1. [Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells].
- Author
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Tchurikov NA, Vartanian AA, Klushevskaya ES, Alembekov IR, Kretova AN, Chechetkin VR, Kravatskaya GI, Kosorukov VS, and Kravatsky YV
- Subjects
- Humans, Cell Line, Tumor, Neovascularization, Pathologic genetics, Neovascularization, Pathologic metabolism, Neovascularization, Pathologic drug therapy, Neovascularization, Pathologic pathology, Transcription Factors genetics, Transcription Factors metabolism, Neoplasm Proteins genetics, Neoplasm Proteins metabolism, Neoplasm Proteins biosynthesis, Cell Cycle drug effects, Gene Expression Regulation, Neoplastic drug effects, Melanoma genetics, Melanoma metabolism, Melanoma pathology, Melanoma drug therapy
- Abstract
Multiple exogenous or endogenous factors alter gene expression patterns by different mechanisms that are poorly understood. We used RNA-Seq analysis in order to study changes in gene expression in melanoma cells that are capable of vasculogenic mimicry that is inhibited upon the action of an inhibitor of vasculogenic mimicry. Here, we show that the drug induces a strong upregulation of 50 genes that control the cell cycle and microtubule cytoskeleton coupled with a strong downregulation of 50 genes that control different cellular metabolic processes. We found that both groups of genes are simultaneously regulated by multiple sets of transcription factors. We conclude that one way for coordinated regulation of large groups of genes is regulation simultaneously by multiple transcription factors.
- Published
- 2024
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