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2 results on '"Khromykh AA"'

1. [Expression of antigens of the tick-borne encephalitis virus by various recombinant variants of the vaccinia virus].

Author

Khromykh AA, Beliaev AS, Rukavishnikov MIu, Daniliuk NK, and Sandakhchiev LS

Subjects
Antigens, Viral analysis, Encephalitis Viruses, Tick-Borne immunology, Genes, Viral, Genetic Vectors genetics, Plasmids genetics, Promoter Regions, Genetic genetics, Vaccinia virus immunology, Antigens, Viral genetics, Encephalitis Viruses, Tick-Borne genetics, Gene Expression Regulation, Viral genetics, Genetic Variation genetics, Recombination, Genetic genetics, Vaccinia virus genetics
Published
1990

2. [Comparative study of interferon inducers obtained from natural sources].

Author

Timofeev IV, Chaplygina SR, Zorin VV, Khromykh AA, and Kolokol'tsov AA

Subjects
Animals, Cytopathogenic Effect, Viral drug effects, DEAE-Dextran pharmacology, DNA isolation & purification, DNA pharmacology, DNA toxicity, Encephalomyocarditis virus drug effects, Influenza A virus drug effects, Interferon Inducers isolation & purification, Interferon Inducers toxicity, Interferons blood, L Cells drug effects, Lethal Dose 50, Mice, RNA, Fungal isolation & purification, RNA, Fungal pharmacology, RNA, Fungal toxicity, RNA, Viral isolation & purification, RNA, Viral pharmacology, RNA, Viral toxicity, Time Factors, Interferon Inducers pharmacology
Abstract

Interferon-inducing and antiviral effects of natural dsRNA preparations of phage phi 6 and yeast cells were studied in the culture of murine cells L-929 and on random bred albino mice. Both the preparations showed interferon inducing activity in the cell culture. However, for realization of their effect modification of the surface cell membrane by polycation exchange resin (DEAE-dextran) was required. The interferon-inducing activity of both of the natural dsRNA in the mice was high. The maximum interferon titers (1280-5120 units/ml) in blood serum were observed 4-6 hours after the inductor intraperitoneal administration. The interferon-inducing activity of the phage dsRNA was high in the cell culture and yeast dsRNA--in mice, respectively. Both the inductors had antiviral activity and protected 15 to 38.9 per cent of the experimental animals from the effect of 100 LD50 of the murine encephalomyocarditis virus and 10 LD50 of the influenza virus A/Aichi 2/68 (H3N2).

Published
1987

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