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This work is an experimental study on 30 rabbits to determine the effect of antioxidants on the process of repair of the esophagus. Chemical agent was 46% acetic acid, a The antioxidant "Mexidol" were injected to core group of test animals in 2 weeks. Animals were taken from the experiment at 5, 14, 21, 30, 45 and 60 hours. We conducted morphometric study of histological exemplars, determining the number of inflammatory cells, epithelial thickness, the area of newformed blood vessels. In the study group we reported an improvement of reparative processes in the wall of the body: it was increased blood supply to the burn surface on 242% and more rapid relief of inflammatory processes on 117% (p < 0.05).

The sampling of 82 patients was included into the study to assess the diagnostic value of laboratory markers of endothelium dysfunction (homocysteine concentration, von Willebrand factor activity) in patients passing the treatment of program hemodialysis. The study detected the reliable increase of homocysteine level and activity of von Willebrand factor in patients passing hemodialysis. The association of increasing of concentration of homocysteine and von Willebrand factor activity with rate of cardiovascular complications in patients passing the program in patients passing hemodialysis was established.

Fragments of different regions of brain, spinal cord and retina obtained from 6 up to 7 wk human embryos were placed into media 199. On 24th hr of cultivation multiple invaginations developed in the explant ventricular surface as a response to its damage while preparing to explantation. Maturity extent of neural and glial elements was not essential to invagination intensity. Fragments of tectum and retina that are characterised by permanent shape of ventricular surface displayed minimal activity. These data suggest that the reaction considered reflects a property of neuroepithelial cells that constitutes an important factor in normal brain morphogenesis.

Processes of the development and growth of the soft palate mucosas in ontogenesis and also proliferation, growth and differentiation of epithelial structures were studied in the experiment. The epithelium of the soft palate nasal surface was established to be more labile and to be characterized with polymorphism forming single-layer and pseudostratified structures. Under these conditions the oral surface epithelium keeps stratified structures firmly. On the basis of discovered differences of the epithelium biological qualities a suggestion is made on the different genetic origin of epithelial tissues of mucosas of the soft palate oral and pharyngeal surfaces.

Extent of the completeness of the tail skin restoration was studied in 30 outbred albino male rats after the induction of full-thickness defect 10 x 5 mm in size with the restoration process running under different conditions: without any effects (control group), with the constant perfusion, of the wounded surface with 0.9% sodium chloride solution up to the complete wound epithelialisation (experimental group 1), with the moisturing of the wounded surface by the gauze napkin, plentifully moisted with the 0.9% sodium chloride solution up to the complete epithelialisation (experimental group 2). Two months after the operation the defect control part was represented by the connective tissue scar in the control group and in the experimental group 2. Structures, resembling the terminal regions of the sebaceous glands, are developing from the newly formed epithelium in the experimental 1. The composition of the regenerate connective tissue closely resembles that of the intact derm. Thus, the constant perfusion of the wounded surface with the isotonic sodium chloride solution promotes the organotypic skin regeneration.