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The article presents a case of granulomatosis with polyangiitis, which is difficult for clinical diagnosis. Recently, the incidence of systemic vasculitis has increased, and given the similarity of clinical symptoms with other pathologies, a doctor of any specialty should carry out differential diagnosis. Granulomatosis with polyangiitis is characterized mainly by damage to the upper respiratory tract, lungs, and kidneys. The main method for diagnosing granulomatosis with polyangiitis is biopsy with histological examination, which allows to detect inflammation in the affected tissues. A feature of granulomatosis with polyangiitis is detection of antineutrophil cytoplasmic antibodies in the blood serum. However, these antibodies are recorded only in 80% of patients and are not detected in the remission phase, which makes diagnosis much more difficult.

The article is devoted to the study of the category of the game and its embodiment in the form of specific game techniques in discourse. The research material was the work of M. Ende «Der Spiegel im Spiegel». The novelty of the research is seen in the fact that the combined connections of artistic stories form irrational worlds. The relevance of the study is due to the growing interest of researchers in the surrealist reflection of reality in a literary text. It is shown in the work that play is a process of personality formation and a kind of free human activity. Special attention is paid to the theoretical analysis of fairytale discourse. The principle of semantic and compositional connection of individual works of the cycle of stories is brought into consideration. The article deals with the issues of realization by characters of literary texts of the key parameters of play and non-play in mythological discourse. Attention is paid to the main variants of human behavior. The question is also raised about the physical properties of mirrors, which are implicit markers of various symbols. Special attention is paid to the spherical mirror. It is shown that M. Ende’s work is based on the principle of the panoramic reflection effect.

Principles of constructing theory of development and establishment of radiobiological reactions in the multilevel hierarchical structures of multicellular organisms are laid down on the bases of mathematical modeling and the theory of biosystems reliability. These principles are consistent with experimental and theoretical studies. Mathematical models were tested on the example of radiobiological effects of the perennial aquatic herbaceous plant Spirodela polyrrhiza. Possibility of using the proposed method for studying radiobiological and biophysical processes for biological structures of various complexity: from cell level to population level of higher plants is justified.

In order to reveal the causes of age-related changes in sensitivity of the organism to oxidative stress, the spectrum of aldoketoreductases in blood serum of rats of different ages was investigated. It was discovered that 0.5- and 24-month old rats have the similar spectrum of aldoketoreductase in the blood. There are only four electrophoretic fractions of aldoketoreductases in their spectrum. The share of 3rd fraction increases the spectrum of 1.5-, 2- and 3- month old rats. The pubertal rats contain additional 5th fraction in aldoketoreductase spectrum of the blood. This electrophoretic fraction has maximal electrophoretic mobility, but there is inconstancy in spectrum. There are 6 electrophoretic fractions of aldoketoreductases in the blood of 3-month old rats. Two of them with maximal electrophoretic mobility are absent in the spectrum of 0.5- and 24- month old rats. There are the same shares of 3rd and 4th fraction in the aldoketoreductase spectrum of the blood 12-month old rats, and 5th fraction there is inconstancy. The cause of age-related changes in the aldoketoreductase spectrum of blood may be coupled with existence of age-related differences in the gene expression of the encoded enzymes of aldoketoreductase family. Due to the fact that 0.5- (early childhood) and 24-month old (senescence) rats have similar aldoketoreductase spectrum of the blood, we propose that the cause ofthat phenomenon coupled with age-related changes in the production and secretion of sex steroids.

In care of existence of possible radioactive contamination from nuclear enterprises and equipment it is usual to develop and apply special protective measures, countermeasures to protect workers, population and the envi-ronment from radionuclides impact. Analysis and assessment of radioecological countermeasures based on the radiocapacity theory have been realized in this article. The principles and methods of remediation proposed in the article can be used for different types of ecosystems and for different pollutants.

Natural and technogenic cataclysms taking place in Ukraine bring to the forefront the problem of estimation and forecast of different ecosystems type. Theory and models of the radio capacity and reliability developed by us allow to describe adequately regularities of radionuclide migration and redistribution in slope ecosystems, and carry out mathematical modeling of investigated phenomena. That will give the possibility to use special coun-termeasures.

Theory and the models of radiocapacity ecosystems using the theory and models of reliability have allowed adequately to describe the laws of migration and radionuclides distribution for different types ecosystems of res-ervoirs and land. The theory and the models of radiocapacity allow strictly to define critical elements of ecosys-tem where it is necessary to expect temporary or final depoting of radionuclides.The approach on the basis of application biogenic tracers allows within the framework of the theory both models of radiocapacity and reliabil-ity simultaneously to estimate the processes of radionuclides migration, to define the dozes of loading on biota ecosystems, and to establish fundamental parameters of radionuclides redistribution speeds and others pollutants in different types of ecosystems.

Results of the analysis of 137Cs radionuclides flows as an example of village Galusia of the Volyn region and in ecosystem of village Kotsyubynchyky in Ternopil region polluted by 90Sr are considered. The analysis is made by the method of box models. The block diagrams of ecosystems were created, and the mathematical models by the method of box models are developed. It has allowed estimating ways of formation doses of an internal irradiation at the expense of products of meal for different groups of population – working people, pensioners and children, and prognosed dynamics of these doses for the next years after Chornobyl NPP accident. It was established, that doses in these villages formed by other ways, depending on radionuclide, pastures structure and levels of their pollution.