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The discovery of the relationship between smoking and genetic factors has been the focus of research over the last 10 years. In the following material we will approach the intervention of genetic factors in nicotine addiction, but also the protection against starting and continuing smoking, the influence on smoking withdrawal, on tobacco-induced medical conditions, the implication in the association of smoking with other types of drugs intake and the way in which these discoveries will influence genetic therapies in the future.

The study of evaluation and rehabilitation of COPD patient (SERBOC) started in January 2004 in the 6th Medical Clinic of the Iaşi Rehabilitation Hospital. One of its goals is to evaluate the left cardiac morphology and function in the chronic obstructive pulmonary disease. The inn-patients have been complexly approached by physical examination, chest X-ray, rest electrocardiogram, echocardiography and Holter monitoring. The stage result is that physical examination, chest X-ray and rest electrocardiogram fails in offering satisfactory information regarding left cardiac dysfunction; it is necessary to add Holter monitoring and especially echocardiography. The conventional and Doppler echocardiography performed in our clinic allowed the possibility to identify diastolic dysfunction in all 9 patients and systolic dysfunction in 7 of them.