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Using etymological methods, the present study has identified two Sinitic and Germanic shared (Sino-Germanic) etymologies (etyma):【南, 陰】. These two etyma form a rhyme correspondence. This regular sound change validates the etymological connection in question. The etymon 【南】 for 'southern sky' has been identified in Sinitic, Germanic, Baltic, Slavic, Celtic, Albanian, Hellenic, Anatolian, Armenian, Indo-Iranian, some Tibeto-Burman, some Uralic and Hungarian. The etymon 【陰】 for 'dark' has been identified in Sinitic, Germanic and Gyalrong. In words of Western linguistics, the Proto-Indo-European root *nebh- 'moist, water from it damp, mist, fog, cloud' is newly identified in Sinitic, some Tibeto-Burman, some Uralic and Hungarian; the Proto-Germanic root *ēbanþ-/ēbunþ- 'evening' is identified in Sinitic and Gyalrong.

Using etymological methods, the present study has researched four Sinitic and Germanic shared (Sino-Germanic) etymologies (etyma) and two Sinitic and Uralic shared (Sino-Uralic) etyma. Two of the Sino-Germanic etyma form a rhyme correspondence. Three of the Sino-Germanic etyma form an onset correspondence. Two of the Sino-Uralic etyma form another rhyme correspondence. These regular sound changes validate the etymological connections in question. The Sino-Germanic term for 'star' and Sino-Uralic term for 'star' are supported.

Using etymological methods, the present study has identified seven Sinitic and Uralic shared etymologies (etyma). Three of them form a rhyme correspondence. Two of them form an onset correspondence. Four of them form another rhyme correspondence. These regular sound changes validate the genetic connection between Sinitic and Uralic. The Sino-Uralic etymology (etymon) for 'Jupiter, year' is among these etyma. It is demonstrated that this term should be aboriginal in Sino-Uralic languages.

Using etymological methods, the present study has researched four Sinitic and Uralic shared etymologies (etyma). Two of them form a rhyme correspondence. Three of them form an onset correspondence. These regular sound changes validate the genetic connection between Sinitic and Uralic. The Sino-Finnic term for 'moon, month' is among these four etyma. It is demonstrated that this term should be aboriginal in Sino-Uralic languages.

Using etymological methods, the present study has identified five Sinitic and Uralic shared etymologies. These five etymologies form a rhyme correspondence. This regular sound change validates the etymological connection between Sinitic and Uralic. The Finnic term for 'sky' is among these five etymologies. It is demonstrated that this word root should be aboriginal in Sino-Uralic languages.

ALDH4A1, a member of the aldehyde dehydrogenase superfamily, is a key enzyme in the mitochondrial proline metabolism pathway. Recent studies have shown that mutations in aldh4a1 lead to reduced fertility and reproductive premature aging of male nematodes. However, the effect of ALDH4A1 on fertility of male mice has not been studied. In this study, we used CRISPR-Cas9 technology to construct a knockout mouse model of Aldh4a1 for the first time to explore the effect of this gene on the reproduction of male mice. The results showed that compared with WT male mice, Aldh4a1^(-/-) male mice were fertile, had normal spermatogenesis but defect in sperm maturation in the epididymis documented by impaired motility, increased morphological abnormalities and increased spontaneous acrosome reaction. In addition, transmission electron microscopy showed vacuoles in the sperm mitochondria, and fracture in the neck of sperms and vacuoles in these mice. These results revealed that ALDH4A1 plays a vital role in the structure of sperm flagellum and the process of sperm maturation in mice.

Conyzasaponins produced by the traditional Chinese herb Conyza blinii are oleanane-type saponins with a wide range of biological activities. Here, we identified a gene, designated CbCYP716A261, encoding a β-amyrin 28-hydroxylase in conyzasaponins biosynthesis. Ten full putative CYP sequences were isolated from Conyza blinii transcript tags. The CbCYP716A261 gene product was selected as the putative β-amyrin 28-hydroxylase by phylogenetic analysis and transcriptional activity analysis of methyl jasmonate-treated Conyza blinii. To identify the enzymatic activity, we performed enzymatic activity experiments in vitro and in vivo. The HPLC results revealed that CbCYP716A261 catalyzes the hydroxylation of β-amyrin at the C-28 position to yield oleanolic acid. Our findings provide new information about the conyzasaponin biosynthesis pathway and widen the list of isolated β-amyrin 28-hydroxylases.

Parameters of water-salt balance in Wistar rats were compared on empty stomach and at standard alimentary regimen (satiated animals). On empty stomach, the blood serum osmolatity amounted to 284 +/- 2, while in satiated rats--to 290 +/- 5 mOsm/kg H2O (p < 0.05); sodium ion concentration on empty stomach lower, whereas no difference in potassium concentration was found. After an intragastric administration of water (5 ml/100 g body mass) to unanaesthetised rats, the blood serum osmolality decreased, while diuresis increased to an equal extent in both groups of rats. For 120 min after the water administration the rats on an empty stomach excreted 92.9% of the administrated fluid, whereas the satiated animals--80.7%. The urine composition differed qualitatively: in fasting rats the increment of diuresis was due to a rise of osmotic free water excretion, whereas in satiated rats--to an increase of excretion of osmotic active substances (including Na and K ions) with water and a simultaneous increase of the osmotic free water reabsorption in the kidney. After the water load and injection of 0.005 nmole/100 g body mass of arginine-vasopressin for 2 hr of the study, diuresis in both groups of animals decreased to an equal extent, but in fasting animals this was due mostly to an increase of the osmotic free water. The data obtained indicate that, under conditions of usual alimentary regimen, the response of kidney to the water load had a character of a volume-regulating response, whereas in fasting rats--of the specific osmorequlating one. A problem is discussed of the concept of norm under usual conditions and at certain clinically accepted restrictions, for instance, on empty stomach.