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Acute respiratory infections (ARIs) remain a leading cause of global mortality and morbidity. Nearly 70% of children between the ages of one and four years and 90% of infants with respiratory illness are hospitalized. The causative agents of nearly 80% of ARIs are viruses. In Bulgaria, according to a study by the National Center of Infectious and Parasitic Diseases, in 82% and 70% of the cases of children with bronchiolitis and pneumonia, respectively, viral causative agents have been proven. This manuscript presents advanced methods for microbiological testing from respiratory specimens, with an accent on multiplex PCR and mass-spectrometry. These methods are a practical diagnostic approach, as they allow quick etiological diagnosis of ARIs in childhood (especially those caused by viruses and difficult-to-cultivate bacteria), detection of co-infections, rapid appointment of appropriate treatment and timely infection control. [ABSTRACT FROM AUTHOR]

Copyright of Stratum Plus Journal is the property of P.P. Stratum plus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zbornik Radova Pravnog Fakulteta u Nisu is the property of Law Faculty in Nis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article involves a critical examination of XIXth century military interventions, as the basic cause of the international contagion. Challenges arising and choices made in a critical reading of the International Sanitary Conferences (ISC) proceedings, reveal case histories and early statistical techniques at use with epidemiological purposes. These episodes in the history of the diseases suggest that relevant military information was circulated among health professionals through the ISCs. Although the evolution of the epidemic process during the latter half of the XIXth century made the Conferences fail to cure the diseases that the Western medicine own expansion engendered. By discussing the ways that prophylactic measures and international interventions were used by medical scientists and diplomats alike, from the detailed records of troop mortality to such ubiquitous terms as "contagion" and "quarantine", the article seriously reflect on what happened when action taken by military forces was a mass phenomenon. As evidenced from the study of the proceedings when comparing different populations, in the pathologies associated with the mass-transport era the rationale of interaction outlined the challenges involved in the train transport of troops. Also, the existence of an environmental risk factor can answer the question on the action taken by military forces as a mass phenomenon with huge impacts on hospitals, harbors and prisons. Materials intended for these international epidemics studies and commissions were prepared by experimented military and civil medical doctors who believed that evidence and common sense proved epidemic diseases capable of being prevented, treated, and controlled by a military approach. This essay demonstrates that Army forces' capability to take control over their host governing apparatus, emphasizes the importance of their aim to follow and accompany the control of the disease in the imperialist competition for land. It grows out of its specific historical context, which due to its origin could become uniform and international, but constituted the principal obstacle on the road to an international health office.

Copyright of Stratum Plus Journal is the property of P.P. Stratum plus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article argues that Michel Foucault's model is too abstracted to function as a tool for the historical examination of specific emergencies, and it proposes an alternative analytical framework. It mentions article reveals that when plague threatened, Florentine and Bolognese health officials projected themselves into a spatio-temporal dimension in which official actions and perceptions were determined solely by the spread of contagion.

Microsporidia Amblyospora opacita Kudo, 1922 was tested in laboratory conditions as an agent of biological control of vectors of pathogens of many dangerous infectious and invasive diseases - blood-sucking mosquitoes (Aedes caspius Pallas, 1771). The effect of microsporidiosis on mortality, growth, developmental period, molting and sex of larvae was studied. It was found that the prepared suspension titer of 1.1×105 spores / ml is more effective (up to 90.7%) against the larvae of bloodsucking mosquitoes. [ABSTRACT FROM AUTHOR]

Copyright of Doxa / Doksa is the property of I. I. Mechnikov Odessa National University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

During the state of emergency, persons deprived of liberty were denied or restricted certain rights. It is primarily about the right to visit of family members and defense attorneys. Also, some persons who were assaigned into custody were sent to "special penitentiary institutions". The author aims to determine the extent to which the rights of persons deprived of their liberty during the state of emergency were denied or restricted, who decided on it, on the basis of which legal basis and which regulation was established. [ABSTRACT FROM AUTHOR]

The results of autopsies performed in the pathological department of the Infectious Diseases Hospital named after. S.P. Botkin during the siege of Leningrad (from September 8, 1941 to January 27, 1944). The structure of diseases of the deceased varied during different periods of the siege of Leningrad. In the first period (September-December 1941), diphtheria, dysentery, measles, typhoid fever, and scarlet fever prevailed among the diseases. The most common causes of death in the second period (April-December 1942) were typhus, dysentery, tuberculosis, lobar pneumonia, and typhoid fever. Nosological structure in the third period of the blockade (January 1943 - January 1944): tuberculosis, dysentery, cachexia, lobar pneumonia, infectious jaundice. The discrepancy between clinical and morphological diagnoses is most often noted for the following nosology: pulmonary tuberculosis, typhoid fever, pneumonia, stomach and hepatopancreatobiliary cancer, measles, influenza. The first period of the blockade was distinguished by a high specific proportion of examination of children's bodies - 51.2% of all autopsies; in subsequent periods, the specific share of autopsies of deceased adults (20-59 years) increased to 76.2%. The difference in the nosological structure and age groups of those who died during different periods of the siege of Leningrad was determined by the epidemiological situation in the city, social and living conditions and medical and organizational factors. Conducted in the pathological-anatomical department of the hospital named after. S.P. Botkin during the siege of Leningrad, pathological studies made it possible to timely establish the causes of deaths and identify the peculiarities of the course of infectious diseases against the background of cachexia. Regularly held clinical and anatomical conferences contributed to the reduction of defects in the diagnosis and treatment of infectious diseases.

Aim. The experience of the routine population vaccination in 53 countries of Europe, including Ukraine has been generalized in the article. Methods and results. The main legislative bases of vaccination in these countries according to the national calendars of preventive vaccination have been determined. The similarities between foreign and national system of routine population vaccination have been defined. It has been established that in most European countries, the calendar of preventive vaccinations has recommending character. Studied countries have been systematized due to the presence of infectious diseases in the national calendars of preventive vaccinations and also a number of infectious nosologies present in the calendars of all the studied countries have been distinguished. Conclusion. Basic measures to improve routine vaccination of national population have been substantiated.

The article describes a development related to the field of public health and molecular biology, in particular, medical diagnostics. We present the Isascreen-8 portable analyzer (Registration Certificate No. RZN 2022/17322, May 24, 2022) and its application for rapid diagnostics of a new coronavirus infection with the use of commercially available sets IsoAmp SARS-CoV-2 (Lytech Co. Ltd., Russia), and also our own development TB-IZATEST (Invention Application No. 2022133809, December 22, 2022) for diagnostics of tuberculosis pathogen. The approach proposed in this article can be used for rapid detection of genetic material (DNA/RNA) of Mycobacterium tuberculosis and SARS-CoV-2 in biological samples using the method of loop isothermal amplification in less than 20 minutes, and also as a universal platform for detection of genetic material of other pathogens in a biological sample. Using the proposed approach, various research tasks for epidemiological monitoring of tuberculosis and new coronavirus infection, qualitative and quantitative analysis of bacterial and viral load in samples, including evaluation of the effectiveness of the prescribed antibiotic therapy regimen, can be solved. The advantage is that this method can be used not only in diagnostic laboratories, but also in field laboratories in the most remote regions of Russia if the mandatory sanitary and epidemiological requirements are observed. With sufficient distribution, the proposed approach could help ensure epidemiological control of the prevalence of these socially significant infections.

The article considers chronologies of events of the opening in the city of Irkutsk of the Irkutsk branch of the Society of struggle with contagious diseases, located in St.Petersburg. It is emphasized that socially necessary need for protection against contagious diseases contributed to organization of the Branch of the Society of Struggle with Contagious Diseases. The history of organization of the structure of the Society's branch, the criteria of recruiting the founding members, collaborating members and competing members, including description of their duties are explored. The mechanism of formation of financial allocations and the state of available capital owned by the Branch of the Society are studied. The structure of financial expenses is demonstrated. The role of benefactors and donations collected for needs of struggle with contagious diseases are emphasized. The correspondence of well-known honorary citizens of Irkutsk concerning issues of increasing the number of donations is presented. The objectives and tasks of the Branch of the Society related to struggle with contagious diseases are considered. The necessity of spreading health culture among population to prevent occurrence of contagious diseases is demonstrated. The conclusion is made about progressive role of the Branch of the Society in the Irkutsk Guberniya.

The relevance of the study included that scarcity of evidence about the burdens of diseases in Ethiopia, in particular to non-communicable diseases along with the impact of COVID-19., Materials and Methods: The systematic analysis and content analysis using GBD 2019 database and health metrics datasets of 2020 was used to analyze diseases burdens trends of Ethiopia. The descriptive retrospective analysis has been performed, and reported in text and charts method., Results: The result of the study showed increment of crude death and premature death due to both communicable and non-communicable diseases such as enteric infections, cardiovascular, neoplasm, others., Conclusion: COVID-19 would be the headache of Ethiopia health systems due to double burdens of diseases have steadily been shooting at ground. Hence, the nation should incite local based innovation work proactively and integrate all health services to fight with COVID-19 based on the experience of Russia.

Objective: The purpose of the study is to investigate the existing normative legal documents governing the activities of doctors specializing in «dentistry», providing medical care in a multidisciplinary hospital., Material and Methods: The normative legal coverage of medical workers' activities on delivering dental care for adult population with infectious diseases in stationary conditions for a thirty-year period was analyzed. The research and information method and content analysis were used., Results: The existing regulatory legal framework governing the activities of medical workers does not contain time standards for one patient who is on inpatient treatment to visit doctors specializing in «dentistry» in a multidisciplinary hospital, which does not correspond with modern requirements and does not allow determining the workload norms and standard numbers of these specialists., Conclusion: Despite the presented modern possibilities of introducing the latest technologies and intensifying the activities of doctors specializing in «dentistry» on an outpatient basis, the organization of medical care and the delivering of dental services in a hospital including to infectious patients require further improvement.

The purpose of the study was to analyze the types and volumes of treatment and prophylactic services provided to the adult population with infectious diseases in the dental office of a multidisciplinary hospital., Materials and Methods: The types and volumes of dental care provided to the adult population with infectious diseases in a multidisciplinary hospital have been analyzed., Results: The study showed that dentists use 49 types of services when treating adults with infectious diseases, which corresponds to 29.88% of the compulsory medical insurance classifier in Moscow. Provided services can be conditionally divided into 4 groups: consultation, diagnostic, preventive and medicinal manipulations. The share of consulting services corresponds to 18.16±0.41% of the total volume of services provided; on average patients made 320.8 visits to the dentist's doctors per year, which corresponds to 2.38 visits for each patient. The proportion of medicinal manipulations, diagnostic and preventive services corresponds to 68.64±0.49%, 7.02±0.27% and 6.17±0.26%, respectively. Services related to the diagnosis and treatment of diseases of the oral mucosa and salivary glands dominate with 69.3%, on average 5.51 services are provided per visit., Conclusion: The compulsory medical insurance program for the city of Moscow should provide services for the diagnosis, treatment and prevention of dental diseases, provided by doctors specializing in «dentistry», for patients with infectious diseases who are undergoing treatment in inpatient conditions.

Objective: The aim of the study is to assess the status of dental care for contagious patients in hospitals using the example of the Volga Federal District., Materials and Methods: The resource allocation of dental care for contagious patients in 313 hospitals of 14 subjects of the Volga Federal District was investigated., Results: It was found that in 86.1% of multidisciplinary hospitals of the Volga Federal District, where infectious beds and dental offices are present, dental care for patients with infectious diseases accompanied by lesions of the oral mucosa is not provided. The bed capacity of 92.9% of infectious hospitals in the Volga Federal District is less than 400 beds, which does not allow to deploy dental offices on their basis., Conclusion: An important condition for improving the quality of medical care to patients of infectious hospitals and infectious diseases departments of multidisciplinary hospitals is the availability of dental offices and dental doctors, which will ensure timely diagnosis, treatment and prevention of lesions of the oral mucosa in diseases of infectious genesis.

The article analyzes the demographic situation in the Republic of Dagestan and presents analysis of indices of population mortality and life expectancy. It is established that number of deaths per 1000 people of the Republic of Dagestan is one of the lowest not only in the Northern Caucasus, but in the country at large. At the same time, high mortality indices are determined in elder age groups both in Dagestan and on average in Russia. The main causes of death in the Republic of Dagestan are diseases of circulatory system and respiratory system, neoplasms, accidents, poisoning and traumas, which account almost three quarters of all cases of deaths. However, mortality indices in Dagestan from diseases of circulatory system, neoplasms, digestive system diseases, infectious and parasitic diseases are significantly lower as compared to the national average level. In Dagestan, one of the highest indices of life expectancy is observed as compared with other subjects of the Russian Federation (2nd place in the Russian Federation) - on 6 years exceeding the national average level (in males, difference in values ​​of indicator amounted to 7.5 years). In Dagestan, during analyzed period, life expectancy at birth increased more than on 5 years.

Objective: The purpose of the study is to substantiate the need and importance of early diagnosis and treatment of oral lesions in infectious diseases (ID) by dentists., Material and Methods: A retrospective analysis of the provision of dental care in multi-specialty hospitals to 780 patients with infectious pathology: herpetic infections (HI) - 320 people (41.03%); ARVI - 160 people (20.51%); acute enteric infections (AEI) - 300 people (38.46%). The diagnosis of the disease was established by infectious diseases doctors. The etiology of ID was confirmed using PCR and IFA., Results: The prevalence of caries is 98.5%, the CPEs index is 10.26±0.04. In 84.1% of patient's oral hygiene was unsatisfactory. In the acute period of ID in HI, ARVI and AEI oral mucosa (OM) lesions were detected in 75.89% of cases: stomatitis (81.75%), gingivitis (69.76%), glossitis (35.98%), cheilitis (23.31%). Incidence of OM lesions in ID: catarrhal stomatitis - HI - 52.8%, ARVI - 64.1%, AEI - 67.9%; catarrhal gingivitis: in patients with HI, it is 1.7 times less frequent than in patients with AEI ( p <0.001), and in ARVI - 1.6 times more often than in patients with HI ( p <0.001). Cheilitis: HI - 25.9%, ARVI - 18.3%, AEI - 23.7%; catarrhal glossitis: AEI - 65.1%, ARVI - 23.2%, HI - 17.0%; candidiasis of the oral mucosal and tongue: HI - 11.1%, ARVI - 27.5%, AEI - 26.9%. A direct relationship between the lesions of OM and the severity of the course of HI, ARVI and AEI was established., Conclusion: Thus, dental pathology in infectious patients is pathogenetically determined by combined and interrelated disorders of the functional state of each organ of the oral cavity, the dental system and the body as a whole. Due to the relatively short duration of inpatient treatment for acute ID, priority should be given to the prevention of postinfectious complications of oral mucosal diseases.

The staffing of medical specialists plays an important role in modern rendering of specialized medical care of population. Despite amelioration of life conditions in developed countries, infectious diseases continue to be the most dangerous ones on the side of epidemiology. The organization of specialized medical care of population is implemented according standards of provision of medical care in case of infectious diseases. Nowadays, high load of physicians is noted that indicates necessity of analyzing provision with infectiologists and their activities. The purpose of study is to analyze provision with infectiologists and their activities in the Russian Federation for organizational decision-making. The study used national data from the Federal statistical monitoring "The information of medical organization" (Form 30) in 2013-2017. The study applied such research methods as statistical, analytical, descriptive techniques. Factually, in all Federal okrugs increasing of provision with infectiologists is traced at decreasing of staffing with out-patient paramedical personnel that correspond to all-Russian trend. Also decreasing of number of visits per one job position of infectiologist. At that, during last three years of the mentioned period, a stability of indicator of visits because of diseases is observed.

Aim - to study the effect of different pathogens (EBV, CMV, HHV-6, and MIXT) on the severity of clinical-paraclinical manifestations of infectious mononucleosis in children. The clinical and laboratory study performed for 410 children aged from 10 months up to 12 years with infectious mononucleosis. The association of herpes viruses, mainly EBV, CMV and HHV type 6, takes part in the formation of the clinical picture of IM in (52,9%) of cases. The sole participation of EBV in the development of IM was observed only in (34,1%), CMV (9,02%) and HHV-6 in (3,17%) patients. The etiology of infectious mononucleosis in children affects the acuity, severity, and intensity of the clinical and paraclinical signs of the disease. Infectious mononucleosis VEB etiology is manifested by acute onset (79,5%), intoxication (70,5%), subfebrile and febrile fever up to 7 days (61,03%), lacunar tonsillitis (85,8%), hepatomegaly ( 88,2%), splenomegaly (63,8%), mostly moderate (81,7%) with lymphocytosis (62,9%) and monocytosis (20,5%). For CMV mononucleosis - acute onset (89,9%), severe course (29,8%), febrile and high fever for up to 7 (56,7%) or more days, neutrophilic leukocytosis (73,55) with atypical mononuclear cells (64,7%) and anemia (29,7%). Severe (33,3%), with prolonged high fever (50%), exanthema syndrome (33,3%), pharyngitis without tonsillitis (66,7%), leukocytosis (66,7%) with accelerated ESR (66,7%) and monocytosis (33,3%) are characteristic of HHV-6 infection. For MIXT - acute onset (78,3%), intoxication (79,7%), lacunar tonsillitis (92,9%), hepatomegaly (84,1%) and splenomegaly (67%), low-grade and febrile fever from 3- x (27,1%) up to 7 days (35,05%), lymphocytosis (55,3%) with neutropenia (57,4%), atypical mononuclear cells (48,2%) and hypochromic anemia (17,29 %).

The existing normative legal framework does not fully correspond to modern requirements for the organization and delivering dental care for adult population with various infectious diseases. The authors basing on the analysis of regulatory guidelines consider that in order to provide timely, high-quality and affordable medical care to patients in the infectious diseases departments and clinical hospitals, it is necessary to update the normative legal framework and develop criteria for monitoring the quality of dental care for infectious patients at the stages of its delivering.

The paper presents a review of numerous clinical observations that indicate an important role of 'focal sepsis' in the development and persistence of the anterior eye segment inflammation. Possible routes of infection spread from local dental infectious foci to the eye are discussed.

The article presents experience of Rospotrebnadzor in the Republic of Tatarstan in the field of preventive medicine concerning training of volunteers on issues of infection safety with purpose of prevention of ictuses of infection diseases during mass activities with international participation in the period of XXVII World Summer Students Games. The model of hygienic training for volunteers provides two directions: training for volunteers ’ leaders on issues of infection safety and remote course for involved volunteers. During period of preparation for the Students Games-2013 hygienic training was organized for volunteers-leaders in the field of infection safety with following attestation. The modern training technologies were applied. The volunteers-leaders familiarized with groups of infection diseases including the most dangerous ones, investigated with expert algorithm of actions to be applied in case of suspicion on infection disease in gest or participant of the Games-2013 to secure one's health and health of immediate population. The active volunteers-leaders became trainers and coaches in the field of infection safety. The second stage of infection safety training organized by youth trainers' pool in number of 30 individuals the training technology "Equal trains equal" was applied for hygienic training of volunteers involved at epidemiologically significant objects (food objects, hotels, accompaniment of guests and sportsmen). The volunteers-leaders trained to infection safety 1400 volunteers. The format of electronic personal cabinet and remote course were selected as tools of post-training monitoring.

Pneumococcal pneumonia and other diseases caused by pneumococci still remain the main factors of high morbidity and mortality rates throughout the world. Pneumococci as the leading pathogens of community-acquired pneumonia (CAP), acute otitis media and sinusitis also cause a number of other serious systemic disorders including invasive infections with high mortality in spite of the antimicrobial resistance status and adequate antimicrobials choice. Pneumococcal infections are responsible for 5-35% or more of community-acquired pneumonias. The burden of pneumonia (up to 100-200 per thousand) is recorded among military recruits in training centers. Since the specific environment of the soldiers could be carrected, their health protection requires medical surveillance. For these reasons, polysaccharide and more immunogenic conjugated pneumococcal vaccines were developed. There is now an urgent need to understand whether such vaccines are effective in military conscripts. Controversy about the effectiveness and value of the polysaccharide (PPV-23) vaccine as a CAP morbidity restriction measure still persists. There were implemented plenty of metaanalyses of pneumococcal vaccines in adults. Some of them showed that the vaccine was effective against bacteremic pneumococcal pneumonia in 'low risk' healthy adults and elders. There have been a number of poor quality observational studies in Russia where 'all pneumonia cases' were considered as an endpoint. It remains controversial whether these observational studies provide adequate evidence to justify the use of the polysaccharide vaccine in the groups of healthy young men for whom it is being advocated. In our analysis we found weak evidence supporting pneumococcal vaccination with PPV-23 for this group. Nevertheless, favorable tendency was found to immunize. It is the reason for a trail to find pharmacoepidemiological support for vaccination by novel conjugated vaccines with better immunogenicity.

The review gives data that reveal the role of succinic acid in providing cells with energy and oxygen under hypoxic conditions. It presents the results of clinical and experimental studies to evaluate the efficacy of succinate-containing drugs in the combination therapy of infectious diseases. The spectrum of biological effects of these drugs, which is provided by the synergy of their active ingredients, is considered.

Aim: To study the semiotics of neurological lesions in patients with tick-borne encephalitis, Ixodes tick-borne borreliosis (ITBB) and mixed infection (MI), their immunopathogenesis, and the possibilities of current pathogenetic pharmacological correction., Subjects and Methods: A total of 220 patients with tick-borne encephalitis, ITBB, and MI concurrent with the syndromes of central nervous system lesions were examined. The immunological studies encompassed the examination of mononuclear cells in the cerebrospinal fluid (CSF), the population and subpopulation composition of lymphocytes, and nitroxidergic processes in the serum and CSF from the total level of final stable nitric oxide metabolites. For pharmacotherapeutic correction, the metabolic drug cytoflavin was used as newly indicated., Results: Cytofluorometric analysis of the CSF cellular composition showed the mononuclear cell predominance of CD3+ (58.6%), CD4+ (57.2%), CD8+ (16.8%) lymphocytes and monocytes (34.4%), which expressed the phenotypic marker CD14+. This reflects the nature of a local immune response: an increase in the immunoregulatory index CD4+/CD8+ from 3.4 to 5.6, respectively, while the normal proportion of these cells in the blood ranges from 1.5 to 2.2. CSF lymphocytes were found to be ready for Fas-mediated apoptosis dependent on the receptor (CD95+ was 64.3%).There was a correlation using the pair correlation coefficient between the total concentration of the metabolites of the nitroxide molecule and the percentage of CD14+ (r=0.5; p<0.05). The paired Wilcoxon test was used to analyze serum NO2, NO3, and NOx, which revealed significant differences in nitrites [2.70 (1.90, 2.95; p=0.001)] and total NO metabolites [18.00 (18.00, 22.60; p=0.006)] and statistically significant changes in nitrates [13.29 (15.70. 20.30; p=0.075)] in patients receiving cytoflavin infusions., Conclusion: The immune response of Th-1 forms between the CSF phagocytic, antigen-presenting, and immunocompetent lymphocytes in patients with tick-borne neuroinfections. The use of cytoflavin as an agent for neurotransmitter support to correct nitroxidergic processes is pathogenetically justified.

Operation experience of specialized anti-epidemic brigades (SAEB) for the support of sanitary-epidemiologic welfare during various emergencies is presented. The order of functioning and SAEB objectives during mass events is examined. Analysis of exercise of Stavropol Institute of Plague Control SAEB was carried out, proposals for augmentation of SAEB equipment table by instruments and reagents for indication and genotyping of pathogen strains are examined.

There are presented the data of placebocontrolled research, which was realized for the purpose of analyze of effectiveness and safety of using of agent "Kagocel" for prophylaxis of acute respiratory virus infections among military servicemen of call-up service. Among persons, got kagocel, was marked a low number of ARVI in comparison with persons, got placebo. The highest prophylactic effect was marked for the first 2 month of getting the agent. A mild disease (ARVI) flow was marked among persons, got placebo. It has approved it self in low frequency of complications. There was shown a grand economic benefit of prophylactic using of kogocel course of treatment.

Different aspects of competition between human and pathogenic microorganisms as well as their role in evolution of the human as biological species and development of its polymorphism were reviewed. Biological consequences of interaction between human and pathogenic microorganisms and also main factors of genetic selection such as tuberculosis, malaria, etc. were characterized. Numerous forms of polymorphism, which determine level of susceptibility and features of clinical course of many infections in humans, were described. It has been concluded that selective pressure of microorganisms results from direct selection due to excessive mortality of infected persons before integration in human genome as well as that immunologic pressure of mass immunization results in changes of pathogenic microorganisms populations leading to emergence of their antigenically distinct variants. New knowledge about competition between human and pathogenic microorganisms requires development of fundamentally new approaches in fight with infectious diseases.

Presented in the paper are data on the health of population in Arkhangelsk Region. Specific features of morbidity are defined. Parameters of morbidity are described; its structure is evaluated and retrospectively analyzed. The key trends are displayed for the recent 5 years, they are: an increasing number of acute diseases, many of which become chronic; and growing primary disability. The regional specificity of morbidity must be taken account of in structuring of medical care.