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Aim. To investigate the relationship between the physical properties of saliva and enamel resistance and caries intensity in drug-addicted patients. Materials and methods. The study involved 70 patients, who were divided into three groups: the main group (1) – 28 drug addicts diagnosed with caries, the comparison group (2) – 22 patients with caries of dental hard tissues without a history of drug addiction, and the control group (3) – 20 persons without carious lesions of dental hard tissues. We examined the rate of salivation, which was calculated by the formula: Rs = V / T, pH of oral fluid using litmus test strips (Kelilong Instruments, China), structural and functional stability of tooth enamel by the express method TER-test (V. R. Okushko, L. I. Kosareva, 1983), clinically assessed the rate of mineralization according to the Clinical Assessment of the Rate of Enamel Remineralization-test (T. L. Redinova, V. K. Leontiev and G. D. Ovrutsky, 1982), dental caries intensity using the DMF index; the International Caries Detection and Assessment System (ICDAS) was used to assess of the dental hard tissues. Results. In drug-addicted patients with caries of dental hard tissues, the slowest rate of salivation and significant changes in the oral fluid pH toward acidic were observed, namely 5.5 ± 0.09 units compared with patients of other groups. In drug addicts, the average TER-test score was 9.1 ± 0.4 points and was significantly higher than that in non-drug-addicted patients with dental caries (5.4 ± 0.2 points) and people without dental caries (1.9 ± 0.2 points). The Clinical Assessment of the Rate of Enamel Remineralization-test indicators of drug-addicted patients (6.1 ± 0.3 days) were also significantly higher than those of non-addicted and control group patients. The DMF index in drug-addicted patients was 16.4 ± 0.2 points showing a very high intensity of caries with a large proportion of deep carious lesions in the dental hard tissues. Conclusions. In drug addicts, the study results have indicated a 23 % pH shift of the oral fluid toward acidic, and a 22 % decrease in the rate of saliva secretion has also been recorded compared to the healthy individuals. These results were associated with a 79 % decrease in the tooth enamel durability and a 66 % decrease in the remineralizing capacity of the oral fluid in drug addicts as compared to the healthy individuals. The DMF index of group 1 patients differed from that of group 2 patients by 50 % and from group 3 individuals – by 98 %. Drug-addicted patients had 78 % more carious lesions in the dentin compared to non-drug-addicted patients with dental caries.

The aim of the paper is to present rehabilitation principles of atypical jaw osteomyelitis — osteonecrosis of lower jaw among addicts to synthetic drug desomorphine. Custom nikelid titanium plates and plexiform guides from superelastic nikelid titanium proved to be effective in reconstruction mandibular defects in drug addicts.

In view of the increase in drug trafficking offences committed through the use of information and telecommunications technologies, the state must seek effective ways to reduce the drug market. Counteracting illegal advertising of drugs and their marketing addresses on the Internet (Darknet) is a promising area of prevention that has been underestimated to date. The purpose of the article is to determine the main directions of Russia’s criminal policy in the field of counteracting open and veiled advertising of online stores selling drugs in a non-contact manner. Methods of statistics, content analysis of Internet resources, systemic, formal-logical and legal analysis are used. Results: illegal advertising in the area of drug trafficking is an independent direction of professional criminal activity, using marketing techniques tested in the legal economy. The advertisement of online drug stores on urban infrastructure facilities, regular websites and social media helps to expand the reach of drug users. Efforts to combat illicit drug advertising, including the criminalization of such advertising, should be part of Russia’s criminal policy.

Summary. School-related health disorders are postural disorders and visual disturbances, and these disorders tend to increase during schooling. One of the reasons for this situation is the lack of awareness of parents about the factors that affect postural disorders, organizational measures to prevent the formation of these pathological conditions. The aim of the study was to determine the awareness of parents of school-age children about the prevention of school-related pathology. Materials and Methods. A survey of 1110 parents of primary school students (first and fifth grades) was conducted on the factors that contribute to the formation of deviations from the musculoskeletal system and visual organs, the organization of the child's workplace when doing homework, visual load. Results. 75 % of surveyed parents of first-graders and 66 % of surveyed parents of fifth-graders whose children have postural disorders agree that posture problems can lead to problems with the learning process. and its illumination. When analyzing the choice of student desks, the number of parents (28% of first-graders and 39% of fifth-graders) who would prefer desks with a flat work surface, as well as parents who are hesitant to answer this question (8 % - parents of first-graders and 26 % - parents of fifth-graders). Against the background of increasing deviations from the musculoskeletal system and visual organs among students from first to fifth grade, take place are unsatisfactory parental awareness of the time of use of gadgets according to age, the optimal distance to the work surface and its lighting, the optimal working position for desk and corrective gymnastics. Conclusions. The obtained data are the basis for the introduction of educational programs for parents and students whose goal is to develop sustainable knowledge and skills to prevent the development of diseases of the musculoskeletal system and visual organs.

Adolescent addiction is a serious social problem, considering the significant danger posed by drugs to the health of the younger generation and the social situation at large. Much of the family's lack of attention to the problems of the younger generation has led to the emergence of adolescent drug addiction and the spread of this phenomenon in modern society. The relevance of the study is conditioned by the alarming rate of spread of adolescent drug addiction in society and the decline in the average age of adolescents who have tried drugs for the first time. Purpose: to identify the root causes of adolescent drug addiction in families and to create methods to prevent this phenomenon. Material and methods: The main method of research is the method of analysis, which was used to comprehensively address the issue of adolescent drug addiction in the family, in particular the causes and consequences of this phenomenon. With the help of quantitative-analytical and logical research methods, the factors that motivate young people to use drugs, despite the obvious threat to their health and life, were comprehensively considered and described. Results: Authors identify the main factors that push modern adolescents to start using drugs, the role of the family in such a phenomenon, the types of relations within families where adolescent addiction develops. The types of family relations and the nature of intra-family relations, in which adolescent drug use begins, are revealed. The paper describes the proposed measures to prevent adolescent drug addiction, which should be used to stop the spread of this phenomenon in society. The applied value of this study is to determine the causes of adolescent drug addiction in the family and to develop measures to prevent the occurrence of this phenomenon and its further spread in society. Conclusions: Adolescent drug addiction is a serious social problem, the roots of which should be sought in each particular family where the adolescent who started taking drugs was born and raised. The causes of drug addiction in modern families are due to a significant amount of social and psychological factors. The issue of adolescent drug addiction in the family should be considered comprehensively, with reference to the place and role of the family in society. In addition, the involvement of adolescents in sports displaces drugs and contributes to their complete elimination from life. By identifying the main social and psychological aspects that motivate modern adolescents to use drugs, it is possible to create conditions to prevent a situation in society in which drug use by Ukrainian adolescents, in general, would be possible.

Difficulties in the rehabilitation and treatment of drug addicts are associated with the peculiarities of their behavior, which are a consequence of a change in their personality. The author conducted an empirical study on two groups of drug-dependent men with a combined form of drug addiction at the stage of treatment (n=30) and rehabilitation with a remission period of about a year (n=30); healthy male volunteers (n=30) acted as a control group. The study was conducted on the basis of the Regional Clinical Psychiatric Hospital, Khabarovsk Territory, Department of Medical Rehabilitation for people with drug addiction disorders in Khabarovsk. All men participating in the study had a higher education, a family, and the average age of all subjects was 32 ± 10.1 years. The study used: Kellerman-Plutchik's “Life style Index” methods (adapted by Wasserman L.I., Eryshev O.F., Klubova E.B. et al., 2005); coping test by Lazarus R. and Folkman S. (adapted by T.L. Kryukova, Kuftyak E.V., Zamishlyaeva M.S., 2005); questionnaire “Proactive coping behavior” Greenglass E., Schwarzer R. et al. (adapted by Belinskaya E.P., Vecherin A.V., Agadullina E.R., 2018). The main features of reactive-proactive coping in groups of drug addicts are defined: in the first group, coping is emotionally-oriented and cognitive-oriented in nature with a focus on social and emotional support, the protection mechanisms “denial”, “projection”, “substitution”, “intellectualization” prevail; in the second group, the intensity of avoidance strategies in combination with proactive overcoming without a focus on external support is identified, intellectual defenses are combined with strategies for reflective analysis. The main differences between the two groups of drug addicts are in the nature of the relationship between defense mechanisms and reactive-proactive coping strategies, in the variation of reactive strategies and their orientation, in the features of building proactive behavior. Understanding the features of reactive-proactive coping with drug addicts can greatly facilitate the work of a psychologist in remedial and rehabilitation activities with patients focused on life planning during remission.

The article analyzes the problems of drug addiction as the most socially dangerous form of deviations among young people. The materials related to the regional aspect of this phenomenon are exceedingly significant. The level of awareness of the respondents about the main types of narcotic and psychoactive substances, their attitude to drug use, as well as about the severe consequences and the possibility of their acquisition were identified. The author makes conclusions about the need to form a strategy for the prevention of drug addiction, including the identification of risk groups, crisis situations in the youth environment, as well as the use of measures and acceptable methods to resolve these situations.

Relevance. The development of the HIV epidemic in different parts of the word is accompanied by the dynamics of its manifestations, including a change in the role in epidemics of various routes of transmission, “risky groups” and shifts in the gender structure of morbidity. The study of the epidemic process in dynamics, including the gender indicators of the epidemic, is important for forecasting the epidemic and modernizing prevention strategies. The aim of the study is to assess the gender characteristics of the manifestations of the epidemic process of HIV infection in the Republic of Tatarstan. Materials and methods. A retrospective analysis of the incidence of HIV-infection among women and men in the Republic of Tatarstan (Russia) for the period of 1996–2018 was carried out. We used information from database of AIDS-centre of Tatarstan Republic. Incidence of HIV in association with age, ways of transmission, social status was calculated for men and women separately. We analyzed the role of main transmission routes in different age groups over the entire period of the epidemic (1987–2018). The data is processed in Microsoft Office Excel 2010. Results. Incidence rate of HIV per year in men is higher then in women from 1999 (p < 0,05). In the structure of the adult population's incidence of HIV infection, the proportion of women increased by 2.4 times: from 14.8 ± 0.7% in 2001 to 35.6 ± 1.3% in 2018 (p < 0.001). During the entire follow - up period of 1996-2018, the most common route of getting infection for men was intravenous (68%); most of women (73,3%) got HIV via sexual rout including women, living in areas with the highest prevalence of drug addiction. The proportion of sexual route of HIV-transmission increased from 5.6 ± 0.5% in 2001 to 52.3 ± 1.7% in 2018 for men, and from 23.7 ± 2.2% in 2001 to 84.6 ± 1.7% in 2018 for women (p < 0.001). Dynamic of HIV-epidemic is presented by involvement of older age groups. With age, the proportion of people who were infected via sexual rout increases in both women and men groups. Conclusion. The dynamics of the epidemiological manifestations of HIV infection in the Republic of Tatarstan for the period 1996–2018 has many similarities among women and men: they have unidirectional changes, and the incidence rates decreases for people under 30 years. The incidence rates for men are higher than those for women, however, the development of the epidemic is accompanied by an increase in the proportion of women, for whom, unlike men, regardless of the age and prevalence of drug addiction in the territory the live, the sexual route of infection is predominant.

The article provides a brief overview of the literature, which deals with the issues of heroin addiction, its history, prevalence, statistics, clinical characteristics, diagnostics, prevention and countermeasures, as well as programs aimed at social rehabilitation and harm reduction from injecting drug use. Issues such as physiological foundations and features of disease and remission formation, withdrawal, motivational attitudes of drug users, structure users of narcotic substances, the impact of pre-morbid features, socio-demographic, clinical-dynamic, regional and gender aspects of heroin addiction, and also existing approaches to therapeutic and preventive measures are considered in narcology. Medical and social consequences expressed in the form of the spread of hemo-contact infections, such as HIV/AIDS and viral hepatitis; risky behavior and its impact on the growth of sexually transmitted infections; reducing and completely losing social status; suicide-aggressive actions have been studied. The analysis of data on the study of the prognostic value of the socio-demographic and clinical-dynamic characteristics of heroin addiction and its effect is provided on the outcome of the disease.

Russia ranks third in the world after the United States of America and Germany by the number of migrants. Migrants bring health risks for the population of host territories. Combined with social factors, this fact differently impacts the indicators of public health. The paper aims to assess the possible impact of various aspects of the internal and external migration in the Russian regions on the prevalence of the socially dangerous diseases: HIV, active tuberculosis, syphilis, drug addiction, acute and chronic viral hepatitis B and C. Correlation and econometric analysis are the main research methods. The main research methods we use are correlation and econometric analysis. We constructed panel models for each of the considered diseases. The models test various socio-economic indicators (including money income, housing improvements, population’s education level, and the incidence of alcoholism), as well as climatic, geographical and demographic indicators. Moreover, we tested various indicators characterizing labour immigration, migrants’ inflow to the region from other countries and other regions, and a share of people born outside the region in resident population. Additionally, we considered the impact of morbidity rate and proximity of some countries’ borders. We tried to track the changes of the factors influencing spread of diseases as time passes. As a result, we established a positive significant statistical correlation of the following indicators of migration and incidence: 1) employment of foreign citizens and incidence of syphilis in 2005; 2) share of internal migrants in the population and incidence of drug addiction in 2005; 3) employment of foreign citizens and incidence of drug addiction in the period from 2006 to 2016; 4) inflow of foreign citizens and detection of chronic viral hepatitis in 2010; 5) inflow of foreigners and incidence of acute viral hepatitis C in the period from 2011 to 2016. The obtained results can be useful for experts and researchers interested in the issues of regulating and optimising the region’s socio-economic policy and medical and demographic processes.

The drug addiction is one of most serious deviant behavior seriously harming both addict person and one's relationship. The drug using is considered as deviant because means using substances from non-legal turn-over or applied in non-medical purposes. Then follows degradation of health of person and one's positioning into physical and mental dependence on them. With time, personal dependence on drugs becomes stronger. The addicted person looses possibility to experience joy from natural stimuli and more difficulties in controlling drug using appear. Persons using drugs frequently commit crimes to have money to maintain one's dependence. Therefore, issues of prevention narcotism and struggle with drug addiction are fundamental ones for whole system of prevention in Novorossiysk. The article presents analysis of implemented activities and adopted measures of struggle with drug addiction in population of Novorossiysk.

Despite the inadequate evidence of effi cacy and safety of opioid use for the treatment of migraine, it has been reported that patients with moderate to severe migraine headaches are prescribed opioids. Migraineurs may experience serious health impacts from opioids such as headache-related disability, psychiatric and cardiovascular comorbidities. The reduction of the risk of opioid abuse and prevention of an opioid epidemic are important public health challenges. The aim of this study was to assess the awareness of opioid therapy for migraine and the frequency of use among Turkish patients with episodic and chronic migraine. Materials and methods: consecutive migraine patients were enrolled in this cross-sectional study. A semi-structured questionnaire was developed and used by the researchers to assess the patients’ awareness of an opiod treatment option and the frequency of use of opioids for migraine treatment. Results. One hundred two patients were enrolled, of which 72 had episodic migraine and 30 had chronic migraine. All subjects reported that they had not been offered or prescribed any kind of opioids by general practitioners and neurologists for their headache. Besides, only 7 % of patients declared that they had heard of opioid treatment for migraine but they had never consulted their doctors about its effects. Conclusions. Our fi ndings demonstrated that opioids were not preferred as an option for acute or preventive migraine treatment by Turkish migraineurs and their physicians. The reduction of opioid prescription will help to prevent the development of medication overuse and opiate-induced headaches and drug addiction.

The article discusses types and forms of an addictive behavior of law enforcement officers (in terms of employees of internal affairs bodies) in conjunction with individual psychological characteristics. The attention is focused on the variety of addictive behavior approaches available in the scientific literature. According to the data obtained, such addictions as relationship, Internet-computer, work, adrenaline are most pronounced among employees of the internal affairs bodies in view of the peculiarities of professional activity. It was revealed that more than half of the internal affairs officers have a tendency to manifest addictive behavior. The particular structures of the manifestation of addictive behavior are described using factor analysis. The chosen five-factor model allowed to describe specific forms of addiction: addiction of negative relations, emotional addiction, distance from society, introverted workaholism, emotional interpersonal relations. The patterns of the relationship of addictive behavior with emotional instability, anxiety, social inclusion, suspicion, and emotional regulation of behavior are revealed.

Objective: To study and present the socio-demographic characteristics of patients with heroin addicts and its impact on the prognosis of the disease, to develop recommendations for improvement of specialized drug treatment services Methods: The paper presents data on the study of the socio-demographic characteristics of 130 patients with heroin addiction. Such parameters as age, level of education, family, labor and social status were taken into account. Results: The socio-demographic indicators of the studied patients testify to the spread of heroin addiction among the socially significant groups of the population, that is expressed in strengthening specific weight of young people with education and with a preserved social and labor status. It has been established that the largest proportion of patients with heroin addiction is in the age of 31-40 years (40%) with secondary education (73.9%) who do not have a permanent job (86.2%) who have not served in the army (73.9%) and married (64.6%). Conclusion: The totality of socio-demographic indices, the most characteristic and often encountered in the present time in patients of heroin addiction allows to determine the group of risk. It should be based on preventive measures for the timely detection of persons suffering from heroin addiction. In the complex of medical and social measures on prevention of heroin addiction, along with pharmacotherapy, a significant place should occupy in the treatment of patients in the programs implemented in the country psycho-social rehabilitation and group psychotherapy programs.

The article analyses the main forms of deviance in modern Russia and in modern China. Found that media of deviant behavior, both in Russia and in China, are recruited from all segments of society. It was revealed that on threats, social urgency and magnitude of the manifestations of the first place both in Russia and in China took the crime, followed by alcoholism, drug abuse, suicide, corruption. There are two opposing trends in the evolution of deviance: in Russia there is in General a spontaneous escalation of deviance in China-minimization of deviance, mixing its manifestations. This article is useful for establishing an effective social control over deviant processes with a view to their elimination.

Medicines used for the treatment of drug addiction nowadays are ineffective. In the last decade, various schools around the world are developing a new approach: the therapeutic vaccine for the treatment of drug addiction. The vaccine injection raises the production of specific antibodies that bind to the drug when it is used and substantially reduces its concentration in the brain. The review describes the main approaches to the design of anti-drug vaccines, their composition, the problems faced by researchers in their development.

The article presents an attempt to evaluate what factors could contribute into significant changes of both amount and structure of social cost of drug consumption in the region. The analysis, based on preserved basic principles of assessment, was applied to processes that occurred in both state and non-state spheres. The purpose of the study was to analyze main causes of dynamics of social cost of drug consumption during re-assessment., Materials and Methods: The social cost of drug consumption in the Samara Oblast was re-assessed in 2017-2020 (first assessment was implemented in 2007-2010). The main causes of increasing of social cost of drug consumption were analyzed on the basis of the study results., Results: In Samara Oblast, due to financial and structural changes in state and non-state spheres, occurred increasing of social cost of drug consumption from 18.0 billion to 25.4 billion rubles per year. At that, percentage of social cost of drug consumption in the gross domestic product decreased from 2.9% to 1.6%. In general structure of expenses greatest changes affected percentage of social aftermath of drug addiction (increase from 17.8% to 26.1%) and expenses of drug consumers (decrease from 69.7% to 62.3%)., Conclusions: The increase of absolute values of financial expenditures of the Oblast related to drug consumption conditioned by financial and structural changes in society, is accompanied by decreasing of percentage of ocial cost of drug consumption in value of gross domestic product. The main cause of its dynamics is significant increasing of gross regional product.

Aim. This study was designed to perform the comparative evaluation of functioning of antioxidant system of blood in patients 137 Kubanskij nauchnyj medicinskij vestnik 2018; 25 (5) suffering from psychostimulants and opioids addiction syndrome.Materials and methods. The study was performed using biological material of 52 patients divided into 3 groups. Patients who were considered to be conditionally healthy were included in the 1st (control) group. The 2nd group was presented by the patients suffering from opioids addiction syndrome, the 3rd group included patients suffering from psychostimulants addiction syndrome. Some parameters of the thiol metabolism and general antioxidant activity were identified in the blood plasma of patients as well as the level of products of oxidative modifications of biomolecules and the activity of enzymes of antioxidant protection in the erythrocytes.Results. In the course of the performed studies it was revealed that the decreased antioxidant activity of the blood plasma by 28-40% was characteristic for the examined patients as well as the imbalance of enzymes of the antiradical protection of erythrocytes and the high intensity of oxidative modifications of biomolecules characterized by the increase in the thiobarbituric value by 2,4-3 times. The activity of superoxide dismutase in erythrocytes of patients of both test groups decreased by 35-43%, while the catalase activity increased by 15-21% in comparison with the relevant indices of the control group. The presence of such changes in the functioning of enzymes of the antioxidant protection can indirectly prove the presence of hypoxia in the examined patients. Besides, the increase in the content of easily-accessible thiol groups by 2,6-2,8 times and the decrease in the content of SH-groups difficult for access by 2,5-3,2 times was noted in patients suffering from the drug addiction. The reconstruction of the balance of various types of thiol groups can be associated with the confirmatory reconstruction of protein molecules induced by the oxidative modifications and combining of toxins.Conclusion. The study in prooxidant-antioxidant status revealed the common traits in the disease pattern in patients suffering from various types of drug addiction. The received data allow us to discuss the perspectives of the criteria search for the laboratory biochemical monitoring of the patients with drug addiction and the possibilities of the antioxidant correction of metabolic disorders as a component of the complex therapy for such patients.

Background. The increase in drug use in the population of Russia and representatives of the youth in particular is a vital issue that is controlled and monitored by the federal state. The rapid rise in drug use in young citizens requires a systematic analysis of the causes, study of criteria and assessment of predisposition for drug use, and also the development of programs to prevent drug addiction in adolescents. Objective. Determination of the psychological predisposition of young men to psychoactive substances using the personality profile of the Multidisciplinary Method of Personality Inventory (MMPI). Research Progress. The research was conducted between 2008 and 2010 on the basis of secondary comprehensive schools, cadet corps, secondary professional educational institutions and universities in Rostov-on-Don and the Rostov region, Russia. The sample included 338 males from 15-16 to 22-23 years old, whose average age is 17-18 years. The evaluation of information reported by applicants on the fact of presence / absence of psychoactive substance samples was made based on the results of the psychophysiological test using a polygraph.Research Results. The results of the MMPI test were statistically analyzed according to the nonparametric MannWhitney test, and to a single-factor analysis of variance. The research results show that the scores of the F-scale in the MMPI profile of young males who used psychoactive substances reveal a statistically significant increase (p = 0.008), compared to those who did not use psychoactive substances. The single-factor analysis of the F- MMPI scale did not show a statistically significant difference (p = 0.128). Conclusion. The paper proposes to consider an increase in the F-scale in the MMPI profile as an indicator of individual predisposition to use psychoactive substances, but not to consider an increase in its indices as a cause that affects primary psychoactive substances in adolescence. The results obtained can be used by practical and clinical psychologists when working with adolescents and youths.

The article considers the market of narcotics as a part of the formal and informal economy. By narcotics, the author means psychoactive substances and plants containing them, which are banned, subject to control or non-prohibited, but have a psychophysical effect on human body. Drug-related psychoactive substances are classified according to the prohibition criterion and restrictions on a turnover with reference to the illegal (criminal) or shadow economy. The author considers the illegal drug market as a latent self-organizing system of socio-economic relations of criminal and shadow nature. Such market is oriented towards the turnover of potentially illegal or dangerous psychoactive substances, which are prohibited or restricted for use in non-medical purposes. The analysis of the state and development of the drug situation on the territory of the entities of the Ural Federal District confirms the relevance of the problem of drug abuse. In recent years, the primary incidence of drug addiction and harmful drug use among the adolescents aged 15–17 have grown. Synthetic narcotics and psychotropic substances of high narcogenicity dominate in the current drug market. Over the past 5 years, the average cost of a single dose of drug remains virtually unchanged. This reflects the conditional balance of purchasing power and competition in the drug market. The disparity in the volume of seized cannabis drugs and the number of cannabinoid users observed by medical institutions suggests a high level of latency in this category of drug users. To assess the degree of negative impact of the drug market, the author proposes to use a method of calculating the socioeconomic costs of the consequences of drug addiction. The methodology is supplemented with tools for determining the number of psychoactive substances consumers on the basis of the mass of these substances withdrawn from illicit trafficking, using the concentration and recalculation coefficients. The author develops a methodology for assessing the economic effect from medical and social rehabilitation of drug-dependant persons. This methodology allows to economically substantiate the development of the national rehabilitation system and determine the economic costs to be reduced from its implementation. As a result of approbation of the methodologies, the author has determined the limiting coefficient of latency of persons, consuming psychoactive substances for non-medical purposes. Furthermore, these methodologies have allowed to define the share of the persons, who successfully completed medical and social rehabilitation. The excess of this share demostrates the positive economic effect of rehabilitation programs. The proposed methods can be applied in economic calculations to justify the establishment and functioning of drug addiction medical and social rehabilitation centres in the subjects of the Federation and to assess their performance.

The article discusses issues concerning the problems of drug addiction, which is distributed mainly among the youth. The Author analyzes the normative legal basis and main directions of activity of subjects on the prevention and suppression of illicit traffic in narcotic drugs. Are also analyzed official statistics of drug abusers and drug addicts and the results of the study on the relevance of the drug problem and the reasons for its spread among minors. Along with the intensification of the activities of all entities engaged in prevention and fight against crime, to strengthen the role of social policies aimed at promoting healthy lifestyles and engaging parents to confrontation anesthesia children. The author proposes that the effective prevention of drug addiction among minors will not only reduce the overall level.

Introduction and the aim: Marijuana is the most commonly used drug in the world (excluding alcohol and tobacco). According to the literature about 16% of Poles at the age of 16 to 64 years old, at least once have used cannabis. The aim of study was to estimate the popularity of marijuana among students of Polish universities. We also asked questions about respondents’ attitude towards marijuana and opinions about its validation. Material and methods: The study was conducted in 2017 on 132 individuals – 60 men and 72 women. The results were analyzed in STATISTICA 10 at p

The article analyses the main forms of deviance in modern Russia and in modern China. Found that media of deviant behavior, both in Russia and in China, are recruited from all segments of society. It was revealed that on threats, social urgency and magnitude of the manifestations of the first place both in Russia and in China took the crime, followed by alcoholism, drug abuse, suicide, corruption. There are two opposing trends in the evolution of deviance: in Russia there is in General a spontaneous escalation of deviance in China-minimization of deviance, mixing its manifestations. This article is useful for establishing an effective social control over deviant processes with a view to their elimination.

Objective: to present a brief overview of the current drug abuse situation and to examine a medical case of intravenous administration of methylenedioxypyrovalerone (MDVP). Materials and methods: clinical follow-up study and analysis of the clinical issues. Results: this article presents a review of MDVP prevalence, causes of toxic manifestations, physical and psychological dependence on MDPV and the development of the phenomenon of parenteral administration. Conclusions: the article may be of interest for specialists in the sphere of chemical analysis of narcotic drugs, experts in psychiatry and narcology, managers and organizers of anti-drug services.

Introduction: chemical dependence on several narcotic or other psychoactive substances at the same time is called poly-drug addiction or complicated drug addiction, the terms "combined addiction" and "combined use" are also often used. It is believed that the simultaneous or alternating regular intake of various psychoactive substances has a more destructive effect on the body than depending on only one drug. In the narcological literature the various forms of combined use of alcohol and heroin were described. There are some data on the psychological characteristics of patients with such forms of addiction, the specifics of these patients in terms of personal readiness for rehabilitation. The aim of the study was to identify the features of interpersonal relations and individual-personal specificity in the field of such relations in patients with heroin-alcohol polydrug addiction. Materials and methods: the Study has been conducted on a sample of 25 patients aged 28 to 50 years using four psychodiagnostic techniques. Tests were used: "Individual typological questionnaire of L.N. Sobchik " (ITO), "Questionnaire of interpersonal relations of A. Rukavishnikov" (OMO), "Diagnosis of interpersonal relations of T. Leary" (DMO), "Diagnosis of interference in the establishment of emotional contacts of V. Boyko". Results: it has been found that heroin and alcohol addicts in the communicative sphere are aggressive, deceitful, tend to dominate, although they retain the need to be accepted by others. Discussion and Conclusions: the obtained data confirm the literature data about more aggressiveness of polynarcomania in the comparison with mononarcomania. The tendency to aggression in interpersonal relations can be attributed to destructive, pathological and socially dangerous features of heroin and alcohol poly-drug addiction. Drug addicts of the studied form are dangerous for others and create communication problems for people forced to communicate with them. A generalizing conclusion is made that heroin-alcohol poly-drug addiction is a source of social destructiveness, and patients with this type of chemical addiction are carriers of this destructiveness.

Study aim - a comparative analysis of dynamics and trends in the prevalence of viral hepatitis B and C and drug addiction in Russia and Moscow in the period from 1999 to 2014. Materials and methods. A retrospective analysis of the prevalence of viral hepatitis B and C, and drug addicts was performed among the population of Moscow and the Russian Federation for the period from 1999 to 2014. The forms of federal statistical observation were applied. To assess the significance of differences between the compared values, the statistical significance error (p) were calculated based on the calculation of Student's test (t). Results and discussion. The tendency of growth in prevalence of drug addiction was verified over the study period in Moscow and in Russia as a whole (in Moscow, 166.3 (1999) to 257.37 100 ths people (2013), in Russia 154.75 (1999) to 227.19 100 ths people (2013)). However, the growth rate of drug addiction prevalence has decreased in recent years mainly due to the decrease in the number of patients who applied for medical help for the first time. It was shown that a composition of the consumed drugs has changed in the studied period in Russia: Portion of cannabinoid addiction has decreased in 2 times, the abuse of stimulants in 19 times. The opium addiction compiled the main portion of consumed drugs (74.5%), the poly addiction - 18.3%, the proportion of addiction to stimulants was 3.5%. Epidemiologic features of the of parenteral viral hepatitis B and C was demonstrated: Reduced prevalence of acute forms and an increased incidence of chronic forms of hepatitis B and C in the population of Moscow; changes toward older age in representation of hepatitis B and C; sexual transition was defined as a main transition way for hepatitis B and C. For the first time it shows a very strong positive correlation (r = from 0.95 to 0.96) between the primary drug addiction and the incidence of acute forms of hepatitis B and C in Moscow and the Russian Federation in 2000 - 2013. Conclusion. The retrospective analysis of the prevalence of drug addiction and viral hepatitis B and C showed the presence of common factors affecting the course of the epidemic process in the studied nosology; drug addicts still represent a risk group for infection with viral hepatitis B and C.

The article presents results of social, psychological and clinical aspects of suicidal behaviour of alcohol addicts and drug addicts with incomplete suicide attempts, admitted to the Department of crisis states and psychosomatic disorders, Sklifosovsky Research Institute of Ambulance Service from November 2014 to June 2015. The majority of addicts (70%) showed an affective kind of suicidal actions. During an acute post-suicidal period all examined patients revealed value-oriented approach to life. Conflict becomes irrelevant as a result of expressed fear of death and fear of social and transcendental consequences of an suicide act. Alcohol addicts feel guilty towards relatives and others, and need of their support. They have significantly increased fear to loss of social identity. Drug addicts have maintained negative view of near and distant future events, they consider the act of suicide as an effective and radical way of solving life problems. Based on our findings we concluded that the risk of repeat suicide attempts in patients with alcohol dependence can be caused by the weakness of self-management skills and lack of microsocial environmental support, while a similar risk in persons with drug addiction can be due to negative view of their own future and the degree of social maladjustment.

This article discusses issues related to trafficking of smoking mixtures, containing narcotic drugs and psychotropic substances or their synthetic analogues in the consumer market of the Russian Federation. The authors study the causes of distribution and consumption of narcotic mixtures by citizens and propose measures (organizational, legal, technical, educational and others) to combat trafficking in smoking mixtures hazardous to health.

The problem of the risks of drug abuse as a form of deviant behavior in the context of adolescence. In this study deviant behavior appears as actions (or willingness to commit them), contrary to the generally accepted cultural and moral values, as well as socio-psychological and legal norms, including the abuse of alcohol, drugs and other psychoactive substances Study prerequisites for the formation of drug addiction in adolescence age allows us to trace the link between awareness about drugs and those at risk of developing dependence on them, which are due to the age and psychological characteristics described L.S. Vygotsky and other scientists working in the paradigm of cultural-historical psychology. The article hypothesized that narcogene information can act as a factor of risk of drug use. It is argued that the basis of the commission of a narcotic substance samples is narcogene information and control over the sources that may contribute to the prevention of mass anesthesia teenagers. This assertion is supported by the results of a retrospective study of social and psychological factors in the emergence of drug abuse conducted in the Kabardino-Balkaria republic dispensary, which was attended by 24 active addict aged 18-28 who are registered with the method of questioning.Purpose. To study the role of information on drugs and drug addiction in the range of solutions «for» or «against» in a situation narcogene risk.Methodology. Questioning of active drug abusers.Results. Based on a retrospective analysis of risk factors for drug abuse as a form of deviant behavior found that narcogene information may lead to introduction to drugs. Lack of knowledge about the effects of drugs on the human body, and the temptation to create a stable, creates a high risk on narcotics debut. Drug use leads to a decrease of expression of fear and inadequate assessment of the degree of its danger. It creates a false impression that the drug is easy to give an adult, strong-willed people, and those who have recently started to use. It was found that adults from teenager entourage (parents, teachers, and others.) Play a minor role in the prevention on narcotics «infection» and their opinion is unconvincing compared with the ideas of potential or actual supporters of drug addiction. The findings suggest the importance of narcogene information in choosing «for» or «against» drug use in adolescence.Practical implications. The system of education.

This article discusses issues related to trafficking of smoking mixtures, containing narcotic drugs and psychotropic substances or their synthetic analogues in the consumer market of the Russian Federation. The authors study the causes of distribution and consumption of narcotic mixtures by citizens and propose measures (organizational, legal, technical, educational and others) to combat trafficking in smoking mixtures hazardous to health

This article is based on the large-scale survey “the problem of drug addiction among the youth in the Republic of North Ossetia-Alania of the RF North Caucasian Federal District”. In April-May North Ossetian Center of Social Research of the Institute of Socio-Political Research RAS together with North Ossetian State University after K.L. Khetagurov conducted a monitoring aimed at evaluating the drug abuse situation in the Republic of North Ossetia-Alania and identifying the causes of drug abuse among young citizens of the republic. It studied the system of beliefs, habits and aspirations of young people. The research focused on the sociological assessment of the drug abuse situation in the Republic of North Ossetia and it was based on the study of systems of beliefs, habits and preferences of the residents, as well as on the identification of the reasons for the spread of drug addiction among the population. The achievement of this goal required solution of the following tasks: • to evaluate beliefs, value systems, life plans, the state of health of the North Ossetia-Alania citizens, learn their opinion on the possibility of rational leisure time and recreation by means of monitoring; • to assess bad habits of the republic citizens, estimate the society’s relation to the problems of drug addiction and drug addicts, analyze the reasons for the emergence and existence of this phenomenon in the society; • to evaluate effectiveness of the measures to combat drug addiction; • to identify reasons for drug addiction, most frequently used types of drugs, the cost of a single dose, a market place and consumers’ access to drugs; • to assess practical activities aimed at improving the drug abuse situation in the republic. The sample size was 600 people

Aim. Pathoplastic modification of addictive disorders with affective spectrum violations, leads to the formation of the psychopathological cluster that have specific structural and dynamic features.Methods and results. In order to assess the dynamics of change of disease-relation type by LOBY questionnaire, 100 patients from «Zaporozhye Regional Narcological Dispensary» suffering from polydrug usage and affective spectrum disorders were examined in the following clinical periods: withdrawal state, further inpatient and outpatient follow-up.Conclusion. The solidity of background psychopathological disorders in perspective of their affiliation to somatogenically-organic register, for the entire study contingent was found. Dynamics of change of disease-relation type illustrates partially reversible character of these disorders.

It is commonly assumed that increasing drug problem is caused by global and multicultural changes, as well as infiltration of trends from more developed European countries. Effects of drug abuse are alarming, among others in development of psychoses, depressive and anxiety conditions, as well as viscera defects – mainly kidneys, liver, hematopoietic necrosis. The problem of drug addiction regards also people from the sick environment, because by their behavior affects destructively on the other individuals. It is related with growing public expenditures for activities associated with the restriction of drug addiction development in Poland. Therefore it is not a surprise that this issue is widely analyzed and often brought up in social discussion. The problem of drug addiction in Poland, as in the world, assumes stronger form, and hence it is necessary to reflect over the questions concerning this addiction. An aim of the study is to describe the phenomenon of drug addiction in Poland and compare the scale of problem in relation to other European countries.

Narkotizatsiya the population has powerful negative impact on all spheres of activity of society. The problem of drug addiction should be considered not only in a physiology context, but also in a context of the personality resorting to drugs in a concrete social situation. The actual direction in this context is studying of the factors influencing success of rehabilitation of narcodependent behavior.

Purpose: To identify factors influencing adherence to therapy in HIV-positive injecting drug users and offer a basic conceptual model aimed at improving adherence.Materials and Methods: Using the method of anonymous questionnaire to assess adherence to therapy in HIV-positive injecting drug users.Results: the factors that affect adherence to treatment, the study of which is necessary for the development of a conceptual model, which is the basis for the planned activities aimed at improving adherence to treatment in HIV-positive drug users.Summary: The individual and personal, health, social and organizational factors are involved in the structure of the conceptual model.

Чугунов В. В., Курило В. О., Данілевська Н. В. Особливості застосування електросудомної терапії при наркологічній патології = Features of the application of electroconvulsive therapy in the treatment of drug abuse pathology Journal of Education, Health and Sport. 2016;6(9):893-901. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.162962 http://ojs.ukw.edu.pl/index.php/johs/article/view/3953 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.09.2016. Revised 24.09.2016. Accepted: 30.09.2016. Особливості застосування електросудомної терапії при наркологічній патології В. В. Чугунов, В. О. Курило, Н. В. Данілевська Запорізький державний медичний університет МОЗ України FEATURES OF THE APPLICATION OF ELECTROCONVULSIVE THERAPY IN THE TREATMENT OF DRUG ABUSE PATHOLOGY V. V. Chugunov, V. A. Kurilo, N. V. Danilevska Zaporizhzhya State Medical University Ministry of Healthcare of Ukraine Summary Objective: to examine the possibility of electroconvulsive therapy (ECT) use for the treatment of patients with addiction to psychoactive substances (PAS). The algorithm of ECT, which consists of 3 stages and IX sub-stages is given. The study of the therapeutic viability of ECT in the case of broad spectrum of addictive pathology (F10-F19) in the context of the relief of addictive attraction to PAS and comorbid disorders, including emotional disorders and resistant to pharmacotherapy of pain syndrome is made. ЕСТ is an effective method for additions therapy and comorbide psychopathological states. High therapeutic effect is connected with sanogenetic effect achieved in stopping of poorly curable pathology and achievement of sustained remission even in the cases where other methods are noneffective. Key words: addiction, substance abuse, drug addiction, alcoholism, electroconvulsive therapy

RETRACTION:Date: 02.05.2022Reason: Partial or full duplication of articles in the Actual Problems of Economics and Law Journal with previously published texts was detected. For example, an article was published in the Journal:SHALAGIN A. FOREIGN LAW IN COMBATING ILLICIT DRUGS // Actual Problems of Economics and Law. 2011. № 4. С. 291-295. (https://www.elibrary.ru/item.asp?id=17073726). The article contains large extracts from the previously published article:ШАЛАГИН А.Е., КАБИРОВ Д.Э. ОТВЕТСТВЕННОСТЬ ЗА НЕЗАКОННЫЙ ОБОРОТ НАРКОТИЧЕСКИХ СРЕДСТВ В ЗАРУБЕЖНОМ ЗАКОНОДАТЕЛЬСТВЕ // Вестник казанского юридического института МВД России. 2011. № 4. С. 291-295. (https://www.elibrary.ru/item.asp?id=17829332).Thr Editorial Board of the Journal, when publishing scientific research materials, bases its performance on the rules of publication ethics observed by the Editorial Board members, reviewers and authors. According to these rules, the author shall guarantee that the article is published for the first time and was not previously published or submitted to another journal. The Editorial Board performed an internal investigation. The Editor-in-Chief and the Publisher made a decision to retract the article from elibrary.ru and the Journal website.

The article analyzes the personality data of the criminals committing a fraud. The research shows that a large part of such criminals are juvenile, as well as people registrated at narcologist's.

Aim. to study a relationship of the plasma activity of elastase-like and collagenase-like proteinases and their inhibitors to hepatic collagen metabolism and to detect the serum markers of fibrosis severity. Subjects and methods. Three hundred and fifty-nine patients with chronic liver diseases (CLD), including 118 patients with chronic viral hepatitis (CVH), 113 with CVH concurrent with alcoholic liver disease (ALD), 109 with ALD, and 19 with CLD in the presence of opiomania were examined. The activities of α1-proteinase inhibitor and α2-macroglobulin (α2-MG) were determined by the unified spectrophometric assay from the inhibition of N-benzoyl-arginine ethyl ester hydrolysis. The activity of elastase-like proteinases was determined by enzymatic assay from the hydrolysis of the synthetic substrate N-butyloxycarbonyl-L-alanine-para-nitrophenyl ester. That of collagenase-like proteinases was determined, by using a collagen type I substrate and expressed in terms of micromoles of the resultant hydroxyproline. The content of hydroxyproline was determined by a color reaction with demethylbenzaldehyde, a free, peptide- and protein-bound hydroxyproline; their fraction was obtained under various conditions of plasma protein isolation and hydrolysis. Plasma fibronectin levels were measured by solid-phase immunoassay. Liver biopsy specimens were morphologically studied in the majority of patients to determine the histological hepatitis activity index and the stage of fibrosis. Results. Fibrosis formation in the liver in its chronic diseases was attended by a significant reduction in the activity of collagenase-like proteinases hydrolyzing collagen and by the lower activity of α2-MG, an inhibitor limiting collagen formation. Conclusion. The identified changes make themselves evident just in early fibrosis, which suggests the rapid onset of imbalance in the mechanisms responsible for regulation of connective tissue synthesis and promotes intensified fibrosis formation.

The current situation presents lack of real coordination in the area of primary preventive health care which includes medical, psychologic-pedagogical and economic subdivisions. The means of optimization of interdepartmental cooperation in health formation of children and youth are under the study

The author imparts experience of narcodependent rehabilitations, organised in a bosom of the Russian Orthodox Church. In article underlined considerably in-creases efficiency of dependence overcoming, if the rehabilitation program includes, except medical and psychological, also pedagogical and spiritually-moral components. In article such program realised in a church community where spiritual work with narcodependent, being the central moment, supplemented with psychological and educational work. 13-year experience of realization of the pro-gram has shown its high efficiency.