1. A glimpse on Staphylococcus aureus translation machinery and its control
- Author
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Stefano Marzi, Alessandra Marenna, M. Yusupov, I. Khusainov, G. Yusupova, Pierre Fechter, M. Cerciat, P. Romby, Yaser Hashem, Régulation de l'expression génétique chez les microorganismes (REGCM), Centre National de la Recherche Scientifique (CNRS), Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0301 basic medicine ,Engineering ,regulatory RNAs ,Staphylococcus aureus ,medicine.drug_class ,[SDV]Life Sciences [q-bio] ,030106 microbiology ,Antibiotics ,Biophysics ,Virulence ,Computational biology ,medicine.disease_cause ,Microbiology ,03 medical and health sciences ,Eukaryotic translation ,Structural Biology ,medicine ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Control (linguistics) ,Pathogen ,ComputingMilieux_MISCELLANEOUS ,biology ,business.industry ,quorum sensing ,Control engineering ,Translation (biology) ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,General Medicine ,biology.organism_classification ,3. Good health ,Quorum sensing ,030104 developmental biology ,business ,Bacteria ,post-transcriptional regulation - Abstract
© 2016, Pleiades Publishing, Inc.Staphylococcus aureus is a major opportunistic and versatile pathogen. Because the bacteria rapidly evolve multi-resistances towards antibiotics, there is an urgent need to find novel targets and alternative strategies to cure bacterial infections. Here, we provide a brief overview on the knowledge acquired on S. aureus ribosomes, which is one of the major antibiotic targets. We will show that subtle differences exist between the translation at the initiation step of Gram-negative and Gram-positive bacteria although their ribosomes display a remarkable degree of resemblance. In addition, we will illustrate using specific examples the diversity of mechanisms controlling translation initiation in S. aureus that contribute to shape the expression of the virulence factors in a temporal and dynamic manner.
- Published
- 2016
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