1. [The anxiolytic effect of the new 2-mercaptobenzimidazole derivative in MR and MNRA rats].
- Author
-
Seredinin SB, Viglinskaia IV, and Kolik LG
- Subjects
- Administration, Oral, Animals, Anti-Anxiety Agents administration & dosage, Anti-Anxiety Agents pharmacology, Antimetabolites administration & dosage, Antimetabolites metabolism, Benzimidazoles administration & dosage, Benzimidazoles therapeutic use, Diazepam administration & dosage, Diazepam pharmacology, Male, Phenotype, Rats, Rats, Inbred Strains, Reference Standards, Species Specificity, Stress, Psychological physiopathology, Anti-Anxiety Agents toxicity, Antimetabolites toxicity, Anxiety chemically induced, Behavior, Animal drug effects, Benzimidazoles toxicity
- Abstract
The effect of the new drug SM-346, a derivative of 2-mercaptobenzimidazole, on the behavior of inbred MR and MNRA rats, differing in the phenotype of the emotional-stress reaction in the open field test was studies. In the Vogel conflict test SM-346 in a dose of 1 mg/kg produced an anxiolytic effect in MR rats but had no effect on the behavior of MNRA rats. The obtained results allow the conclusion that SM-346 possesses a selective anxiolytic action.
- Published
- 1997