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В данной статье рассмотрены дискурс-анализ и исследование культурного дискурса в интерпретации Ши Сюя., The current discourse analysis is based on the Western scientific tradition, takes little account of Eastern cultures and discourses, and restricts innovation. In this regard, some scholars have put forward innovative concepts in the field of Cultural Discourse Studies. Shi-Xu is one of the main representatives of this scientific direction. He develops a re-search paradigm aimed at the study of the modern Chinese discourse and taking into account its specific features. This arti-cle discusses the discourse analysis and study of cultural discourse in the interpretation of Shi-Xu. Special attention is paid to the research paradigm, which is focused on modern Chinese discourse and has Chinese philosophical, methodological and cultural foundations., Политическая лингвистика, Issue № 4 (76), Pages 12-20

С целью поиска активных соединений, способных оказывать ингибирующее действие на протеинкиназу MST1 (Mammaliansterile 20-like kinase 1) мы провели компьютерный дизайн, применяя методы, основанные на структуре макромолекулы-мишени (Target-Based Drug Design), и методы, основанные на структуре лигандов (Ligand-Based Drug Design). Для оценки нежелательных эффектов использовали программу PASS (Prediction of Activity Spectra for Substances), для построения количественных зависимостей «структура-активность» QSAR (Quantitative Structure-Activity Relationship) и оценки ингибирующей активности компьютерную программу GUSAR (General Unrestricted Structure-Activity Relationships). В результате эксперимента было отобрано 6 потенциальных ингибиторов MST1, относящихся к различным классам органических соединений., At present time, diabetes is regarded as polygenic, multifactorial disease: genetic predisposition in combination with environmental triggers activates specific autoimmune processes, which lead to the death of β-cells. Therefore, violations in the processes of initiation and implementation of apoptosis are fundamental in the development of the disease. Preservation or restoration of pancreatic β-cells in diabetic patients is an ultimate therapy for diabetes, but is an unmet medical challenge Protein kinase MST1 has been recently identified as a key mediator of cell apoptosis, and recent studies have shown that it could serve as a target for developing new drugs to treat diabetes. In order to find active compounds capable to inhibit MST1 (Mammalian sterile 20-like kinase 1), we carried out a computer-aided design, using methods based on the structure of macromolecule-target (Target-Based Drug Design) and methods based on the structure of ligands (Ligand-Based Drug Design). To assess the undesirable effects we used the computer program PASS (Prediction of Activity Spectra for Substances); for construction of quantitative relationships «structure-activity» (Quantitative Structure-Activity Relationship) and evaluation of inhibitory activity computer program GUSAR (General Unrestricted Structure-Activity Relationships) was used. As a result of experiment, 6 potential inhibitors of MST1were selected. These compounds do not exhibit mutagenic or toxic properties but have high level of activity in comparison with already known inhibitors. This fact makes it possible to suppose, that our compounds are suitable for future synthesis and in vitro screening.