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The paper gives information on the prevalence of allergic diseases in Aktobe depending on the level of an anthropotechnogenic load area. The findings indicate that children that the degree of immunodeficiency in persons living in different micro-areas of the city depends on the magnitude of environmental pollution. Among allergic diseases, pollinoses (58.6%) rank first, asthma (19.9%) and allergic rhinitis (15.6%) occupy the second and third places, respectively. At the same time, the incidence of allergic diseases is 21.2-30.3% of all cases in the areas near an industrial area and 9.1-12.1% in those maximally remote from it. The impact of environmental quality on the incidence of allergic diseases depends on gender and age.