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Antisecretory effect of intravenous quamatel (Q) and gastrocepin (G) was studied in 59 patients with duodenal ulcer. Mean maximal pH and delta-pH in antral portion of the stomach and its body were similar for Q and G, but pH responded to Q administration faster. The antisecretory effect of Q was more pronounced in males and young patients and was inversely proportional to initial acidity.

Literature references and author's own results on the role of the pancreatic secret in the intestinal phase of pancreatic secretion, are reviewed. Particular attention was paid to formation of correcting effects of the duodenum upon pancreatic secretion in respect to the ratio of solubilised and absorbed pancreatic enzymes, enzymes, substrates and the products of their hydrolysis in the duodenal chyme.

Intravenous injection of caseine hydrolysate, hydrolysin or amino-peptide to dogs was not attended by any substantial changes in the activity of retinylpalmitate- and retinyl-acetate-hydrolase in the intestinal juice, as compared to the juice secreted on an empty stomach. The mutual relation of these enzymes activity in the intestinal juice and jejunal wall was dissimilar, which testifies to their different localization in the intestinal tissues.

Chronic experiments on dogs with gastric and duodenal fistulas were made to study the effect of pentagastrin (6 micrograms/kg, s. c.) on the motor and secretory components of periodical activity of the gastroduodenal organs. Gastric secretion was collected from the open fistulas. To detect the role of the nervous mechanisms, subject to comparison were similar parameters of the periodic activity in 5 dogs with intact stomach innervation and in 6 dogs with preliminary circular gastrotomy in the upper third of the fundal part. Gastrotomy did not impair the periodical rhythm but led to the prolongation of the activity periods, decreased the contraction amplitude and shortened the periods of rest. The quantity of the periodical duodenal secretion was also diminished. In dogs with intact stomach innervation, pentagastrin inhibited the periodic contractions, stimulated the duodenum motility and caused an intensive special period of duodenal secretion. In disturbed innervation, these effects were less pronounced or completely disappeared. It is concluded that central parasympathetic innervation plays an important role in he mechanism of the pentagastrin effect on the periodic activity of the gastroduodenal organs.

A study was made of rabbit small intestine secretion induced by cholera and salmonellosis toxins. Application of electron impact mass-spectrometry and chemical ionization permitted identification of 9 and structure assignment for 14 out of 27 secretion components. The assay demonstrated the major part of the components to be the monosaccharides, glucose and galactose. Fatty acids, cholesterol and hydroxyacids were found to be present in negligible amounts. It was discovered that the action of the toxins primarily affected the metabolism of unsaturated fatty acids.

The effect of intravenous infusion of proteinic hydrolysates on the secretory function of the intestines was studied in dogs with an intestinal loop isolated starting from the initial portion of the jejunum. The preparation of proteinic hydrolysates, such as the caseine hydrolysate TSOLIPK, aminopeptide and hydrolysine L-103 with their drop-by-drop infusion into the posterior vena cava to dogs on an empty stomach were found to have in most cases an effect on the periodicity of the small intestine secretory activity. The infusion of proteinic hydrolyastes failed to exert any essential influence on the secretion of the dense proportion of the juice, whereas the secretion of the liquid component of the intestinal juice increased in all experiments involving introduction of all the proteinic hydrolysates. The concentration of the total protein in the liquid part of the intestinal juice with intravenous infusion of the preparations remained unchanged. At the same time, the amount of protein secreted together with the intestinal juice at the rate of single secretory action was in the instance of the caseine hydrolysate TSOLIPK and aminopeptide infusion proved 1 1/2--3 times as great as in the tests without infusion.

The TMTD does not change the secretory activity of the dogs' stomach with its one-time administration by mouth in doses of 0.5--10 mg/kg. With its multiple introduction (10 mg per kg once a day for a space of consecutive 30 days) the secretion of juice increases, while the pepsin content in the juice of dags diminishes. The DEDCS, EEDMDCA, TMTD and EBDCC (singly into the stomach in a dose of 1l5LD50 per kg) bring down the glycogen-forming and secretory function of the liver in rats and inhibit the propulsive activity of the intestines in mice, stimulated with 5-oxytryptophan. The mechanism of the intestinal motor activity inhibition is caused by the inhibition of oxytryptophandecarboxylase (CP 4.1.1.28) in the intestines of the animals with the DTCA derivatives.