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Introduction and purpose The prevalence of chronic pain is estimated at around 30% of the world's population. The risk of developing chronic pain depends, among others, on from genetic factors. Considering that chronic pain is a serious diagnostic and therapeutic problem, and if treated inadequately constitutes a serious threat to public health, focus should be on identifying the risk factors for its occurrence in order to establish an effective treatment. The aim of the work is to summarize the latest knowledge about the influence of functional polymorphism of the COMT gene on the formation of chronic pain. Material and methods The material for this literature review were publications on the subject of research from the last 5 years. Relevant articles have been identified by two authors using PubMed, Google Scholar and Researchgate publishing bases using key words: "gene COMT", "headache", "chronic pain", "chronic back pain", "fibromyalgia", "temporomandibular disorder", "postoperative pain" according to Medical Subject Headings. The review of articles consisted of 3 stages. Finally, 19 works were qualified for the review. Results Functional polymorphism of the COMT gene is one of the factors affecting the modulation of pain. Its single genetic variants will positively correlate with the occurrence of temporomandibular disorders and chronic lower back pain. Differences in genetic variants of the COMT gene will also affect the susceptibility to fibromyalgia and increase the severity of clinical symptoms. The COMT gene polymorphism does not seem to correlate with chronic headaches. Conclusions Research to determine the effect of COMT gene polymorphism can significantly affect the diagnosis and treatment of chronic pain.

Aim. To study the parameters of aortic stiffness and polymorphisms of matrix metalloproteases genes MMP2 (-1306) and MMP9 (-1564) in patients with arterial hypertension (AH) of young and middle age.Material and methods. Totally, 58 patients studied with AH, age 25-60 y.o., and 59 healthy volunteers. The pulse wave velocity (PWV) assessed, and augmentation index (arteriography on TensioClinic TL1, Hungary). The specimens of DNA extracted, from blood leucocytes, and gene typing of promotor regions of the genes MMP2 (-1306) and MMP9 (-1564).Results. Genotypes MMP2 (-1306) (CT and ТТ) are found in AH patients with the signs of metabolic syndrome (MS) 1,72 times more commonly than in controls (p=0,23). Genotypes MMP9 (-1564) (CT and ТТ) are slightly more common in the general AH group comparing to controls (OR=1,4; p=0,39). In AH patients with no MS signs the genotypes MMP9 (-1564) (CT and ТТ) are predominant and found 2,66 times more frequently, than in the healthy (р=0,04). In cases of high PWV in AH, genotype MMP9 (-1564) (СТ and ТТ) is found 1,9 times more often than in controls with AH and normal PWV with no statistical significance (р=0,14).Conclusion. The polymorphism MMP9 (-1564 C/T) finding in AH patients can be used for prediction of additional risk for cardiovascular catastrophes with the individualized monitoring of collected factors.