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The purpose of this study was to verify the influence of antinociceptiv effect by associating an opioid drog respectively a NSAID with an angiotensin converting enzyme inhibitor . We also tested the analgesic effect of each drug used and we compared the results. Material and method: We used 5 groups of 10 mice Swiss breed and device Tail Flick Unit, standardized assessment to analgesics activities in animal experiments. The 5 groups were treated as follows: Group I: Tramadol; Group II: Etoricoxib; Group III: Enalapril; Group IV: Tramadol and Enalapril; Group V: Etoricoxib and Enalapril. Subsequently each animal from the lots above were exposed to pain stimulus 0, 15, 30, 60 and 90 minutes after treatment. Results: The mice from each lots had the maximum analgesic point at 30 minutes after the treatment administration. Among the 5 groups at the same time (T 30) animals in group I had the lowest sensitivity to pain stimulus (p <0.0001) followed by the animals in group II, III respectively group V. Conclusions: Among all the treatments done, the most effective was for the group treated with tramadol, although the measurements done at T 60 and T 90, its analgesic effect was matched by Etoricoxib. We observed a decrease in analgesic effect when we associated tramadol respectively Etoricoxib with Enalapril. Between the two was the more effective combinations that I used along with Enalapril Tramadol to all measurements (p <0.05), although the group treated with enalapril had a mild analgesic effect measurements made at 15', 30', 60 'and 90' compared with the time T0 (p<0.05) [ABSTRACT FROM AUTHOR]