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Purpose: To perform cost-effectiveness analysis of using different types of monofocal intraocular lenses (IOL) for cataract surgery in adults in Russian Federation. Materials and methods. MS Excel based model of medical care patients with cataract has been developed for 1 patient undergoing surgery treatment. “cost-effectiveness” and “budget impact” analyses (BIA) were used to measure the costs associated with cataract treatment with different types of monofocal IOLs for the state budget. Direct medical costs included IOLs cost, treatment of PCO with neodymium-doped uttrium aluminium garnet laser capsulotomy (Nd:YAG), side effects treatment associated with Nd:YAG and were calculated from the Russian healthcare system perspective. Results. Cost-effectiveness analysis among monofocal IOLs demonstrated that the lowest costs for 1 case of successful cataract surgery followed by implantation of the IOL are connected with the use of the AcrySof® Single Piece model — 4,938 rubles, the largest costs — using the Tecnis® One model — 11,753.5 rubles. The use of others hydrophobic IOLs on the AcrySof® platform demonstrated economic feasibility, analyzed models have costs for 1 effective cataract treatment -AcrySof® IQ 9,858 rubles, AcrySof® Natural 6,452 rubles. The conducted BIA has showed that direct medical costs for surgical treatment of cataracts with the implantation of monofocal IOLs from different manufacturers for 100 patients amount to 708,121 rubles. If ua monofocal IOL are used alone on an AcrySof® platform, the cost will be 691,261 rubles, the difference is in favor of monofocal IOL on an AcrySof® platform — 16,860 rubles. Conclusion. Using AcrySof® IOLs for cataract surgery in adult patients is an effective and an economically justified treatment option in Russia Federation.

Objectives: to perfom analysis of the clinical efficacy and safety of using monofocal IOLs in the surgical treatment of cataracts in adult patients. Material and methods. In available sources (databases of the Cochrane Library and Medline) a search was conducted to evaluate the effectiveness and safety of using monofocal IOLs in cataract surgery in adult patients according to the PICO(S) regimen. A literature review was conducted in July 2018 for the keywords “intraocular lenses” and “cataract” using the following filters: clinical trial, randomized clinical trial, meta-analysis, systematic review (clinical trial, randomized clinical trial, meta-analysis, systematic review). Posting languages: English. Depth of search — 5 years. Last search date is July 27, 2018. Results. An initial search in the Medline database found 21,737 publications and 2157 in the Cochrane Library database. A total of 17,894 links were found. In a meta-analysis Zhao Y. et al., 2017, a comparison of the incidence of opacities of the posterior capsule (secondary cataract) after surgical treatment with the implantation of hydrophobic and hydrophilic IOLs was made. In multicenter retrospective cohort study Ursell P., et al, 2018 assessed the frequency of the Nd: YAG-laser capsulotomy for the treatment of secondary cataract which developed after the implantation of the IOL within the first 3 years after surgery. Conclusion. During the systematic review, the relationship between the incidence of complications (secondary cataracts) and the properties of the IOL material was found. The implantation of lenses from a hydrophobic material is associated with a lower incidence of secondary cataracts than the implantation of lenses from a hydrophilic material.

Background. Lagohilus inebrians Bge plant has been used as an effective drug in stopping various bleeding processes. The substance tetracetyllagoxilin obtained on the basis of lagoxilin diterpennoid derived from this plant is not well soluble in water and therefore its biological activity is not high. Purpose. Obtaining a water-soluble supramolecular complex compound of tetraacetyllagoxylin (TetAL) and glycyrrhizinic acid (GKMAT) and studying the nature of the forces acting on the viscosity of aqueous solutions and the structure of aqueous solutions of the complex compound. Methodology. To obtain GKMAT supramolecular complexes with tetraacetyllagoxylin (TetAL), 50% of GKMAT was dissolved in acetone and stirred in a magnetic stirrer, tetraacetyllagoxylin was added accordingly. leophil is dried in a dryer. The resulting supramolecular complex is broken down in a mortar. A 0.1% aqueous solution of light yellow amorphous powder has gel properties. Тliquid = 199-2010S, / a / D25 = + 16 (dis.suv.ethanol 1: 1), Rf = 0.26. Originality. For the first time supramolecular complexes of tetraacetyllagoxylin with GKMAT were obtained and the nature of the forces acting on the viscosity of aqueous solutions and the structure of aqueous solutions of the complex compound were studied. Findings. For the first time, the nature of the forces acting on the viscosity of aqueous solutions of supramolecular complexes of GKMAT with tetraacetyllagoxylin and the structure of aqueous solutions of complex compounds is explained by the formation of "hydrophobic-hydrophobic" interactions and hydrogen bonds. [ABSTRACT FROM AUTHOR]