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The transient electromagnetic method is the most effective in the studying of multi-string wells. First, the nonstationary field is measured after the current is turned off (without the primary field) that reduces the coil spacing to zero, i.e. combine the generator and receiver coils. This significantly improves the vertical characteristic of the probe, allows the probe to register small defects. Second, the non-stationary mode allows separating signals from the first, second, third, etc. strings much easier than the harmonic mode. It improves the accuracy of thickness estimation and defect detection. The paper proposes an algorithm for interpreting the measurement results.

Aim. To compare the effectiveness of Health School (HS) initiative in male and female patients with chronic heart failure (CHF). Material and methods. The study included 239 CHF patients: 118 women and 119 men. For both genders, the patients were randomised into intervention groups, studying at HS (58 women and 59 men), and control groups, not receiving any educational intervention (60 women, 60 men). The follow-up period lasted for one year. The criteria of HS effectiveness included relative and absolute parameters of hospitalisation due to decompensated CHF; seeking for urgent medical care due to CHF decompensation; unplanned visits to the doctor; clinical CHF status dynamics by the scale modified by V.Yu. Mareev (2000); 6-minute walk test results; electrocardiography (ECG) and echocardiography (EchoCG) results. Results. HS effectiveness was significantly different in female and male intervention vs. control groups. In women, being educated at HS did not affect the incidence of hospitalizations and unplanned visits to the doctor due to decompensated CHF, while in men, the same parameters were substantially lower in those from the intervention group. Similarly, clinical CHF status, 6-minute walk test results, and ECG repolarization parameters were not changed by HS participation in women, but were improved in men attending HS. At the same time, the incidence of seeking for urgent medical help was significantly lower in both female and male HS groups. Conclusion. Planning the strategy of secondary CHF prevention should take into account the gender differences; otherwise, the effectiveness could be inadequate in female patients.

An overview analysis of research and development in the field of volumetric rotary machines for low power energy, refrigeration and climate technology, as well as the state of the world and Russian market of compressor and expansion machines of this type is presented. It is shown that in this sector of domestic industry, the existing level and scale of production does not meet the requirements of ensuring the technological independence of the Russian Federation and the implementation of critical technologies. The analysis of the existing designs of rotary machines, as well as the nomenclature of domestic refrigeration and compressor engineering, allowed us to conclude that rotary machines of screw and spiral type are preferred for the implementation of existing licensed technologies at Russian enterprises. However, taking into account the urgency of ensuring import independence, rotary-plate compressor and expansion machines are of considerable interest. The prerequisites for improving the technical level and competitiveness of rotary-plate machines based on domestic technologies and new promising technical solutions are identified and formulated.

Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort of patients with COVID-19. Materials and methods. We included 315 patients, who were hospitalized with COVID-19 from October 2020 till February 2021. The diagnosis was established on the basis of the positive SARS-CoV-2 swab test and/or typical radiologic findings on CT scans. Results. AKI complicated the clinical course in 92 (29.21%) cases. The independent risk factors of AKI were female sex, underline chronic kidney disease and the highest level of C-reactive protein during hospitalization. In the general group of patients were 41 (13%) lethal cases, in the group with AKI 32 (34.8%). Compared with those without AKI, patients with AKI had 4.065 (95% confidence interval 2.154 to 7.671) times the odds of death. Respiratory support, the highest serum creatinine and glucose levels appeared to be the risk factors of death among patients with AKI in the multivariable Cox regression. Conclusion. The clinical course of COVID-19 was complicated by AKI in 29% cases. The independent risk factors of AKI in patients with COVID-19 are underline chronic kidney disease, circulatory disorder and the highest level of C-reactive protein during hospitalization.

Background: Among the modern methods of surgical treatment of the lumbar spines degenerative stenoses, decompressive-stabilizing surgical interventions using transpedicular screw-rod structures occupy an important place. The use of metal structures is justified not so much by the degenerative process specifics, degree or length of stenosis, but by the presence of instability in the spinal motion segments. In turn, the widespread use of fixing structures has naturally led to an increase in the specific complications, reaching 1020 per cent of the total number of operated patients. One of the threatening complications of decompressive-stabilizing operations is the fracture of structural elements, often with the formation of pathology at the adjacent levels. The reasons for these complications are associated with both an erroneous choice of the construct parameters and a violation of the technique for installing the transpedicular fixation system (TPS). Clinical case description: The article presents an analysis of the clinical symptoms appearing with the formation of the adjacent level syndrome due to a fracture of the TPS system screws used to treat central stenosis of the spinal canal at the LIV -LV level. The correction of the pathology was carried out with a repeated surgical intervention. Conclusion: This clinical example draws attention to the combination of the adjacent level syndrome with a fracture of the metal structure in a patient after a decompressive-stabilizing operation using screw-rod fixation. An early diagnosis and adequate correction of the pathology helps to avoid the aggravation of symptoms and disability of patients.

Background: Degenerative pathology of the facet joints of the lumbar spine remains a significant medical and social problem due to persistent pain syndrome, high incidence and disability rate. Clinical case description: A patient complaining of pain and discomfort in the lumbosacral spine on the right, arising in the upright position, intensifying with bending and flexion-extension of the trunk, and periodically spreading to the right gluteal region and along the posterior surface of the thigh, was admitted to the neurosurgical department of the Irkutsk Scientific Center of Surgery and Traumatology. A surgical treatment was performed in the form of dereception of the LIILIII, LIIILIV, LIVLV arch-process joints. In the postoperative period, the patient noted a decrease in the intensity of pain in the lumbosacral spine to 3 points by a visual analog scale and was discharged from the department on the 5th day after the surgery in a satisfactory condition. Conclusion: Facet joint pathologies represent a most common nosological form of the degenerative-dystrophic process (spondyloarthrosis) and a potential source of pain with the formation of instability of the spinal motion segment and chronic pain syndrome. The complex anatomical and topographic relationships between the facet joints, intervertebral discs, and radicular nerves force clinicians to pay attention to the pathology of facet syndrome. Understanding the morphological, clinical, and radiological features of the course of the facet joint degeneration makes it possible to increase the diagnostic capabilities for detecting facet syndrome of the lumbar spine and effectively apply transcutaneous surgical technologies for the treatment of chronic pain syndromes.

All existing companies today want not only to remain in the service market, but also to gain a foothold in it, and methodically develop from year to year. And in the modern world, this is simply impossible to imagine without corporate intelligence. Those firms that did not realize this in time simply went bankrupt or their business does not develop, and economic indicators remain in one place from year to year. Today, there is a wide variety of ways of business intelligence in the world. All types of competitive intelligence can be divided into two large groups: direct and indirect business intelligence. Let’s look at each of them in more detail. A separate subspecies is business intelligence, which can relate to both indirect and direct intelligence, depending on the surrounding circumstances.

The paper considers the construction of optoelectronic systems for monitoring near-Earth space, the choice of algorithms for identifying and obtaining the most reliable coordinate and non-coordinate information about space objects of natural and man-made origin. Experimental mock-up studies using the developed installation were performed. The plant allows the calibration of the optoelectronic system and the study of algorithms for obtaining coordinate and detailed data about the observed objects. The authors apply the method of image registration by a telescopic system in the astrograph with a digital camera mode and a digital camera with a microlens array mode. The work uses the methods for analyzing two-dimensional images by algorithms for measuring binary clusters in an image structure, investigating the brightness structure of an image with a circular boundary in a given area, determining the centers and radii of the circles inscribed in clusters, calculating and estimating the maxima for the curves of the coefficients of continuous wavelet transformation in the image profile lines with real wavelets. The composition and structure of a complex of algorithms and a methodology for their application have been developed. The methodology makes it possible to increase the accuracy and reliability of information obtained about the observed objects in a wide range of changes in the characteristics of the background target environment. The results substantiate the possibility of increasing the accuracy and reliability of coordinate information about the observed objects by analyzing the curves of the coefficients of continuous wavelet transform or analyzing the brightness gradient, provided that the algorithm for analyzing clusters of binarized images is used. The algorithm makes it possible to determine the areas of localization of objects of interest in the observed space. The developed methodology can be applied to assess the accuracy and reliability of the results of determining the coordinates and detailed features of objects. At the same time, it is possible to scale the algorithms to the means of observation and the tasks being solved, which makes it possible to use them in automated monitoring systems for near-earth space and increases the efficiency of detection and identification of objects.

Introduction. Synthetic aperture radars (SAR) are important components of aviation-based systems for remote sensing of the Earth. The current level of such systems allows simultaneous radar surveys in several frequency ranges. Such surveys require complexing of the images formed in each of the frequency channels, which task is yet to be resolved.Aim. To review the formation principles and methods for joint processing of images using space and aviation-based multi-band synthetic aperture radar systems.Materials and methods. The methodology of systems analysis, involving the integral stages of decomposition, analysis and synthesis, was used. Decomposition of integrating multi-band radar images was performed considering the effect of various factors on the characteristics of radar images in different frequency ranges. Such factors include the principles of radar imaging, issues of radar images of multi-band synthetic aperture radars with real characteristics, and complexing levels.Results. According to the classical systems approach, the results of review and analysis are corresponded by appropriate conclusions on the shortcomings of each decomposition element and the synthesis of a proposal for achieving the goal. It was shown that joint processing of multi-band radar images can be carried out at the levels of signals, pixels, features and solutions, as well as their aggregates. Each approach is characterised by its shortcomings, which impede implementation of full integration of multi-band radar images without loss of information, which is due to the absence of information redundancy of radar images, compared to, e.g., optical images.Conclusion. Recommendations on the application of a particular method and the synthesis of a system for radar complexing images based on the texture-fractal approach were formulated. Directions for further work meeting all the requirements for completeness, reliability and information content of remote sensing of the Earth were outlined.

Research aim: to investigate the proliferative status of endometrium in the different morphotypes of endometrial hyperplasia based upon the identification of key molecular markers of the cell cycle. Materials and methods. Endometrial samples taken from 137 women were investigated: 40 – normal endometrium (NE), 61 – non-atypical endometrial hyperplasia (ЕH), 36 – atypical hyperplasia (AHE). Expression of gene cyclin D1, nuclear antigen Кі-67, glycoproteins Е-cadherin and β-catenin, estradiol receptors (ER) and progesterone receptors (PGR) were investigated. Results. ER expression of NE was high in the proliferative phase and decreased significantly in the secretory phase. PGR expression was high in both phases. ER expression of EH in glandular (180 ± 8.3) and in stromal cells (170.5 ± 4.1) exceed the indicators of the secretory phase. PGR expression in the stromal cells of EH (197.5 ± 9.3) exceed significantly indicators of NE. ER and PGR expression significantly and reliably decreased if there was AHE. ER expression of glandular cells was 2.6 times lower (74.6 ± 3.9) compere to proliferative NE (p

Subject of Research. The paper presents the study of algorithms for key point detection and description, widely used in computer vision. Typically, the corner detector acts as a key point detector, including neural key point detectors. For some types of images obtained in medicine, the application of such detectors is problematic due to the small number of detected key points. The paper considers a problem of a neural network key point detector training on unlabeled images. Method. We proposed the definition of key points not depending on specific visual features. A method was considered for training of a neural network model meant for detecting and describing key points on unlabeled data. The application of homographic image transformation was basic to the method. The neural network model was trained to detect the same key points on pairs of noisy images related to a homographic transformation. Only positive examples were used for detector training, just points correctly matched with features produced by the neural network model for key point description. Main Results. The unsupervised learning algorithm is used to train the neural network model. For the ease of comparison, the proposed model has a similar architecture and the same number of parameters as the supervised model. Model evaluation is performed on the three different datasets: natural images, synthetic images, and retinal photographs. The proposed model shows similar results to the supervised model on the natural images and better results on retinal photographs. Improvement of results is demonstrated after additional training of the proposed model on images from the target domain. This is an advantage over a model trained on a labeled dataset. For comparison, the harmonic average of such metrics is used as: the accuracy and the depth of matching by descriptors, reproducibility of key points and image coverage. Practical Relevance. The proposed algorithm makes it possible to train the neural network key point detector together with the feature extraction model on images from the target domain without costly dataset labeling and reduce labor costs for the development of the system that uses the detector.

The paper provides a narrative review of cognitive deficits in patients with gambling disorder. We discuss several types of these deficits, namely, cognitive impairments due to deficits in executive functioning, impulsive and risky decision-making, gambling-related cognitive distortions, and cognitive errors in cognitive-behavioral terms. These deficits are reviewed from the perspective of their relevance for psychotherapy and the development of differentiated psychotherapeutic interventions for gambling disorder treatment.

Aim. In a retrospective study, we evaluated factors associated with the early development of septic shock in patients with severe COVID-19. Materials and methods. We collected medical records of the intensive care unit patients submitted by the local COVID-19 hospitals across Russia to the Federal Center for the Critical Care at the Sechenov First Moscow State Medical University (Sechenov University). Septic shock in crticially ill patients requiring mechanical ventilation was defined as a need in vasopressors to maintain blood pressure. Results. We studied 1078 patients with severe COVID-19 who were admitted to the intensive care units for respiratory support. There were 611 males and 467 females. The mean age was 61.013.7 years. Five hundred twenty five medical records (48.7%) were received from the Moscow hospitals, 159 (14.7%) from the Moscow region, and 394 (36.5%) from the hospitals located in 58 regions of the Russian Federation. In 613 (56.9%) patients, diagnosis of SARS-CoV-2 infection was confirmed by PCR, and in the other cases it was established on the basis of the clinical picture and the results of the chest CT scan. Septic shock developed in 214 (19.9%) of 1078 patients. In the logistic regression model, the risk of septic shock in patients older than 50 years was higher than in patients of a younger age (OR 2.34; 95% CI 1.533.67; p0.0001). In patients with more severe SARS-CoV-2 infection, there was an increase in the prevalence of cardiovascular diseases, including coronary heart disease and atrial fibrillation, type 2 diabetes and malignant tumors. The risk of septic shock in patients with three or more concomitant diseases was higher than in patients without any concomitant chronic diseases (OR 1.76; 95% CI 1.762.70). Conclusion. The risk of septic shock in patients with acute respiratory distress syndrome induced by SARS-CoV-2 is higher in patients older than 50 years with concomitant diseases, although a severe course of the disease is also possible in younger patients without any concomitant disorders.

Leishmaniasis is a vector-born parasitic disease characterized by predominant cutaneous or visceral involvement with fever, hepatosplenomegaly and anemia. Leishmaniasis has relatively high prevalence in tropical and subtropical areas. Several sporadic and mostly imported cases are detected in Russian Federation. Nevertheless, some local incidents are noted in southern areas (Crimea, Dagestan). Lack of epidemiological alertness hampers confirmation of diagnosis and may lead to incorrect treatment. The article summarizes current state of knowledge in epidemiology, diagnostic approach and treatment of leishmaniasis. Particular clinical case is discussed.

The relevance of the study is caused by the necessity to assess the current radiation and geo-ecological situation at the sites of peaceful underground nuclear explosions. In addition, this study will allow us to predict possible scenarios for development at such items located near settlements. The circumstantial research of the structure of the geotechnogenic system «center of an underground nuclear explosion – the host geological environment – the surface of the Earth» involves magnetic study. The land magnetic survey allow us to separate geoelectric anomalies caused by buried iron objects from other items that have a different nature. The aim of the research is to detect and localize the buried iron objects on the site of the peaceful underground nuclear explosions «Crystal» based on the data of land magnetic survey. Object. The area of the emplacement hole of the peaceful underground nuclear explosion «Crystal» was chosen for study. The capacity of the peaceful underground nuclear explosions «Crystal» was of 1,7 kt in TNT equivalent. It was made on October 2, 1974 at a depth of 98 m in frozen rocks at a distance of 6,7 km away from Udachny town (Western Yakutia). The debri mound (or sarcophagus) was built on the mouth of the emplacement hole in two steps – in 1992 and 2007. The diameter of the mound is 260 m, the maximal height of it is 20 m. Methods. The magnetic survey was carried out on the profiles with a proton magnetometer MMPOS-1 with a reference frequency of 3 s. Georeferencing of points was performed using the Garmin 64st GPS receiver. Variations of the Earth's natural magnetic field were registered by a GSM-19 quantum magnetometer with a frequency of 10 s in a forest area near «Crystal» sarcophagus. Software complexes of statistical and spectral-correlation analysis of geophysical data «KOSKAD 3D» (author A.A. Nikitin, A.V. Petrov, A.S. Aleksashin) and of numerical modelling PRISMA (author A.S. Dolgal) are used for the data analysis. Results. 5323 readings of magnetic field on the area 430×330 m around the emplacement hole of the peaceful underground nuclear explosion «Crystal» were taken and systemized. The anomalous magnetic field ΔТа of the site of the peaceful underground nuclear explosion «Crystal» was mapped based on these data. The local magnetic anomalies formed by buried iron objects were revealed. The widest and most intense anomaly with a diameter of 46 m and an amplitude of up to 8000 nT is located above the emplacement hole at the center of the sarcophagus. The sequential energy filtering of measured magnetic data allowed separating this magnetic anomaly into parts associated with different fragments of the emplacement hole casing. The results of modeling magnetic anomalies caused by the hole casing fragments are consistent with the measured magnetic data. So, the additive character of the magnetic anomaly is revealed. The other magnetic anomalies are presumably caused by casing pipes of research and technical wells that existed before the explosion at the site and were randomly removed by the explosion.

Subject of Research. Image matching and classification methods, as well as synchronous location and mapping, are widely used on embedded and mobile devices. Their most resource-intensive part is the detection and description of the image key points. In case of classical methods for detection and description of key points they can be executed in real time on mobile devices but for modern neural network methods with better quality, such approach is difficult due to trading off performance. Thus, the issue of speeding for neural network models applied for the detection and description of key points is currently topical. The subject of research is distillation as one of the methods for reducing neural network models. The aim of the study is to obtain more compact model for detection and description of key points and a description of the procedure for this model design. Method. We proposed a method for pairing the original and more compact new model for its subsequent training on the output values of the original model. In this regard, the new model is learned to reconstruct the output of the original model without using image labels. Both networks accept identical images as input. Main Results. Neural network distillation method for detection and description of key points is tested. The objective function and training parameters that provide the best results in the framework of the study are proposed. A new data set is created for testing key point detection methods, and a new quality indicator of the allocated key points and their corresponding local features is added. New model training in the way suggested with the same number of parameters, shows greater accuracy in key points compared to the original model. A new model with a significantly smaller number of parameters shows the accuracy of point matching close to the accuracy of the original model. Practical Relevance. More compact model for detection and description of image key points is created applying the proposed method. The model is applicable on embedded and mobile devices for synchronous location and mapping. Such model application can also increase the service efficiency of the image search on the server side.

In the period from 8 to 15 July 2018, the employees of the Laboratory of Geoelectricity of Trofimuk Institute of Petroleum Geology and Geophysics SB RAS conducted field studies under the RFBR grant no. 17-05-00083 A. This effect should be very weak in all signals of controlled source transient electromagnetic method. The studies were carried out by the following electric prospecting methods: complex of electrical prospecting methods was chosen due to the methodical efficiency and relative simplicity of the work.Research problems: work area selection; measurement of transient electromagnetic signals byfour radial MN linesfor registration of components,caused by the Hall effect; measurement of components for measurements control. The relevance of the researchis primarilycaused by the fact that the galvanomagnetic effects (including the Hall effect), arising in crossed electric and magnetic fields, are well known in physics, but have not been studied in relation to the geological environment – this means that these effects are not yet accounted for affect the signals of geoelectromagnetic soundings. The main aimof the research is todiscover the Hall effect in the geological media. Object: the Hall effect in the geological media. Methods: controlled source transient electromagnetic method, magnetotelluric sounding method. Results. The field studies in 2018 are the first purposeful field studies to detect the Hall effect in the geological environment by electromagnetic sensing methods. In researchers opinion, the goal of research, according to preliminary data, was achieved. The Hall conductivity was estimated at~1–2·10–3S/m.

Subject. The aim of the work is to study the mechanism and sources of water formation, as well as the peculiarities of carbonate mineralization in the aquifer of the Kyndyg thermal water deposit. Materials and methods. The samples of water (8) and deposited carbonates (15), collected at different seasons at three sites, characterized by different temperatures and distances from the source, were investigated. pH, Eh, and electrical conductivity were determined by an electrochemical method. For the determination of HCO3 – , Cl– , SO4 2–, titrimetric, mercurymetric and turbidimetric methods were used. Trace element composition was determined by ICP-MS (NexION 300S); strontium isotopic composition – by MC-ICP-MS (Neptune Plus) using the bracketing technique after Sr chromatographic separation. Results. The chloride-calcium hydrochemical type prevails in the studied waters. A number of trace elements in water exceeds the clarke concentrations for groundwater in the supergene zone of mountain landscapes. 87Sr/86Sr isotope ratios (0.7065–0.7072) in thermal waters suggest that their composition is determined rather by the isotopic characteristics of the rocks through which water drains than by the influence of sea water. Among the newly formed carbonates, aragonite prevails. In contrast to thermal water, the concentrations of most metals in carbonates are below the clarke values; only Sr and Se are increased, which content is significantly increased in water as well. Deposited carbonates are characterized by 87Sr/86Sr values (0.7028–0.7074), which are lower than in the source thermal waters. Conclusions. On the basis of hydrogeological, hydrochemical and geochemical data, it can be assumed that the waters of this aquifer complex are formed mainly due to fresh fractured karst waters of lower Cretaceous limestones with submerged monocline dipping into the zone of slow circulation and mixing with sedimentogenic sodium chloride waters. The geochemical data and the presence of scandium anomaly suggest that the underlying Jurassic volcanogenic rocks also participate in water exchange.

Background. In recent years, the problem of pancreatic necrosis in urgent surgery has been at the forefront. Infected pancreatic necrosis (IPN) occurs in 38–69 % of patients with severe acute pancreatitis, mortality in this pathology reaches 8–49 %. The aim of the work – to increase the efficiency of treatment of patients with infected pancreatic necrosis and acute destructive pancreatitis by using an original drainage device. Materials and methods. The analysis of the results of treatment of 102 patients with IPN, who underwent different types of operations, depending on the prevalence of the process, was carried out. Women were 29 (28.4 %), men – 73 (71.6 %), aged from 27 to 74 years. We used traditional methods of patient examination. Two groups were formed. The 1st group (main) consisted of 43 (42.1 %) patients, in whom the traditional complex of therapeutic and diagnostic measures was used in combination with the developed “drainage device”. 59 (57.9 %) patients of the 2nd group (control) underwent standard medical and diagnostic practice. Results. A total of 102 patients underwent 186 operations: 96 - minimally invasive and 90 – by the traditional “open” method. The number of postoperative complications in the 1st group of patients was 8 (7.8 %), in the 2nd group – 18 (17.6 %) with a mortality rate of 5 (11.6 %) and 16 (27.1 %), respectively. The most common cause of death was sepsis with multiple organ failure. Conclusions. It is necessary to combine minimally invasive and “open” operations for infected pancreatic necrosis against the background of complex therapy. In 23.4 % of patients, minimally invasive technologies are the final method of treatment. The use of the developed “drainage device” leads to a significant reduction in complications and mortality.

Background. The purpose of the research is to establish the presence or absence of a connection between the acquired valvular heart disease of people with a change in the values of physicochemical blood serum parameters. Materials and methods. The physicochemical parameters of blood serum were studied in patients of both sexes (30 people, 16 women and 14 men) aged 62.1 ± 0.9 years, with acquired valvular heart diseases, operated using artificial circulation technology. The control group included individuals (22 volunteers, 10 women, 12 men) who did not have chronic diseases. Average age 62 ± 1.0 years. A prospective study of physicochemical parameters (dilatational viscoelasticity and dynamic surface tension) of blood serum was carried out. The method used was bubble and drop shape. Results. A statistically significant difference in the values of physicochemical parameters of blood serum in the group of patients and volunteers before the operation to correct heart defects was established. On the first day after the operation, there was a statistically significant change in the values of the studied parameters. By the seventh day of the postoperative period, the viscoelasticity modulus | E | at frequencies of 0.1 Hz was statistically significantly higher than the preoperative level. At the same time, the values of the studied biochemical parameters demonstrate positive dynamics, approaching the norm. Conclusion. A statistically significant relationship was established between the acquired valvular pathology of the heart of people with changes in the values of physicochemical parameters of blood serum. A decrease in the values of the parameters characterizing the physical and chemical properties of blood serum in patients of the study group was found, which may be associated with an increase in the values of the concentration of surfactants. Changes in the values of routine indicators that determine the rheology of blood lead to significant changes in the values of the parameters characterizing the dilated viscoelasticity and surface tension of blood serum.

Background. Creating a new safe, inexpensive and effective method of early diagnosis of chronic heart failure is an urgent task. The purpose of the work is to present a new method of early chronic heart failure diagnosis that meets modern requirements. Results. A new method of early chronic heart failure diagnosis by centrifugation of a patient’s blood sample, further study and analysis of the results, characterized by measuring: the value of dynamic surface tension of serum at adsorption time 100 s, and the value of its equilibrium surface tension at adsorption time 2500 s, if the value of the first indicator is 44.3 mN / m or less, and the second – 38.3 mN / m or less diagnose the development of chronic heart failure in the early stages. Conclusions. The presented method relates to medicine, namely to cardiology, and can be used for early chronic heart failure diagnosis, as well as monitoring the effectiveness of its treatment.

Background. Increasing of the testicular germ cell tumors (TGCT)incidence in combination with the young age of the patients attaches to this problem high medical and social importance. Objective. The aim of investigation was to establish peculiaritiesof MMP-1, MMP-3, MMP-9 and TIMP-1 expression in testicular postpubertal-type yolk sac tumor (YSTPT), postpubertal-type teratoma (TPT), spermatocytic tumor (ST) and teratoma with somatic-type malignancy (TSTM). Methods. YSTPT, TPT, ST and TSTM as well as medical histories of patientswere studied. All TGCTwere divided into groups according to the pTNM classification of WHO. Using antibodies to MMP-1, MMP-3, MMP-9 and TIMP-1 the state of extracellular matrix was investigated. Statistical data processing was performed using the statistical package "STATISTICA 13.3 EN trial version".Results. It is proved that MMP are involved in carcinogenesis starting with the early stages of tumor progression.A more expressive expression of MMP in YSTPT indicates its inclination for an aggressive course. It was identified that in patients with YSTPT and TPT who had vascular invasion, lymphogenous and distant metastases the relative area (S) and intensity (L) of expression of all investigated MMP (with the exception of S of MMP-3) were significantly higher than in patients without these signs of tumor aggressiveness. In ST the S of MMP-1 expression was lower than that in YSTPT and TPT, while the S of MMP-3 expression, on the contrary, was higher than the corresponding index in TPT, and was at the same level with the YSTPT. L of MMP-3 expression was at the border of moderate values.S of MMP-9 expression was greater than that in YSTPT and TPT, and its L was at a high level. In TSTM of group «4» S of MMP-1, MMP-3 and MMP-9 expression was higher (p

In the electric power industry of Russia and abroad, special attention is paid to the problem of an increase in the number of accidents caused by damage to high-voltage insulators in high-voltage equipment. An analysis of emergencies at substations and open switchgears [1- 2, 4] was carried out, which showed that in most cases the causes of damage to high-voltage insulators are natural aging in an applied electric field, overvoltage, and the presence of initial defects in the manufacture of high-voltage insulators. Based on this fact, we developed various methods of non-contact diagnostics of high-voltage insulators in order to identify defects at an early stage of their development. Particular attention was paid to the method of partial discharges because the characteristics of partial discharges provide information on the parameters of defects. The article describes a set of non-contact methods for remote diagnostics of high-voltage insulators; a two-channel method for remote diagnostics of the operating state of high-voltage insulators, based on the registration of partial discharges by electromagnetic and acoustic sensors; a device that allows visual inspection and the search for faulty high-voltage equipment; remote non-contact method for recording electric fields of high tension of industrial frequency, as well as their spatial orientation based on the electro-optical effect. We developed a mock-up of a portable diagnostic device for implementing research methods for high-voltage dielectric elements to diagnose their technical condition using the described complex of non-contact methods. The measuring device as part of a portable diagnostic device consists of a set of sensors for collecting diagnostic information detected by electromagnetic, acoustic and electro-optical sensors and a voltage phase signal applied to the studied highvoltage insulator. The simultaneous use of several sensors at once made it possible to increase the accuracy of localization of partial discharges in high-voltage insulators. Visualization of diagnostic results is possible at the control room in the form of amplitude-phase, frequencyphase and amplitude-frequency diagrams of the distribution of characteristics of partial discharges and on a portable device in the form of radiation intensity from the selected sensor. A portable diagnostic device made it possible in laboratory conditions to study electrophysical processes in various dielectric materials and products under the influence of strong alternating electric fields. A study was made of the features of defects on the rod and the terminal-terminal contact, a diagram of the electrophysical processes accompanying the emission of partial discharges was constructed, and the causes of their occurrence were established.

Testicular germ cell tumors (TGCT) is a group of neoplasms which develop from the germ cell epithelium and account 94-96% of all testicular tumors. Seminoma is the most common testicular germ cell neoplasm and accounts for about 50% of all TGCT.There is an increasing evidence that metastatic disease in both early and late stages depends on the degree of tumor vascularization. But despite the large number of publications on this subject, the ways of new vessels formation in invasive neoplasms and effect of the intratumoral vessels density on overall and relapse-free survival rate remain unclear.The performed investigation of neoangiogenesis in the dynamics of testicular seminoma progression revealed: significant increasing of relative area of CD31 and CD34 expression as well as vascular density during transition from the initial to the late stages of tumor progression; formation of intratumoral vessels in the seminoma occurs by angiogenesis and vasculogenesis with participation of progenitor endothelial cells; seminoma is characterized by vasculogenic mimicry in the form of channels formation that do not have endothelial lining.

Despite the relatively low incidence of testicular germ cell tumors (TGCT), which amount only 1% of all cancers in men worldwide in the epidemiological aspect, unlike tumors of other localizations, it does not become more frequent with age, but reaches its peak in young men of working age what attaches to the problem not only great medical, but also social significance. Estimation of angiogenesis in the tumor is considered as one of the markers for predicting the course of disease, presence of metastases and sensitivity to antitumor antiangiogenic therapy. At the same time, data concerning the study of the mechanisms of blood vessels formation, the work out of methods for estimation of tumorous angiogenesis as well as the use habits of IHC markers of endothelial cells (CD31 and CD34) for assessing the aggressiveness and prognosis of TGCT and, in particular, EC, are absent in the available literature sources. Investigation of peculiarities of neoangiogenesis in the dynamics of testicular embryonal carcinoma progression revealed: significant increasing of relative area of CD31 and CD34 expression as well as vascular density during transition from the initial to the late stages of tumor progression; formation of intratumoral vessels in the embryonal carcinoma occurs by angiogenesis and vasculogenesis with participation of progenitor endothelial cells; embryonal carcinoma is characterized by vasculogenic mimicry in the form of channels formation that do not have endothelial lining.

Актуальність. Пухлини яєчка відносяться до рідких новоутворень (1-2% усіх злоякісних пухлин у чоловіків) і частіше зустрічаються у молодих чоловіків, що надає проблемі як медичну, так і соціальну значимість. Метою роботи було вивчення проліферативно-апоптотичних процесів в семіномі яєчка. Методи. Дослідження виконано на матеріалі 13 оперативно видалених яєчок, уражених семіномою. Результати. В дослідженні визначено зростання середніх значень S, L експресії Кі-67 та ІП, а також встановлений дуже високий і помірний позитивний кореляційні зв'язки між ІП та S і L експресії Кі-67 (r= +0,98; r= +0,60; р

Background. Periarticular cysts of the facet joint, due to their rare occurrence, often slip away from the attention of clinicians. However their formation and progression may cause compression of vascular-neural structures with subsequent manifestations of severe neurological disorders. Description of the clinical case. We present a rare clinical case of surgical treatment of a periarticular cyst of the facet joint. A comprehensive examination of the patient S. revealed: Dorsopathy with degenerative spinal canal stenosis at LV-SI level; spondyloarthrosis; periarticular facet cyst at LV-SI level on the left; radiculopathy LV on the left, in the acute stage; pronounced pain and musculo-tonic syndrome. Complaints of the patient: constant pain in the lumbar spine, extending to the left lower extremity and aggravating when walking at a distance of 50-100 meters; feeling numb when walking on the plantar surface of the left foot. When examining the local status, a forced posture with a bowed head and torso forward was noted; smooth lumbar lordosis and antalgic right-sided scoliosis; tension of paravertebral muscles. Neurological examination revealed LVradiculopathy on the left with moderate paresis of the extensor muscles of the left foot and ipsilateral Lasgue's positive test. MRI examination revealed spinal canal stenosis, facet joint cyst at the level of LV-SI with dimensions of 1488.5 mm. An operative intervention was performed: reconstructive decompressive-stabilizing spinal surgery with a single block removing the articular facet with a periarticular cyst at the left LV-SI level with subsequent posterior transpedicular fixation of the vertebral motor segment. Two months after the operation, complete medical and social rehabilitation of the patient was achieved. No complaints. Conclusion. In case of compression of a periarticular cyst of vascular-neural structures with severe neurological disorders, surgical treatment with the cyst removal is recommended.

The paper shows the possibility to use hydrothermal nanosilica as a modifying additive to increase the strength of concrete based on portland cement. The technology of obtaining hydrothermal nanosilica in the form of sols and nanopowders by ultrafiltration membrane concentration and cryochemical vacuum sublimation is proposed. The results of increased strength of concrete under compression by the addition of hydrothermal nanosilica Sol are presented. The experiments were performed on highly mobile concretes (ST = 10–19 cm) on equal-moving mixtures with water-cement ratio W/C = 0.61–0.71 at a dose of SiO2 2 wt.% and the rate of superplasticizer polycarboxylate 0.95±0.05 mas.% by cement. At the initial stage of hardening when the age is 1 day, the increase in the compressive strength of concrete reached 90–128% compared to the control sample. At the age of 28 days the increase in strength was 40%. High chemisorption activity of hydrothermal nanopowder with respect to Ca(OH)2 was determined in the experiment with lime medium. This indicates that the amorphous nanoadditive SiO2 , which has a high specific surface area, causes the formation of high-strength hydrates of calcium silicates in the cement (lime) medium as a result of the pozzolan reaction, and this causes an increase in the strength of concrete.

The Exner equation in conjunction phenomenological sediment transport models is widely used for mathematical modeling non-cohesive river bed. This approach allows to obtain an accurate solution without any difficulty if one models evolution of simple shape bed. However if one models evolution of complex shape bed with unstable soil the numerical instability occurs in some cases. It is difficult to detach this numerical instability from the natural physical instability of bed. This paper analyses the causes of numerical instability occurring while modeling evolution of complex shape bed by using the Exner equation and phenomenological sediment rate models. The paper shows that two kinds of indeterminateness may occur while solving numerically the Exner equation closed by phenomenological model of sediment transport. The first indeterminateness occurs in the bed area where sediment transport is transit and bed is not changed. The second indeterminateness occurs at the extreme point of bed profile when the sediment rate varies and the bed remains the same. Authors performed the closure of the Exner equation by the analytical sediment transport model, which allowed to transform the Exner equation to parabolic type equation. Analysis of the obtained equation showed that its numerical solving does not lead to occurring of the indeterminateness mentioned above. Parabolic form of the transformed Exner equation allows to apply the effective and stable implicit central difference scheme for this equation solving. The model problem of bed evolution in presence of periodic distribution of the bed shear stress is carried out. The authors used the explicit central difference scheme with and without filtration method application and implicit central difference scheme for numerical solution of the problem. It is shown that the explicit central difference scheme is unstable in the area of the bed profile extremum. Using the filtration method resulted to increased dissipation of the solution. The solution obtained by using the implicit central difference scheme corresponds to the distribution law of bed shear stress and is stable throughout the calculation area.

The first results of the U-Pb dating of zircons from the metamorphic rocks of the Nerkayuskiy eclogite-schist complex are discussed. The minimum age of detrital zircons suggests that the initial sedimentary formations, the protoliths of garnet-mica crystalline schists, were formed in the Paleoproterozoic. The time of manifestation of the early stage of rock metamorphism dates back to about 2.0 billion years ago. The isea, which has long been supported by the authors, considers the Nerkayuskiy eclogite-schist complex as a tectonically displaced fragment of the Lower Precambrian crystalline basement included in the structure of the Uralides.

The electrical capacitance and corresponding moisture content of cotton sample used as a sweat absorption container were investigated. Dependencies of interdigital sensor electrical capacitance from relative moisture content of fabric sample under investigation placed upon the sensor were plotted as the result of simulation in COMSOL Multiphysics software suite and experiments. The resulting dependence of the study allows the implementation of the human skin moisture content sensor for hyperhidrosis diagnostics.

The performed analysis, based on the examination of pathologists’ reports and medical case histories of the patients of Kharkiv regional clinical center of urology and nephrology named after Shapovalov V.I., for the period covering years 1998-2017, is devoted to the investigation of correlation between the degree of tumorous lesion of the testes and categories of pTNM classification in patients with TGCT. According to the obtained data, there are significant differences between the different histological types of the TGCT. It is concluded that the most aggressive TGCT is embryonic cancer and yolk sac tumor, postpubertal-type; the least aggressive of all is seminoma and teratoma, postpubertal-type; the mixed TGCT hold an intermediate position.

The performed analyses of incidence rate of testicular germ cell tumors and clinical and pathologic analysis, based on the examination of pathologists’ reports and medical case histories of the patients of Kharkiv regional clinical center of urology and nephrology named after Shapovalov V.I., for the period covering years 1998-2017, revealed: unfavorable increasing tendency in testicular GCT incidences, the most typical age of patients with mentioned pathology, and average duration of the disease by the time the patient visited the doctor; determined the possible risk factors of testicular GCT development, as well as the morphological traits in accordance with WНO updated classification.

Let M be a finite von Neumann algebra equipped with a finite faithful normal trace and let Lp(M; ) be the corresponding noncommutative Lp space of -measurable operators associated with the couple (M; ), 1 ≤ p < ∞. Let MN be the algebra of all complex N × N-matrices equipped with the standard trace Tr. In this note we study the properties of Arens “algebras” over finite dimensional matrix spaces, given by Trunov’s construction for noncommutative Lp-spaces. In this work we show that the Arens “algebras” built upon Trunov’s noncommutative Lp-spaces fails to form an algebra in general. We also show that the Arens space L!(; h), with 0 ≤ ≤ 1, fails to form an algebra in general, even in the setting of finite algebras associated to a trace, in contrast to L!(M; ): In particular, we provide an example of a finite von Neumann algebra, with an associated trace, such that L!(; h) is not an algebra, for any choice of ∈ [0; 1].

Background. Set the values of surface tension and dilatational viscoelasticity: 1) serum and plasma in patients operated on for the heart under cardiopulmonary bypass, in the peri-and intraoperative periods; 2) blood serum during cardiopulmonary bypass. Materials and methods. In 70 patients with ischemic heart disease, the average age 62,1±0,9, operated on under cardiopulmonary bypass for coronary heart disease and acquired valvular heart disease, the prospective study of surface tension and dilatation viscoelasticity of blood serum and plasma was performed. There were used the methods of drop and bubble form (Tensiometers PAT-1 and РАТ-2P SINTERFACE Technologies, Berlin, Germany).The blood for research was sampled an hour before operation, in the 5th minute of cardiopulmonary bypass, after 12 hours (1-st day) and in 7 days after operation. The rheological active markers (glucose, protein, albumen, urea and creatinine) were choose from routine biochemical parameters to evaluate. Results. On the 1st day after surgery, there was a statistically significant increase in glucose, urea and creatinine levels and a statistically significant decrease in total protein and albumin. Against this background, the nature of the changes in surface tension and viscoelastic modulus indicated a significant increase in serum surfactants. By the 7th day of the postoperative period, positive dynamics of the studied biochemical parameters was noted. Of the rheological indicators, an increase in the module at a frequency of 0.01 Hz can be noted with a simultaneous decrease in the phase angle. This indicates an increase in surface elasticity with a practically constant surface viscosity. Noteworthy are close to zero coefficients of the dependence of dilatational viscosity on the oscillation frequency. At the same time, the group of patients during cardiopulmonary bypass reliably stands out among other groups of patients in terms of the size bviscosity. This indicates a change in the mechanism of formation of dilatational viscosity, probably due to the introduction of large volumes of infusion media into the vascular bed in a short time. Conclusion. Pathological changes in biochemical markers which influence blood viscosity (glucose, protein, albumen, urea and creatinine) were accompanied by significant changes in surface tension and dilatation viscoelasticity of serum and plasma blood. The same time these biochemical markers are not the dominant predictors of the changes in blood rheology and viscosity.

Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease.

In summer 2017 we found a Steller’s Sea Eagle (Haliaeetus pelagicus) carrying the red ring 8E on the right leg. The bird was a member of a territorial pair occupying the M-12 breeding territory at the Kava river, Tauy River basin, Magadan State Nature Reserve, Northern part of the Sea of Okhotsk.

The aim of the study – to evaluate the effectiveness of pathogenetic therapy in patients with ankylosing spondylitis (AS) and the prognostic value of the initial levels of osteoassociated hormones and chemical elements in hair and blood. Materials and methods. 79 patients with AS (95 % of men and 5 % of women at the age of 38.3 ± 1.3 years) were under observation. The duration of the clinical manifestation was 11.4 ± 0.8 years, the I degree of the disease activity was detected in 32 % of the cases, II – 39 %, III – 29 %, seropositivity for HLA-B27 was diagnosed in 88 % of the surveyed, for antibodies to cyclic citrulline peptide – in 3.6 % of cases, for rheumatoid factor – in 6.3 % of cases. Osteodeficiency in the form of osteopenia and osteoporosis occurred in 49 % of AS observations. Patients were examined with two-energy X-ray osteodensitometry of the proximal femoral part. Blood levels of parathyroid hormone (PH), osteocalcin (OC), calcitonin (CT) and alkaline phosphatase (AP) were studied in blood. Osteoassociated chemical elements (Ca, Co, Cu, Fe, Li, Mg, Mn, P, Pb, Sr, Zn) were estimated in blood and hair. Results. There was no effect of the treatment in 4% of the patients, the mild improvement was detected in 21% of the examined patients, the improvement – in 70 %, significant improvement – in 4 %. In AS, there is an increase in the content of PH, OC and the activity of AP in blood with decrease of CT, which is accompanied by increase in Li, Mg, Pb and Sr concentrations in blood with decrease in Ca, Fe, Mn, P parameters. In hair, the level of Pb increases with the inhibition of Ca, Co, Li and Sr, the indices of which correlate with PH, OC, CT and AP, relate to the degree of disease activity, the severity of bone-destructive joint changes and the presence of extraarticular (systemic) signs of the autoimmune process. The initial indices in blood of PT, Co and Mg and in hair of Ca, Fe, Mg, Mn, P, Pb and Sr influence on the effectiveness of pathogenetic medicamentous basic treatment of AS patients. Sulfasalazine and leflunomide play a part in the integral dynamics of bone metabolism parameters, which, along with the parallel prescription of calcemin and ranelate Sr, affect the overall elemental compound of the organism. Under the influence of complex pathogenetic basis therapy, Ca concentration in blood increases and Mg content in hair decreases, and against the background of the additional prescription of calcemin and ranelate Sr, the level of Sr is restored in hair. The combined use of calcemine and ranelate Sr is necessery to all AS patients with osteodeficiency (osteoporosis, osteopenia). Prognostically favorable criteria for the subsequent pathogenetic basis therapy of the disease can be Mg concentration in blood 250 μg / g, while the blood level of the PH >60 pg / ml is a prognosis negative factor in the effectiveness of further treatment. Conclusions. The effectiveness of basic therapy in patients with AS depends on the initial state of bone metabolism. The presented data will allow to improve the quality of medical technology in the future for early diagnosis and predicting the further course of individual manifestations of the disease, to optimize the nature of rehabilitation activities in patients with osteopenia/osteoporosis, to improve control over the effectiveness of treatment.

The movement of bed load along the closed conduit can lead to a loss of stability of the bed surface, when bed waves arise at the bed of the channel. Investigation of the development of bed waves is associated with the possibility of determining of the bed load nature along the bed of the periodic form. Despite the great attention of many researchers to this problem, the question of the development of bed waves remains open at the present time. This is due to the fact that in the analysis of this process many researchers use phenomenological formulas for sediment transport in their work. The results obtained in such models allow only assess qualitatly the development of bed waves. For this reason, it is of interest to carry out an analysis of the development of bed waves using the analytical model for sediment transport. The paper proposed two-dimensional profile mathematical riverbed model, which allows to investigate the movement of sediment over a periodic bed. A feature of the mathematical model is the possibility of calculating the bed load transport according to an analytical model with the Coulomb-Prandtl rheology, which takes into account the influence of bottom surface slopes, bed normal and tangential stresses on the movement of bed material. It is shown that when the bed material moves along the bed of periodic form, the diffusion and pressure transport of bed load are multidirectional and dominant with respect to the transit flow. Influence of the effects of changes in wave shape on the contribution of transit, diffusion and pressure transport to the total sediment transport has been studied. Comparison of the received results with numerical solutions of the other authors has shown their good qualitative initiation.

The Blakiston’s Fish Owl (Ketupa blakistoni) is a rare endemic of eastern Asia, breeding in the Sea of Japan and Sea of Okhotsk basin. Up until now, the northern limits of the breeding range was thought to be the Chelomdja and the Yana rivers of the Tauy bay of the Sea of Okhotsk species were reported from the beginning of 21 Century in the Yama portion of the Magadan State Reserve. This means that the breeding range limits is located 280 km further East. The Yama river is estimated to have from 3 to 5 breeding territories of the Blakiston’s Fish Owl.

A great amount of mine waste creates serious problems for economy and ecology in mining regions. Keeping of dumps and tailings storages requires huge capital costs and material inputs. Removal of overburden volumes cause ecological disequilibrium, ingress of chemical agents and heavy metals in ground and surface water have an adverse influence on eco-systems and human health. These hazards are particularly high under extreme climatic conditions, when mines create vast desert lands around themselves. Foreign researchers use the terms "acid mine drainage" (AМD) and "acid rock drainage" (ARD) when speaking on mine water oxidation and contamination of the environment with heavy metals. AMD is induced by underground mine drainage, natural sulfide-bearing rock exposures, etc. The processes occurring in the interaction the mine water with fine dust particles, as well as water filtering through the thick sulfide rocks have been studied. It has been shown that the reduction in potential environmental hazard of mine water of JSC "Kola MMC" is achieved through precipitation of heavy metals by iron hydroxide and magnesium hydrosilicate. Preliminary assessment of the feasibility of hydrometallurgical processing of disseminated copper-nickel ores has been made

1Moscow Clinical Research-and-Practical Center, Moscow Healthcare Department, Moscow; 2A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow; 3Children’s Health Research Center, Ministry of Health of Russia, Moscow; 4I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint Petersburg; 5M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow; 6Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow; 7Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk; 8Russian Children’s Clinical Hospital, Moscow; 9Department of Pediatrics, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow; 10I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg; 11Acad. Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 12Clinic Four, Department of Pediatrics, I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg; 13Childhood Diseases Department Two, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 14Research Laboratory of Surgical Gastroenterology and Endoscopy, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 15Department of Endoscopic Surgery, City Clinical Hospital Thirty-One, Moscow Healthcare Department, Moscow; 16A.N. Ryzhikh State Research Center of Coloproctology, Ministry of Health of Russia, Moscow; 17Department of Intermediate-Level Therapy, Tver State Medical University, Ministry of Health of Russia, Tver; 18Laboratory of Medical Genetics, Diagnostic Center of Medical Genetics, Saint Petersburg; 19HLA Typing Laboratory, Blood Transfusion Station, Moscow Healthcare Department, Moscow; 20S.P. Botkin City Clinical Hospital, Moscow Healthcare Department, Moscow; 21Department of Nervous System Diseases, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow; 22Department of Endocrinology and Diabetology, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow; 23Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow; 24Department of Therapy, Kazan State Medical Academy, Ministry of Health of Russia, Kazan; 25Department of Intermediate-Level Therapy with Course of Occupational Diseases, Faculty of General Medicine, Omsk State Medical University, Ministry of Health of Russia, Omsk; 26Dmitry Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Health of Russia, Moscow The paper presents the All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults, which has been elaborated by leading experts, such as gastroenterologists and pediatricians of Russia on the basis of the existing Russian and international guidelines. The consensus approved at the 42nd Annual Scientific Session of the Central Research Institute of Gastroenterology on Principles of Evidence-Based Medicine into Clinical Practice (March 2—3, 2016). The consensus is intended for practitioners engaged in the management and treatment of patients with celiac disease. Evidence for the main provisions of the consensus was sought in electronic databases. In making recommendations, the main source was the publications included in the Cochrane Library, EMBASE, MEDLINE, and PubMed. The search depth was 10 years. Recommendations in the preliminary version were reviewed by independent experts. Voting was done by the Delphic polling system.

More than 140 years astrocytes were described as passive cellularelements of the brain, and their function was limited participationin providing trophic potential of neurons. It was describedas doctrine of neuronism which supported such famous scientistsas H.W. von Waldeyer and S. Ramun y Cajal, who is theauthor of phrases each nerve cell a fully autonomous physiologicalcanton. During last time we can see a revision ofviews on the role of astrocytes in the brain. Astrocyte is equalpartner of the neuron in such fundamental functions of thebrain, as modulation of synaptic transmission, gliotransmissionand regulation of microcirculation. Discovery of a new elementof glia NG2 cells, identification of the relationship betweenneuronal networks and astrocyte syncytium have changed thedoctrine of neuronism. New paradigm revises the role ofastroglia in the brain in health and disease.

The authors report on the problem of Traumatic Brain Injury(TBI) and main ways of its solution. Special emphasis is beingplaced on literature data bank and personal experience in studyingand making precise diagnosis of diffuse and focal brain damageusing Diffuse-tensor MRI (DT-MRI) and its other modalities.A comparative analysis of DT-MRI findings in 8 healthyvolunteers and 22 patients in coma with severe diffuse axonalinjury (DAI) at the period of 217 days after trauma demonstratedsignificant changes in the corpus callosum and corticospinaltracts (CST) caused by DAI. Fractional anisotropy wasconsidered the most sensitive indicator of their damage in theearly stage of DAI. The authors developed and described a newapproach to the management of brain concussion which allows out-patient treatment of such patients provided there is no focaldamage at GCS 15 and on condition thorough neurological andregular CT- and MRI examinations are performed.

Objective. Estimation of expediency for peritonization of the stapler resection line, aiming to prevent the stapler suture hemorrhage and insufficiency. Маterials and methods. The investigation was conducted on laboratory rabbits, to which the sleeve gastric resection was performed: in 9 experimental animals (Group 1) – with peritonization of the stapler suture line, in experimental animals (Group 2) – without peritonization. Structural changes of gastric wall in the stapler suture portion in both groups of experimental animals were investigated. Results. Peritonization of the stapler suture line have caused exaggeration of the gastric walls ischemic changes. Conclusion. Peritonization of the sleeve gastric resection line promotes prophylaxis of postoperative hemorrhage from the stapler suture, but do not prevent its insufficiency.

We proposed a method for calculating statical indeterminacy frames taking into account plastic defor­mations, which is based on the use of a schematized diagram of material with hardening. Two types of standard beams with supports are used during the implementation of the displacement method (DM) and the elastic solu­tion of the problem: “fixed” - “pinned” and “fixed” - “fixed”, but unlike the elastic solution, standard beams con­tain plastic zones (PZs). So as the stresses in these zones did not exceed the limit of yielding in the nonlinear frame calculation, we took measures to transform the PZs into equal strength plastic zones (ESPZ). The calcula­tions were made for both types of beams for all single and load impacts. The frame calculation consists of two stages (elastic and plastic). At the elastic stage, we determine an elastic moment diagram and the corresponding load. For a practical use of the DM in a nonlinear frame calculation, we introduced a simplifying prerequisite sup­plementing the well-known hypotheses of the classical version of the method, and formulated a Statement of the limiting load. According to the Statement, each length of the PZ can correspond to the lower boundary of the lim­iting load. The plastic stage of the calculation is performed at a given length of the PZ using the method of se­quential loadings. At each loading stage, incremental equations are written using the DM equations, which estab­lish relations between incremental moments and the incremental load, that allows you to get the resulting moment diagram. This diagram represents a sum of the elastic diagram and the diagrams of incremental moments at all previous loading stages. According to the resulting diagram, we calculate the length of the PZ, together with the limiting load. The calculation is considered complete if the length of the PZ does not exceed the specified value within the margin of error.

Pelletized slag of copper-nickel smelter ("Pechenganikel" combine, "Kola MMC" JSC) has been investigated as a potential technogenic deposit. It has been shown that nonferrous metals can be re-extracted from slag using flotation. The work presents the results of laboratory simulation of heap leaching of non-ferrous metals. Ceramic building materials from slag-based feed have been produced and their main properties have been studied