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Menopause and the associated symptoms are a continuing challenge for a more specific therapy that presents a good benefit-risk ratio. Hormone replacement therapy remains the first treatment option, despite its present risks. It is very important to individualize the therapy, depending on age, the characteristics of the symptoms and the patient's history. Another important aspect is the choice of the most suitable pharmaceutical form for the patient. [ABSTRACT FROM AUTHOR]

Acute pancreatitis is an acute inflammatory process of the pancreatic acinar cells. In severe cases of acute pancreatitis development can lead to multiple organ dysfunction. International studies in recent decades have highlighted numerous prognostic factors in severe acute pancreatitis: clinical, biological, intraopera-tive and pathological. Our research aims to identify the factors of prognosis in severe acute pancreatitis. The study was prospective and included a sample of 238 patients diagnosed with acute pancreatitis and its complications. Of all patients, 43.28% had severe acute pancreatitis, and 58.83% were male. Age over 55 years was found in 52.43% of patients with severe form and only 33.33% of patients with mild form. Female patients with obesity and aged between 60 and 80 years more frequently develop acute pancreatitis. Mortality among obese patients with the severe form is four times higher than in obese patients with mild form. Although female patients appear more frequently develop complications, total number of deaths occurring in obese patients is higher in males compared to the females. Conclusion. Age and obesity are factors useful for more precise prediction of severity of acute pancreatitis. [ABSTRACT FROM AUTHOR]

Introduction - Myeloperoxidase (MPO) is an abundant hemoproteine released mainly by activated neutrophil and is present in some tissue macrophages such as those in vascular lesions. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation and acute complication phases of the atherosclerotic process. Objective - We have examined the association between myeloperoxidase serum levels and the prognosis of pacients with unstable angina. Methods - We have evaluated 37 patients, age under 75, consequently hospitalized in the Cardiology Clinic of Emergency Clinic Hospital of Constanta, diagnosed with unstable angina and 18 healthy volunteers (without cardiovascular affections, hypercholesterolemia, diabetes and non-smokers). After discharge, the patients were monitored and the following data was recorded: death due cardiovascular cause and onset of major cardiovascular events or the need for coronary revascularization during 6 months of follow-up. The patients were divided in two groups: the first group - 10 patients with unstable angina with readmission in the following 6 months and the second group - 27 patients with unstable angina and good evolution. Myeloperoxidase activity was measured over a fixed time: T1 at hospital admission, T2 - at 48 hours and T3 - at discharge. Results - Serum MPO levels in patients with unstable angina and readmission in following months were significantly higher than in patients with good evolution (T1 - 2.4700 vs. 1.2259, pT = 0.0016; T2 - 2.9800 vs. 1.9667, pT = 0.0426; T3 - 3.2200 vs. 16259, pT = 0.0012) or in age-matched control patients (2.4700 vs 0.8444, pT=0.0002; 2.9800 vs 0.8444, pT<0.0001; 3.2200 vs 0.8444, pT<0.0001). Conclusion - Based on our study, we conclude that myeloperoxidase are elevated in serum after acute coronary event. In patients with unstable angina, increased MPO serum levels predicts an increased risk for subsequent cardiovascular events, so that MPO may serve both as a marker of diagnosis and as prognosis in patients who present chest pain. [ABSTRACT FROM AUTHOR]

The sinovial sarcoma is extremely rare; seven cases have been described in the literature of specialty. The majority of synovial sarcomas are localized in the right heart. Dispnoea, palpitations and syncopa are the major symptoms of the heart tumors. Th e echocardiography allows the detection of masses and of the pericardial liquid. The heart synovial sarcoma has a bad prognosis, in general, the medium survival being about 6 month. In this paper we will present a case of synovial heart sarcoma, localized in the left ventricle in which the echocardiography allowed the visualization of pericardial liquid and the cardiac masses. The pericardiocentesis shows the hemoragycal nature of pericardial liquid. Th e case presented, evolutes to death in 10 month from the surgery, the survival being above the medium survival described in literature, probably due to the low grade of the mitotic activity. [ABSTRACT FROM AUTHOR]