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Human health is largely determined by the level of physical development and functionality of the body, the foundations of which are laid in childhood. Currently, social and environmental conditions, difficulties in organizing health care have led to an increase in all types of morbidity. Indicators of physical development decrease, the number of children with manifestations of acceleration of development decreases, at each fourth child the posture disturbance is noted. The disability of children is growing. Individuality of physical development and functional state of the body of children (boys and girls) certainly exists, it is the basis of well-known clinicians situations such as “paradoxical” reactions of the body, differences in the clinical picture of the disease at the same dose of infectious agent, abnormal effects in individuals and are referred to by clinicians as “individual features of the reactivity of the organism.” Based on this, in our work we use and present individual indicators of physical development (indicators of anthropometric status, external respiration, physical development and functional status) of the body of children with visual pathology, boys and girls of different ages. The physical condition of a person determines the degree of endo- and exointoxication and immunological reactivity. Therefore, the study of the impact of a new set of rehabilitation measures on immuno-hematological parameters that characterize the overall immunological reactivity of children aged 7-10 years with visual pathology is necessary to address its possible use. The aim of the study was to study the effect of the developed method of physical rehabilitation on the immunological reactivity of the body of children aged 7-10 years with visual pathology. Object and methods of research. Approbation of the complex method of physical rehabilitation carried out at children (31 children) aged 7-10 years of comprehensive special boarding school of I-III degrees № 23 (director Kotlyarov MV) Slavyansk under the control of medical workers of institution who carried out peripheral blood collection for laboratory examination of children on a hematology analyzer of the HB series, which was discussed in the previous section. Carrying out of rehabilitation measures of the method developed by us which is directed on improvement of physical development of these children and improvement of immunological reactivity of an organism of children, aged 7-10 years, with pathology of sight. For the rehabilitation of children with visual pathology of 7-10 years, we used the method of exercise for these children, developed plans based on the sex of deep disorders, and so on. The stage of the study of the use of this method in children with visual pathology 7-10 was found to influence the effects of rehabilitation measures on the immunological reactivity of the organism. First, the definitions summarize the impact on all adolescents with visual pathology, and then separately on boys and girls depending on age. Research results and their discussion. In children aged 7-10 years with visual pathology, who underwent a set of rehabilitation measures, the value of the index of the ratio of agranulocytes and ESR increases by 39.16%, which is evidence of stimulation of adaptive immune activity. This reduces the value of lymphocyte-granulocyte index by 12.20%, which confirms the activation of granulocyte leukocytes – neutrophilic polymorphonuclear leukocytes and eosinophils. Along with this, there is a tendency to decrease (P> 0.05) the index of immunological reactivity – by 10.71%, nonspecific resistance – by 12.20%, lymphocyte-granulocyte index – by 10.21%, the index of the ratio of lymphocytes and monocytes – at 11.49%. These changes in immuno-hematological parameters indicate that the rehabilitation measures in children aged 7-10 years with visual pathology, positively and slowly affect the overall immunological reactivity of the body of children with visual pathology. There is no immuno-hematological indicator that would indicate a negative impact on the physical development of the body and a significant decrease in immunohematological parameters that characterize the functional and immune status of children with visual pathology. Conclusions. Thus, the development of a set of rehabilitation measures for both boys and girls aged 7-10 years with visual pathology, improves immune and hematological parameters that characterize the state of nonspecific anti-infective and specific immune protection (immunological reactivity) of children aged 7-10 years with visual pathology. No changes in immuno-hematological parameters in these children, which could be a contraindication to the use of new sets of rehabilitation measures. Prospects for further research. The main scientific provisions obtained and presented in the article are the basis for studying the impact of measures and tools aimed at improving the state of non-specific anti-infective and specific immune protection (immunological reactivity) of children with visual pathology aged 10-14 years.

One of the most important points in assessing the effectiveness of physical rehabilitation in children with scoliosis is the dynamics of the indicators of functioning of the cardiorespiratory and vascular systems. Purpose of the research: the scientific research is to study the effectiveness of the developed physical education program on the dynamics of changes in additional parameters of the functioning of the cardiorespiratory and vascular systems in school-age children with scoliosis at the age of 11-14 years. Materials and methods of the research. The bases for the research were specialized general sanatorium boarding school № 13 for children with scoliosis in OleksiyevoDruzhkivka, Donetsk region.The study was conducted among 19 children at the age of 11-14 years with scoliosis (9 boys and 10 girls). A comprehensive program of physical exercises for long-term rehabilitation of school-age children with spinal defects (scoliosis) has been developed. The research was based on the results of the impact of a comprehensive program of developed exercise technology on the leading indicators of physical performance, absolute and relative heart volume, stroke volume and minute blood circulation; cardiac index by PWC; MSC by heart volume; blood flow rate. The response of the cardiovascular and respiratory systems to the results of physical education was assessed by left ventricular capacity, oxygen pulse, minute blood volume, arteriovenous difference, Brelov’s shock index and vascular resistance. Results. The program of physical education has a positive effect on the functioning of the cardio-respiratory system, according to the definition of left ventricular capacity in children with scoliosis at the age of 11-14 years showed that the indicators in girls were statistically significantly higher than in boys. There was a general trend: an increase in the power of the left ventricular myocardium during exercise and its gradual decrease during rest, there was also a statistically significant increase in oxygen pulse at rest as in boys (12.24±0.06 vs. 9.29±0.05), and in girls (13.06±0.04 vs. 8.69±0.15) compared with the “background” value before exercise. Minute blood volume in boys was statistically significantly lower than the corresponding rate before exercise, while in girls – minute blood volume increased on the background of exercise, the rate of arteriovenous difference in girls was statistically significantly lower than the corresponding the importance of boys at rest, during exercise and at rest, as well as after exercise, there was a statistically significant increase in vascular resistance both at rest and during exercise and rest. At the same time, the rate in boys was statistically significantly higher than the corresponding rates in girls of this age group both at rest and during exercise and rest. Conclusions. Thus, a special program of physical education for children with scoliosis aged 11-14 years has a positive effect on the functioning of the cardio-respiratory system, according to the definition of left ventricular capacity and oxygen pulse. Determination of vascular specific resistance allowed to show the same gender distribution of the indicator before physical education activities (p>0.05). Thus, under load, the resistivity of the vessels decreased, and then increased again to the appropriate “background” values. Prospects for further research. The multidirectional in the quality changes in the dynamics of additional parameters of the cardiovascular and vascular systems that have been presented in the research, require the development of individual exercise programs to improve the physical performance of children at the age of 15-17 years with scoliosis

The article analyzes the adherence to home blood pressure monitoring (HBPM) with different measurement frequency during the day in 90 patients with hypertension. It was found that after 2 weeks of blood pressure monitoring the greatest was patients' adherence to blood pressure measurement at home once (96.7%) or 2 times a day (90.0%), the lowest - at home pressure measurement every 2– 3 hours during the day (76.6%).The adherence to frequent HBPM (2-3 hours during the day) appeared to be significantly less compared to HBPM once or twice daily, due to more frequent violations of HBPM. Regardless of the frequency of measurements at HBPM, adherence to monitoring is most commonly impaired in working men, compared with women of similar age and employment.

The article considers the results of analysis of the personality psychological type of patients with resistant arterial hypertension in the formation of adherence to treatment for the purpose of effective blood pressure control by a doctor and a patient. Obtained data is demonstrated that the overwhelming majority of both adherent and non-adherent patients are characterized by “adaptive” types of attitude to disease (harmonic, ergopathic, anosognostic), that is, types without impairment of mental and social adaptation.Non-adherent patients more often have types of attitude to disease, such as apathetic, melancholic, mixed ergopathic and hypochondriac-sensitive types, which were characterized by indifference to their illness, depressed mood, fear of becoming a burden to relatives, a fear of side effects of medication, which in general may contribute to patients' non-adherence to treatment.Adherent patients more often have types of attitude to disease, such as harmonic, ergopathic, anosognostic and mixed ergopathic-anosognostic types, which indicated the patient's desire to save working capacity and unwillingness to assume the role of "patient". The motivation for active continuation of treatment in such patients may be the desire to return to a full-fledged lifestyle, to maintain their ability to work, which in general can contribute to the patient's adherence to treatment.

The article is devoted to the study of indicators of function of the autonomic and cardiorespiratory systems in children. A study was conducted of 43 children of 11-14 years, including 19 children with scoliosis, and 24 practically healthy peers. The purpose of the study was to study the dynamics of individual indicators of the function of the autonomic nervous and cardiorespiratory systems of children aged 11-14 years with scoliosis compared with their almost healthy peers from secondary school. Analysis of the dynamics of the test of physical performance of children aged 11-14 years showed that the need for myocardium in oxygen both during rest and during exercise, as well as the first and second rest was the same among practically healthy children and boys and girls with scoliosis. During physical activity, myocardial oxygen demand increased sharply and equally both among girls and boys of 11-14 years of age as in the control group and in experimental control group without significant gender difference. There were no gender differences in the Kerdo index in the group of almost healthy adolescents of 11-14 years and adolescents with scoliosis of the same age. However, when comparing between observation groups, one immediately draws attention is that several times exceeding the value of the Kerdo index in the group of children with scoliosis, and this pattern is characteristic for both girls and boys. The determined fact indicates that the extremely powerful activation of the sympathetic nervous system is found in children with scoliosis also persists in adolescence. During physical activity the same tendency persists in the distribution of the parameter of the Kerdo index: a significant excess of the index in the group of girls and boys aged 11-14 years with scoliosis compared with the control group. Determination of the degree of training of the cardiovascular system on the basis of the calculation of the endurance coefficient allowed us to establish that the corresponding coefficient was not significantly different among the groups under study in the state of rest and physical activity, as well as the first and second rest from the physical activity. Analysis of the systolic heart rate according to the Robinson index showed that in the rest state the highest index was found in almost healthy adolescent girls, although statistically significant difference was found only among the girls of the experimental and control groups. The best energy potential of the body of adolescents with scoliosis in comparison with almost healthy adolescents persists since childhood. The Robinson index increased while physical activity, with a statistically significantly higher index in the experimental group of girls compared to male adolescents. The same tendency was found both during the first and the second rest. The highest maximum stroke volume of blood at rest was found in adolescent girls with scoliosis. Moreover, this indicator statistically significantly exceeded both the corresponding value in boys with scoliosis and the stroke volume of blood in almost healthy boys and girls. The value of minute volume of blood at rest and during the first and second rest was not significantly different among almost healthy children aged 11-14 years compared with their peers with scoliosis. During physical exercises a statistically significant lower value of minute blood volume was observed only in adolescent girls with scoliosis compared to adolescent boys in the study group. Conclusions. Thus in the result of our study it was found that children with scoliosis are behindhand their almost healthy peers in terms of autonomic nervous function and cardiorespiratory systems. Myocardial oxygen demand at rest, during physical activity and during restitution was lower in scoliosis children than in practically healthy ones. The Kerdo index in children with scoliosis before, during and after exercises was higher than in practically healthy ones. Children with scoliosis had lower Robinson’s index. Prospects for further research were to study the dynamics of autonomic nervous and cardiorespiratory function in adolescents aged 15-17 years with scoliosis compared with their relatively healthy peers from secondary school.

Introduction. For today, the treatment of patients with comorbid pathology arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) remains insufficiently effective. The reason for this may be not only mutually aggravating course of these diseases, but also violations of adherence to antihypertensive and bronchodi-lator therapy in this category of patients. Aim. To determine the effectiveness of patient – oriented correction of adherence to treatment in patients with comorbid pathology arterial hypertension and chronic obstructive pulmonary disease after determining and elimi­nating the main causes of violations of adherence to antihypertensive (AHT) and bronchodilator treatment (BDT). Materials and methods. 94 patients with the established diagnosis of stage II hypertension and COPD of the 2nd or 3rd clinical groups (groups B and C) were examined, divided into two groups: the main group – 51 patients (54.3 %) with hypertension and concomitant COPD and comparison group – 43 patients (45.7 %) with essential hypertension. The data were analyzed by office and home blood pressure monitoring, spirometry parameters, the results of the questionnaires mMRS (modified Medical Research Council), CAT (COPD Assessment Test) and D. E. Morisky – L. W. Green’s commitment to the treatment. Results. It was found that in patients with AH and concomitant COPD, in addition to the significant reduction in overall adherence to treatment, low attachment to bronchodilator therapy is more often than antihypertensive: 84.3 ± 5.1 % and 64.7 ± 6.7 % respectively (p < 0.02). Conducting the patient-oriented correction of adherence to treat­ment leads to significantly better control of blood pressure in patients with hypertension associated with COPD – in 73.1 ± 6.9 % of COPD patients in clinical group B and only in 57.6 ± 5.3 % of patients with clinical group C (p < 0,02) and improves the function of external respiration, including FEVj/FVC at 9.4 ± 4.1 % (p < 0,05). Conclusions. In patients with comorbid pathology of AH and COPD, in addition to the significant reduction in overall adherence to treatment, low bronchodilator tolerance is significantly more common than antihypertensive therapy. Conducting the patient-oriented correction of adherence to treatment leads to significantly better control of blood pressure in patients with hypertension associated with COPD and improves the function of external respiration.

Introduction. The prevalence of arterial hypertension in Ukraine reaches 35.0 % among the adult population. The frequency of cases of resistant hypertension in the population of patients with hypertension varies from 5.0 to 18.0 %. In the structure of resistant arterial hypertension, pseudoresistant is observed in 90.0-95.0 % of cases. Aim. To compare the various methods of the differential diagnosis of essential resistant and pseudoresistant arterial hypertension in the practice of a doctor of general practice. Materials and methods. 120 patients with uncontrolled essential arterial hypertension, taking three antihypertensive drugs, and randomly divided into two groups – the main group – 60 patients (26 (43.3%) women and 34 (56.7 %) men, middle age 54.6 ± 9.2 years) and comparison group – 60 patients (24 (40.0 %) women and 36 (60.0 %) men, middle age 55.4 ± 8.5 years) were examined. The study consisted of three stages. At the first stage, the differential diagnosis of essential resistant and pseudoresistant arterial hypertension, using the method proposed by us for the patients from the main group was performed. Subsequently, the patients with detected by our acute pharmacological test pseudoresistant arterial hypertension continued to participate in the study and to take three previously assigned antihypertensive drugs in maximal tolerated doses in order to evaluate the sensitivity and specificity of our method and to verify the authenticity of pseudoresistant arterial hypertension by the traditional method. At the second stage, the differential diagnosis of essential resistant and pseudoresistant arterial hypertension using the traditional method for the patients from the comparison group was performed and the frequency of resistant and pseudoresistant arterial hypertension in both groups was determined. In the third stage, the assessment of the parameters of office blood pressure in the patients of both groups was performed on each visit. Results. Based on the conducted research, the effectiveness of the new method of differential diagnosis of essential resistant and pseudoresistant arterial hypertension in the reduction of the timing of the diagnosis of pseudoresistant arterial hypertension and the faster achievement of blood pressure control in this category of patients is scientifically substantiated. Conclusions. The sensitivity of the proposed method of differential diagnosis of essential resistant and pseudoresistant arterial hypertension, in comparison with the traditional one, is 95.7 % (95% CI 91.8-99.6), the specificity is 57.2 % (95% CI 47.5-66.9), the accuracy index (diagnostic value of the test) is 86.7 % (95% CI 80.1-93.3), compared to the traditional one. The frequency of pseudoresistant arterial hypertension detection in the comparison group of patients was 80.0 %, in the main group – 88.0 %, the incidence of resistant arterial hypertension was 20.0 and 12.0 %, respectively = 1.7; df = 1; p > 0.05). The application of the developed by us method of differential diagnosis of essential resistant and pseudoresistant arterial hypertension can significantly reduce the timing of differential diagnosis and accelerate the timing of the diagnosis of pseudoresistant arterial hypertension – to 3.9 і 2.6 days, compared with the traditional method – 16.4 і 6.8 days (p < 0.05), that allows to achieve the significant reduction of systolic blood pressure (>10.0% of the baseline level) on average 4.5 і 1.5 days earlier than using the traditional method – 20.2 і 3.6 days (p < 0.05).

Modern domestic preventive dentistry has success in the theory of the origin and development of major dental diseases, practice of treatment, including dental caries, and uses these results to prevent children’s diseases in the country. However, the desired effectiveness of preventive measures have not been achieved primarily among the population and individual level, taking into account some specific characteristics of residence region, etiology and pathogenesis of the demineralization phenomena of hard dental tissues in different periods of child’s development. Adverse environmental conditions and technogenic character are not taken into account, when air, soil and groundwater are oversaturated with environmental contaminants and toxicants. They cause fatal breakage in biochemical reactions and metabolic processes in childhood and at a young age, when defective dental health brings a lot of problems in the adult period of life, and, as a result, reduces the life. Investigation of dental health had been conducted in 251 preschool age children (first age group consisted of 3-4 years-old, II group consisted of 5-6 – years-old with 123 and 128 people respectively). In addition, all the observed children were divided into two groups depending on the use of prophylactic anti-caries interventions: the basic group was in compliance with the "Program- maximum" and control the "Program- minimum". Approximately 60 members were in the monitoring teams of different age groups. The "Program-minimum" included measures of general health, balanced diet with the significant restriction of carbohydrate and perform twice a day hygiene actions in the oral cavity. The “Program – maximum” also included the ingestion of calcium citrate and amino acids with SH-group of methionine. Such treatment and prophylactic complex has the adaptive, antioxidant, antidote and immune resolving action. It makes sense for neutralization of eco toxicants – heavy metals in the area of children’s residence. It was found that level of Fe and Zn was in the threatening degree of content, and Cd is moderate in the living environment of the examined children. It provokes and enhances the glycolytic processes in the oral cavity. Harmful effect of toxicants in the oral cavity, and also in a children's organism as a whole, was clearly fixed in the mineralization of the skeleton flat bones of children. It was revealed with densitometry of the calcaneus that 53 individuals had indicators, particularly BUA. They indicated the weakening of the skeleton mineralization. It indirectly pointed to problems in the hard tissues of the teeth. However, the use of treatment and prophylactic complex improved the bone structures density. The level of calcium and phosphate in the oral fluid of the observed individuals had recovered to optimal after three years of use of treatment and prophylactic complex, contributed to effective secondary mineralization both in temporary and in permanent teeth. Thus, the use of treatment and prophylactic complex in people of the basic group allowed quite convincingly and positively to impact on the incidence of caries of deciduous and permanent teeth. The rate of growth of dental caries intensity after three years of preventive interventions in the basic group was three times less than in the control group. At the same time, the caries preventive efficacy was 59-62%, and this is a very positive indicator. These results are evidence of proven necessity of prophylactic of dental health correction in children years of those people who reside in areas with a very complex technogenic environment due to metallurgical plants located in the Prydniprovsk region.

Objective: to study the reaction of the cardiovascular system on physical activity in school pupils aged 11-14 years with vision pathology.Materials and methods: the study was conducted with the participation of 113 school pupils aged 11-14 years. The main group consisted of 58 blind and poor-sighted children, the control group consisted of 55 healthy. To assess the level of the exchange-energy processes occurring in the body using the index Robinson.Status activityof the autonomic nervous system was evaluated on the index Kerdo.Results: the myocardial oxygen demand is lower in boys withvision pathology of the load at height PWC150 and higher in girls of the same group at the 5th minute of rest than inthe children of the same age in terms of healthy. Kerdo index in children of the main group was higher than in healthy and pointed to the significant prevalence of the activity of the sympathetic nervous system (SNS). Endurance factor in children with vision pathology,regardless of gender, to the load and on the 1st, 5th min rest did not significantly differ from the healthy group.Robinson index during exercise in boys with vision pathologywasof lower and girls in the same group is higher than the children of the same age in terms of healthy.The minute volume of blood (MVB), mean arterial pressure (MAP) at rest was substantially higher and lower load in children with vision pathology.Conclusions: school pupils with vision pathology of predominant activity of the sympathetic nervous system, reduced Robinson index, minute volume of blood and mean arterial pressure, minor violations of the activity of the cardiovascular system.

Voloshyna O., Zbitnieva V., Busel S., Chaika A., Samorukova V., Dychko T. The role of additional correction methods of insufficient adherence to treatment for effective blood pressure control in patients with resistant arterial hypertension. Journal of Education, Health and Sport. 2016;6(12):857-865. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.252818 http://ojs.ukw.edu.pl/index.php/johs/article/view/4184 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016). 754 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.12.2016. Revised 20.12.2016. Accepted: 25.12.2016. УДК 616.12-008.331.1-036.8 THE ROLE OF ADDITIONAL CORRECTION METHODS OF INSUFFICIENT ADHERENCE TO TREATMENT FOR EFFECTIVE BLOOD PRESSURE CONTROL IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION O. Voloshyna, V. Zbitnieva, S. Busel, A. Chaika, V. Samorukova, T. Dychko Odessa National Medical University, Ukraine Abstract The article considers the results of applying the different correction methods of insufficient adherence to treatment in patients with resistant and pseudo-resistant arterial hypertension on the background of the optimization of antihypertensive therapy in the effective blood pressure control by a doctor and a patient. Keywords: resistant hypertension, pseudo-resistant hypertension, uncontrolled blood pressure, adherence

High incidence of basic dental disease poses the problem of their treatment and prevention in a number of the most important in the practice of dentistry. If the secondary and tertiary dental prophylaxis has a frank success, the primary is in the process of development and improvement. Therefore, to talk about the successes in the national preventive dentistry, particularly in the child population, it is not necessary they are quite modest. At the same time, the countries of Europe and North America have achieved significant results in the prevention of major dental diseases, thus reducing the prevalence and intensity of dental caries and periodontal inflammation to impressive numbers. A whole set of adverse conditions, including financial, organizational and cultural nature does not allow to achieve tangible results in the national preventive dentistry. However, scientific dentistry has sufficient expertise in the nature of the origin and formation of teeth and periodontal disease, to achieve convincing successes in preventive dentistry. However, there are features of the etiology and pathogenesis of diseases in different living conditions of specific populations of people that need to learn. In this regard, studied dental status in 1500 students of three secondary schools, which were located in the region of intensive technogenic pollution. The analysis included quantitative measures of viscosity of saliva and salivation rate, the pH of oral fluid, FER test, micro-hardness of enamel, obtained by conventional techniques. Also Systematics students by age, all surveyed are grouped as they autonomic innervation: sympathotonics, vagotonics and normotonics. Children held a three-year course of prevention of dental caries twice during each year, therapeutic and preventive complex, including an antidote methionine or cysteamine, sodium fluoride, broth peppermint orally at a dose according to the child's body weight, as well as electrophoresis dentition 5% solution of calcium gluconate via electrode grafitizovannoy tissue within one month. It is known that the inhabitants of the region with intense industrial development of metallurgical direction is further subjected to the action of your body waste products are ecotoxicants as cariogenic metals. They contribute not only to a change in optimal properties and composition of oral fluid, but increase and accelerate the glycolytic processes on the tooth surface, causing the process of demineralization. But regularly used PBL containing antidotes toxicants and sodium fluoride, acts as an inhibitor of cariogenic and metal along with basic preventative measures (optimal nutrition, health-building activities, oral hygiene) contribute to a significant reduction in prevalence and intensity of dental caries. Particularly effective were the results of preventive measures in schoolchildren sympathicotonic group. If children are constantly exposed to the effects of toxicants, the incidence of tooth twice the control group, the result of three years of systematic preventive action designed PBL significantly reduced the prevalence and intensity of caries in relation to control. Results protivokarioznye prevention suggests the feasibility of implementing similar programs of primary dental prophylaxis under the same conditions the children live.

Despite the significant prevalence in the population of major dental diseases is 30-70%, a relatively high proportion are pathological processes of periodontal tissues and mucous membranes of the mouth (GPRS). They hit 10-50% of the population. If the problem of dental caries, pulpitis and periodontitis in the current environment can be solved quite efficiently and to a dentist presents no particular difficulty in diagnosis, treatment and prevention, the therapeutic intervention in case of periodontitis or stomatitis always require in-depth examination of the patient to determine the true origin and factors the specific mechanism of this pathological process. This is possible only if the rational specialization of care for people with periodontal disease and GPRS, a sufficient level of professionalism of the doctor. Particular difficulties exist for patients with diseases neyrostomatologicheskimi what are glossodiniya and glosalgiya. Unprofessional actions of the doctor, only symptomatic treatment of choice, lack of an integrated approach to health-care actions at PBF RBCU fraught with lack of complete izlicheniya or significant effect, exacerbating the patient's condition and generates a lack of confidence in the final positive outcome, dramatically reduces the quality of life of the sick person. Therefore studied the possibility to increase the efficiency of complex treatment neyrostomatologicheskih diseases using electrophoresis Sopra where implemented PBB A total of 250 patients with PBF GPRS (glossodeniya at 101 and at 149 glossalgia persons) who have studied the clinical and laboratory parameters, including the state of the sympathetic-adrenal, and kallikrein-kinin vascular system. It was found that the vast majority of patients have chronic diseases place of the digestive system (glossodeniya) and neuro-vascular disorders (glossalgia). These same individuals indicated the presence of activation of adrenal system at reduced kinin activity, as a counterweight to the first, which is implemented in the vascular system, especially in the microvasculature Sopra vascular hypertension. Arose ischemic condition is algogenic hearth, where realized paresteticheski-pain phenomenon. Such profound changes in people PBF should be adjusted medical and non-medical means, napravlennmi at eliminating or mitigating the causes algogenic factors in the form of suggestive effects of antihypertensive drugs generic along with soothing and sedative drugs on the West course of treatment. Simultaneously, patients underwent physical therapy in the form of electrophoresis solution andekolina into sections GPRS where implemented paresthesia and pain. The active substance kallikrein entered using the DC of persistent vasodilator action, you remove the effect of hypoxia and paresteticheski-pain. There will come a cure or significant improvement occurred no less than 98% of patients with PMF, which is significantly higher than previously used methods.

The paresthetica’s pain maxillofacial have enough ubiquitous disease and includes glossodiniyu, glossalgia, neuralgia, neuritis and causalgia, what may constitute together 2-3% of dental patients. There are most interested neurologists, psychiatrists and neuro-dentists, which often refer patients for medical assistance in the study of the nature of this phenomenon. Experts tend to believe that the mechanism of pain is dominated by vascular disorders of the structural or functional nature, mainly, in the microvasculature, causing the tissue ischemia, the imbalance of tissue hormones, the failure of metabolic processes, the accumulation of acid radicals, the excessive irritation of sensory pain receptors of the nociceptive substances. However, the value of biologically active substances tissue stills not be examined, especially to ensure the tone of preand capillary vessels and forming the main chain links of the pathogenesis of pain paresthetica’s maxillofacial region, that will facilitate the development of therapeutic and preventive correction with the higher effect. Therefore, we examined the 37 individuals suffering from the parestetica’s pain in the mouth, one to three years, but were treated the general practice dentists unsuccessfully. Among the patients were women aged from 42 to 62 years, they had underlying chronic diseases of the nervous, digestive and cardiovascular systems. Clinical signs glossalgia were typical of both subjective and objective plan. The control group consisted of 35 healthy subjects. The status of the kallikrein-kinin system was determined in 5 ml. fresh blood by level prekallikrein (PK), spontaneous esterase activity (SEA) and the level of kallikrein inhibitor (IC) according to known methods R.W. Colman et al. (1969). The studies found out the vast number of patients glossalgia and noted elevated blood pressure both in large, medium and small sized blood vessels and, especially, in the covering of the site that localized the paresthetica’s algic sensations. The structural disorders predominantly cerebral blood vessels in the internal carotid artery were less defined. Obviously, hypertension, vascular tone phenomena arise due to an imbalance of tissue hormones that regulate the vascular tonic properties. Previously, we found that patients with glossalgia takes place excessive stress in the catecholamine system, that is accompanied by excessive production of tissue adrenaline and his predecessors. It can be assumed that it’s counterbalance has signs of weakening both the level of activity in the form of hormones cholinergic and kinin systems and the result of this provokes are the chemia in the cover tissues(GPRS) and skin. The hypoxia and excessive formation of oxidized form of the acid radical products are the potent nociceptive stimuli, sensory devices. This is confirmed by the level and activity of hormones kinin system. So, the glossalgia reduce the levels of the hormone kallikrein precursor prekallikrein significantly, as well as, the spontaneous esterase activity with a significant increase in the level of kallikrein inhibitor. The imbalance of the tissue biogenic amines towards the activation of the adrenal system modifies the tonic properties of blood vessels, especially in the microvasculature and in the direction of vasospasm. This is one of the main links in the chain of pathogenesis of pain phenomenon that must be taken into account in the preparation of therapeutic and preventive action of glossalgia.

Disadvantages of the concept of maximum admissible concentrations call into question the reliability of modern methods for assessment and prediction of environmental conditions, so there is a need to develop new approaches. These approaches are based on the bioindication methods, as they are sensitive, reliable and sufficient for an adequate environmental assessment. The method of assessing the pollutant impact on the urboecosystem state was first introduced in the paper. It differs from the known by the fact that it uses biomonitoring data and considers environmentally admissible concentrations, defined on the basis of the determined dependence of abortiveness indicator of plant-bioindicator pollen on the pollutant concentration value for assessing the environmental condition. Also, the adequacy of this method was verified on the example of Kyiv. Environmentally admissible concentrations for significant abiotic factors and environmentally safe limits for relatively significant were determined. It is shown that existing standards exceed the values of environmentally admissible concentrations and environmentally safe limits by about 20 %. [ABSTRACT FROM AUTHOR]