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Background. The term “family pain” is used in family system psychotherapy to refer to the emotional state of members in a dysfunctional family. Despite the widespread use of this term in practical psychology, the structure of the phenomenon of “family pain” has not yet been described and introduced into clinical and family psychology. This study provides a scientific substantiation of the psychological construct “family pain” in the etiology and functioning of codependent behaviour based on the cultural-historical approach of L.S. Vygotsky. Objectives. The aim is to characterize the concept of experiencing “family pain” based on a cultural-historical approach, and also to analyse the characteristics of experiencing “family pain” among people whose parents were alcoholics. Study Participants. The sample included adults who were conditionally mentally healthy (N=52; 11 men and 41 women; Mage=24.5 years, SD=4.4), who grew up in alcoholic families and regularly attended the 12-step rehabilitation programme “Adult Children of Alcoholics”. Methods. A phenomenological analysis of the motives for people applying to the 12-step rehabilitation programme “Adult children of alcoholics”. Results. Individuals who grew up in alcoholic families describe “family pain” as a constant experience that accompanies them throughout their lives, due to traumatic childhood experiences in the past. Six motives for applying to the self-help rehabilitation programme “Adult Children of Alcoholics” for people who grew up in alcoholic families and experienced “family pain” were identified. They included: to overcome difficulties in communication, to cope with the death of parents, to find support and approval, to find people with similar experiences, to justify one’s own failures through the illness of a parent, to cope with current negative states connected to childhood experiences. It has been shown that attending rehabilitation programmes can both help a person to cope with the experience of “family pain” and strengthen fixation on the negative experiences of childhood. Conclusions. The process of experiencing a common family problem by people whose parents were alcoholics can be presented and described as a special systemic psychological construct “family pain”.

Introduction. Myelodysplasia (MD) in children is accompanied by disorders of the musculoskeletal system and pelvic functions, causing a decrease in activity and restriction of participation in society, leading to disability and contributing to social isolation. The rehabilitation potential, determined by the International Classification of Functioning, Disability and Health (ICF), is realized when the child is active and participates in the processes of life. The improvement of methods and technologies for the rehabilitation of children with MD remains relevant. Aim. To study the effect of medical rehabilitation in children with MD on the development of motor skills in all children and self-care in children over the age of 1 year. Materials and methods. The study included 117 children diagnosed with male and female MD between the ages of 6 months and 13 years, 11 months and 30 days (average age 6 years and 9 ± 6 months). The diagnosis of the functioning of the body was performed in the categorical profile of the ICF using a ranking system for the degree of disorders / limitations of functioning. The subjects are divided into three groups. Patients of group I received physical rehabilitation, ergotherapy, magnetic stimulation of the spinal cord (MS) and electromyostimulation (EMS); group II — physical rehabilitation, ergotherapy and MS; group III — standard physical therapy techniques, massage, ergotherapy, therapy with sinusoidal modulated currents (SMT-therapy) on the muscles of the lower extremities. Results and discussion. The effectiveness of consistent use of MS, EMS during physical exercises for the development of motor skills, classes with an occupational therapist on self-service skills has been demonstrated in children with MD, which is confirmed by positive dynamics in mobility and self-service skills assessed using functional scales and questionnaires. Medical rehabilitation increases muscle strength in children with MMD, and the combined use of MS with EMS during targeted exercises contributes to the effective development of motor functions. The development of motor skills and classes with an occupational therapist increase the level of independence in children with MD. Conclusion. Medical rehabilitation with the inclusion of MS and EMS during the performance of targeted exercises contributes to the better development of motor skills and improves self-care in children with MD.

INTRODUCTION. 1.5 thousand children with myelodysplasia (MD) are born in Russia every year. To improve the quality of life, most of them need lifelong medical supervision and rehabilitation. The topic of medical rehabilitation in MD in children is poorly covered. AIM. To search and analysis published data on the rehabilitation of children with MD identify the most effective methods. MATERIALS AND METHODS. The collection and analysis of publications on this topic from the PubMed and eLibrary databases published from 2014 to 2024 was carried out. Earlier fundamental works on secondary disorders in myelodysplasia and Spina bifida were also included in the review. A total of 512 publications in PubMed and 1096 publications in eLibrary were analyzed, 584 of them were unique. Publications of reviews, systematic reviews and clinical observations were included. RESULTS AND DISCUSSION. Rehabilitation for MD in children is multidisciplinary in nature, a violation of the structure of the nervous system entails, already in utero, the formation of deformities of the musculoskeletal system, combined changes in the functioning of the lower urinary tract and intestines. It is known that rehabilitation started from an early age helps to master motor skills in a timely manner, contributes to the prevention of metabolic syndrome, contractures, pressure sores, urodynamic disorders and constipation. There are different approaches regarding the intensity of physical activity during the day and week, following the recommendations of the World Health Organization (WHO), children should exercise for more than 60 minutes a day. Physical exercises should be carried out from the perspective of the concept of neuroplasticity and enhanced by the influence of magnetic stimulation, low-intensity laser, electromyostimulation, vibration therapy. It will be possible to effectively use acupuncture and massage. In addition, it is important to include urological and orthopedic care in medical rehabilitation from an early age. CONCLUSION. Due to the high disability, there is a question of effective methods for improving rehabilitation potential and improving the standard of living. Among the described methods, physiotherapy is distinguished, including therapeutic exercises, magnetic stimulation, low-intensity laser therapy, electromyostimulation, and ergotherapy. It is necessary to continue to study the effectiveness of the use of various physical factors in children with MD.

The active development of production has a negative impact on the environment. Millions of cubic meters of forest are cut down annualy for production needs. These volumes need to be restored. Therefore, research in the field of reforestation is relevant and important. The aim of this study has been to evaluate the technology of rooting coniferous trees during summer grafting. Various terms of green cuttings of coniferous trees of the Pinaceae family were considered, common representatives in the region (Pinus sylvestris L., Picea obovata Ledeb., Picea obovata var. coerulea Malyschev, Pinus sibirica Du Tour) have been considered. The cuttings have been harvested in four terms, starting from the 3rd ten-day-period of June to the end of July. The grafting has been carried out in different conditions: in a green house with a fog plant and a climate chamber with manual watering. Several methods have been used to prepare the cuttings for planting: with and without needle removing on the lower part of the cutting. Before planting, the tested cuttings have been treated with the root formation preparation “Kornevin” (control grop – without treatment). As a result of the study, the optimal time for grafting coniferous trees for the Baikal region has been determined as the 3rd ten-day-period of June and July. The minimum rooting period for the cuttings has been figured out as 155 days. It has been noted that the cuttings whose lower part needles have not been removed, have taken root faster. Their rooting share is 10 % higher. The best rooting rate has been recorded in cuttings obtained from the plants Picea obovata Ledeb. and P. obovata var. coerulea Malyschev – 22–30%. The cuttings from Pinus sylvestris L. and P. sibirica Du Tour have a very low rooting share – less than 1 %. To determine the quality of rooting, biometric indicators of the formed roots have been obtained. The cuttings planted in the 3rd ten-day-period of June in cultivation beds with regulated fogging are characterized by powerful roots.

Adalimumab is a biological drug effectively used in the treatment of several immune-mediated inflammatory diseases, including ankylosing spondylitis, juvenile idiopathic arthritis, and psoriasis. This study analyzed the therapeutic and economic benefits of adalimumab. Patients with ankylosing spondylitis showed significant improvements in quality of life and work productivity after treatment with adalimumab, confirming its clinical and economic efficacy. In the case of juvenile idiopathic arthritis and psoriasis, adalimumab demonstrated high efficacy and safety, significantly improving patients' conditions, establishing it as the gold standard of therapy. The use of adalimumab biosimilars offers accessible alternatives to the original drugs, expanding treatment options and reducing the economic burden on patients.

The formation of youth identity in communication is on the agenda of many areas of humanitarian knowledge. We analyzed communication within the framework of an educational media project, which resulted in the construction of the expected identity. In the course of the analysis, we used a conceptual model of communication that combines the stages of identity construction in interaction with the environment and the actions of actors from the standpoint of the methodology of actor-network theory. A three-dimensional model of communication is presented for the first time, where actors and actants change the communicative process by their affordances and resistance. The obtained results allow to delineate the necessary actions of human and non-human actors at each stage of communication and identity integration, giving the opportunity to justify a new theoretical direction in the study of the problems of identity construction through media communication. The methodology requires further testing, but there are already positive results. The tendency of actualization of urban identity of young people depending on the focus on interaction with the heritage of the city and according to the stages of communication, according to the conceptual model, has been established. The article is intended for specialists in mass communication and journalism, and will also be useful for those interested in the ontological turn in humanitarian knowledge, actor-network theory, discourse and media text analysis.

The article addresses the debatable points of research into present-day media genres: memes, surveys, comments, social network posts, etc. that become the materials for forensic linguistic expertise. The issue of identifying the object of linguistic expertise of information materials is discussed. The ways the new discursive reality transforms the existing methodological approaches are conceptualized. The brevity of the texts under examination, the dependence on the sociocultural context and the communicative situation, the presence of hypertext determine the complexity of the expert assessment of new media materials. The cases of ambiguous interpretation of brief comments and the peculiarities of defining the subject of speech in them are dealt with in the article. Special attention is paid to the techniques of play on words (pun) and irony as well as the linguistic semiotic analysis of creolized texts. The problem areas of expert research into new media materials included in the space of social communications are characterized. Special attention is paid to the problem of multi-discipline expertise, since the specificity of the material under study and the tasks to be solved determine the involvement of specialists of the socio-humanistic profile (psychologists, sociologists, political scientists, religious scholars, etc.) and necessitate solving the issue of the boundaries of experts’ competence. The new discursive reality associated with the involvement of mass audience in the production of media content suggests some changes in approaches to the linguistic expert assessment of the materials under scrutiny.

Aim. To evaluate the effectiveness and safety of Extimia® (empegfilgrastim, JSC "BIOCAD") in reducing the frequency, duration of neutropenia, the incidence of febrile neutropenia (FN) and infections caused by FN in patients with solid tumors receiving myelosuppressive therapy. Materials and methods. The paper presents the final results of a multicenter prospective observational post-marketing study of the safety and effectiveness of Extimia® (empegfilgrastim) in patients with solid tumors receiving cytotoxic therapy. For the primary prevention of FN, all patients received empegfilgrastim at 7.5 mg subcutaneously once per course of chemotherapy (CT) 24 hours after the end of CT administration. The primary endpoint included an assessment of the relative dose-intensity (RDI) of the CT courses administered. The endpoints of interest included the assessment of the RDI of CT courses by nosology and CT regimen, the frequency of dose-limiting neutropenia, and the incidence of all adverse events (AEs) in patients who received at least one dose of the study medication, including serious AEs. Results. From February 2021 to December 2022, 3218 patients with various malignancies were included in 41 study centers of the Russian Fede- ration. Of these, 3217 (99.97%) patients received at least one dose of the study drug, and 2663 (82.8%) patients were included in the RDI evaluation population according to the study protocol. The mean age in this group was 56.9 (18–84) years. RDI ≥85% was achieved in 2,415 (90.7%) patients. The mean RDI was 96.2%, with a median of 100%. FN risk factors were present in 1216 (45.7%) patients, with age ≥65 years being the most common risk factor at 761/2663 (28.6%). It should be noted that in patients younger than 65 years, the RDI was 91.5%, and in elderly patients (≥65 years) 88.7%. Dose-limiting neutropenia was reported in 19 (0.7%) patients. There were 74 cases of grade 3–4 AEs (according to CTCAE v.5) in 59 (1.8%) patients. The most common were neutropenia, anemia, and diarrhea in 19 (0.7%), 7 (0.2%), and 6 (0.2%) patients, respectively. Serious AEs were reported in 17 patients (0.5%). Conclusion. Primary prophylaxis of FN with long-acting granulocyte colony-stimulating factor empegfilgrastim effectively maintains RDI in various nosological and therapeutic groups of patients with different CT regimens in real-world clinical practice.

Background. The article presents materials on the study of the main tree species especially valuable for reforestation in the Kon Chu Rang nature reserve (Vietnam). It has been established that the diversity, as well as the physico-chemical and granulometric composition of the soil cover of the mountain range are due to the diversity of rocks in connection with the geological structures to which they are confined (the Pleiku plateau is located on basalt shales). It was revealed that the climatic conditions of the Kon Chu Rang nature reserve are characterized by high humidity and an abundance of precipitation throughout the year, which is why, due to the high washing regime, the soils are depleted of elements valuable for the growth and development of tree species. Most of the species grown in the nurseries of Vietnam are introduced, in this regard, the cultivation of seedlings and seedlings of valuable species for reforestation with a closed root system and an established irrigation regime, herbicides and fertilizers is required. Purpose. To study the possibility of reproduction of native forest tree species in the conditions of the mountain plateau of Central Vietnam. Materials and methods. The object of research was the climatic conditions of Vietnam, the soils of various relief elements of the Kon Chu Rang nature reserve, rare and especially valuable tree species: Dacridyum elatum Roxb. Wall. ex Hook., Michelia tonkinensis A. Chev., Dialium cochinchinense Pierre, Dipterocarpus kerrii King., Dacrycarpus imbricatus de Laub., as well as methods of their accelerated reproduction for reforestation. In order to determine the physico-mechanical and physico-chemical, chemical, agrochemical and biological properties of soils on the territory of the Kon Chu Rang nature reserve, soil samples were taken to a depth of 120 cm in increments of 10 cm on various elements of the mountain relief: on a shrub meadow site, in a forest with native tree species, on a pilot site of a hospital in the area of the reserve reserved for a forest nursery. When solving the tasks, methods of field experiment, expedition research were used, with the help of the Garmin device, the coordinates of the seed and seedling collection points were determined and fixed in order to build a route survey map. Seasonal development of trees was studied on the basis of field and research. The height of seedlings was measured at the beginning and end of the study period. Every plant in the collection was measured. The reproductive ability of species was studied by quantitative and qualitative characteristics of fruiting. In laboratory analyses were used the Kapel’ – 105M, capillary electrophoresis system, laboratory scales TO VK-600, analytical scales VL-220C, spectrophotometer PE-5400 UV. Mathematical processing of the results is carried out in the MS Exel and Statistica application programs using small arrays of observational data that were combined into homogeneous clusters. Results. The article contains data from studies of mountain forest territories, relief and soils of the Kon Chu Rang nature reserve (Vietnam), the main results of which are aimed at preserving and reproducing indigenous especially valuable tree species exposed to anthropogenic impact. It has been determined that many introduced species of 12 nurseries in Vietnam are extremely difficult to reproduce in mountainous terrain due to their morphological and biological characteristics, as a result of which they cannot be used for reforestation. It was revealed that the soil cover of the Kon Chu Rang nature reserve is characterized by variegation, distribution of areas, granulometric composition and humus content. Due to the large amount of precipitation, the soils are depleted of the necessary composition of elements necessary for good growth and development of woody species. It is determined that for the successful cultivation of especially valuable tree species in the nursery, surface watering and constant maintenance of soil moisture, treatment with herbicides and fertilizers are necessary. Seedlings are recommended to be grown in containers with a closed root system. Conclusions. Based on the data obtained as a result of studying the soil and climatic conditions of the Kon Chu Rang nature reserve (Vietnam), as well as the results of creating an experimental nursery of seed material for reforestation, it can be concluded that with the correct selection of irrigation standards, herbicides and fertilizers, it is possible to obtain a standard yield of standard planting material from a unit to ensure a high survival rate of seedlings and seedlings, as well as their subsequent growth, which will solve the urgent problems of improving the species composition of the indigenous forests of the Vietnam. Sponsorship information. The work was carried out within the framework of the topic E-1.6 "Development of technology for growing seedlings of the main native trees species of indigenous forests in Vietnam as the basis for solving the fundamental scientific problem of tropical forest restoration." Joint Vietnam-Russian Tropical Science and Technology Research Center.

Background. The relevance of the study is due to the need for investigating the professional development of senior schoolchildren and students under the conditions of increasing influence of stress factors. Objectives. The study set the purpose to review and analyze modern scientific ideas on the problem of psychological resources of professional self-determination in students under stress. Methods. Search for and analysis of recent theoretical and empirical research publications was carried out. Abstraction, and generalization of obtained data relevant to the topic of the article were applied. Methods also included identification of theoretical foundations and promising directions for research into the problem of psychological resources of professional self-determination of students under stress. Results. Analysis of the recent publications allowed to reveal conceptual differences in understanding the phenomenon of professional self-determination of the individual. It identified a variety of approaches to the study of human professional behaviour. The authors highlighted and characterized the main directions of modern research on the topic discussed, indicating the demand for studying human professional behaviour in the changing conditions of life. The study systematized theoretical foundations and empirical data on the psychological resources for students’ professional self-determination and for overcoming life stress. Conclusions. The study revealed the potential of a resource-based approach to the study of the stress influence on the professional self-determination of students and substantiated the role of conscious self-regulation resources in choosing and mastering a profession.

Introduction The study of the kinematic and kinetic parameters of gait in children with achondroplasia would allow a more detailed understanding of the features of their locomotion and determine the strategy of planned treatment. Purpose To evaluate features of locomotor kinematics and kinetics in children with achondroplasia and compare with peers without orthopedic pathology. Materials and methods The locomotor profile was assessed by video gait analysis. Kinematic data were recorded by Qualisys7+ optical cameras (8 cameras) with passive marker video capture technology synchronized with six dynamic platforms KISTLER (Switzerland). The analysis of kinematics and kinetics was carried out in the QTM (Qualisys) and Visual3D (C-Motion) programs with automated calculation of the values of indicators of the total peak power in the joints. Three groups were formed for gait analysis: 1) children 6–7 years old, achondroplasia (6 subjectsle, n = 12 limbs); 2) their peers, children without orthopedic pathology, 6–7 years old (8 subjects, n = 16 limbs); 3) children without orthopedic pathology 3–4 years old similar in height (8 subjects, n = 16 limbs). Results In children with achondroplasia, statistically significant disorder in locomotor kinetics and kinematics were found. The former are associated with a longitudinal deficiency of limb segments and decreased walking speed. The latter are not associated with a longitudinal deficit, but manifested in all planes, namely: an increase in the maximum forward inclination of the pelvis, a flexion position in the hip and knee joints, and dorsal flexion of the ankle joint; increased maximum angle of hip abduction and varus deformity of the knee joint; increased rotational range of motion of the pelvis. Discussion Since the characteristic features of the main gait profile begin to appear in children by the age of 4–5 years, and is associated with the formation of the activity of central and spinal generators that induce the self-organization of motor stereotypes, we believe that the deviations detected in the locomotor kinematics are secondary pathogenetic manifestations of the kinetics due to the longitudinal deficit in limb segments. Conclusion Features of locomotor kinetics in children with achondroplasia are due to the longitudinal deficit of the limb length and are associated with low walking speed. Significant deviations of the locomotor kinematics were not associated with the longitudinal deficit of the segments, but were detected in all planes and are related to the entire biomechanical chain.

The skin is the most vulnerable organ when spraying pesticides on fields. Farmers are also exposed to pesticides during mixing, loading of pesticides, and when cleaning equipment and disposing of empty containers. The aim. To study and analyze the features of the risk of pesticides dermal exposure to professional contingents during treatments using the innovative 3RIVE 3D pesticide application technology. Materials and methods. The 3RIVE 3D innovative technological system of introducing was used to applicate Brigade 3Rive 3D, SC formulation. Field experiments on the study of working conditions when using the pesticide were conducted in various soil and climatic regions of Eastern Europe. Statistical processing of the results was carried out using a package of licensed statistical programs IBM SPSS StatisticsBase v.22 and MS Excel. Research results and discussion. During the conducted research, no bifenthrin contamination was found on the open skin of the operator and the tractor driver, who were processing corn crops with the Brigade 3Rive 3D, SC formulation. However, the operator's gloves were found to contain 0.025 mg of bifenthrin. Calculation of the unitless CASd value on the possibility of skin acute effects when applying the formulation showed that bifenthrin and the Brigade 3Rive 3D, SC formulation based on it are characterized by sufficient selectivity of action on the target object (CASd – 645 and 162, respectively, i.e. > 100) and a low level of danger acute dermal toxic effects for workers, which is due to low values of effective consumption rates. The real dermal risk of bifenthrin exposure when using the Brigade 3Rive3D, SC formulation was significantly lower compared to the risk of workers involved in “traditional” air treatment and treatment with unmanned aerial vehicles (UAVs) (p=0.009-0.048 according to Wilcoxon's W-criterion); in comparison with rod and fan processing – it is non-significantly lower (р=0.262-1.000). There was a similar picture in comparison with the dermal aggravated risk – significantly lower in comparison with the risk of workers involved in “traditional” air treatment and processing with the help of UAVs (p=0.009 according to Wilcoxon's W-criterion); in comparison with rod and fan treatment – non-significantly lower (р=0.262-1.000). Conclusion. It was established that the studied active substance bifenthrin and the Brigade 3Rive 3D, SC formulation based on it are characterized by sufficient selectivity of dermal action on the target object and a low probability of acute dermal effects. A higher probability of acute inhalation poisoning than dermal exposure was revealed.

Background. The experience of using the like-SJMB03 therapeutic program is presented. The aim of this study was to assess the potential possibility of reducing the dose of craniospinal and local radiation therapy in the standard and high-risk group patients, and to identify clinical, therapeutic, morphological and molecular-biological factors that determine disease prognosis. Materials and methods. From 2008 till 2016 years 48 patients with newly diagnosed medulloblastoma were included in the study. In most cases (85%), localization of the primary tumor site was presented by a lesion of the cerebellar vermis with spread into the 4-th ventricle cavity. Gross total or near gross total resection of the primary tumor focus (R0 status) was achieved in 32 (66.7%) cases. The presence of a metastatic disease was established in 15 (31.2%) patients. Molecular biological characteristics of tumor samples were assessed using fluorescent hybridization in situ (FISH), Sanger PCR sequencing, and Illumina Infinium Human Methylation 450/850K BeadChip. Risk group stratification was according to SJMB03 (standard risk group was defined as: R0, M0 status; high-risk group: R1M0 or R0/1M+). A distinctive feature of this protocol was a reduction of the craniospinal irradiation dose down to 36 Gy for patients with M2/M3 status (without additional irradiation of metastatic foci) and the local irradiation dose down to 54 Gy (regardless of R status). Results. In the standard risk group (R0M0), 5-year and 10-year EFS were 84.0±7.3% and 67.2±9.6%, 5-year and 10-year OS were 92.0±5.4% and 76.4±9.9%, in the high-risk group (R1M0): 5-year and 10-year EFS – 62.5±17.1% and 62.5±17.1%, 5-year and 10-year OS – 75.0±15.3% and 62.5±17.1%, in the high-risk group (R0/1M+): 5-year and 10-year EFS – 33.3±12.2% and 33.3±12.2%, 5-year and 10-year OS – 60.0±12.6% and 33.3±12.2%. Structure of events was presented by 15 disease recurrences (7 localized – 2 early, 5 late; 8 disseminated – 3 early, 5 late), 2 cases of disease progression, 2 cases of secondary tumors (in the first – osteosarcoma, in the second – glioblastoma) and 2 episodes of fatal septic complications. Most of the events were found in patients with a Group 4 tumor. Two peaks of the events were established in standard risk group (the first peak was within 2 years after the end of treatment program, mainly in the age group of 8 years and older, the second peak was within 3 years after the fifth year of observation, predominantly in the group from 3 to 7 years). CSI dose reduction down to 36 Gy for patients with M2/M3 status (without additional irradiation of metastatic foci) in the high-risk group led to a dramatic decrease of 5-year EFS. There was a trend towards a decrease in 5-year EFS and OS in patients aged 8 years and older, as well as in the presence of the C-MYC, N-MYC genes amplification, isochromosome 17q in tumor cells. Conclusion. Despite the accumulated experience, it is necessary to continue studying the relationship between age groups and the molecular biology of tumor cells in medulloblastoma.

Background. Gingivitis is an important medical and social problem that can have a significant impact on the human life quality. Treatment of gingivitis in most cases is carried out at the stage of chronic inflammation or its exacerbation. The reason for late seeking dental care for gingivitis is the lack of pronounced symptoms of the disease and patients' lack of awareness of possible risks. Alkaline phosphatase of oral fluid is considered to be one of the markers of the development of the inflammatory process in the oral cavity. Monitoring of its activity at the stages of treatment makes it possible to evaluate the effectiveness of therapy in patients with chronic gingival inflammation. The purpose of the study is to reserach the dynamics of alkaline phosphatase activity in the treatment of patients with chronic generalized gingivitis when using various forms of silver-containing drugs in a comprehensive treatment plan. Materials and methods. 3 groups of 25 patients from 21 to 36 years old with a diagnosis of chronic generalized gingivitis were formed. Patients received topical antimicrobial therapy twice a day for 10 days. Patients of the first group were applied with Vitargol, patients of the second group were applied Argogel, patients of the third group (comparison group) were prescribed rinses with 0.05% solution of chlorhexidine bigluconate. Results. 6 months after treatment, the activity of alkaline phosphatase decreased by 28.1% compared to baseline values in the first group, by 31.9% in the second group, and by 44.7% in the third group. Conclusions. Silver-containing drugs can serve as a worthy alternative if there are restrictions on the use of antibacterial drugs in patients with chronic generalized gingivitis.

Background. Presented research was carried out in the context of relevant in modern psychology differential approach to the study of the psychological characteristics ensuring students’ academic achievement. Objective. The study had its purpose to identify differential features of regulatory and personality resources of academic performance in the students with different profiles of school engagement. Sample. The sample consisted of 1056 schoolchildren of 5-11 grades. Methods. V.I. Morosanova’s “The Self-Regulation Profile of Learning Activity Questionnaire (SRPLAQ)”; “A Multidimensional School Engagement Scale” (Wang et al., 2019; Russian adaptation Fomina, Morosanova, 2020); “Big Five Questionnaire — Children version (BFQ-C)” (Russian adaptation Malykh et al., 2015); “Academic Motivation Scale - School (AMS-S)” (Gordeeva et al., 2017); “Attitude towards learning in middle and high school” (modification of «Method of diagnostic of learning motivation and emotional attitude to learning in secondary and high school») (Andreeva, Prikhozhan, 2006). Academic achievement indicator was calculated as the average score in all subjects. Results. The study revealed 4 groups with different levels of school engagement and its components. An analysis of differences in achievement resources in the identified groups showed that students with a high level of school engagement were characterized by the highest levels of self-regulation, internal academic motivation, extraversion, conscientiousness and openness to experience. The most successful in terms of academic achievement were the students with a high level of all engagement components, as well as those with a high cognitive engagement. Conclusion. The study provides empirical data on the differential features of regulatory and personality resources of academic achievement in the students with different profiles of school engagement. Further studies might be aimed at investigating the age specificity of the identified engagement profiles and individual typological features of academic achievement resources.

The underground space development is associated with the emergence of complex and dangerous situations, often leading to accidents. The condition for their development is the potential geotechnical risks. High-quality execution and analysis of design work at all the stages of design, starting from the early stages, is one of the effective ways to control risks. Clarification of the characteristics and features of the rock mass adjacent to the projected underground structure makes it possible to identify the potential cause of the occurrence of an adverse event with a certain probability during the construction and operation of an underground structure. The purpose of a qualitative risk analysis is to identify risk factors in underground construction. The value of the total geotechnical risk, expressed by the sum of each of the possible risks, should be numerically estimated at the design stage of a specific underground facility. At the same time, it is extremely important to develop a methodology for managing geotechnical risks, which would make it possible to assess their probability of development at an early stage of project preparation and propose measures to reduce or prevent them. This technique is given in the article. The results of the study conducted in accordance with the presented methodology showed that geotechnical risk control proved an effective method in preventing accidents during underground construction.

The article is devoted tо the specific question in Russian art history – to the problem of light in the works of J. Balla from the perspective of Light art genesis. The insufficiently researched genesis of light art .in Modernism and Italian Futurism is followed by the incomplete understanding of phenomenon. This circumstance requires an appeal to the historical roots of Light art, particularly, to the period when artists started including artificial light into the practice of fine art and started using it as a medium. As a result of the research in the art of J. Balla the genesis of Light art has been revealed. The article examines the consistent change in the approach to light in the main futuristic manifestos and works of art. In Balla’s paintings of the 1910s, light was used as an image and element of art, while in plastic complexes and scenography of the theatrical production “Fireworks” it was used as a material (medium). The ballet “Fireworks” is proposed to be considered as prototypical work of light art. The results of the study can be used in the art historical research and cultural analysis of the history and modernity of light art. The research methodology is based on the art historical analysis of texts and works of art, as well as on the comparative method.

Relevance. In studying the history of medical and biological disciplines, an important part is the identification of the stages of their formation and development. In this regard, it seems important to make a historical and scientific analytical review of the development of ideas about aviation physiology, covering different stages of the history of science and reflecting the contribution of researchers from different regions. It will be useful for teaching historical and scientific and special disciplines, as well as for researchers involved in the study of aviation physiology. The need to understand how the human body functions in flight arose along with the development of aeronautics. The study is devoted to the analysis of the main stages in the development of aviation physiology. The purpose of the study - to characterize the stages of formation and development of aviation physiology. Research methods. In preparing this publication, articles in publications included in the RSCI, PubMed, and Scopus were mainly used. Preference was given to materials published in the last 15 years. The main results present the stages of development of aviation physiology with a description of the contribution of the main researchers in this field. The achievements of domestic scientists, doctors, physiologists I.M. Sechenov, L.A. Orbeli, G.M. Zarakovsky are analyzed, their scientific priorities in the development of this scientific direction are presented. The process of formation and development of aviation physiology as a direction of biomedical knowledge is presented. Before the advent of aviation (19th century), hypoxia was studied in the study of balloon flights. With the advent of high-speed and maneuverable aircraft, aviation physiology began to study the body’s response to overloads caused by highly maneuverable flights. Conclusion . The development of aviation physiology can be divided into two stages. 1. Pre-aviation, within which the emergence of this area of medico-biological knowledge takes place. 2. Aviation, at this stage scientists have the opportunity to study different multidirectional overloads and their effect on the human body. Currently, aviation physiology is one of the important branches of physiology, aviation and space medicine.

During the last 30 years, unique international experience has been accumulated in the treatment of children with medulloblastoma, especially in the age group over 3 years. Evolutionary representations about one of the most well – known international protocols – SJMB (in versions since 1996 – SJMB96, since 2003 – SJMB03, since 2012 – SJMB12) are shown in this article. Innovative criteria for stratifying patients into risk groups were established according to clinical, therapeutic, morphological and molecular-biological prognostic factors. Despite the accumulated experience, it is necessary to continue studying the relationship between age groups and the molecular biology of tumor cells for the purpose of subsequent optimization of the treatment program.

Aim. To assess the proportion and profile of patients at high risk of febrile neutropenia (FN) receiving cytotoxic chemotherapy (CT), as well as the incidence of FN and dose-limiting neutropenia after one cycle of CT. Materials and methods. The paper presents the results of the FLAME study, the first Russian observational study in patients with solid tumors who received only cytotoxic CT or a combination with targeted, immuno-oncological drugs. By random sampling, the study retrospectively included 500 patients with a median age of 59 years (18–83 years) from 25 medical institutions in the Russian Federation. Results. CT regimens with a high (20%) risk of FN were received by 25.2% (126/500) of patients; 53% (265/500) of patients had intermediate risk, and half of them (132/265 [49.8%]) had at least one additional risk FN factor following international NCCN guidelines. Thus, a high risk of FN, according to the therapy and the assessment of individual prognostic adverse factors, was noted in 51.6% (258/500) of patients. 36.8% (95/258) of patients with high risk for FN received primary prophylaxis with granulocyte colony-stimulating factors. Conclusion. The study showed a significant proportion of patients with a high risk of FN, and most of them do not receive primary prophylaxis of FN.

For more than three decades, media researchers have seen Actor-Network Theory (ANT) as a suitable approach to form a new theory of media roles and to study communication technologies as actors, but this relationship has been surprisingly understudied. A review of recent articles on the use of ANT in media theory and related fields shows that there are explications of networks and translations, but it is the key method of uncertainty or contraversion that has not yet been integrated into communication theory. The aim of this article is to integrate the method of contraversion into the structure of communication, the conceptual model of communication, which will allow us to nuance networks and collectives, to see the unnoticed entities that “knock” to be seen and accounted for. This is the essence of the politics of participation of non-human actors, nonhumans, according to Latour. The model allows to follow the process of differentiation of socio-technical hybrid objects in communication. The unfolding of this process of becoming represents the stages of communication development, which can be roughly divided into 4 stages, and focus both on the whole process of assemblage and on its stages, in order to notice the influencing entities. In the ANT concept, all assemblages, hybrid entities, consist of actors or non-figurative actants, and all actants are themselves assemblages. In the process of zooming in and describing phenomena, one should go after the actors on the one hand and determine the level of complexity of the network on the other. The conceptual model of communication, complemented by the ANT contraverses, helps to map reality and is an influential political tool as it reveals hidden actors and shows the asymmetry of influence.

A comparative analysis of 3 AI-based smartphone applications for self-service skin cancer risk assessment: ProRodinki, Skinive and Skin Vision. Analysis consists of description of applications and its ways of work, and results, such as sensitivity and specificity, done on the base of the practical experiment conducted with processing 516 images of the skin neoplasms and pathologies confirmed by histological research via each app. Every application is unique and differs from each other by its principles or work, algorithms, user experience and design, and of course AI model and the set of input data that is analyzed by neural networks. Current research and practical experiment were made with focus on images processing and the app risk assessment for each of the image, other details and mole prescription information were set neutral. This leads to a conclusion that there is a lack of methodology for testing and analysis of different AI-based applications and services. Having such methodology, the comparison analysis results can be more objective and transparent.

Purpose: to determine elements of irrigation technology for young vineyard plantations using the drip irrigation method on various types of soil in the Republic of Crimea and test them under the conditions of this region. Materials and methods. The research was carried out in the village of Pavlovka, Belogorsky district of the Republic of Crimea. The establishment of field experiments and observations were carried out using generally accepted methods for setting up and conducting field experiments. Results. As a result of the research, the water-physical properties of soils of the Republic of Crimea were analyzed and rational elements of the technology for irrigating young vineyard plantations using drip irrigation on various types of soils (limits of optimal soil moisture, dripper consumption, wetted depth, irrigation period and water application rate) were calculated. When calculating the irrigation regime for the drip irrigation method, it is necessary to take into account the wetted layer depth, the physical properties of soil, the planting pattern, the moisture contour shape, the dripper flow rate and pre-irrigation soil moisture. The elements of irrigation technology for young vineyard plantations vary significantly, for example, the recommended flow rate of drippers varies from 2–4 l/h on chernozems to 6–8 l/h on light chestnut soils and steppe solonetzes, while the duration of irrigation varies from 2–3 h on light chestnut soils up to 6–9 h on ordinary chernozems. Conclusions. When testing the results, it was found that the drip irrigation method has a positive effect on the survival rate of table grape cuttings. On average, this indicator for varieties was 98.8%. For soil and climatic conditions of the Republic of Crimea, the varieties Sport, Podarok to Irina, Baikonur and Zabava turned out to be the most responsive in terms of their morphological characteristics. During the growing season of the first year young table grapes (in a medium-dry year), 16 irrigations of 30 cubic m/ha with an irrigation rate of 480 cubic m/ha were carried out, while the total water consumption excluding the use of moisture from soil was 3740 cubic m/ha.

Introduction Timely diagnosis, etiopathogenesis, treatment and prevention of the progression of pediatric flexible pes planovalgus (FPPV) are essential to prevent irreversible complications. The objective was to determine a correlation between whole-blood serotonin level and flexible pes planovalgus in children and adolescents over a period of four years with progression of the condition. Material and methods The whole-blood serotonin level was measured in children and adolescents aged 5-15 years with FPPV and compared with data from photoplantograms, a pronation angle of the calcaneus and radiographs of the feet. Based on serotonin measurements and photoplantograms, two groups were identified according to the course of flexible pes planovalgus and measurements during the next four years. Results Normal serotonin levels were maintained in the non-progressive FPPV group throughout the study with a 9.2 % decrease in the pronation of the calcaneus at 4 years. Progressive FPPV patients showed higher serum serotonin at one year with a 38.3 % increase at 4 years, increased pronation of the calcaneus by 21.2% and radiologically decreased height of the arch by 18.7 %. A moderate correlation between whole-blood serotonin levels, pronation of the calcaneus and the height of the foot arch was radiologically revealed in patients with a different course of FPPV. Analysis of the diagnostic effectiveness of the whole-blood serotonin test in patients with FPPV showed high sensitivity and specificity in predicting the risk of progression of FPPV. Discussion Literature review showed a paucity of research on clinical and laboratory detection of the progression of FPPV and examination of neurotransmitter mechanisms in the foot pathology. Plantography, 3D scanning and radiography were the main methods for the diagnosis of the flat feet. Conclusion The correlation between whole-blood serotonin level and flexible pes planovalgus in children and adolescents was identified and suggested involvement of the serotoninergic system in the formation and progression of foot pathology.

The practice of the functioning of the United Nations and the actual mechanisms of peacekeeping differ significantly from the theoretical ideas about them. Anna Mikhailovna Evstigneeva, Deputy Permanent Representative of the Russian Federation to the United Nations (UN), who has been dealing with peacekeeping issues for many years, answers a number of important questions about contemporary peacekeeping and peacebuilding in her interview. She argues that while the West is building a “rules-based order,” for Russia the rules are the UN Charter. The key to ensuring the effectiveness of an international organization, according to A.M. Evstigneeva, is the ability of the parties to reach mutually beneficial solutions and to take each other’s interests into account. The rest is a “superstructure,” which, however, is partially enshrined in the doctrine. Dozens of factors (dialogue with civil society, gender, climate, etc.) play a special role, which over time become universal. Often, the beautiful Western theories of liberal peacebuilding do not stand up to the harsh reality; and in a number of cases there is silence on the part of decision-makers about the real situation on the ground. This interview highlights the challenges of the existing system of international peacekeeping in the context of the formation of a multipolar world.

Goals. The article analyzes materials from anniversary events, historical discussions, examines fundamental publications and academic editions for an insight into the evolution of ideas about Buryatia’s historical path. Ceremonial events and publications issued on the occasion of anniversaries are of particular historiographic value: on the one hand, those reflect achievements and problems of a certain period, and, on the other hand, narrate about dominant political ideologies and patterns of historical consciousness. In the meantime, anniversary scientific conferences usually attended by leading officials and scholars of the Republic were to somewhat comprehend actual results and discuss further development prospects. Materials and methods. The paper examines documents stored at the State Archive of Buryatia, Scientific Archives of the Buryat Scientific Center (SB RAS), Center of Oriental Manuscripts and Xylographs affiliated to the Institute for Mongolian, Buddhist and Tibetan Studies (SB RAS). The principle of historicism proves instrumental in reconstructing how historical thought has evolved within the general trends of state development and Buryatia’s political life throughout the 100 years. Results. On 30 May 1923, the Presidium of the All-Russian Central Executive Committee decided to unite Siberian and Far Eastern autonomous oblasts of Buryat-Mongols into one autonomous socialist Soviet republic to be centered around the city of Verkhneudinsk. In terms of theory pertaining to historical science and historical enlightenment, the formation of the Buryat-Mongol ASSR set forth a most important task of comprehending experiences and paths of Buryatia’s peoples in accordance with the Marxist-Leninist paradigm of historical process, while in terms of practice it was urgent to substantiate the Soviet ideology and socialist reforms. All this required that experts joined their efforts to develop conventional approaches in the field of historical knowledge and nation/state building. So, the history of Buryatia was to be generalized and systemized by the academic publications as follows: History of the Buryat-Mongol ASSR (1951, 1954, 1959); Essays on Buryatia’s History and Culture (1972, 1974); History of Buryatia in three volumes (2011), etc. The 100th anniversary of the Republic has been welcomed with another two-volume edition — Republic of Buryatia in the 20th–21st Centuries: Chronicles, Events, Comments — that provides a systemic overview of its peoples’ historical paths (and milestones), illustrates quantitative and qualitative transformations in politics, economy, culture, and demography, that had formed a vector of progressive and constructive development which survived even in most dramatic periods. The centenary celebrations have been pinnacled by the international scientific conference — Cross-Border Regions of Russia’s East in Modernization Processes, 20th–21st Centuries: [Celebrating the] 100th Anniversary of the Republic of Buryatia.

The issue of the influence of the concentration of the solid phase on the reduction of energy costs and specific energy consumption during pulp transportation is considered. The procedure for preparing slurry from the current enrichment tailings is shown. A scheme is given and the operation of a hydroficated unit for thickening and hydraulic transport of backfill mixtures is described. A diagram of the movement of solid particles in one of the units of the complex – a lamellar thickener is shown. The summary table shows the main design parameters and characteristics of the lamellar thickener. A general view of the laboratory setup used for experimental studies with slurry at various concentrations is given. An example of calculating productivity, density and specific load is presented. The dependence of the shear stress on the velocity gradient was determined for various pulp concentrations. Experimental studies of the process of thickening the production of slurry from the current enrichment tailings have been carried out. It was found that the geometric dimensions of the thickener depend on the concentration of the solid phase in the transported mixture. It is concluded that the flow rate of the slurry and the head loss are functions of the rheological characteristics of the viscoplastic slurry and can be calculated from the derived calculated dependencies.

The weakening of the manmade load on the environment has become a global goal of humanity. The accumulation of toxic substances in effl uents can increase the acceleration of pollution of the planet’s watersheds, resulting in biota pollution. To solve this problem, it is necessary to create photocatalysts that cause self-excitation under the ignition of light. Also, important parameters of photocatalysts are simple synthesis and low cost. This article demonstrates a one-step approach to the synthesis of carbon nanostructures (CNS) with photocatalytic activity. For this purpose, the “green chemistry ” method is used – hydrothermal treatment of various polysaccharides (sodium dextran sulfate (SDS), starch, pectin), which opens up the possibility of recycling products. A comprehensive study of the properties of the synthesized CNS has been carried out. To study the optical properties of CNS, absorption and luminescence spectroscopy, and IR spectroscopy, have been used. The CNS obtained have been successfully used in the processes of photocatalytic destruction of a model of the organic dye tartrazine, which is widely used in the fi ber and textile industries. The eff ect of lyophilization on the photocatalytic properties of СNS has been studied, and cytotoxicity has been evaluated.

The phenomenon of intractable intergroup conflict is being actively studied in modern foreign psychology. The study of conflicts of this type is now becoming especially important due to the increase in their number in today’s reality. Of great importance are the works of the Israeli scientific school, which considers the phenomena of the ethos of the conflict, the collective memory of the conflict and the collective emotional orientation, which are the basis for interpreting information about the conflict situation. Despite the large number of models and approaches, there are still quite a few gaps in the research of intractable conflicts (for example, there is no generally accepted definition of an intractable conflict, and many research methods are poorly operationalized). The representations regarding an intractable conflict in the Russian and Ukrainian media discourse are analyzed. The ways of constructing such representations in the media discourse are considered through a reference to the socio-psychological infrastructure of the conflict. The main research method was critical discourse analysis in the interpretation of J. Potter and M. Weatherell. It was found that in both Russian and Ukrainian media discourse representations regarding the conflict were constructed through references to the ethos of the conflict: in particular, through the justification of group goals, the presentation of the opponent’s actions as illegitimate and unfair, the victimization of opposition groups, and the maintenance of positive image of the group. It was revealed that in both Russian and Ukrainian media there are references to collective memory, but the frequency of their occurrence does not allow to talk about a trend. The results can be used to develop measures to reduce bias in media coverage of conflicts. The prospects for further research are discussed, in particular, the analysis of intractable conflict representations in audiences of different media and their comparison with those repertoires that have been identified in the media discourse.

Introduction. The article deals with exports and imports of precious metals between Russia and the Qing Empire in the 19th and early 20th centuries. Special attention is paid to activities of the Russo-Chinese Bank that established its offices across Russia-Mongolia frontiers for the latter to arrange silver trade with China. Goals. The paper aims to reveal actual causes, conditions and mechanisms of silver transit from Europe to China — and identify the role played by the Russo-Chinese Bank therein. Materials and methods. The study examines statutes and regulations, reports of the Russo-Chinese Bank, and previously unpublished records management and statistical documents stored at the State Archive of Buryatia (Collection of Kyakhta Customs Station and that of Kyakhta-based first-guild merchant M. Nemchinov, respectively). The work employs a number of historical research methods, special emphasis be laid on the principle of historicism and the comprehensive analysis method that have proved instrumental in interrelating the mid-to-late nineteenth and early twentieth century geopolitical events across Asia-Pacific — to the intensification of Russia-China precious metals trade. Results. The paper virtually reconstructs the mechanism developed by the Russo-Chinese Bank in Russia-Mongolia frontier territories to export precious metals from Western Europe to the Qing Empire. Conclusions. The late nineteenth-century weakening of the Qing Empire and subsequent changes in the balance of power across Inner Asia significantly modified the region’s geopolitical agenda. The altered vectors of external policies towards Asia Pacific enabled the Russian Empire to successfully expand its economic presence in China at the turn of the 20th century. The Tsarist government did succeed in holding strong positions in China’s market of precious metals via a specially created ‘tool’ — the Russo-Chinese Bank. The efficient combination of Russia’s smart trade strategies and special customs preferences yielded a highly profitable business of precious metals transit from Europe to China. And it was Kyakhta Office of the Russo-Chinese Bank that played a key role in securing uninterrupted supply of precious metals.

Goals. The article aims to consider some key historical milestones and achievements in Buryatia’s nation-state building for over 100 years. The paper analyzes the conditions for the emergence of Buryat-Mongolian autonomy, and the factors that prompted reorganizations of the Republic’s political structure in the context of changes witnessed in the nationwide political agenda. Special attention is paid to the contribution of the Republic to the Great Victory, certain analytical emphases be laid on present-day challenges, achievements and development prospects. Materials and methods. The work examines unpublished documents stored at the State Archive of the Russian Federation, Russian State Archive of Sociopolitical History, and State Archive of Buryatia. The principles of historicism and consistency prove instrumental enough in reconstructing the process of nation-state building in Buryatia, identifying specific features, and tracing general trends of state development in the Republic’s political life. Results. On 30 May 1923, the Presidium of the All-Russia Central Executive Committee decided to unite Siberian and Far Eastern autonomous domains (oblasts) of Buryat-Mongols into one autonomous socialist Soviet republic centered around the city of Verkhneudinsk. It is then and there that the statehood of Buryat-Mongols — consolidated by a single territory, economic integrity, and historical ties of all resident peoples — was proclaimed. The shaping and rapid development of industries in the Republic, transformations in agriculture, education and health care converted the territory of Buryatia into a strong supporting point that would render every possible assistance to the nation during the Great Patriotic War. The post-war years up to the 1960s and early 1970s became a period of progressive development in all spheres of life. At the all-Union level, merits of the Republic were distinguished with the Order of Lenin (1958), Order of Friendship of Peoples (1972), and Order of the October Revolution (1973). Events of the late 1980s and the subsequent collapse of the USSR served as a test of state viability to the Republic. The economic depression led to an unprecedented deterioration of the social situation which could actually result in a severest interethnic conflict. However, the accumulated experiences of cross-cultural interaction, flexible administrative and managerial systems, high educational and scientific levels of the population, and a unified language environment proved instrumental in neutralizing negative trends and strengthening constructive ones — as part of interethnic dialogue within the new statehood of Russia. Despite the complicated processes of the 1980s–1990s, Buryatia confirmed its loyalty to the principles of federalism and integrity of Russia. Another important milestone was the 1994 adoption of the Constitution of the Republic of Buryatia. Over the past hundred years, the Republic has developed as a major political/legal entity of the Russian Federation — in cultural, economic, and other aspects. Nowadays, the peoples of Buryatia — regardless of faith and ethnic identity — join efforts to develop public economy and culture, shape a common destiny of the Republic and the country on the basis of friendship, harmony, and mutual understanding.

Aim. To assess the effect of febrile neutropenia (FN) prophylaxis with granulocyte colony-stimulating factors (G-CSF) in real-world cancer patients. Materials and methods. We conducted a statistical analysis of anonymized medical records collected in the Webiomed platform. Before analysis, the cards were validated by clinical experts. Electronic records were extracted according to two principles: mentioning D70 in the diagnosis or mentioning a chemotherapy regimen associated with a high risk of FN (20%), requiring the primary prevention of neutropenia. Thus, we obtained two datasets comprising 47.085 (590 patients) and 30.523 (398 patients) records, respectively. Results. Based on the analysis results, the most common risk factors for FN development were highly hematologically toxic chemotherapy regimens and elderly age about 50% in the adult population. In both datasets, the number of female patients prevailed (63.7% in dataset 1, 91.2% in dataset 2), so the most common was breast cancer. Less common were cervical cancer, digestive cancer, and lung cancer. Despite the indications for primary prevention of FN, for safety and importance of achieving the planned dose intensity, it was administered in 18.3% of patients in dataset 1 and 2.3% in dataset 2. No FN or G-CSF-related adverse events were reported in patients who received adequate primary prevention. Conclusion. Some issues related to G-CSF administration in cancer patients were identified. We identified the insufficient provision of patients with primary prevention of FN, which negatively affects survival rates and reduces adherence to antitumor therapy. Real-world data demonstrate the efficacy and safety of FN prevention and planned dose intensity maintance in cytotoxic therapy regimens.

Background. Chronic diarrhea can be a symptom of a wide variety of diseases, either of which requires special therapy approaches. The diagnosis of rare causes of chronic diarrhea is especially difficulty as it may be associated with inflammatory bowel disease (IBD) with very early (under 1 year of age) debut.Clinical case description. Boy E. had chronic diarrhea manifested on the first year of life. Ulcerative colitis was diagnosed at the age of 1.5 years, then the diagnosis was changed to Crohn’s disease at the age of 2.5 years. The results of 6-years-follow-up of the patient were presented, as well as analysis of diagnosis and treatment difficulties was carried out.Conclusion. The clinical case of Crohn’s disease with diarrhea as the leading clinical manifestation at the disease onset is described. Sequential diagnostic search allowed us to establish the diagnosis of IBD and to exclude other causes of chronic diarrhea that determined the correct therapeutic strategy.

Studies of recent years have shown a weakening of the urban identity of the youth of St. Petersburg, a lack of interest in the preservation of cultural heritage. The purpose of the study is to deconstruct discourses and identify the value-oriented and goal-oriented components of dispositives that allow understanding the drives of communication in social networks and adjusting the policy of urban identity. The article applies the actor-network theory to data reconstructed from the texts of social networks of residents and city defenders about the St. Petersburg cultural architectural heritage, which allowed us to adapt the ANT for a systematic analysis of urban identity politics, taking into account infl uential factors in the modern environment of network communications and related policies. Identity is considered simultaneously as a discursive construction and as an effect of the confi guration of human and non-human actors that respond in social practice to the current transformation of the symbiotic relationship between man and the environment. On the material of the media and social networks regarding the destruction of the building, the content was analyzed using the discursive method and actor-network theory. Three possible levels of use of ANT in the analysis of political communication around cultural heritage are identifi ed and illustrated: 1) material objects stabilize social relations; 2) have real and sensual qualities that contribute to projective identifi cation; 3) ensure the spatiality and integrity of the city. In the course of analyzing the boundaries of network interactions, the psychoanalytic concept of “lack” is actualized as an insoluble contradiction and antagonism of discourses, as a projection of anxiety in texts, with the prevailing uncertainty of the current motivation. The result of the study was the identifi cation of value-oriented and goal-oriented dispositives of discourses in the fi eld of urban identity and the development of a program for the policy of communication with network actors. The identifi cation of dispositives allowed us to establish the conditions for productive communication as a determining factor in symbiotic regimes in the modern city

In 2022, the Professional Student Society of the RUDN University Ecology Institute turned 10 years old. The Society has made a significant contribution to the environmental education of many generations of environmental students. Many interesting expeditions, volunteer work, quests, round tables, reports were organized. Based on the results of field work, scientific articles and graduation papers were written, agreements were signed with national parks.

Goals. The article seeks to reveal specifics of historical science’s institutionalization in the Buryat-Mongol ASSR throughout the 1920s and 1930s. It analyzes the conditions to have accompanied the development of historical science in the prerevolutionary era, peculiarities in the shaping of new organizational forms for historical research in the Republic (scientific institution, scientific society, museums and archives), and a corresponding educational infrastructure. Much attention is paid to the analysis of history and ethnography research endeavors of scientific societies (Dorzhi Banzarov Buryat-Mongol Society, Troitskosavsk-Kyakhta Branch of the Russian Geographical Society) and the first scientific institution of the Republic to have evolved from Buryat-Mongol Scientific Committee into the State Institute of Language, Literature and Cultural History during the mentioned period. Materials and methods. The paper examines unpublished documents stored at the Center of Oriental Manuscripts and Xylographs (Institute for Mongolian, Buddhist and Tibetan Studies SB RAS), Scientific Archive of the Buryat Scientific Center (SB RAS), and the State Archive of Buryatia. The principles of historicism and systemacity employed make it possible to reconstruct the process of historical science’s institutionalization in the young Buryat-Mongol autonomy, the latter having been determined by objectives of scientific, cultural, social, economic and political development of the Soviet state. This has yielded a balanced approach aimed to characterize the ideological predicaments faced by the humanities in earliest decades of the BMASSR. Results. The first post-October decade witnessed the shaping of a conceptually new paradigm of historical science based on Marxist-Leninist ideologies — paralleled by the formation of Buryat-Mongolia’s infrastructure of historical science represented by institutions of science and education, public organizations and archives. In methodological terms, the very historical science was being developed ‘under the flag of local history’ with the typically insufficient detailing and generalizing nature of historical problem statements. The first 1926 meeting on ethnic culture and the 1934 meeting on controversial issues of Buryat-Mongolia’s history did articulate consolidated ideas pertaining to development directions and objectives for historical science in the Republic. Despite the ideological extremities had had most negative impacts on human resources and potentials of regional historical science, by the late 1930s there were a source base and theoretical/methodological tools generally compliant with Marxist-Leninist ideologies. All that helped P. Khaptaev, A. Okladnikov, F. Kudryavtsev and many others prepare generalized works on the history of Buryatia that have become classics of Russian historiography.

The article provides a discourse-analysis of the contemporary conflict over the preservation of Historic Centre of Saint Petersburg and Related Groups of Monuments. The main participants in this conflict are 10 interest groups, which are reassembled each time in the process of articulating the discourse of their group. These actors are: UNESCO, local and federal governments, businesses, urban conservationists, residents and existing physical heritage. The article considers the dispositive of discourses that supports group formation and group identity. The results found are presented visually and graphically. From the media and social networks, the case of the destruction of the heritage is reconstructed and the discourse of city defenders is considered. The conflict of discourses and new types of antagonisms associated with different ones are reconstructed: the regime of affects, the visualization of the city, the development of the objective environment, the instruments of social action, and representation in the media and social networks. The article is intended for those interested in discursive analysis, actor-network theory, affect theory, world heritage, visualization of space, media, identity, and urbanism.

Introduction. The formation of new blood vessels is called angiogenesis. As the tumor grows, the oxygen and nutrient requirements of the abnormal cells continuously increase, and new blood vessels are formed. These processes are disrupted by angiogenesis inhibitors. Therefore, it is warranted to investigate ways to enhance the capabilities of angiogenesis inhibitors alkaloids, flavonoids, and glycosides. Aim. To justify the extension of clinical use of alkaloids, flavonoids and glycosides (Conium maculatum and Hydrastis canadensis, Thuja occidentalis), being a part of the complex medical product Mastopol, taking into account the obtained data on the angiogenic balance in the nodular form of benign mammary dysplasia (BMD). Materials and methods. The study included 69 volunteers divided into two groups: Group 1 included 27 patients with medical history of surgery for nodular BMD who received antiproliferative preoperative therapy with Mastopol for 12 weeks. Group 2 (comparison group), n=42, also included patients with medical history of surgery for nodular BMD but without preoperative therapy with the herbal medicine Mastopol. We studied angiogenesis markers (VEGF-A [vascular endothelial growth factor] and pVEGF-1) and immunohistochemical marker CD34 (cluster of differentiation CD). Results. We found a significantly higher (p0.001) rate of CD34 detection on medium and small caliber vessels in the comparison group, i.e., in the patients who were not treated preoperatively with alkaloids, flavonoids, and glycosides (Mastopol), while blood supply to the nodules by the medium and small vessels was 1.4 and 1.8 times lower in the Group 1, respectively. Analysis of VEGF expression shows an increase of angiogenic promoters VEGF-A and pVEGF-1 in serum before treatment with biologically active herbal components of Mastopol in both groups. There were no statistically significant differences in vascular markers. However, a statistically significant decrease in VEGF-A and pVEGF-1 (p0.001) was noted in Group 1 after Mastopol therapy. Note the presence of a moderate direct correlation (rs=0.49) of CD34 expression with VEGF-A expression in Group 1 and rs=0.41 in Group 2, which indicated a direct relationship between angiogenesis and proangiogenic factors. Conclusion. In addition to the proven antiproliferative, anti-inflammatory, cytokine stabilizing, analgesic, and anti-edema properties of Mastopol, the study also showed the antiangiogenic effect of the herbal drug components. Considering the decreased vascular growth in fibroadenomas during Mastopol treatment, the indications for its use in patients with fibroadenomas before the surgery can be extended. Specific immunological test to measure VEGF can be proposed as a noninvasive screening method to evaluate the effectiveness of conservative treatment in general clinical practice.

Link for citation: Zubareva A.M., Glagolev V.A., Zhuchkov D.V. Influence of vegetation fires on the state of atmospheric air in Birobidzhan. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 6, рр.113-119. In Rus. The relevance. About 50 % of the population of the Jewish Autonomous Region lives on the territory of Birobidzhan and a 10-kilometer zone from its border. In this regard, it is important to analyze the features of the spread of vegetation fires in the vicinity of the city and the intensity of smoke exposure. The main aim: analysis of the influence of vegetation fires on the state of atmospheric air in Birobidzhan. Objects: vegetation fires in a 10-kilometer zone from the border of Birobidzhan. Methods. The work is based on the data about the number of fires in the vicinity of Birobidzhan for 2010–2015 and 2017–2020 according to the Department of Forest Management of the Government of the Jewish Autonomous Region. To display the spread of fires, a vegetation burnability map was made in the study area in the MapInfo Professional 9.0 geoinformation system. The analysis of smoke transport was carried out using wind rose graphs. The basis for the construction of maps reflecting the smoke effect was an upgraded formula for modeling Sutton emissions and a method for calculating concentrations of harmful impurities in the atmospheric air OND-86. The author's algorithm is implemented in the MapBasic programming environment, which is included in the MapInfo Professional 9.0 geoinformation system package. A scale of the intensity of smoke exposure to the atmosphere for the studied area is obtained. Results. The most and least fire-hazardous months for 2010–2015 and 2017–2020 were identified. Territories that are constantly exposed to vegetation fires were marked. In accordance with the graphs of the wind rose, cartograms reflecting the intensity of the smoke effect on the atmosphere of Birobidzhan were made.

The development of strategic alliances between Russian and foreign pharmaceutical companies allows not only to introduce biotechnologies in the domestic market, but also to strengthen the policy of import substitution and increase export volumes. That is why it is important to support the creation and functioning of strategic alliances at the state level. The purpose of this article is to study the creation and development of strategic alliances between Russia and Hungary, paying attention to the formation of alliances in the field of pharmaceuticals. In order to achieve this goal, the indicators of export-import operations between Russia and Hungary in the field of “pharmaceutical products”, as well as the main strategic alliances operating between the two countries were considered. It is assumed that the development of Russian-Hungarian strategic alliances in the field of pharmaceuticals with localization of production will help to achieve the goals of the import substitution policy in the field of drug production, as well as to intensify export operations. To test this hypothesis, documents published in the public domain were analyzed, including statistical data on export-import operations in the pharmaceutical market between Russia and Hungary. In general, it was proved that at the present stage of development of the pharmaceutical market of the Russian Federation, it is important to support the creation and functioning of strategic alliances, which will strengthen Russian positions not only in the domestic market, but also in the international market. Thus, the Russian Federation should actively develop and support the development of localized strategic alliances using various methods, which will increase the share of domestic biotechnologies and ensure their export.

Introduction Optimization of the conditions of distraction osteogenesis using the method of G.A. Ilizarov remains an important challenge to ensure a reduction in the number of complications and an increase in the effectiveness of this technology. The aim of the study was to study the changes in the antioxidant/prooxidant balance in patients with acquired shortening of the lower leg bones at the stages of the Ilizarov lengthening procedure. Methods The antioxidant/prooxidant status was studied in 12 patients with shortening of one of the lower legs resulting from hematogenous osteomyelitis (group 1) and in 13 patients with post-traumatic shortening of one of the lower legs (group 2). The level of peroxidation products, the activity of superoxide dismutase and vitamins E and A in the blood of these patients were assessed in the dynamics of monofocal bone lengthening using the Ilizarov method. Results It was found that in patients with acquired shortening of the shin bones, regardless of the shortening etiology, during surgical lengthening, an increase in the level of peroxidation products in the blood was observed with a decrease in the level of vitamin E and an increase in superoxide dismutase activity. Discussion The data obtained, together with the current findings from fundamental research, allow us to note that the use of antioxidants (AOs) in patients undergoing segment length correction using the Ilizarov technology is possible from two positions. 1. The positive effect of AOs in terms of stimulation of distraction osteogenesis has been proven. 2. AOs have a systemic effect in the regulation of the recovery processes in the paraosseous tissues of the limb segment under lengthening. Conclusion Peroxidation is activated in the course of surgical lengthening of the lower leg bones in patients with acquired shortenings, regardless of the shortening etiology. The use of antioxidants in such patients can specifically inhibit peroxidation, thereby reducing the risk of provoking bone formation disorders.

The article is aimed at defining the concept of international taxation and its role in the development of society, the impact of tax systems on the economic growth of the countries of the world, the peculiarities of the tax systems of developed countries and their place in the ranking on the index of international competitiveness of a tax system. The main changes in taxation in developed countries are also investigated, a rating was compiled and an analysis is carried out on the basis of indicators of tax revenues and competitiveness. Analyzing, systematizing and generalizing the scientific works of many scholars, contemporary models of taxation, along with features and differences of tax systems of the leading countries of the world were considered. Thus, it is found that the main source of budget revenues compared to other sources is taxes – both in developed and developing countries. Taxation is the main function of management. It has the potential to form relations between the State and society. Tax revenues allow countries to ensure security and provide public goods. In addition, tax policy, which complements monetary policy, is vital in maintaining economic stability by limiting inflation and balancing equilibrium in the market. As a result of the study, the main taxes used to measure the International Tax Competitiveness Index concerning a particular tax system are determined, an analysis of the change in the position in the rating of the International Tax Competitiveness Index of the G7 countries is presented. Prospects for further research in this direction are to substantiate the relationship between the functioning of the tax systems of the G7 countries and the economic situation and development of these countries, as well as the impact of tax revenues on GDP. There is a need to identify the main tendencies in the functioning of tax systems of the leading world countries, determine the impact of external factors on tax policy, as well as assess the tax systems of developed countries according to the International Tax Competitiveness Index.

In the modern world, allergic respiratory diseases hold a huge place among all chronic diseases. The annual increase in the prevalence of allergic rhinitis and bronchial asthma among the global population makes relevant studies underlying their pathogenesis. Changes in the nasal mucosa alter its most important function protection from aggressive environmental factors allergens and pollutants. Inflammatory processes in the nasal cavity interfere with the normal mucosa functioning as a non-specific barrier, and facilitate their further penetration into the macroorganism. Objective of the study is to provide a comparative microbiological characteristic of the nasal mucosa of patients with respiratory allergies of various origin and level of respiratory tract damage. Patients with respiratory allergies aged 23 to 51 years old as well as sex- and age-matched apparently healthy subjects (n = 120) were examined. The study groups were as follows: atopic rhinosinusitis (AR, n = 28), atopic bronchial asthma (ABA, n = 28), polyposis rhinosinusitis (PRS, n = 68), and asthmatic triad (AT, n = 28). Diagnostics were carried out by an allergist-immunologist as well as an otorhinolaryngologist. Isolation of microorganisms was carried out by placing them on nutrient differential diagnostic media. Seeding was carried out by using the sector method. The culture media were incubated in a thermostat at 37C for 48 hours. Statistical processing was performed using the Statistica 7.0 software package. The study sample is described by calculating median as well as 25 and 75 percentiles. The normality distribution was checked by using the KolmogorovSmirnov method. The significance of differences between parameters of independent samples was assessed by using the nonparametric MannWhitney test. Dominance of opportunistic microorganisms in respiratory atopy (AR, ABA) relative to respiratory pseudoatopia (PRS, AT) was noted. The increased number of bacteria from the family Enterobacteriaceae and Enterococcus on the nasal mucosa characterizes dysbacteriosis, emphasizing the greatest importance of these families in the initiation of allergic pathology in the upper and lower respiratory tract during atopy. A distinctive intergroup feature is a high concentration of the Enterobacteriaceae family members in AR vs. PRS as well as microorganisms of the genus Enterococcus in ABA vs. AT. Thus, regardless of the cause of inflammation, allergic rhinosinusitis and bronchial asthma were featured with a pronounced dysbacteriosis due to rise in the opportunistic microflora on the nasal mucosa compared to the control group.

The article describes a rare clinical case of the patient with pulmonary hypertension associated with hereditary hemorrhagic telangiectasia and discusses the issues of the treatment choice of these patients. The presented clinical case is of interest because pulmonary hypertension was initially revealed, then its hereditary nature was confirmed and OslerWeberRendu disease was diagnosed.

Background. The research was carried out in the context of the relevant problem of academic success and was focused on its least studied aspect — individual-typological manifestations of non-cognitive predictors of academic achievement. Objective. The study had its purpose to analyze the individual-typological features of the relationship between conscious self-regulation, psychological well-being and academic achievement in 6th grade students. Sample. The sample consisted of 169 students (mean age — 11.99 years). Methods. V.I. Morosanova’s “Self-Regulation Pro^ le of Learning Activity Questionnaire” (SRPLAQ), Russian version of “Big Five Questionnaire — Children version” (BFQ-C) (Malykh et al.), Russian adaptation of “Well-Being Manifestation Measure Scale” (Morosanova et al.), “Attitude towards learning in middle and high school” questionnaire (modi^ - cation of “Method of diagnostic of learning motivation and emotional attitude to learning in secondary and high school” (Andreeva, Prikhozhan), “Academic Motivation Scale — School” (AMS-S) questionnaire (Gordeeva et al.). Results. The cluster analysis allowed to identify ^ ve individual-typological pro^ les with varying manifestations of psychological well-being, conscious self-regulation and academic achievement. Thregression analysis shows that high academic achievement is supported by academic motivation and psychological well-being. Psychological well-being of students with average academic achievement is supported by conscious self-regulation. Academic achievement of these students, if their well-being and self-regulation are low, might increase due to regulatory ` exibility, learning motivation and conscientiousness, and if they are average, then academic success is supported by achievement motivation and self-esteem motivation, as well as motivation to avoid failure. Students with low academic achievement can potentially improve it through self-development motivation, achievement motivation and results evaluation. The resources for maintaining psychological well-being\ in this group are planning, responsibility and learning motivation. Conclusion.The obtained results can be used to prepare individualized psychological and pedagogical programs aimed at the development of conscious self-regulation, as well as maintaining psychological well-being and academic success of schoolchildren. The article concludes with discussion of new results that require additional research to explain them.

The relevance of the study is due to the necessity to deepen the theoretical and methodological analysis of social development. The article is aimed at substantiating and generalizing the impact of social entrepreneurship and corporate social responsibility of business on the level of social development of Ukraine. The components of social development, upon which the greatest influence occurs, are determined. The current trends in the development and spread of social business are analytically substantiated, the growth of the number of socially responsible business entities is proved. Thus, it is substantiated that social entrepreneurship overwhelmingly affects the solution of social problems of the population, in particular, employment; helps vulnerable groups of the population, including persons with disabilities; improves the state of community social infrastructure, etc. Instead, within the terms of corporate social responsibility, the social effect concerns ensuring decent work for its employees; responsible behavior toward stakeholders and society; solving social problems through the implementation of social projects or other social initiatives (in particular, charity and volunteering), as well as ecological problems. It is emphasized that the effectiveness of social influence largely depends on the coordinated interaction between business, the population and the State. The examined aspects of the activities of social entrepreneurship and corporate social responsibility allow to further substantiate a more efficient mechanism for increasing the level of social development of Ukraine.

Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384. Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.

The article aims at shedding light on the history of the Buryat-Mongolian Scientific Committee: stages of its growth, contributions of its staff members in the organization of research and its implementation. Materials and methods. Both published and unpublished documents kept in the Center for Oriental Manuscripts and Xylographs of the Institute for Mongolian, Buddhist, and Tibetan Studies of the Siberian Branch of the Russian Academy of Sciences and in the State Archive of the Republic of Buryatia were used as the main sources for the reconstruction of the past events while the data analysis was based on the main scientific principles of historicism, systematicity, and objectivity; the paper’s comprehensive approach was implemented via the method of system analysis, problem-chronological and historical-comparative methods, and local history. Results. The Buryat-Mongolian Scientific Committee (Buruchkom), established in July 1922, was designed to promote the national-cultural construction in Buryat-Mongolia while focusing on research and educational tasks. It had to begin its operation under far from favorable conditions, such as poor funding, illiteracy of the population, a shortage of personnel, and practically non-existent printing and publishing, especially in the Buryat-Mongolian language. Nevertheless, Buruchkom organized the studies of Buryat history, archaeology, spiritual and material culture, language and religion, and started field work as well. A significant portion of its activities was initially directed towards translation of educational and socio-political literature into the Buryat language, related terminological and lexical studies, preparation and publication of teaching materials, such as textbooks and teaching manuals for Buryat-Mongolian schools. The academic environment was enhanced with establishing a library and museum, which were of much relevance for future scientific work. Buruchkom’s final success was due to its fruitful cooperation with the central scientific institutions of the country and the Mongolian Scientific Committee. Conclusion. Despite that its team of researchers was not numerous, Buruchkom managed to organize, as well as conduct research projects in the fields of history, archaeology, ethnography, and linguistics. Having accomplished an important objective of laying the foundations of science in the region, it has now become a leading academic center of the Republic, known for its research in the arts and humanities.

The article aims to analyze the principal directions in the activities of Buryat-Mongolian State Institute of Culture (1929–1936) / Buryat-Mongolian State Institute of Language, Literature and History (1936–1944), the successor of the first scientific organization in Burya­tia — the Buryat-Mongolian Scientific Committee (1922–1929). It focuses on the achievements and problems in the organization and implementation of scientific research in the humanities in the 1930s. Materials. The sources used are unpublished documents of the Center for Oriental Manuscripts and Xylographs of the IMBT SB RAS, such as annual plans and reports on research work, minutes of meetings of the Directorate, expedition reports, presentations, abstracts and minutes of conferences, correspondence with various organizations and offices, and other materials that were instrumental in reconstructing the history of reorganizations of the scientific institute under study, in following the changes in its scientific program, and in showing its effectiveness and efficiency. Results. In the 1930–1940s, the studies in the field of history, language, literature, and arts of the Buryat-Mongolian people were the principal directions of research in the Institute. Archaeological expeditions were useful in drawing a general picture of the ancient history of Buryatia and the first cultural-historical schemes. Historians’ work resulted in publishing a significant number of documents devoted to the history of the Buryat-Mongolian people, the publications included materials on issues of the pre-revolutionary Buryat-Mongolia, the revolutionary movement and the Civil war period, culture, and education, including monographs on the history of Buryatia recognized today as classical scientific works. Within the framework of the established ideological attitudes, there was a discussion on controversial issues of the history of Buryat-Mongolia, which accepted the one-line nature of the historical process in Buryat studies. Thanks to the successes of Buryat linguistics, a reform of the Buryat-Mongolian writing was carried out, first based on the Latin, and then on the Cyrillic alphabet. The linguists of the Institute made a decisive contribution to the elaboration of the literary Buryat language, enriching its lexical resources and standardizing spelling and grammar. Collection, systematization and study of oral folk art and musical folklore, adding to the Manuscript Department of the Institute manuscripts and woodcuts in Tibetan, Mongolian, Buryat-Mongolian languages, as well as uligers, chronicles, and other historical and literary monuments, and translation work — these and other areas of scientific research shaped the development of the humanities in Buryatia in the 1930–1940s. Throughout the period of persecutions and repressions, despite personnel shortage and everyday hardships, the Institute’s team continued their work, conducting large-scale studies of the socio-political and economic history, the culture and art of Buryat-Mongolia.

Gastrointestinal stromal tumors (GIST) are the most common type of mesenchymal malignancies of the gastrointestinal (GI) tract. Almost 10% of them are originated outside of the GI tract (extra-GIST), while GIST of the greater omentum constitutes about 1% among stromal tumors. More than 80% of GIST have mutations in c-KIT and PDGFRA genes. Herein we demonstrate the case of successful treatment of patient with giant omental GIST with c-KIT exon 11 mutation. 64-years-old woman, was admitted to the Department of abdominal oncology with complaints of shortness of breath and abdominal enlargement in volume. CT-scan revealed a large tumor in the abdominal cavity with tumor size of 543422 cm. The patient underwent left thoraco-abdominal approach. It was found that the tumor was originated from the greater omentum with several metastases located on the peritoneum of the left lateral channel. Resection of the large omentum, splenectomy, liver resection and was done. Postoperative immunohistochemical study showed the expression of CD117, CD34 in tumor cells. Ki-67 index was 1215%. Genetic study revealed c-KIT exon 11 mutation. Treatment with imatinib 400 mg per day was started. Patient has been treated with imatinib for 12 years. On control examination we have found a metastasis in the anterior abdominal wall 3,532,5 cm in diameter. Afterwards we performed resection of anterior abdominal wall with metastasis on 9 November 2017. Immunohistochemical study confirmed metastasis of GIST. The index of tumor proliferation activity (Ki-67) was 45%. Patient prolonged imatinib treatment at the dose of 400 mg per day after operation. No signs of progression have been revealed on control examination 72 months after the operation. 12-year progression-free survival during imatinib treatment is unique in our practice. Moreover, in the case of further progression, we have second and third-line targeted therapy (sunitinib and regorafenib) and surgery treatment in local progression.