary heart disease (CHD) using red and infra-red (IR) low-intensity laser irradiation. The study included a total of 90 patients of working age (62.2% of men and 37.8% of women) having AH associated with coronary heart disease and abnormal blood lipid spectrum. They were allocated to three groups each comprising 30 patients matched for age, sex, severity of clinical conditions, and character of maintenance medicamental therapy. Patients of group 1 were treated by intravenous blood irradiation with laser light; those in group 2 were given similar treatment in combination with external low-intensity IR laser therapy; patients of group 3 received basal medicamental therapy. The study allowed the clinical value of different variants of low-intensity laser therapy to be assessed as regards efficiency of correction of hypersympaticotony, disturbances of lipid metabolism, and refractoriness to pharmaceutical products as well as improved tolerance of physical exercises, anti-hypertensive, anti-ischemic, and anti-anginal effects, diastolic function, and quality of life as targets of the comprehensive rehabilitative program designed for patients with AH associated with coronary heart disease. An optimized therapeutic modality is proposed for patients presenting with these pathologies based on the application of the low-intensity laser irradiation regime characterized by mutual amplification and complementary action of red and infrared lights.

Application of ozone therapy was based on the notions of a significant role of lipid peroxidation in the pathogenesis of migraine attacks. A therapy was performed in form of intravenous infusions of the ozonized physiologic solutions with ozone, concentration 1200 micrograms/l; a therapy course included 8-9 procedures. 68 patients with migraine attacks, followed by the pronounced autonomic changes, that developed in the frequency range from 5-6 times a year to 2-3 times a week were examined. 40 patients formed a study group and 28 individuals control one (in a control group the physiologic solution was used without ozone). The intensity of a headache, the expression of an anxiety, the state of the vessels of the brain and some biochemical indices were determined. Positive dynamics of the disease was 25% higher in the study group than made up a those in the controls (p < 0.05). In 58% of the patients the attacks were absent during 3-5 months after ozone therapy; less intensity of headache was observed after their relapse. Improvements in the patients coincides with changes in biochemical parameters.

The content of cAMP, cGMP and cAMP phosphodiesterase activity were studied in lymphocytes of bronchial asthma patients and normal persons before and 15 min after euphylline administration in a dose of 4 mg/kg. The cAMP/cGMP ratio was significantly lowered in patients. Euphylline administration led to its significant increase. In normal persons, this ratio remained unchanged. Some patients manifested an elevated activity of cAMP phosphodiesterase. In these cases, administration of euphylline brought about a significant increase in cAMP level in lymphocytes in the presence of the lowered activity of the enzyme phosphodiesterase. In the remaining patients and in normal persons, these indicators did not significantly change. It is suggested that the mechanism of euphylline action is dependent on cAMP phosphodiesterase activity.