Search

The catheterization technique was used to study the effect of 100 mg of water soluble hydrocortisone "Russel" upon the cardiac activity and greater circulation in patients with acquired heart diseases. Hydrocortisone was found to produce different effects upon the cardiac output and tonicity of the greater circulation vessels--increases or decreases them, or does not change at all. The varying dynamics of these indices serves as a manifestation of the optimizing effect of hydrocortisone on the cardiovascular system, depends on the initial values of the parameters in question, and is directed towards normalizing the oxygen consumption in the body (its blood flow). No direct correlation was found between the cardiac output and the pressure in the ventricles in patients with acquired heart diseases prior to and following hydrocortisone administration.

Fibrinogen levels and aortic and pulmonary-artery blood pressure were measured in 143 patients with acquired heart diseases and pulmonary hypertension and in 60 control patients. The lungs were shown to participate in the regulation of fibrinogen levels both in the controls and patients with heart diseases, as reflected in the deposition-balance-mobilization phases by positive, zero, negative arterio-venous difference of fibrinogen levels. The association between the metabolic and hemodynamic functions of the lungs is particularly obvious, if pressure gradients (pulmonary-capillary and bronchial perfusion ones), making for blood inflow into the alveolar-capillary region, are examined.

Sixty essentially healthy subjects were examined manometrically with blood withdrawn from the coronary sinus, pulmonary artery, aorta, veins of the right kidney and the right liver lobe. Together with the traditional parameters of the gas contents and gradients of plasma, it is proposed to use tests measuring additive O2 and CO2 parameters. It has been demonstrated that the above organs can be discriminated using tests that are additive with respect to the gas pressure. It is emphasized that the tests proposed here, when used in addition to the traditional ones, allow identification of the gas and non-gas parameters of homeostasis as a single system of tests to assess the human body function.

The author studied the state of hemeostasis in normals and in patients with acquired heart insufficiency. By means of bloody methods of triple probe samples of the blood inflow and outflow from the brain, and by biochemical methods they also studied 22 normals and 100 patients with acquired heart insufficiency for interrelations between the gas metabolism indices and acid-base equilibrium of the central pulmonary hemodynamics. As a results it was established that the brain blood flux in patients with acquired heart insufficiency in different degrees of pulmonary hypertension is adequate to the metabolic requirement of the brain in oxygen and corresponds to identical indices in normals. There was no relation between the state of pulmonary circulation and brain circulation.