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Your search keyword '"Ivanov, Alexey"' showing total 5 results
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5 results on '"Ivanov, Alexey"'

1. Effect of electric field pulses on the suspension of microcontainers based on organic polymer and magnetite nanoparticles

Author

Lengert, Ekaterina Vladimirovna, Ermakov, Alexey Vadimovich, and Ivanov, Alexey Nikolaevich

Subjects
hydrogel, microspheres, magnetite, silver nanoparticles, electric field, Physics, QC1-999
Abstract

Background and Objectives: Here, non-thermal effects induced in the suspension of hollow alginate silver microcontainers after application of short electric field pulses (about 1 ms) of high intensity (about 1 kV/cm) were studied as a prospective tool for remote activation of microcontainers. Alterations in microcontaner’s shells were studied as a function of their composition. Magnetic nanoparticles immobilized within microcontainer’s shells were found to enhance effects that occurred after application of electric field pulses. Alterations found in microcontaner’s shells can be further employed for remote activation of microcontainers and release of encapsulated cargo. Results: The obtained results are the basis for further research of multifunctional microcontainers based on an organic alginate matrix and inorganic metal nanoparticles of silver and magnetite as drug carriers, the permeability, and structure of which can be switched using a non-thermal pulsed electrical action. Conclusion: The proposed microcontainers can be employed as carriers in new effective systems for encapsulation, targeted delivery, and controlled release of various substances in aqueous media responsive towards electric and magnetic fields which are promising in a wide range of biomedical tasks and other applications.

Published
2021
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2. Regulatory effects of terahertz waves

Author

Kirichuk, Vyacheslav and Ivanov, Alexey

Abstract

There are modern data about biological effects of terahertz (THz) waves in this article. Items of interaction of THz waves with bio objects of different organization level. A complex of the data indicates that the realization of a THz wave effect in biosystems is possible at molecular, cellular, tissular, organ and system levels of regulation. There are data about changes in nervous and humoral regulation of an organism and metabolic effects of THz waves.

Published
2013

3. Correction of disorders in tissue perfusion, blood coagulation and fibrinolysis with Orbita apparatus on terahertz waves of cell metabolites

Author

Kirichuk, Vyacheslav, Tsymbal, Alexander, Ivanov, Alexey, Kiriyazi, Tatyana, Antipova, Olga, Andronov, Evgeny, Velikanova, Tatyana, Velikanov, Vitaly, Parshina, Svetlana, Babichenko, Natalia, Ponukalina, Elena, Smyshlyaeva, Irina, Tokaeva, Liliana, and Krenitsyky, Alexander

Abstract

This article contains information on principle of operation, technical parameters and possible application of Orbita {transliteration from Russian} apparatus for hemodynamic, fibrinolytic and peripheral perfusion disorders treatment. A single exposure to terahertz waves emitted by Orbita apparatus, corresponding to frequencies of molecular absorption and emission spectra of atmospheric oxygen (129.0 GHz), completely cures coagulant and fibrinolytic disorders of animals with acute immobilization stress. A course of treatment with electromagnetic waves corresponding to frequencies of molecular absorption and emission spectra of nitrogen oxide (150.176 – 150.664) leads to normalization of disrupted peripheral tissue perfusion parameters of animal undergoing treatment and stimulates basal and induced output of nitrogen oxide. This leads to decrease in peripheral vascular resistance to microcirculation and increase in blood flow to microvasculature. Experimental data provided in this article serves as a proof of viability of Orbita apparatus for treatment of coagulant, fibrinolytic and tissue perfusion disorders.

Published
2013

4. Hemodynamic changes Caused by exposure of animals with acute immobilization stress to continuous terahertz radiation with frequencies equal to absorption and emission frequencies of nitrogen oxide and atmospheric oxygen

Author

Kirichuk, Vyacheslav, Velikanov, Vitaly, Velikanova, Tatyana, Antipova, Olga, Andronov, Evgeny, Ivanov, Alexey, Parshina, Svetlana, Babichenko, Natalia, Kiriyazi, Tatyana, Ponukalina, Elena, Smyshlyaeva, Irina, Tokaeva, Liliana, and Tsymbal, Alexander

Abstract

The aim was to study the effects of exposure of albino rats to continuous terahertz radiation with frequencies equal to absorption and emission frequencies of nitrogen oxide (150.176-150.664 GHz) and atmospheric oxygen (129.0 ± 0.75 GHz) during their immobilization stress on their blood flow rate. Methods – The group of 120 male non-pedigree albino rats with average weight of 180-220 g was chosen as a test subject. Simulation of hemodynamic disorders was achieved by incurring active immobilization stress. All rats were exposed to electromagnetic terahertz radiation equal to absorption and emission frequencies of nitrogen oxide (150.176-150.664 GHz) and atmospheric oxygen (129.0 ± 0.75 GHz) for 5, 15 and 30 minutes. Results – Experimental simulation of hemodynamic disorders during acute immobilization stress has shown that exposure to continuous terahertz radiation with frequencies equal to absorption and emission frequencies of nitrogen oxide (150.176-150.664 GHz) and atmospheric oxygen (129.0 ± 0.75 GHz) for 5, 15 and 30 minutes allows to revert post-stress hemodynamic changes in great vessels. Conclusion – This allows using terahertz electromagnetic radiation with frequencies equal to absorption and emission frequencies of nitrogen oxide (150.176-150.664 GHz) and atmospheric oxygen (129.0 ± 0.75 GHz) to treat hemodynamic disorders accompanying some of pathologic diseases.

Published
2012

5. [The role of diabetes in the onset and development of endothelial dysfunction].

Author

Popyhova EB, Stepanova TV, Lagutina DD, Kiriiazi TS, and Ivanov AN

Subjects
Endothelial Cells, Endothelium, Vascular, Humans, Diabetes Complications, Diabetes Mellitus, Hyperglycemia
Abstract

The vascular endothelium performs many functions. It is a key regulator of vascular homeostasis, maintains a balance between vasodilation and vasoconstriction, inhibition and stimulation of smooth muscle cell migration and proliferation, fibrinolysis and thrombosis, and is involved to regulation of platelet adhesion and aggregation. Endothelial dysfunction (ED) plays the critical role in pathogenesis of diabetes mellitus (DM) vascular complications. The purpose of this review was to consider the mechanisms leading to the occurrence of ED in DM. The paper discusses current literature data concerning the role of hyperglycemia, oxidative stress, advanced glycation end products in endothelial alteration. A separate section is devoted to the particularities of the functioning of the antioxidant system and their significance in the development of ED in DM. The analysis of the literature allows to conclude that pathological activation of glucose utilization pathways causes damage of endothelial cells, which is accompanied by disorders of all their basic functions. Metabolic disorders in DM cause a pronounced imbalance of free radical processes and antioxidant defense, accompanied by oxidative stress of endotheliocytes, which contributes to the progression of ED and the development of vascular complications. Many aspects of multicomponent regulatory reactions in the pathogenesis of the development of ED in DM have not been sufficiently studied.

Published
2020
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