1. Abordări farmacoterapeutice ale tusei cronice.
- Author
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Bacinschi, Nicolae, Țurcan, Lucia, Podgurschi, Lilia, Untură, Ludmila, Chianu, Marin, Guțu, Ina, Caracaș, Anastasia, and Mihalachi-Anghel, Maria
- Subjects
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TRP channels , *GABA receptors , *GABA agonists , *INFLAMMATORY mediators , *PURINERGIC receptors , *COUGH - Abstract
Cough is a common symptom which makes the patient to address for medical attention when it no longer improves and becomes annoying. Cough lasting more than 8 weeks is evaluated as chronic, refractory, idiopathic or unexplained, that does not respond to classic antitussive preparations and requires a differentiated and thorough approach. Cough and non-cough stimuli, including subtreshold, through a series of biological peptides, mediators of inflammation and immune processes, can generate a series of nonspecific mechanisms. In these cases, new strategies are needed based on the elucidation of peripheral and central mechanisms of hypersensitivity to cough. Research on centrally acting neuromodulators – GABA agonists (baclofen), antidepressants (amitriptyline), antiepileptics (gabepentin, pregabalin), potential transient receptor channel antagonists, new tachykin antagonists, P2X3 purinergic receptor blockers (gefapixant), H1-antihistamines and opioids – opens new perspectives in the pharmacotherapy of chronic refractory cough. [ABSTRACT FROM AUTHOR]
- Published
- 2021