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Aim. To compare ivabradine (IB) and verapamil (VP) effects on left ventricle (LV) diastolic function in patients with diastolic heart failure (DHF) caused by left ventricle impaired relaxation.Methods. It was comparative randomized study. 238 patients (190 men, 48 women; aged 63±10 y.o.) with DHF were randomized in two groups to receive IB (7,5 mg bid, n=119) or VP (240 mg o.d., n=119). Echocardiography (EchoCG) indices, total ischemic burden (TIB) and N-terminal fragment of pro-brain natriuretic peptide (NT-pro-BNP) were evaluated initially and after 1, 3, 6 and 12 months of therapy.Results. After 3 months of therapy some EchoCG parameters (E/A, transmitral E wave deceleration time [EDT]) as well as TIB improved more significantly in IB group. After 6 months in IB group in comparison with VP group additional differences appeared (midwall fractional shortening; E/Em of lateral mitral annulus – 8,6±4,7 and 12,3±4,7, respectively, p

Aim: To study dynamic dimensional and functional changes of both ventricles after myocardial infarctions (MI) of different locations., Material and Methods: Patients with first acute ST elevation MI (n=180) were distribution to 3 groups: anterior (AMI), inferior (IMI), and posterolateral (PLMI). EchoCG dimensional parameters of LV and RV as well as functional two dimensional EchoCG, flow and tissue doppler parameters were measured on days 7, 90 and after 1 year of follow up to reveal systolic or diastolic dysfunction of both chambers., Results: After 1 year of follow up significant LV remodeling with systolic and diastolic dysfunction was observed in AMI compared with IMI and PLMI. Pronounced RV remodeling was revealed in acute stage of IMI, compared with AMI and PLMI. Dynamic follow up showed reversed RV remodeling in IMI with relative restoration of systolic and diastolic parameters, and progressive RV remodeling in AMI with significant systolic and diastolic dysfunction compared with IMI and PLMI., Conclusion: Thus, dynamic structural and functional changes occurr in both ventricles and depend on Ml site, with most ventricular compromise in AMI due to asynergy of the septum, as common ventricular wall plays major role in RV performance.