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Increasingly, scientists are turning to the study of marine, or fish, collagen, which is increasingly replacing collagen of terrestrial animals, due to the fact that it is hypoallergenic, since it is 96% identical to human protein. Materials based on fish collagen have a number of advantages over their analogue of animal origin: it is not a carrier of infectious diseases of animals transmitted to humans, it has a greater structural similarity to human collagen, which provides a higher level of biocompatibility. Materials based on collagen copolymers with synthetic monomers are promising. The use of hybrid materials also helps to reduce the consumption of non-renewable natural resources. Synthesis of grafted collagen copolymers with polybutyl acrylate was carried out at azobisisobutyronitrile initiation and triethyl borane – oxygen system initiation under comparable conditions under intensive stirring of aqueous solution dispersion of collagen and butyl acrylate. After the synthesis, the aqueous and organic phases of the reaction mixture were analyzed by composition and molecular weight parameters using infrared spectroscopy and size-exclusion chromatography. Changes indicating the formation of a copolymer are observed in the copolymer isolated from the aqueous phase, more pronounced in the triethyl borane – oxygen system. It is assumed that the formation of copolymer macromolecules for azobisisobutyronitrile and organoelement initiator takes place according to different schemes. Schemes for the formation of copolymer macromolecules for AIBN and an organoelement initiator are proposed. Only polybutyl acrylate is present in the organic phase. Biological studies were carried out for fungal resistance and bactericidal activity of the obtained copolymers.