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24-hour hypokinetic stress expressed in decrease of sensitivity of cellular and humoral immu nity to subsequent immunization with sheep erythrocytes was studied. The development of this phenomenon is associated with sensitization of lymphoid tissue to hypoplasia effect of glycocorticoid hormones. In introduction of glycocorticoid stress, the animals revealed a more pronounced depression of proliferative activity of thymocytes compared with non stressed animals.

Immune response to intermittent fasting was studied in rats. The immunomodulating effect was registered. To a certain degree, this may be due to fasting-induced reduction in blood levels of antiproteolytic proteins and lipid peroxidation products which have immunosuppressive activity.

The feature of blood neutrophils to phagocyte BCG Mycobacterium and Staphylococcus in healthy children and those with acute bronchitis having both positive and negative tuberculin tests was analysed. Healthy children with an altered tuberculin response demonstrate an intensified phagocytic Myco. reaction and a relative inhibition of staphylococcal phagocytosis. In case of acute bronchitis, there is no increase in the overall absorbing capacity of neutrophils, typical of the tuberculin-negative children, and consequently, the detected feature of the phagocytosis is eliminated. The absence of variations in the total phagocytic response of the affected children is considered as a decrease of their adaptation potential. It is presumed that such an immunological status can predetermine the course of respiratory diseases and be the cause of tuberculous infection reactivation with intercurrent diseases.

The effect of hypophysis adrenocorticotropic function on the immune response to the ram erythrocytes in rats was studied after hypophysectomy or centragenous dexametasone blockade; the humoral immune response was more obviously activated in animals fed with dexametasone whereas indices of the cellular immunity: the delayed hypersensitivity response (DHR)--were more obvious in hypophysectomised animals. The T-cell populations are normally much more suppressed with glycocorticoids than the cells participating in humoral immune response.

The purpose of a new method elaborated for treatment of allergic inflammation of the eye is to rise effectiveness of treatment and to prevent exacerbation of allergic inflammation by means of increasing the accuracy of determining the therapeutic allergen dilution when conducting specific hyposensitization. This is achieved in the following way: in addition to control, when conducting allergometric titration, the syringe needle is introduced intracutaneously without subsequent administration of the allergen. In respective terms, the thermometry of skin is made in the sites of administration of different allergen dilutions and in the control site. Considering the minimum hyperthermia in the site of administration of the highest allergen dilution as compared with the control site, the therapeutic allergen dilution is chosen. This method of treatment was used in 38 patients (54 eyes) with recurrent uveitis and proved to be highly effective in 34 patients (50 eyes), i.e. in 92%. In remote terms of observation, no further recurrences were recorded in 65% of cases.

Complex study of the immunologic status of rats from the first days after the injection of nephrotoxic serum up to formation of chronic renal failure in comparison with functional and morphological characteristics of the disease confirmed the hypothesis on the phasic development and different pathogenetic role of the hypersensitivity reactions of the immediate and delayed types during nephritis. Signs of the immediate hypersensitivity predominated during the initial stages of the disease; realization of this hypersensitivity is indicated both by the liberation of the mediators of the pathochemical phase and by the change of the renal processes. The development of delayed hypersensitivity reactions plays the basic role in the pathogenesis of chronic nephritis.