Search

The article provides a brief overview of the emergence of the legal market of online cinemas in Russia. The paper reveals that the Governments of many countries have a national policy that is aimed at maintaining internal programming on traditional video platforms. Such policies range from licensing, which requires serving the “public interest” and defines rules for the distribution of certain types of content produced domestically, to requiring content distributors to contribute to the financing of the production of domestic content. The authors investigate that during the implementation of these rules, the Russian government decided on the allocation of limited resources. There was also regulation on whether platforms can solely decide what content to offer their users, or whether viewers should also participate directly. The study concludes that the transition from traditional platforms to online distribution can reduce the effectiveness of existing regulatory regimes and deprive traditional platforms of audience and revenue.The world and Russian experiences of using the Internet prove that today modern information and telecommunications technologies can contain real threats to the violation of fundamental rights and freedoms of citizens, as well as to question the security of society and the state. The only exceptions are progressive or innovative areas related to the provision of new services and the expansion of opportunities for socio-economic development.As a result of the study, the paper identified four problems of Russian film distribution on digital platforms. The authors chose piracy as the first problem of online cinemas. Pirate sites not only illegally copy content from online movie theaters, but they also create copies of their own services to transfer their servers to another platform in case of blocking. The second problem was highlighted by the requirement for foreign owners. The third problem was highlighted by the high cost of online movie theater subscriptions. The authors consider the fourth problem the lack of financial support from the state.

Introduction. The new digital economy and its constantly evolving paradigm have completely transformed the model of doing business and the learning methods. MOOCs (massive-open-online-courses) and micro-credentials are the educations interfaces, have become an important teaching environment tool. Distance learning has become an indispensable alternative teaching method in updating and transferring classical education materials according to real-world settings, especially for learners in higher education.Aim. The current research is aimed to address the society's readiness and attitude direction to the concept of MOOCs and distance learning, highlighting its emergence and inevitability for educational institutions of all types in order to make a fundamental change in their curricula, especially in e-business courses, which are the most demanded training courses on MOOCs platforms.Methodology and research methods. In the study, the awareness and recognition of the online community on the MOOCs concept is examined. In this direction, Turkish people's perception and attitudes toward MOOCs have been addressed via sentiment analysis on Eksi Sozluk, the largest social communication and discussion platform in Turkey.Results. According to the sentiment analysis results, it has been determined that 52% of respondents have positive judgments on distance education and MOOCs, 29% of responses are neutral and 18% are negative. In general, distance education and MOOCs are perceived as a useful new education model by the Turkish people.Scientific novelty. This paper is the first sentiment analysis of learners' opinions on MOOCs and distance learning in Turkey. Considering the increasing awareness of MOOCs and the need for e-business education, as the most demanded type of MOOCs, this is the first study investigating the priority of these two phenomena within the context of COVID-19.Practical significance. It is thought that this study will contribute to the stakeholders in terms of showing how MOOCs and micro-credentials have a high potential to understanding trends in education especially in the new normal after the COVID-19 pandemic. The holistic education model of institutions has difficulty meeting the competitive nature and result-oriented approach of the e-business ecosystem. This market reality requires the institutions to offer more to-the-point and applied education solutions. In terms of e-business (e-commerce, digital marketing) education, the importance of MOOCs as a solution-focused on “how” rather than “what” has been comprehensively discussed in the paper. Введение. Новая цифровая экономика и ее постоянно развивающаяся парадигма полностью изменили модель ведения бизнеса и методы обучения. MOOK (массовые открытые онлайн-курсы) и программы микроквалификаций - это образовательные интерфейсы, которые превратились в важный инструмент учебной среды. В высших учебных заведениях дистанционное обучение стало незаменимым альтернативным методом преподавания при обновлении и передаче классических учебных материалов в соответствии с реальными условиями.Цель данного исследования - определить готовность и отношение общества к концепции МООК и дистанционного обучения, а также подчеркнуть неизбежность их использования в образовательных учреждениях любого уровня, для того чтобы внести фундаментальные изменения в учебные планы, особенно в программы курсов электронного бизнеса - наиболее востребованного направления образовательных курсов на платформах МООК.Методология и методы исследования. В исследовании анализируется осведомленность общества о концепции MOOK. Восприятие и отношение респондентов к МООК было рассмотрено с помощью сентимент-анализа на платформе Eksi Sozluk (социальная коммуникационно-дискуссионная онлайн-площадка). Результаты. Согласно результатам сентимент-анализа, 52 % опрошенных оценивают дистанционное обучение и МООК положительно, 29 % - нейтрально и 18 % - отрицательно. В общем, дистанционное образование и МООК воспринимаются респондентами как новая полезная модель образования. Научная новизна. Авторы впервые провели сентимент-анализ мнений о МООК и дистанционном обучении среди пользователей этих платформ в Турции. Это первое исследование, в котором рассматривается приоритетность растущей осведомленности о МООК и необходимости в дистанционном бизнес-образовании как наиболее предпочтительном типе МООК в условиях пандемии COVID-19. Практическая значимость. Предполагается, что данное исследование будет способствовать демонстрации заинтересованным участникам того, что МООК и программы микроквалификаций имеют высокий потенциал для осмысления тенденций изменения образования, особенно в условиях модели новой нормальности после пандемии COVID-19. Целостная образовательная модель учреждения образования сопряжена с трудностями в плане соответствия конкурентному характеру и ориентированному на результат подходу экосистемы электронного бизнеса. Рыночная реальность требует, чтобы учебные заведения предлагали более целенаправленные и прикладные образовательные решения для развития данной сферы обучения. Что касается курсов электронного бизнеса (электронная коммерция, цифровой маркетинг), то важность MOOК как решения, ориентированного на то, как, а не что, подробно обсуждается в статье. The present research is supported by Inonu University Scientific Research Projects Coordination Unit (Project No. SBA-2021-2442). Данное исследование поддержано Отделом координации научно-исследовательских проектов Университета Инёню (проект № SBA-2021-2442).

The article provides the results of a search empirical study of the impact of digital communications on the protest behavior of young people in the digital environment. The authors conducted the study on the basis of the State University of Management from November 2019 to April 2020. In the course of its implementation, the civil and political practices of student youth during the first wave of the COVID-19 pandemic and mass self-isolation were studied and updated. The paper determines the most common forms of protest activity of university students, names the main reasons for their participation or non-participation in mass protest actions. It has been empirically proven that the increase in protest behavior of young people is determined by an increase in the amount of political information with a high number of likes and reposts. In order to deactivate protest moods among young people, reduce the threats of their protest behavior and improve attitudes towards the authorities, the authors developed practical recommendations that involve social monitoring of sites, forums, pages and communities on the Internet, where young people can freely express their opinions, express dissatisfaction, and receive explanations about the actions of the authorities. The study also recommends to stimulate “feedback” with the authorities, improve public opinion on the actions or inaction of the authorities, increase the influence of citizens’ assessments on the work of state and municipal authorities. The paper states the importance of tracking youth groups prone to extremism, carrying out preventive measures with students in schools, students in colleges and universities, teaching them legal literacy. To get answers to questions about the political and economic consequences awaiting our country after the end of the coronavirus pandemic, as well as about the essence of the predicted threats, the authors plan the study on a more representative sample.

During the care of patients with novel coronavirus infection at the Lomonosov MSU Medical Research and Education Center from April 21 to June 13, 2020, we observed cases of spontaneous mediastinal emphysema (spontaneous pneumomediastinum) as a manifestation or a probable complication of COVID-19.The aim of the paper. To provide clinical case descriptions and approaches to the management of patients with spontaneous pneumomediastinum in COVID-19 associated pneumonia, as they are not addressed in the current clinical guidelines, and therefore are worthy of special attention.Among 224 patients with laboratory-confirmed diagnosis of the novel coronavirus infection COVID-19, five cases of pneumomediastinum without pneumothorax were identified. Of these, in two cases the pneumomediastinum developed during noninvasive lung ventilation (NLV) (one case) and invasive lung ventilation (one case). In three cases, spontaneous mediastinal emphysema was not associated with lung ventilation. By the time of publication, one case of pneumomediastinum was completed, and four patients remained hospitalized. All five patients were males aged from 52 to 84 years.This paper presents in depth the description of two cases of mediastinal and subcutaneous emphysema in patients with COVID-19.

The purpose of the paper is to improve the methods of using test technologies in the educational process and to develop an optimal schedule for conducting tests in higher education when teaching programming languages. The article considers the advantages and disadvantages of test technologies. The author investigates the effectiveness of one-time and step-by-step testing and studies the role of testing at different stages of the educational process. In the course of the study, the author used written and computer forms of testing. The paper shows that step-by-step testing is more effective than one-time testing. The article identifies the expediency of testing that precedes the implementation of practical work. The results of the study allow us to develop an optimal schedule for conducting tests, which contributes to improving the quality of learning material and increasing students’ motivation.

Objective: to analyze the roles of undifferentiated connective tissue dysplasia (UCTD) in the development of cartilage and ligamentous apparatus diseases.Material and methods. This paper presents the results of analyzing the literature on fundamental and clinical studies of relationships between chondroitin sulfate (CS) and connective tissue (CT) disease. A total of 922 publications on the relationship between CT dysplasia and CS and 2249 publications on CS receptor molecules were analyzed. These arrays of publications were analyzed using topological and metric approaches to data analysis.Results and discussion. The genetic predisposition to UCTD is substantially aggravated by inadequate nutrition that leads to deficiency of certain micronutrients that support CT reconstructive processes. The paper presents the results of a systematic analysis of prospects for the use of drugs based on standardized CS substances in patients with UCTD. CS is a material for CT reconstruction. CS increases the activity of growth factors and reduces CT inflammatory destruction (inhibition of the secretion of histamine, pro-inflammatory chemokines, Toll-like receptors, and the NF-κB cascade through exposure to the CD44 receptor).Conclusion. The pharmacological effects of CS indicate the importance of using standardized CS forms in the treatment of patients with UCTD.

This article considers the current state and evolution of the Russian publication flow in the field of Computer Science in the Web of Science (WOS) database. In this article, we use the term "Informatics" for "Computer Science". The study analyzes the Russian flow to determine its position in the world Computer Science publication flow and its compliance to the National project "Science" requirements.We analyzed the Russian publication flow in 2010–2019 and compared it with other countries. The structure of the flow by the document type and its temporal dynamics was studied as well as the impact on citation metrics. Compliance of the flow characteristics to the requirements of the Ministry of Higher Education and Science of the Russian Federation (Ministry) requirements was analyzed.The analysis indicates an increase in the number of Russian computer science publications within 2010-2019,which outstrips the increase in the total number of world publications in Computer Science. This allowed Russia to move from 34 to 15 positions in the world rating in the studied research area. However, this position is not sufficient to achieve the goal of the "Science" National Project, namely, at least, the fifth position in the world rating.According to the methodic requirements of the Ministry, four types of documents were studied: Journals Articles, Conferences Proceeding Papers, Book Chapters, and Reviews. All journals have been classified into the WOS journal quartiles. Our analysis shows that the percentage of publications in the journals of higher quartiles (first and second) increases constantly and made 42 % in 2019.An increase in the number of the Conference Proceeding Papers was the highest among the studied document types.The number of citations of the published documents was studied for each document type. It was shown thatthe citing of the Journal Articles is by the order of magnitude higher than that of the Conference Proceeding Papers. This result indicates the very low interest of the Scientific Society to the Conference Proceeding Papers as compared with the Journal Articles. We conclude that an increase in the number and relative share of the Conference Proceeding Papers together with their low citation results in the low numbers of the overall citation of the Russian publication flow in comparison with other countries neighboring Russia in the world rating.The "Quality Coefficient" was calculated according to the Ministry’s methodic requirements. It was shown that the contribution of Conference Proceedings Papers to this coefficient is much lower than Journals Articles despite the number of the Conference Proceeding Papers is significantly higher.As a result, the flow of Russian publications in the field of Informatics demonstrates significant, though insufficient, growth within the analyzed period. Special attention should be paid to the document type structure of the flow.

The paper is devoted to frontotemporal dementia (FTD), one of the most common forms of frontotemporal degeneration. The main symptoms of the disease include disinhibition, lack of empathy, obsessive-compulsive symptoms, apathy, cognitive impairment, appetite changes, and progressive changes in social behavior. In parallel, there are personality changes that are characterized by lower levels of self-awareness and by progressive psychological and social maladaptation of patients in society.The paper describes a clinical case of FTD in a female patient with marked behavioral changes and personality disorder. A 52-year-old woman was admitted to the alcoholism treatment department for alcohol intoxication and symptoms of mental confusion. According to her relatives, drinking too much alcohol every day, she was found to become rude, indifferent to others and her own duties, sharply limited the range of her activities and communication, and showed a decline in memory for current events. Psychopathological examination determined a distinct motivational-volitional decrease, the patient’s inability to mobilize mental activity, non-critical thinking, and indifference. X-ray diagnosis revealed the changes characteristic of frontotemporal neurodegeneration (atrophy of the frontal and temporal lobes prevails). The described case confirms that alcohol abuse can mask organic disorders that develop in systemic cerebral atrophy.

The modern tendencies in the Russian system of education, the emergence of competition and market relations in this sphere facilitated the reconsideration of the scientific grounds for the higher educational establishments activity. The suggested theoretical and methodological approaches to the domestic higher educational institutions’ management are subject to debate. The paper analyses the most essential terminology for the theoretical grounds of production management applicable for higher education processes. The terms "production", "activity", "production process" are clarified. The frequently used term "the education services production" is proved to be incorrect. The paper specifies the educational service in the context of the higher educational establishment activity, taking into consideration that the educational service should provide the student with the appropriate knowledge, training management, teaching support and student’s own educational activity control. The educational production process with which the student interfaces is divided into three subsequent stages: preparatory, main and final. The essence of each stage is defined. The students’ and teachers’ educational activity subject and result identification ways are suggested. These ways are aimed at making ultimate decisions for educational establishment production management optimization and other aspects improvement.

The paper is devoted to the problems of civil pilots upset recovery training. This is quite a new problem, which occurred due to the change in civil aviation pilots training programs that became possible due to the high level of modern civil aircraft automation. The upset recovery training removal negatively affected the level of flight safety both in our country and all over the world. The paper presents legal documents for flight simulations certification. Types of aircraft for civil pilots initial training used all over the world are described too. The analysis of the new types of light training aircraft that can be used as a change in the civil aviation academies was conducted. Modern upset recovery training program and its blind spots were studied in this paper in details. The problems of modern studies in upset recovery in civil aviation are the central part of this work. The paper contains information about legislative framework obsolescence, and creation of a new type of aviation simulator, that can simulate upset recovery situations concept. Current legislative framework of aviation simulators licensing is analyzed in this paper in comparison with the best international practices, regulations and recommendations. Conducted analysis showed that current certification legislative framework became obsolete and needs a revision for maintaining high standards in flight safety. Recommendations connected with the change of initial training types of aircraft in civil aviation academies are given.

The aim of the study is to analyse the mechanism for increasing staff engagement through broadcasting corporate values and internal PR. The article substantiates the relevance of informing as a verbal means of positive content. The paper gives an approximate list of proclaimed and denied values. The authors consider corporate events with the aim of conveying the mission, values and ideology of the company to all employees. The study notes the role of regular informing for uniting employees into a single team, forming a sense of pride in the company for the staff. The article reviews the option of monitoring the level of awareness through a feedback questionnaire, notes the need for analysis of incoming data. The paper focuses attention on the formation of personnel identity and loyalty, the use of company symbols, the creation of corporate values and traditions.

This paper addresses travelogues by English author Mary Holderness who spent the years 1816–1820 in the settlement of Karagoz in the Crimean Peninsula. Scholarship has used this source but rarely, mostly for cultural-anthropological facts. This paper provides an integral analysis of these travel writings as the most detailed account of Crimean ethno-confessional communes from the period. The works by Holderness are studied in the context of contemporary Western knowledge of the Crimea and specific ethnographic ideas in early Romanticism. The “involved observer’s” experience allowed Holderness to collect unique information about the economy and ethnography of the country. The source provides various accounts on the economic activities and taxation specificities, traditional costumes and cuisine, matrimonial relations and funeral rituals, entertainment and superstitions, religion, and other features of Crimean Russians and Tatars, Greeks and Germans, Bulgarians and Armenians, Karaites, and other ethnocultural communities. These materials allow one to disclose the features of the British perception of other peoples. Thus, foreigners tended to generalisation and typisation, making conclusions about the general trends of the national character relying on a few cases known to them from their own experience. The traveller put her fellow countrymen at the top of the “stairs of peoples” going from “barbarism” to “civilization,” while Crimean ethno-confessional communes occupied the stairs below them. She “supplied” them with various combinations of such features as primitive religiosity and superstitions, bad morals and disinclination to work according to Protestant ethics, laziness and stealing combined with a good heart, hospitality, empathy, etc.

Introduction. The area of intercultural communication with its system-forming theory, empirical research and implementation is gaining currency both in academic research and in the professional training of students. Regarding the latter aspect, there is a need (a) for developing a concept for the training of master’s students with knowledge of foreign languages; (b) for the introduction of new educational practices that successfully combine intercultural communication, foreign language and the modeling of communicative behavior in foreign language communication with its further reproduction in language practice in the students’ native language as well as (c) for the introduction of an educational project using modern technologies in the practice of institutions of higher education. The paper discusses the concept, structure and content of an educational project relying on the experience of higher education in Russia and Germany and aims to work towards an understanding of the social significance of future professional activities, primarily concerning the specific problems as well as of the adequacy of social and professional contacts in intercultural communication. Materials and Methods. Based on the subject, object and objectives of the study, the project’s methodological plan was implemented in the following stages: project planning, development of the fundamental features of the concept; determination of the project’s content; project modeling; introduction to the training of master’s students of various specialties at institutions of higher education. The methodological basis of the project consisted of the analysis of intercultural communication between representatives of the German and the Russian linguocultural community as well as the exchange of experience between them and their comparison. Results. Following the study and the exchange of experience between the institutions of higher education of Russia and Germany, the need for an integrative educational course was revealed, aiming at the improvement and optimization of intercultural communication skills at the level of both professional and personal communication with the goal to prepare master’s students for their future as researchers and practitioners. The educational project presented in the paper drawing on an eponymous integrative course will increase the efficiency of the training of master’s students from various specialized fields and prepare them for successful communication processes with representatives of other linguocultural communities. Discussion and Conclusion. The contents of this paper will be useful for researchers interested in optimizing the preparation of master’s students with knowledge in foreign languages by applying international experience.

The subject of the study is the social network theory for the management of international migration. The theory suggests that migration from the society of origin to the hosting society can occur if links exist between these two societies, and that the flow of migrants follows the established links. The theoretical prediction which one can make is that, if the political administration wishes to establish a flow of migrants between any two societies, a link between these two societies must be established first. The author tested the theory on the case of managing the emigration of workers by the government of Bangladesh. The paper found that, firstly, the links between the origin society and the host society were created artificially, however, in contrast to the theoretical forecast, the author observed that such links usually do not correspond to the geographical distribution of maximum proximity to origin or destination society. Instead, the study revealed, that the closeness of communication between two societies is generated by the proximity between political administrations of the same societies, which contradicts the theoretical expectations. In this regard, the author proposed to expand the theory of international migration in the social network, suggesting that the proximity between two political administrations, and not between two societies as a whole, is a condition necessary for international migration. This, in turn, allows us to fill a theoretical gap that is associated with the relationship between social network theory and the management of international migration. The paper concludes that it is possible to generate arbitrary migration flows, creating appropriate links between any two societies.

The article assesses the main functional elements of public Finance management: planning, operational management and control. Financial planning and forecasting presently depend not only on macroeconomic and microeconomic factors, but also on geopolitical factors. Economic sanctions, which are still ongoing, have a particular impact, so it is impossible to make an accurate forecast in the management of public finances. Operational public financial management can never be considered without public resources designed to support and implement the activities of all areas of the country’s life. The paper pays special attention to the control function due to the lack of a single objective control system. To improve efficiency, the authors propose to use certain criteria: the performance criterion and the criterion of inappropriate use of budget funds. The paper calculates the dependence of Federal budget revenues on the level of gross domestic product (GDP) and the level of unemployment. The authors use for the calculation a standard form of regression equation that takes into account statistical correlations. The results of this study can be used to improve the efficiency of Federal budget revenue planning.

The article considers the processes of digitalization of migration as a state policy aimed at improving the regulation of migration flows. The purpose of the study is to show the possibilities of digitalization of migration in Russia and at the international level, the positive aspects of this process and the main risks and threats arising during the implementation of digital technologies for making managerial decisions. The relevance of the study is associated with the necessity of introduction of digital technologies in the state management of migration processes. The paper reveals the concepts of digital transformation and the digital state. The authors note the difficulties that arise when trying to define digital technologies due to the unique and changeable social environment in which they are created. The study used systematic and comparative methods, content analysis of print and electronic media, analysis of scientific sources, which made it possible to study digital technologies as an object of state management of migration processes. According to the results of the analysis the paper concludes that digital transformation technology can influence the management of international migration in three different dimensions: 1) increase the gap between developed and developing countries; 2) contribute to the modernization of traditional methods used in the practices of international organizations; 3) influence the adoption of new, more informed management decisions in the field of migration to ensure border security. The authors reveal the main problems that developers of digital technologies and representatives of government bodies may face when mass implementing these technologies in migration practice. The conclusions of the article can be useful for interested government authorities involved in the regulation of migration processes.

The 21st century aviation and aerospace technologies have evolved and become more complex and technical. Turbofan jet engines as well as their cousins, the rocket engines (liquid/solid) have gone through several design upgrades and enhancements during the course of their design and exploitation. These technological upgrades have made engines very complex and expensive machines which need constant monitoring during their working phase. As the demand and use of such engines is growing steadily, both in the civilian and military sectors, it becomes necessary to monitor and predict the behavior of parametric data generated by these complex engines during their working phases. In this paper flight parameters such as Exhaust Gas Temperature (EGT), Engine Fan Speeds (N1 and N2), Fuel Flow (FF), Oil Temperature (OT), Oil Pressure (OP), Vibration and others where used to determine engine fault. All turbo fan engines go through several distinctly different working phases: Take-off phase, Cruise phase and Landing phase. Recording generated parametric data during these different phases leads to a massive amount of in-flight data and maintenance reports, which makes the task of designing and developing a fault diagnostic system highly challenging. It becomes imperative to use modern techniques in data analysis that can handle large volumes of generated data and provide clear visual results for determining the technical status of the engine under investigation/monitoring. These modern techniques should be able to give clear and objective assessment of the object under investigation. Cluster analysis methods based on Neural Networks such as c-means, k-means, self-organizing maps and DBSCAN algorithm have been used to build clusters. Differences in cluster groupings/patterns between healthy engine and engine with degraded performance are compared and used as the bases for defining faults. Fault diagnosis plays a crucial role in aircraft engine management. Timely and accurate detection of faults is the foundation on which maintenance turnaround times, operational costs and flight safety are based. The data used in this paper for analysis was obtained from flight data recorder during one flight cycle. The final decision on a fault is taken by an engineer.

One of priority issues of the present-day healthcare system is development of new vaccines and improvement of existing ones due to decreasing immunocompetence of the population, emergence of new infections and reemergence of old ones which were previously thought to be under control. Adjuvants have proven to be integral and important components of modern vaccines, as they enhance immune response to the vaccine antigen. However, despite a lot of effort put into their development, only a small number of adjuvants are currently used in clinical practice.The aim of the study was to systematise literature data on the adjuvants’ mechanisms of action, their specific structure, composition, and stimulation effects that mediate their immunoadjuvant properties. The paper summarises data on adjuvants used as components in licensed vaccines, describes their characteristics, analyses molecular mechanisms of their action in order to establish correlation between their structure and activity, which is important for the development of more efficacious and safe adjuvants. The paper cites advanced developments aimed at enhancing stimulation effects of existing adjuvants. It concludes by stating that the key research area aimed at improving vaccination efficacy is the study of mechanisms that contribute to the development of effective protection against infectious agents, as well as analysis of how to use adjuvants to stimulate the body’s defensive mechanisms, primarily by impacting the innate immunity.

Chronic pain (CP) is still one of the urgent problems of modern medicine. The paper provides a review of the main pharmacotherapeutic approaches from the standpoint of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) guidelines. When preparing this material, the authors have analyzed the publications available in the resources: PubMed, EMBASE, Cochrane, and еLIBRARY. The paper presents the main pathogenetic mechanisms of pain syndrome development in osteoarthritis (OA), including synovial inflammation and associated immune disorders. It considers the types of development of pain syndrome and the main prognostic outcomes according the mechanism of pain, providing a rationale for the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or chondroprotectors (CPs). In accordance with the ESCEO guidelines, it is noted that when starting OA therapy, CPs should be considered as the first step (in their long-term prescription and pharmaceutical quality), then NSAIDs should be added (topically), then (if ineffective) orally, by excluding patients with hip OA. It is known that the intramuscular administration of CPs (chondroitin sulfate (CS) in particular) can increase their bioavailability. The use of glucosamine sulfate (GS) is recommended for patients over 60 years of age. According to the recommendations of the 2019 ESCEO experts, CS and GS should be used as a disease-modifying OA drug from the first step and at all subsequent stages.

The paper considers scientific approaches to determining the essence of rural tourism and agrotourism. The authors conduct a review of the current state and trends in the development of tourism, including rural tourism, in the Vologda region. The article characterizes the activities of the government bodies of the Vologda region to create conditions for the development of the tourism industry. The study proves the prospects for the development of rural tourism in the region, shows the possibilities of forming complex tourist products. The article identifies the main problems of rural tourism development in the region and determines the directions of their solution. The paper considers the role of local governments in the development of rural tourism. The authors justify the necessity of more active implementation of the project approach in the practice of municipal administration in order to fully apply the tourist potential of the region’s territories. The study emphasizes public-private and municipal-private partnerships as one of the most effective ways to attract investment in the development of tourist infrastructure.

The aim of the study is to identify the level of staff interest in the functions and activities of the company. The article substantiates the relevance of increasing staff involvement. The paper considers the results of the study of the influence of involvement on labor productivity according to the American Institute of Public Opinion Gallup. The authors highlight the qualities characteristic of the employee involved. The study gives characteristics that make it possible to talk about the effectiveness of the employees involved. The article notes the “symptoms” of low engagement, considers the main mistakes made by management that reduce engagement, highlights the necessary incentives for the fruitful work of the organization’s employees. The authors focuse attention on the criteria for assessing staff involvement and ways to analyse the level of staff involvement. The paper presents the main methods for assessing staff involvement. The study notes the influence of a highly developed moral and psychological climate on the personnel’s commitment to the core values of the company, the observance of the rules and compliance with established standards. The article emphasizes the role of corporate culture. The paper considers the experience of employee involvement of ABC Supply, Zappos, Reeebok, FullContact companies.

The article presents arguments substantiating the influence of tax factors on the indicators of economic efficiency of oil and gas enterprises. The paper gives an interpretation of the influence of tax, customs-tariff, and macroeconomic factors on the indicators of economic efficiency of oil refining enterprises. The authors consider and set the objectives of the influence of tax, customs-tariff and macroeconomic factors. The study provides statistics of the Ministry of Finance of the Russian Federation on the amounts of lost oil and gas revenues from the federal budget. The article considers the exchange rate as one of the key factors influencing the dynamics of macroeconomic indicators. The paper analyses the prices of “Urals” crude oil on the world oil industry markets. The authors discuss changes and modernization of the oil-refining industry.

The article deals with the problems of perishable goods handling process at Russian airports on delivery in international supply chains (ISC). The investigation was carried out on the basis of operational analysis. The initial stage of the study, which was performed applying statistical analysis, revealed that the major category of perishable goods which establish air transportation demand into Russia is the fresh exotic fruits. The investigation was performed taking the mango supply chain as an example, due to its non-standard thermal and storage requirements. The second stage resulted in the perishable goods airport handling quality criteria set formation: the number of mandatory cargo while handling operations, the required time for these operations, the amount of paper work, the number of multi-temperature chambers at the airport and their area, ULD temperature storage system availability. The study revealed that about 90% of perishable goods, which are imported to Russia, are handled at the airports of Moscow aviation hub because other airports in Russia lack the temperature storage facilities infrastructure. This restriction raises the price of perishable goods logistics on the territory of the country considerably as well as reduces their quality. Four international airports of strategic importance outside the boarders of the central federal district which have the potential of forming central hubs for perishable goods handling as well as processing of transit and transfer flows were chosen in the context of this study. Among them are the airports of Novosibirsk, Vladivostok, Yekaterinburg and Krasnoyarsk. The airports of Moscow aviation hub were offered specialization on the subject of perishable goods export-import flow handling. The materials received from airlines, major cargo terminals at Russian airports, transport companies, specialized international air transport enterprises and logistics associations were exploited as the data for this study. The research registered that the deterrence to the speed of supply chain operation is the time of cargo ground service at Russian airports which considerably exceeds the cargo ground service time in the exporting country. The delays are connected with the poor development of perishable goods handling cargo terminals and also with loads of paper work because the system of electronic workflow and automated checking of markings doesn’t exist. The model of electronic workflow in the International Supply Chain which utilizes pre-flight and pre-loading preliminary information about the cargo was offered. Block Chain system for checking the correct presentation of documents at all stages of the supply chain was introduced which reduces the total time of cargo ground handling process.

The article considers the role of strategic partnerships in the practice of integration interactions of industrial enterprises in the modern economic environment. The authors highlight the distinctive features of strategic partnerships from other forms of business integration. The paper ascertains that for industrial enterprises, strategic partnerships based on the mechanism of subcontracting are most applicable. The study develops a model of strategic partnership based on subcontracting. The article gives practical examples of creating strategic partnerships. The paper analyses the level of development of strategic partnerships in industry, as well as studies the infrastructure that provides this process. The authors focus on the problems that hinder the activation of the processes of creating strategic partnerships based on subcontracting in the regions. Based on the results of the article, the authors offer recommendations aimed at the successful implementation of the creation of strategic business partnerships in industry.

The article considers business process outsourcing from the point of view of the strategic basis for the activities of enterprises in an unstable economy. The paper shows that, presently, the outsourcing strategy is becoming the new norm and is changing the entire world economy. The study uses the author’s approach, based on the methods of scientific generalization, comparative analysis, systemic and situational approach. The paper justifies the application of the outsourcing strategy at enterprises, ascertains the main advantages and disadvantages of its implementation. The author develops a model of enterprise transformation based on business process outsourcing. The study gives recommendations for outsourcing business processes, the implementation of which will allow enterprises to optimize their management strategy in an unstable economic situation. This article can serve as a basis for further research in the field of strategic management based on outsourcing technologies.

Herbal medicines make up a large part of all medicinal products in the Russian market. Complex combinations of biologically active substances that are used as components in herbal medicines not only determine their therapeutic efficacy, but can also cause adverse reactions. The aim of this review was to analyse data on adverse effects of herbal medicines, and reasons and mechanisms behind their development. Special attention should be given to hepatotoxic and nephrotoxic effects of biologically active substances that are used as components in herbal medicines, because liver and kidney failure may lead to life-threatening conditions. The paper addresses hepatic adverse effects, including sinusoidal obstruction syndrome, caused by toxic biologically active substances of the pyrrolizidine alkaloids group. The paper summarises data on herbal medicines and toxic biologically active substances causing acute kidney injury and chronic kidney disease. It analyses potential clinically significant interactions that may occur during co-use of herbal and other types of medicines due to their pharmacokinetic and pharmacodynamic interactions. Further research involving collection, systematisation, and analysis of adverse effects of herbal medicines used alone or in combination with other medicinal products is needed to improve the safety of pharmacotherapy.

Introduction. The article is focused on differences in quality assurance-related obligations and responsibilities between Marketing Authorisation Holders (MAHs) and manufacturing authorisation holder (manufacturers) in pharmaceutical industry. In case of outsourcing and technical agreements there is a need to differentiate responsibilities related to quality assurance between the above mentioned categories.Text. The guidelines for the pharmaceutical sector of the European Union (EU) provide guidance on the responsibilities of the MAHs in relation to the GMP rules, which are scattered throughout the various chapters of the GMP and its appendices. In addition, certain provisions on this topic are contained in the EU directives. With this in mind the European Medicines Agency (EMA) issued in January 2020 a draft Reflection paper on Good manufacturing practice and Marketing Authorisation Holders. The draft clarifies that while certain activities of an MAH may be delegated to the manufacturer, MAH retains ultimate responsibility for the performance of a medicinal product, its safety, quality and efficacy. The important obligation of MAH in this context is to facilitate GMP compliance by establishing a robust two-way communication system with national competent authorities, manufacturing sites, Qualified Persons (QPs) certifying batches before release, and other interested parties. The MAH ought to communicate to manufacturing personnel, normally through QPs, production processes and related quality control procedures, including subsequent variations, described in registration dossiers.Conclusion. A general one conclusion: in view of rapid developments in the EU GMP Guide, the Eurasian Economic Union GMP requirements ought to be updated. In respect of specific responsibilities of MAH pertaining to GMP compliance the EMA draft Reflection paper merits attention as a guidance regarding separation of obligations and responsibilities between MAH and personnel of manufacturing sights.

Implementation of the task of creating a digital platform for a full-featured system of information and analytical support for public administration at the federal, regional and municipal levels, requires a lot of resources and serious expertise.In this regard, the subject of the study was the experience and trends in the construction and operation of digital platforms for state and public administration. The aim of the paper was to summarize the international practice of creating, operating and developing digital public administration platforms. As part of the study, the authors carry out a systematic, content and comparative analysis of various sources: regulatory documents, scientific papers, analytical materials of a number of international organizations, etc.The article presents the results of a study of world experience in the application of various tools to support e-government and support digital governance platforms. The authors describe global trends in the use of information and communication technologies to support public administration. The paper presents a list of general principles for the operation of digital platforms, gives the results of the analysis on the compliance with these principles of the state digital platform of the European Union, highlights its distinctive properties.The article forms proposals and development directions, based on the results and available studies on the development and promotion of digital management platforms, that can help accelerate the spread of digital transformation of public administration in the Russian Federation. The results of the study can be applied to identify the potential of the existing platform, its strengths and weaknesses, including in the context of the possibilities of developing the process of digital transformation of governance, as well as effectively moving towards the formation of the digital platform of public administration in the Russian Federation.

The article considers the possibilities of developing marketing interaction of higher education organizations with stakeholders using digital marketing tools and technologies. The study presents an overview of the University stakeholder groups in Russia and their classification according to the quadrants of influence. The author provides the tools and means of digital marketing communications in the context of stakeholder groups and the prospects for their use for organizing marketing communicative interaction of the University. The paper studies in detail the possibilities of developing marketing interaction between the university and students on the basis of modeling the student’s experience on the path of his movement from the applicant to the graduate.The presented student experience includes six main stages, including the search for a University for admission; submission of documents and enrollment; educational and extracurricular activities; graduation and graduation; employment; career development. The author highlights within each stage of the student’s experience the main points of contact with the University. The paper presents opportunities for the development of marketing interaction between the University and students through the introduction of digital tools and marketing technologies, as well as their impact on the student experience model.The article considers the possibility of developing software services as promising digital tools and technologies for use in higher education organizations, including the functional requirements for such services at the level of user requirements, including the applicant and student, as well asthe possibilities of digital marketing communications with students, including both online and offline communications.Based on the study, the author makes a conclusion about the main advantages of the development of digital tools and marketing technologies in organizing marketing interaction between the University and students, as one of the key groups of stakeholders.

The article describes the methodological, methodic and socio-project aspects of the views of the modern sociologist and political scientist M. Castells in the framework of a discursive analysis of the possibilities of their use in the further institutionalization of digital sociology, as a relatively autonomous set of scientific data of sociology. The author considers literary sources related to the scientific work of M. Castells, methodological tools of discursive analysis and databases. The paper describes theoretical approaches to the study of the concept of the power of communication in ontological and socio-cultural contexts, as well as the characteristics of the author’s empirical sociological research in the framework of disclosing the logical and semantic components of the concept under consideration. Based on the discursive analysis, the author reveals structural, functional, procedural, organizational and managerial components of the theoretical views of the scientist, which help to clarify the object-subject sphere and the methodological arsenal of sociological research in the field of information and communication network “Internet”. The article considers the scientific approaches of the scientist to clarify the concept of “power” by explaining the role and place of actors in it, as well as use by them of social networks for their influence. The author highlights separately the scientist`s disclosure of the “network society” concept, which determines the network structure of connections based on the activation of information. The paper describes the features of the scientific method of M. Castells, associated with the postulation of the thesis of the regularity of the continuous replacement of scientific concepts in the knowledge of power relations and communications, the importance of flexibility and changing the angle of view of the scientist to solve specific research problems. The author emphasizes the interdisciplinary nature of the scientific methodology, method and socio-project approaches of the scientist. The study gives the directions of implementation of scientific developments of M. Castells in digital sociology, substantiates socio-project ways of increasing the positive potential of Internet communications in the context of digital society development.

In the operation schemes of optical electronic devices (OED), such as digital autocollimators, direction finders, Shack-Hartmann sensors, as well as astro-orientation systems, projection measuring systems, geometric calibration schemes for OED, the photo-detector acts not only as a receiving device, but also as a measuring device. The tasks facing the OED photo-detectors. The solution to the problem is the use of several photo-detectors installed on one electronic board. Since OED photo-detectors act, inter alia, as measuring devices, it is necessary to perform their geometric calibration. Geometric calibration involves the measurement of interior orientation parameters used in the processing of OED images. Geometric calibration makes it possible to eliminate errors in mutual exposure of photo-detectors on one electronic board installed in the focal plane, as well as distortions introduced by the OED lens, primarily by distortion. The correctness of the interior orientation parameter determination is influenced by the relative position of the collimator, with the help of which the geometric calibration is performed, and the calibrated OED itself, i. e. the external orientation elements. The task is to separate the interior orientation parameters and the elements of external orientation. This is achieved using the method of mathematical processing of measured data in the forward and inverted positions of the collimator. This method of geometric calibration allows to use it for geometric calibration of OED with a large number of photo-detectors. The paper presents the results of the geometric calibration of the interior orientation parameters when the collimator projects a test object onto three photo-detectors of the OED layout. The factors influencing on the accuracy of the geometric calibration of the interior orientation elements for OED are determined in the paper. The developed method for geometric calibration of the interior orientation parameters for multi-matrix OED provides high measurement accuracy – not more than 0.1''–0.2''.

The author summarizes key science theories of the funded pension system and its development. Theaimof the article is to review and discuss the studies on the efficiency of the funded elements of the pension system from the perspective of international practices. The researchmethodsincluded generalization; classification and comparative analysis of theoretical and methodological approaches to evaluating the efficiency of a pension system and its elements; abstraction, which allowed us to classify existing pension plans on the basis of the materials presented in the paper; as well as scientific and grouping methods. The theoretical background of the research is based on the scientific studies indexed in Scopus, Web of Science and RSCI (Russian science citation index) for the period 1981–2019. To organize the presented data this period was divided into four stages depending on the role of the funded elements in the public pension system of the reviewed countries. Theresultsof the research are the systematization and classification of the studies under consideration. Cross-country analysis according to the selected criteria showed that distributive pension systems generally demonstrate a higher level of sustainability and efficiency, as well as are better at ensuring a decent standard of living for the population. The authorconcludesthat in order to increase the efficiency of funded elements it is necessary to reduce their influence on the national economic stability; develop additional regulations for pension investment schemes; implement macroeconomic reforms aimed at the development of funded elements, which require a sustainable national capital market. Theconclusions and resultsof the paper can be useful for further development of the Russian funded pension system and analytical work of the public and research organizations.

The paper presents the current etiopathogenetic classification of chronic cerebrovascular diseases (CVD) and discusses the role of hypertension, cerebral amyloid angiopathy, and genetically determined syndromes in the development of this pathological condition. It gives recommendations for the neuroradiological diagnosis of chronic CVD in accordance with the international standards. The paper discusses the clinical manifestations of chronic CVD, primarily vascular cognitive impairment. It discusses international guidelines for the examination and treatment of patients with chronic CVD, as well as the rules for stroke prevention in this patient cohort. The possibilities of pathogenetically based therapy in decreasing the severity of vascular cognitive impairment in the presence of chronic CVD are also highlighted.

Nowadays there are a lot of modern technologies in electronic lexicography: speech synthesis technology, cross-referencing between dictionary modules, spell-checking functions, etc. The increasing availability of online information has necessitated intensive research in the area of automatic text summarization within the Natural Language Processing community. Belarusian scientists are also interested in this sphere and new lexicographical approaches for creating a linguistic database are shown in the paper. The authors present English-Belarusian-Russian electronic dictionary TechLex. This is the project of the 2nd English Department and the Department of Software for Information Systems and Technologies of the Belarusian National Technical University. The linguistic database of the dictionary is compiled not by the traditional method of processing a large number of paper dictionaries and combining the received translations, but by sequential processing of scientific and technical English-language periodicals. While the designing the dictionary the authors have taken into account the analysis of modern electronic multilingual translation dictionaries and created a client-server application in the Java programming language. The client part of the system contains a mobile application for the Android operating system, which has been tested on tablets and smartphones with different screen diagonals. The interface of the TechLex dictionary is designed taking into account the possibility of adding new subject areas and filling them with appropriate lexical material. The main advantage of our dictionary is that it is the first technical multilingual electronic dictionary having a Belarusian version.

The paper deals with the actual problem of managing patients with drug-induced headache (DIH) in patients with primary headaches. It describes a clinical case of extremely severe DIH in a patient with chronic tension headache (TH). The paper analyzes the typical and atypical manifestations of DIH and discusses the role of prolonged stress in the development of TH. Special attention is paid to the problems with therapy and compliance during a long-term follow-up of the patient. Based on the clinical features of pain syndrome in the described patient, the authors suggest for the first time that the use of extremely high number of daily doses of combined narcotic analgesics for many years can result in recurrent DIH statuses. The paper discusses whether it is expedient to introduce the concept “DIH severity” and whether an additional clinical parameter “the number of doses of painkillers per month” can be of informative value, which has not been proposed yet in the literature. All the issues given in the paper are conjectural and are raised by the authors for further investigation of the DIH problem.

Studies on the influence of applying various technologies for combustion knock reduction have been presented in the paper. Among others, investigation concerning the following: over-expanded cycle, variable valve timing, internal and exhaust gas recirculation, leaning the combustible mixture and cooling the in-cylinder charge were of the interest. The research works were focused on impact of these technologies on both knock intensity reduction, and engine performance and toxic emissions. Results presented in the paper were coming from experimental investigation based on in-cylinder combustion pressure data acquisition. Additionally, knock intensity calculation methods were discussed. They are based on incylinder combustion pressure pulsations. Combustion knock intensity expressed by the maximum peak of the incylinder pressure pulsations shows a strong negative correlation with both the EGR ratio and relative equivalence ratio – lambda. With respect to a catalytic converter installed on the exhaust pipe line, applying EGR appears as better solution for knock reduction then leaning the combustible mixture because the catalytic converter needs stoichiometric mixture for effective NO x reduction. Furthermore, application of the over-expanded cycle to the hydrogen or coke gas fueled IC engine significantly reduces intensity of potential knock by 50 % in comparison to Otto cycle for all loads. Additionally, over-expanded cycle contributes to increase in engine thermal efficiency. Summing up, all the presented measures and technologies can be successfully implemented into practice in stationary engines as well as in traction engines, both of them working on either natural gas or gaseous renewable fuels.

The article provides an overview of the most influential papers on the topic of “male infertility”. The selection criteria were the practical significance of the article and the impact factor of the journal in which it was published, according to SCImago Journal Rank (SJR). As a result, we created the list of 10 papers published in the I quarter (January – March) of 2020. The review included articles on the following issues: the effectiveness and safety of antioxidants, zinc and folic acid in the treatment of male infertility; the effect of obesity on sperm DNA-fragmentation; the possibility of obtaining of spermatogonia in children and adolescents with Kleinfelter syndrome; comparison of intracytoplasmic sperm injection (ICSI) and intracytoplasmic morphologically selected spermatozoa injection (IMSI); the reaction of the female reproductive system to the seminal fluid; viral profile in seminal fluid of men receiving the antiretroviral therapy, the effect of sleep duration on fertility and the risk of diabetes mellitus in children, conceived using assisted reproductive technologies.

The paper discribes the method of remote voting at shareholders meetings via the Internet. The methodology of the study is based on the theory of agent costs. It means that costs associated with the exercise of control are important to investors within making investment decisions. The author considers conditions to the digitalization of voting processes: the Russian legislative framework; Internet access in the country; development of digital voting services; the provision of remote voting services by registrars and the Information Disclosure Center of JSC National Settlement Depository. The paper presents results of the analysis of the practice of using electronic voting services in Russian public companies. It has been proved that the creation of the Internet voting infrastructure has contributed to the activity growth of shareholders’ participation in Annual General Meetings. This, in turn, has a positive effect on the quality of corporate governance in these companies. The theoretical and practical significance of the study is to generalize the practice of using electronic voting technology in Russian corporations.

Digital transformation (digitization) of the financial industry is the reason behind the deep change in the models of interaction between actors in the financial market. However, a generally accepted interpretation of digitalization has not yet been proposed. The paper discusses the distinctive features of the financial industry digitalization and uses them as a basis for offering a unified description of the nature of this transformation. The methodological framework is the notion of three types of innovation – technology, organization, and product. The research methods used in the article are analysis and synthesis. The paper demonstrates how the types of innovation determine the nature of the digital transformation of the financial industry and how they are manifested in various digital financial products. Digital transformation of finance includes two aspects: (a) Fintech revolution, i.e. technological companies entering the financial market, and (b) adoption of innovative digital technologies by traditional financial companies. We propose the 4U model to describe the marketing aspect of the financial industry digital transformation and introduce the concept of flexible finance as a way to provide financial services that suggest lower liability of financial institutions. The research results show that, firstly, digital transformation of the financial industry is not limited to the technological aspect but also includes organizational and product-related elements. Secondly, the trends in the financial industry digitalization are similar to those in the digital transformation of the global economy.

The paper substantiates the need to harmonize the financial and non-financial statements of the company and to develop the corrspodig strategy in climate risks. The study assesses the impact of climate change risks on financial reporting indicators and formulates requirements for disclosing information in financial and non-financial statements. There a demand for such disclosures by investors is emphasized, as well as other interested parties, and the relevance of expanding and reorienting their contents from the task of describing the company’s environmental impact to the task of reflecting the climate impact on the company, its financial performance and strategy. The paper presents the results of a comparative analysis of the international standards` conceptual foundations for financial and non-financial reporting and shows their mutual consistency. Based on a comparative analysis of the international standards conceptual foundations, their mutual consistency has been proved, as well as there have been revealed accounting problems and disclosing information on climate risks in financial and corporate reporting. The results of the study (based on methods of logical analysis, abstraction, analogies, groupings, comparative analysis) are the key provisions formulated for developing a strategy for harmonizing financial and non-financial reporting, including climate risks. Also, there are shown recommendations for the preparation of disclosures regarding the interdependence of climate change and the results achieved with the development prospects of the company. The study may be of interest to Government bodies of the Russian Federation, relevant international organizations in the formation of standards for financial and nonfinancial reporting, interested users, as well as economic entities in the development of internal accounting and reporting standards.

This paper highlights published hypotheses on the possibility of coronavirus SARS-CoV-2 entry into the bloodstream, its interaction with vascular endothelium, red blood cells, hemoglobin and its fragments. As a result of such interaction, iron ions may be released into the bloodstream and, subsequently, a cytokine storm may occur. In this context, it is important to find a cytoprotective agent capable of blocking such processes. The perfluorocarbon emulsion could be a candidate for this role.The aim of the paper is to show the feasibility of biophysical methods to study the molecular mechanisms of action of SARS-CoV-2 on human red blood cells and hemoglobin as well as the restorative and cytoprotective effect of the perfluorocarbon emulsion during Fe2+ oxidation in heme.Materials and methods. High resolution spectroscopy, atomic force microscopy, atomic force spectroscopy, electroporation were used. Blood was exposed to oxidizing agents of different nature. Perfluorocarbon emulsion was added in various concentrations and its effect at various incubation times was studied. Concentration of hemoglobin derivatives was calculated considering multicollinearity, and statistical analysis of the results was performed.Results. The perfluorocarbon emulsion was shown to have an effective restorative and cytoprotective action in iron ion oxidation in the heme: Fe3+ was restored to Fe2+. The degree of MetHb reduction to HbO2 and Hb depended on the concentration of the oxidizing agent and incubation time. We observed a change in MetHb content from 80-90% to 5-12%. The perfluorocarbon emulsion in clinical concentrations helped eliminate local membrane defects and restored normal erythrocyte morphology.Conclusion. In the light of the studied hypotheses, the use of perfluorocarbon emulsion can become an effective method for blocking the consequences of coronavirus effect on the blood cells and restoring a normal gas exchange.

By examining the role of theaters and cinemas in daily life of the Yenissei province townspeople, the paper aims to analytically reconstruct their leisure activities in the early 1920s. During the period, one of the decisive factors in fundamental changes of socio-political relations was formation of a new Soviet sociocultural space and everyday practices of people, including leisure ones, fell into the sphere of dedicated state regulations. The sources the author has relied upon are primarily Siberian newspaper publications (Krasnoyarsky Rabochyi, published during the period 1920–25), previously unused, and legal sources of that time. Given the lack of the materials of personal origin, textual evidence of local periodicals should be considered as one of the important sources of information on everyday, including leisure, practices of townspeople. Although history of early Soviet society has been at the core of attention recently, the findings of the paper seek to contribute to a more complete understanding of the processes at work from the regional perspective of Siberia and analyze some features of cultural leisure practices at the grassroots level of Soviet society. This is what determined the choice of the territorial and chronological framework of the paper and, in turn, determined its relevance and novelty. The author has applied interdisciplinary, systemic, sociocultural approaches and analysis of historical sources on leisure.

The paper deals with a problem of the obfuscated JavaScript code detection and classification based on Abstract Syntax Trees (AST) coloring. Colors of the AST vertexes and edges are assigned with regard to the types of the AST vertexes specified by the program lexical and syntax structure and the programming language standard. Research involved a few stages. First of the all, a non-obfuscated JavaScript programs dataset was collected by the public repositories evaluation. Secondly, obfuscated samples were created using eight open-source obfuscators. Classifier models were built using an algorithm of gradient boosting on the decision trees (GBDT). We built two types of the classifiers. The first one is the model that classifies the program according to the type of the obfuscator used, i.e. based on what obfuscator created the sample. The second one tries to detect samples obfuscated by the obfuscator whose samples are not observed during training. The quality of the obtained models is on par with the known published results. The feature engineering method proposed in the paper does not require a preliminary analysis of the obfuscators and obfuscating transformations. In the final part of the paper we analyze a quality of models estimated, discussing the certain statistical properties of the obfuscated and non-obfuscated samples obtained and corresponding colored ASTs. Analysis of generated samples of obfuscated programs has shown that the method proposed in the paper has some limitations. In particular, it is difficult to recognize minifiers or other obfuscating programs, which change the lexical structure to a greater extent and the syntax to a lesser extent. To improve the quality of detection of this kind of obscuring transformations, one can built combined classifiers using both the method based on the AST coloring and the additional information about lexemes and punctuation, for example, entropy of identifiers and strings, proportion of characters in upper and lower case, usage frequency of certain characters etc.

Purpose of the research. The aim of the study is to develop recommendations on the selection of parameters for modifying the ant colony method when searching for a rational solution to the task of appointing employees to work, subject to setting the time to complete the work using fuzzy sets and taking into account the interaction time between employees assigned to one task. The algorithm is proposed for modifying the ant colony method. Various stopping algorithms of the modified ant colony method are considered.Materials and research methods. The use of the ant colony method developed for finding the traveling salesman’s path for the assignment problem requires the creation of a “decision graph” and some modifications of the algorithm associated with entering weights (pheromone) on the graph. The paper proposes to create a graph of solutions by creating a set of vertices that determine the appointment of an employee for tasks for each employee and calculating the path in the graph that determines the solution to the assignment problem. To stop the algorithm of the ant colony method, two different algorithms are considered: the stop when performing a certain number of iterations and the stop when finding a solution that satisfies the constraints. To evaluate the effectiveness of the algorithm, the following criteria were considered: the estimate of the mathematical expectation of the number of iterations of the algorithm, the estimate of the mathematical expectation of the criterion value, the estimate of the mathematical expectation of the number of considered solutions, etc. For all estimates of mathematical expectation, a confidence interval is also calculated. According to the estimates, the paper gives recommendations on the selection of parameters of the ant colony method: the number of agents, evaporation rate, parameters of the elite and ranked method of ant colonies, etc. Both the speed and the ability to find rational solutions for different values of constraints are evaluated.Results. The work considered the task of appointing 35 employees for 15 tasks. As a result, the following recommendations were identified on the choice of parameters to the modified method of ant colonies. The more agents, the better solution found, but the number of the considered solutions increases, which leads to an increase in search time. For the evaporation coefficient, it is recommended to choose a value in the range (0.8; 0.95). It is recommended to use a ranked algorithm with a parameter 4 times less than the number of agents in the group. The problem of “cycling” of the ant colony method, caused by the passage of agents along the same routes, is determined.Conclusion. The developed recommendations make it possible to use the ant colony method to solve the problem of assigning employees to tasks. The proposed recommendations on the parameters provide high speed and accuracy of finding a rational solution to the problem. The problem of “cycling” of the ant colony method is described.

Accumulation of knowledge on Crohn’s disease, and development of biological products intended for the treatment of its underlying cause formed the basis for the development of objective methods for assessing the intensity of the pathological process, which in turn affected scientific approaches to the planning of clinical trials in this field. To date, many international recommendations related to planning, conduct of clinical trials, and analysis of their results, have been updated. Considerable experience has been gained with clinical trials of medicines intended for the treatment of Crohn’s disease. Therefore, the methodological approach to the planning of pivotal clinical studies needs to be reviewed. The aim of the study was to develop requirements for planning and expert evaluation of clinical trials conducted with the aim of obtaining marketing authorisation for medicinal products for the treatment of Crohn’s disease. The paper analyses regulations, recommendations, and scientific literature on the treatment of Crohn’s disease and describes the methodology for planning clinical trials. It describes the evolution of approaches to clinical research planning since biological medicines appeared. The authors substantiate the need for an integrated concept of clinical research, which covers goals, estimated therapeutic effect, design, and choice of the statistical analysis method. They also provide scientific arguments in favour of a combined primary endpoint including endoscopic remission and the assessment of treatment results by the patient. The paper lists patient eligibility criteria in terms of “inducing and/or maintaining remission of the disease”. The authors analyse the main intercurrent events, their influence on the therapeutic effect, and propose approaches to the planning of endpoints, including assessment of intercurrent events. The paper highlights the fact that the principles of planning and conducting Phase III clinical trials need to be consistent with the evidence-based strategies of reducing the risk of incorrect assessment of efficacy and safety of new medicines, and that the obtained results have to meet the requirements of the regulatory authorities at the stage of marketing authorisation.

The paper discusses specific features of acute respiratory infections (ARI) progression in patients with comorbidity. The relevance of this study is accounted for by severe progression of ARIs in this group of patients, as well as by specific considerations of combining causal treatment of infections with life-long treatment of chronic diseases.The aim of the study was to use a clinical case to substantiate an optimal treatment strategy for influenza and associated complications in a comorbid patient.Results: the analysis of the clinical case showed that an unfavourable course of ARI in the patient was due to the lack of timely antiviral therapy, adverse effects of paracetamol during statin therapy, exposure to pneumonia pathogen degradation products, general intoxication, and immune response. The compromised medical history contributed to the development of severe complications. The paper proposes a strategy for selecting the most eff ective and safe approach to the treatment of ARIs in a comorbid patient.Conclusions: ARIs in patients with chronic diseases entail increased risks of complications that may arise both due to specific characteristics of the infection and unfavourable combination of drugs. Treatment regimens for infl uenza and other ARIs in comorbid patients should be eff ective and timely. Early antiviral treatment is especially important in patients with comorbidity. When choosing a treatment regimen, it is necessary to assess potential benefi ts of pharmacotherapy as well as associated risks, including those related to previously prescribed medicines.

The paper considers spatial organization of energy facilities with an emphasis on modern practice of the Republic of Belarus. The efficiency of enterprise operation in any industry including power industry is largely due to their architectural and planning organization. Knowledge of mechanisms and specific features of the changes taking place here makes it possible to justify a promising strategy for project activities, and therefore, it allows to manage development processes of the industry and thereby avoid many negative consequences. Energy facilities are a typological unit of industrial architecture, their formation has been started due to transition of industrial production to electric energy. Today the typology shows functional approach in architectural shaping, it includes a fairly large variety of constituent units and demonstrates a tendency towards diversification. In Belarus energy facilities in the architectural aspect of their classification are limited mostly to thermal power plants operating on different types of fuel. Currently the diversification is developing in the following areas: construction of hydropower facilities (small plants on reservoirs, medium power plants, low-pressure plants, run-of-the-river hydraulic power stations), alternative energy (wind power stations, photovoltaic power stations and biogas plants) and conventional energy (thermal power plant, mini-combined heat and power plant operating on renewable fuel). The results of Belarusian practice in construction of all types of facilities (hydropower, alternative and conventional energy), peculiarities of the architectural and planning organization of facilities at the current stage, correlation with global trends in the development of industrial architecture have been characterized in the paper. The paper has determined typological features of alternative energy facility architecture, opportunities and directions for implementation of architectural approaches, problems and prospects to develop scientific support for the project process.

In this article, the authors consider the possibility of using a hybrid energy storage system to even out the load profile of the enterprise. Solving the problem of rational use of energy storage taking into account the initial variable load schedule will significantly reduce not only the cost of electricity consumption by the enterprise, but also the costs of its production. Detailed characteristics of batteries with various types of electrolytes and supercapacitors are given. A model of the active scheme of a hybrid electric energy storage system consisting of a lithium-ion battery and a supercapacitor unit with the corresponding characteristics is presented. The model was carried out by using the SimPowerSystems software in MatLab. During the simulation, the temperature and the aging effects and of the batteries were not taken into account. The selfdischarge parameter of the battery was also not presented. As a result of the simulation, discharge characteristics of supercapacitors and batteries were obtained based upon which the expediency of their combined use for leveling load profiles of various types was substantiated. The paper presents the results of the simulation of operating modes of a hybrid energy storage device, combining the advantages of two types of energy storage devices, as well as a diagram of delivered power to the network, corresponding to the specified parameters. The paper provides a mathematical description of the increasing power by hybrid storage system resulting from the combined use of supercapacitors and batteries. The paper presents the dependence of the power increase ratio on the frequency and the pulse current duty ratio, which proves that the maximum possible output power of the hybrid storage system can be several times greater than the power of a single battery having the same parameters.

The present paper consists of two parts. In the first part, the issues of communication between government and business entities have been considered. The role of the communication for the modern society development has been assessed. Implementation of concepts of open government, public participation and corporate governance are the requirements to the governments who would like to “keep in touch” with business entities. In many countries, cooperation, awareness and continuous interaction not only with citizens, but also with business entities became important factors of changes in the system of management, especially in the government information policy. In such countries, a shift is observed of regulatory function toward more open and more interactive interaction. Business entities have a real chance now to influence the improvement and development of public policy and management system. The publications on this subject mainly those published abroad, have been analysed. A particular emphasis is on the characteristics of communication channels: reliability, speed and effectiveness (efficiency). In the second part of the paper, the issues of creation of “digital government”, as well as special aspects of creation of “digital government” in developing countries have been considered, although in many ways the processes of “digitalization” of government organs are characteristic for the developed countries as well. It has been noted, that the implementation of digital information technologies and digital communications in the public sector organization would have a favorable impact on the way the public services are provided. With proper implementation, the digital government may decrease the cost of provision of public services and establish conditions for better contacts with citizens, especially in distant and less populated regions. Digital government can also influence the creation of better transparency and accountability of the decisions made, stimulate the development of local digital culture and promote the development of democracy. To determine the efficiency of any particular act of communication the concept of “communicative result” is introduced. The cultural dependence of the communication result has been noticed.

The paper provides a review of the data available in the literature on the relationship of pain to the risk of OA progression. Network analyses and numerous studies, including those conducted at the V.A. Nasonova Research Institute of Rheumatology, have confirmed that pain syndrome is one of the significant predictors of knee OA progression. The major class of medications for OA pain includes nonsteroidal anti-inflammatory drugs. The paper gives data on the efficacy of meloxicam in OA patients, which is widely used in both Russia and other countries of the world. Meloxicam is characterized by a good safety profile in the gastrointestinal tract, cardiovascular and renal systems. It is the drug of choice in patients with musculoskeletal diseases, in particular OA. Good results in severe pain syndrome have been shown by a step-by-step regimen of meloxicam when the injection formulation of the drug is used in the first days of treatment, and then, to consolidate what has been gained from therapy, its oral dosage form is administered in terms of concomitant diseases.