1. [Pharmacological correction of nonspecific resistance and production of proinflammatory cytokines during chronic intoxication with organophosphorus compound VX].
- Author
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Zabrodskiĭ PF and Grishin VA
- Subjects
- Animals, Antidotes therapeutic use, Female, Gas Poisoning drug therapy, Gas Poisoning immunology, Immunologic Factors therapeutic use, Interleukin-1beta blood, Interleukin-6 blood, Male, Muramidase blood, Neutrophils drug effects, Neutrophils immunology, Oligopeptides therapeutic use, Organothiophosphorus Compounds antagonists & inhibitors, Peptides pharmacology, Phagocytosis drug effects, Piperazines therapeutic use, Polymers therapeutic use, Rats, Thymus Extracts pharmacology, Tumor Necrosis Factor-alpha blood, Antidotes pharmacology, Chemical Warfare Agents toxicity, Immunologic Factors pharmacology, Oligopeptides pharmacology, Organothiophosphorus Compounds toxicity, Piperazines pharmacology, Polymers pharmacology
- Abstract
It is established in experiments on noninbred rats that the use of imunofan (20 mg/kg daily) and polyoxidonium (150 mg/kg daily) for 7 days on the background of chronic intoxication with organophosphorus agent VX (0.01 LD50, single daily treatment for 30 days) resulted in almost complete recovery of phagocytic-metabolic activity of neutrophils, the content of lysozyme, cationic protein of platelet, and levels of proinflammatory cytokines TNFa, IL-1b and IL-6 in the blood. The administration of T-activin (20 mg/kg daily for 7 days) restores these parameters insignificantly. The maximum overall stimulatory effect was produced by polyoxidonium, while the minimum effect was observed for T-activin.
- Published
- 2012