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Cleft lip and palate are the most widespread orofacial malformations, being considered by the World Health Organization to be a relevant public health problem, afflicting 1 in 700-1000 newborns worldwide. The anomaly is characterized by the lack of continuity of the tissues that form the upper lip, the alveolar process, and the soft and hard palate. The severity varies from a small cleft lip to a complete cleft that extends to the palate, sometimes also to the nose and hearing apparatus. Because of their disturbing appearance in many cases, these malformations have attracted much attention in terms of treatment and patient management. The major impact of cleft lip and palate on physiognomy and functionality places this type of malformations in the category of major public health problems worldwide. Advances in fetal ultrasound and MRI have significantly increased the accuracy of diagnosing fetal abnormalities. Once a malformation is suspected, genetic tests can be performed to verify the results of the ultrasound and/or MRI examination. Ultrasound is widely used to diagnose clefts prenatally and, not surprisingly, 3D ultrasound is superior to 2D ultrasound in accurately detecting cleft lip. While ultrasound is excellent for assessing prenatal craniofacial morphology, visualizations can be limited by overlapping hard structures. As a result, MRI is increasingly being used to overcome this problem and to complement ultrasound. Using fetal ultrasound and magnetic resonance imaging (MRI), there is the opportunity for diagnosis in utero, which will allow for the customization of care throughout pregnancy and then in the postnatal period throughout the child’s life. At the same time, patients with cleft lip and palate may have associated intracranial and extracranial anomalies and dentofacial deformities that represent the sequelae of the cleft, aspects for which the imaging examination provides extremely valuable information and has an impact on the optimal therapeutic management of children with such pathology. [ABSTRACT FROM AUTHOR]