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Start Over Author "H, Lôo" Language russian
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1. [Clinical and electroencephalographic study of a new antidepressive agent, mono-methyl-amino-propyl-dibenzo-bicyclo-octadine hydrochloride (Ciba 34, 276 Ba)].

Author

Deniker P, Lôo H, Verdeaux G, and Oughourlian JM

Subjects
Adjustment Disorders drug therapy, Adult, Aged, Bipolar Disorder drug therapy, Depression drug therapy, Drug Evaluation, Female, Humans, Male, Maprotiline administration & dosage, Maprotiline adverse effects, Anthracenes therapeutic use, Maprotiline therapeutic use, Mental Disorders drug therapy
Abstract

A clinical trial on fifty patients studied a new compound with a quadricyclic structure, Ciba 34.276-Ba or Maprotiline in any category of depression. The product was found to have notable antidepressive properties, capable to act on the melancholic depressions of the manic depressive psychosis and of involutive melancholia. The best results were noted in the neurotic and reactive depressions perhaps because a tranquilizing activity marked in the majority of the cases. The clinical tolerance was found good and the side effects which reminded of those caused by derivates of Imipramine, remained moderate while the biological tolerance was perfect. The modifications of the electroencephalogram were of two types, one of them suggesting thymoanaleptic activity, the other suggesting rather a sedative activity.

Published
1975

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