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Your search keyword '"HIV Envelope Protein gp120 metabolism"' showing total 7 results
Start Over Descriptor "HIV Envelope Protein gp120 metabolism" Language russian
7 results on '"HIV Envelope Protein gp120 metabolism"'

1. [Interaction of human apolipoprotein AI and HIV-1 envelope proteins with the native and recombinant CD4 receptors].

Author

Panin LE and Kostina NE

Subjects
Apolipoprotein A-I chemistry, Binding, Competitive, CD4 Antigens chemistry, Cell Line, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, HIV Envelope Protein gp120 metabolism, HIV Envelope Protein gp41 metabolism, Humans, Lymphocytes immunology, Receptors, Lipoprotein chemistry, Recombinant Proteins chemistry, Viral Envelope Proteins chemistry, Apolipoprotein A-I metabolism, CD4 Antigens metabolism, HIV-1, Lymphocytes metabolism, Viral Envelope Proteins metabolism
Abstract

The method of enzyme-linked immunosorbent assay (ELISA) was used to show an interaction of soluble recombinant CD4-receptor (rsCD4) with human apolipoprotein A-1. Competitive interactions between envelope proteins VIH-1 (gp120 and gp41), on the one hand, and human apolipoprotein A-1 with CD4 receptor, present in the cellular membranes of line MT4 human lymphocytes, were demonstrated by the method of flow cytofluorimetry. It was suggested that the competitive interactions between the above proteins could manifest in respect to the apolipoprotein A-1 receptor, which affects the involvement of the latter in the regulation of protein biosynthesis and which leads to a decrease in the body weight of HIV-infected patients.

Published
2003

2. [Immunochemical homology of HIV-1 envelope proteins and human apolipoprotein AI].

Author

Panin LE, Kostina NE, Poteriaeva ON, and Fediuk NV

Subjects
Acquired Immunodeficiency Syndrome blood, Acquired Immunodeficiency Syndrome immunology, Apolipoprotein A-I immunology, Blotting, Western, Enzyme-Linked Immunosorbent Assay, HIV Antibodies immunology, HIV Envelope Protein gp120 immunology, HIV Envelope Protein gp41 immunology, Humans, Protein Binding, Apolipoprotein A-I metabolism, HIV Envelope Protein gp120 metabolism, HIV Envelope Protein gp41 metabolism, HIV-1 metabolism
Abstract

Immunochemical homology of envelope HIV proteins and human apolipoprotein A-I was for the first time detected by ELISA. Immunochemical reactions between antibodies to apoA-I and HIV envelope proteins and between apoA-I and anti-HIV antibodies present in the blood of AIDS patients were shown. These data suggest that the homology of surface HIV proteins and human apoA-I can lead to competitive relationships impeding the involvement of human apoA-I in gene expression regulation.

Published
2001

3. [General trends in design of drugs for chemotherapy of AIDS].

Author

Bibikova MV, Ivanitskaia LP, and Grammatikova NE

Subjects
Drug Design, HIV Envelope Protein gp120 metabolism, HIV Integrase Inhibitors therapeutic use, HIV Protease Inhibitors therapeutic use, HIV Reverse Transcriptase antagonists & inhibitors, Humans, Receptors, HIV metabolism, Reverse Transcriptase Inhibitors therapeutic use, Zidovudine analogs & derivatives, Zidovudine therapeutic use, Acquired Immunodeficiency Syndrome drug therapy
Published
2000

4. [Interaction of peptides of human immunodeficiency viral proteins with continuous cell lines of varying origin].

Author

Khromykh LM, Skliarov LIu, Sbitneva IN, Kopina NA, Zaĭtseva MB, and Kazanskiĭ DB

Subjects
Amino Acid Sequence, Animals, Cell Line, Cell Movement, HIV Envelope Protein gp120 chemistry, HIV Envelope Protein gp41 chemistry, Humans, Mice, Molecular Sequence Data, HIV Envelope Protein gp120 metabolism, HIV Envelope Protein gp41 metabolism, Peptide Fragments metabolism
Published
1998

5. [Inhibition of human immunodeficiency virus replication by anionic dyes].

Author

Iakubov LA, Pliasunova OA, Fediuk NV, Pokrovskiĭ AG, and Vlasov VV

Subjects
Anions, Antiviral Agents metabolism, CD4 Antigens metabolism, Cell Line, Coloring Agents metabolism, HIV Envelope Protein gp120 metabolism, HIV-1 physiology, Humans, Antiviral Agents pharmacology, Coloring Agents pharmacology, HIV-1 drug effects, Virus Replication drug effects
Published
1996

6. [Isolation of human B-cells, specific for viral peptides, using magnetic spheres].

Author

Sidorova EV, Borisova TK, and Rozen A

Subjects
Antigens, Viral chemistry, Antigens, Viral immunology, Antigens, Viral metabolism, B-Lymphocytes metabolism, Cell Separation, Cells, Cultured, DNA-Binding Proteins chemistry, DNA-Binding Proteins immunology, DNA-Binding Proteins metabolism, Epstein-Barr Virus Nuclear Antigens, HIV Envelope Protein gp120 chemistry, HIV Envelope Protein gp120 immunology, HIV Envelope Protein gp120 metabolism, HIV-1 metabolism, Humans, Immunoglobulins biosynthesis, Magnetics, Peptide Fragments immunology, B-Lymphocytes cytology, Peptide Fragments metabolism
Abstract

A method for isolation of human B cells specific to viral peptides using magnetic beads has been developed. The method was used for the isolation from human tonsils of B cells specific to HIV-1 gp 120 MN-24 peptide (residues 302-322) and to Epstein-Barr virus 107 EBNA-1 peptide. The cells selected with beads were transformed by Epstein-Barr virus. The resultant cell cultures produce human immunoglobulin antibodies to HIV-1 MN-24 and to Epstein-Barr EBNA-1 p107 peptides.

Published
1994

7. [The antiviral action of recombinant forms of the human T-lymphocyte CD4 receptor].

Author

Zverev VV, Maliushova VV, Sidorov AV, Pugach AV, Shukhmina NR, Pille ER, Mel'nikova NL, and Andzhaparidze OG

Subjects
Antibodies, Monoclonal drug effects, Antibodies, Monoclonal metabolism, Antiviral Agents chemical synthesis, CD4 Antigens drug effects, CD4 Antigens immunology, CD4 Antigens metabolism, Cells, Cultured drug effects, Cells, Cultured metabolism, Depression, Chemical, Dose-Response Relationship, Drug, Giant Cells drug effects, HIV Envelope Protein gp120 drug effects, HIV Envelope Protein gp120 metabolism, HIV-1 metabolism, Humans, Protein Binding drug effects, RNA-Directed DNA Polymerase drug effects, Recombinant Proteins chemical synthesis, Recombinant Proteins pharmacology, T-Lymphocytes drug effects, T-Lymphocytes metabolism, Virus Cultivation, Antiviral Agents pharmacology, CD4 Antigens pharmacology, HIV-1 drug effects
Abstract

A recombinant protein containing the first 179 N-terminus amino acids of human T-lymphocyte CD4-receptor was synthesized in E. coli cells. This recombinant protein was shown to interact with OKT4A and Leu3a monoclonal antibodies competing with HIV gp120 glycoprotein for binding with the native CD4 receptor. Experiments in vitro in human T-lymphocyte cultures showed that the recombinant CD4-protein in concentrations of 1 to 10 micrograms/ml inhibited the virus-induced syncytium formation, HIV replication in cell culture, synthesis of HIV reverse transcriptase and other virus-specific proteins, that is, behaved as a HIV inhibitor.

Published
1994

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