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Determining the factors of formation of severity of parodontal inflammatory diseases (PID) in adolescent girls with menstrual dysfunction (MD) makes it possible to determine the predictors of severity of PID and, on this basis, to develop differentiated methods for their prevention. The aim. To determine the factors responsible for formation of PID severity in adolescent girls with MD. The materials and methods. The following data were studied in adolescent girls with MD with varying severity of PID: obstetric and genealogical anamnesis, lifestyles of adolescents, indices of oral hygiene, dental status, densitometry, content of CA ++ and sIgA in saliva, lysozyme and urease activity in saliva, cytobiophysical potential of buccal epithelium nuclei. The findings. In patients with more severe course of PID, in comparison to milder course of PID, there was determined a more significant degree of weakened heredity in relation to chronic dental and somatic pathology, unfavorable course of pregnancy and childbirth, violations of a healthy lifestyle and oral hygiene in adolescents, anomalies in the development of dentoalveolar system, dysbiosis of oral cavity, reduced local and systemic immunoresistance. Conclusion: The determined predictors of the severity of PID in adolescent girls with MD make it possible to develop differentiated methods for their prevention.

Aim: To study efficacy of maintenance therapy of patients with acute promyelocytic leukemia (APL) in the APL treatment Russian multicenter trial., Material and Methods: The trial was made with participation of 18 hematological departments of clinics in Russia. A total of 68 APL patients entered the trial. The maintenance therapy consisted of 5-day courses of cytostatic drugs which alternated or did not alternate with 5-day courses of ATRA. Cytogenetic tests were made in 31 patients, t(15;17) was detected in 26 of them. Molecular examination conducted in 28 patients discovered chimeric transcript PML/RARa in 26 of them. Of 20 patients examined in Hematological Research Center, 7 (35%) had a bcr 1/2 variant of the transcript PML/RARa, 13 (65%)--bcr 3 variant., Results: 65 patients were eligible for assessment. A complete remission was achieved in 90% cases. No resistance was observed. In follow-up within 30 months the recurrence rate was similar on both treatments. The results of the induction therapy and survival in patients with different variants of the transcripts were also similar. Overall 2.5 year survival for all the patients was 77%, recurrence-free--80%. The survival analysis in patients with leukocytosis higher and lower 10 x 10(9)/l found no statistical differences by the survival. Patients with hyperleukocytosis had higher early lethality than patients with leukocytes under 10 x 10(9)/l (25% vs 5.3%, p = 0.03)., Conclusion: The APL 06.01 protocol showed high efficacy of the relevant maintenance which provides a complete molecular remission in the majority of patients with probable recurrence-free 2.5 year survival 80%.