1. [HLA-E molecule induction on the surface of tumor cells protects them from cytotoxic lymphocytes].
- Author
-
Berezhnoĭ AE, Chernisheva AD, Zakeeva IR, Danilova AB, Danilov AO, Moiseenko VM, Geraghty D, Gnuchev NV, Georgiev GP, Kibardin AV, and Larin SS
- Subjects
- Antineoplastic Agents therapeutic use, Cell Line, Tumor, Flow Cytometry, Gene Expression Regulation, Neoplastic drug effects, Gene Expression Regulation, Neoplastic immunology, HLA Antigens biosynthesis, Histocompatibility Antigens Class I biosynthesis, Humans, Immunoblotting, Interferon-gamma therapeutic use, Polymerase Chain Reaction, HLA-E Antigens, Antineoplastic Agents pharmacology, HLA Antigens metabolism, Histocompatibility Antigens Class I metabolism, Interferon-gamma pharmacology, Melanoma drug therapy, Melanoma immunology, T-Lymphocytes, Cytotoxic immunology
- Abstract
Modern immunotherapy has developed powerful tools for mounting antitumor response which nevertheless have had only limited success in clinic. Tumor cells use different mechanisms to escape from immune system. Thus, one of the reasons of unsuccessful immunotherapy might be induction of tolerance of tumor-specific cytotoxic lymphocytes by tumor cells. Previously we have demonstrated expression of HLA-E molecule by the cells of melanoma cell lines. In this paper we have studied HLA-E-dependent mechanism of melanoma cell escape from immune response.
- Published
- 2009